公开(公告)号：US10086214B2

公开(公告)日：2018-10-02

申请号：US15191433

申请日：2016-06-23

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  G21K1/093 ,  G21K5/04 ,  G21K1/087 ,  A61B6/03 ,  A61B6/04 ,  A61B6/00

Abstract: The invention relates to a method and apparatus for generation of two-dimensional images using X-rays, proton tomography, and/or carbon ion tomography to form one or more independent and/or integrated three-dimensional images of a tumor, where the proton and carbon cation beams use common elements of a tumor treatment beam, such as an injector, accelerator, and/or beam transport device. A previously collected image of the tumor and/or a current/real-time image control slice is used in control of a multi-axes and/or a multi-field tumor irradiation system for cancer irradiation.

公开(公告)号：US20170056690A1

公开(公告)日：2017-03-02

申请号：US15228514

申请日：2016-08-04

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  H05H7/10 ,  H05H7/08 ,  H05H7/12 ,  H05H13/04 ,  H05H7/00

CPC classification number: A61N5/1077 ,  A61N5/1037 ,  A61N5/1043 ,  A61N5/1067 ,  A61N5/1068 ,  A61N5/107 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1097 ,  H05H7/001 ,  H05H7/08 ,  H05H7/10 ,  H05H7/12 ,  H05H13/04 ,  H05H2007/082 ,  H05H2007/087 ,  H05H2007/125

Abstract: The invention comprises a multi-axis charged particle irradiation method and apparatus. The multi-axis controls includes separate or independent control of one or more of horizontal position, vertical position, energy control, and intensity control of the charged particle irradiation beam. Optionally, the charged particle beam is additionally controlled in terms of timing. Timing is coordinated with patient respiration and/or patient rotational positioning. Combined, the system allows multi-axis and multi-field charged particle irradiation of tumors yielding precise and accurate irradiation dosages to a tumor with distribution of harmful proximal distal energy about the tumor.

Abstract translation: 本发明包括多轴带电粒子照射方法和装置。 多轴控制包括对带电粒子照射束的水平位置，垂直位置，能量控制和强度控制中的一个或多个的单独或独立的控制。 可选地，带电粒子束根据定时被附加地控制。 时间与患者呼吸和/或患者旋转定位相协调。 综合起来，该系统允许肿瘤的多轴和多场带电粒子照射产生精确和准确的辐照剂量，使肿瘤附近有害近端远端能量分布。

公开(公告)号：US09543106B2

公开(公告)日：2017-01-10

申请号：US14860577

申请日：2015-09-21

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J27/00 ,  H01J27/20 ,  A61N5/10 ,  G21K1/093 ,  G21K5/04 ,  H01J35/14

CPC classification number: H01J27/20 ,  A61N5/1077 ,  A61N2005/1087 ,  G21K1/093 ,  G21K5/04 ,  H01J35/14

Abstract: A charged particle cancer therapy system is used to accelerate an anion, such a C−, and to convert the anion to a cation, such as C6+, through use of one or more electron extraction subsystems. A first example of an electron extraction subsystem is a hydrogen gas electron stripping system. A second example of an electron extraction subsystem is a carbon foil electron stripping system. The resultant cation is accelerated in a synchrotron, transported along a beam-line, and targeted to a tumor resulting in ablation of the tumor.

Abstract translation: 使用带电粒子癌症治疗系统来加速阴离子，如C-，并通过使用一个或多个电子提取子系统将阴离子转化成阳离子，如C6 +。 电子提取子系统的第一个例子是氢气电子剥离系统。 电子提取子系统的第二个例子是碳箔电子剥离系统。 所得阳离子在同步加速器中加速，沿着束线传输，并靶向肿瘤，导致肿瘤的消融。

公开(公告)号：US09498649B2

公开(公告)日：2016-11-22

申请号：US14293861

申请日：2014-06-02

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G01N21/00 ,  A61N5/10

CPC classification number: A61N5/10 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1087 ,  A61N2005/1097

Abstract: A patient positioning/constraint apparatus and method of use thereof is described in combination with a charged particle cancer therapy system. In one embodiment, a patient is tilted about a longitudinal axis, such as rotation about a head-to-foot axis of the patient where the head-to-foot axis of the patient is horizontal. Optional side support constraints are optionally used to constrain radial movement of the patient on the tilted patient support. The side support constraints are optionally pre-formed to or coupled to a radially outer shape of an individual patient, such as the dexter or sinister side of the individual's head, arm, torso, hip, and/or leg. Patient tilt is optionally combined with rotation of the patient about a vertical axis, rotation of the entire patient about an axis not overlapped by the patient, and/or dynamic control of angles of incident charged particles directed by beamline magnets of the charged particle therapy system.

Abstract translation: 与带电粒子癌症治疗系统结合描述患者定位/约束装置及其使用方法。 在一个实施例中，患者围绕纵向轴线倾斜，例如围绕患者的头部到脚部轴线的旋转，其中患者的头部到脚部轴线是水平的。 可选的侧支撑约束可选地用于限制患者在倾斜患者支架上的径向运动。 侧支撑约束可选地预先形成为或联接到个体患者的径向外部形状，例如个体头部，手臂，躯干，髋部和/或腿部的屈曲或阴性侧面。 患者倾斜可选地与患者围绕垂直轴的旋转组合，整个患者围绕不与患者重叠的轴的旋转，和/或由带电粒子治疗系统的束线磁体引导的入射带电粒子的角度的动态控制 。

公开(公告)号：US20160303399A1

公开(公告)日：2016-10-20

申请号：US15191433

申请日：2016-06-23

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  A61B6/03 ,  A61B6/00

CPC classification number: A61N5/1039 ,  A61B6/032 ,  A61B6/0421 ,  A61B6/0478 ,  A61B6/541 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1052 ,  A61N2005/1054 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/087 ,  G21K1/093 ,  G21K5/04

Abstract: The invention relates to a method and apparatus for generation of two-dimensional images using X-rays, proton tomography, and/or carbon ion tomography to form one or more independent and/or integrated three-dimensional images of a tumor, where the proton and carbon cation beams use common elements of a tumor treatment beam, such as an injector, accelerator, and/or beam transport device. A previously collected image of the tumor and/or a current/real-time image control slice is used in control of a multi-axes and/or a multi-field tumor irradiation system for cancer irradiation.

Abstract translation: 本发明涉及一种使用X射线，质子断层摄影和/或碳离子层析成像产生二维图像以形成肿瘤的一个或多个独立和/或集成的三维图像的方法和装置，其中质子 并且碳阳离子束使用诸如注射器，加速器和/或束传输装置的肿瘤治疗束的共同元件。 先前收集的肿瘤图像和/或当前/实时图像控制切片用于控制用于癌症照射的多轴和/或多场肿瘤辐射系统。

公开(公告)号：US20160250503A1

公开(公告)日：2016-09-01

申请号：US15152479

申请日：2016-05-11

Applicant: Vladimir Balakin ,  Stephen L. Spotts

Inventor： Vladimir Balakin ,  Stephen L. Spotts

IPC: A61N5/10 ,  A61B6/03

CPC classification number: A61N5/1077 ,  A61B6/03 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1082 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/087 ,  G21K1/093 ,  G21K5/04 ,  H01J35/14

Abstract: The invention relates to a method and apparatus for control of a charged particle cancer therapy system. A treatment delivery control system is used to directly control multiple subsystems of the cancer therapy system without direct communication between selected subsystems, which enhances safety, simplifies quality assurance and quality control, and facilitates programming. For example, the treatment delivery control system directly controls one or more of: an imaging system, a positioning system, an injection system, a radio-frequency quadrupole system, a ring accelerator or synchrotron, an extraction system, a beam line, an irradiation nozzle, a gantry, a display system, a targeting system, and a verification system. Generally, the control system integrates subsystems and/or integrates output of one or more of the above described cancer therapy system elements with inputs of one or more of the above described cancer therapy system elements.

Abstract translation: 本发明涉及一种用于控制带电粒子癌症治疗系统的方法和装置。 治疗传递控制系统用于直接控制癌症治疗系统的多个子系统，而不选择子系统之间的直接通信，这增强了安全性，简化了质量保证和质量控制，并且有助于编程。 例如，治疗传递控制系统直接控制成像系统，定位系统，注射系统，射频四极杆系统，环加速器或同步加速器，提取系统，束线，照射中的一个或多个 喷嘴，龙门架，显示系统，瞄准系统和验证系统。 通常，控制系统集成子系统和/或将上述癌症治疗系统元件中的一个或多个的输出与上述癌症治疗系统元件中的一个或多个的输入集成。

公开(公告)号：US09314649B2

公开(公告)日：2016-04-19

申请号：US14231020

申请日：2014-03-31

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G21K1/08 ,  A61N5/10 ,  H01J37/141

CPC classification number: A61N5/1082 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1081 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/093 ,  G21K5/04 ,  H01J37/141 ,  H01J2237/0815 ,  H05H2007/007 ,  H05H2007/082

Abstract: A fast magnet switching method and apparatus used to rapidly redirect cations, such as H+ or C6+, in a beam path, such as during or between treatment of individual volumes or voxels of a tumor of the patient, is described. Switching means include rapidly increasing or decreasing applied current to a coil about a magnet, which rapidly alters a magnetic field crossing the charged particle path and redirects a charged particle beam away from the patient, such as to a charged particle beam stop. Means to rapidly induce the current change include: (1) using a separate high voltage power supply and/or (2) opening a switch to redirect current through a resistor. In both cases, the rapid current change to the coil yields a rapid change the magnetic field and a corresponding rapid change in direction of the charged particles in the charged particle cancer therapy system.

Abstract translation: 描述了用于在诸如患者的肿瘤的个体体积或体素的处理期间或之间的波束路径中快速重定向阳离子（例如H +或C6 +）的快速磁体切换方法和装置。 切换装置包括对围绕磁体的线圈的施加电流迅速增加或减小，其迅速改变穿过带电粒子路径的磁场并将带电粒子束重新定向远离患者，诸如带电粒子束停止。 快速引起电流变化的手段包括：（1）使用单独的高压电源和/或（2）打开开关以使电流重新定向通过电阻器。 在这两种情况下，线圈的快速电流变化都会迅速改变带电粒子癌症治疗系统中带电粒子的磁场和相应的方向快速变化。

公开(公告)号：US20150273242A1

公开(公告)日：2015-10-01

申请号：US14257516

申请日：2014-04-21

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: A61N5/1081 ,  A61N5/1044 ,  A61N2005/1087 ,  A61N2005/1095 ,  H05H13/04 ,  H05H2007/002 ,  H05H2007/007

Abstract: A rotatable patient positioning apparatus and method of use thereof is described in combination with a rotatable magnet at a termination of a beamline arc. The rotatable patient positioning system optionally: (1) rotates a median of the person in place about a vertical axis and/or (2) rotates the entire person along a path around a vector, such as a vertical axis, where no part of the person intersects the vector. The rotatable targeting magnet rotates independently of a beamline arc at the end of the beamline arc, where the arc is after an accelerator and before the patient in a cancer therapy system. The rotatable targeting magnet directs the charged particle beam, such as vertically, using applied current to the targeting magnet while rotation of the magnet allows scanning across the tumor. The rotatable patient positioning system and targeting magnet combine to target the tumor in three-dimensions.

Abstract translation: 可旋转的患者定位装置及其使用方法与束线弧终止处的可旋转磁体一起进行描述。 可旋转的患者定位系统可选地：（1）使人的中位数围绕垂直轴旋转，和/或（2）沿着诸如垂直轴的矢量周围的路径旋转整个人，其中， 人与矢量相交。 可转动的定向磁体与束线弧的末端处的波束线弧独立地旋转，其中电弧在加速器之后并且在癌症治疗系统中的患者之前。 可旋转定向磁体通过使用施加的电流将带电粒子束（例如垂直）引导到靶向磁体，同时磁体的旋转允许跨越肿瘤扫描。 可旋转的患者定位系统和靶向磁体组合成三维靶向肿瘤。

公开(公告)号：US08969834B2

公开(公告)日：2015-03-03

申请号：US13572567

申请日：2012-08-10

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00 ,  A61N5/10 ,  A61B6/02 ,  H05H7/10 ,  H05H13/04

CPC classification number: A61N5/1077 ,  A61B6/02 ,  A61N5/10 ,  A61N5/1043 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a rapid patient positioning system including a computer and motor controlled patient constraint system, such as a patient head and/or back support system having multiple adjustable degrees of freedom that facilitates accurate, precise, and rapid alignment of a patient relative to a support or table. The patient support system is preferably integrated with a rapid patient positioning system including steps of: positioning a patient relative to the table in a substantially vertical orientation, transitioning the table through a semi-vertical orientation, such as with a robot arm, and orientating the patient and the table in a substantially horizontal orientation, such as in a position for charged particle tumor therapy. Preferably, the robot arm is in common with an arm used to move the patient in traditional proton therapy.

Abstract translation: 本发明包括快速的患者定位系统，其包括计算机和马达控制的患者约束系统，例如具有多个可调节自由度的患者头部和/或后支撑系统，其有助于患者相对于患者的准确，精确和快速对准 支持或表。 患者支撑系统优选地与快速患者定位系统集成，包括以下步骤：将患者相对于桌子以基本竖直的方向定位，使得桌子通过诸如机器人手臂的半垂直取向过渡，并将 患者和桌子处于基本水平的方向，例如用于带电粒子肿瘤治疗的位置。 优选地，机器人臂与用于在传统质子治疗中移动患者的手臂相同。

公开(公告)号：US08637818B2

公开(公告)日：2014-01-28

申请号：US13456840

申请日：2012-04-26

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J49/30

CPC classification number: H05H13/04 ,  H05H7/04

Abstract: The invention comprises a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, flat surface incident magnetic field surfaces, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌性肿瘤的带电粒子束放射治疗一起使用的带电粒子束加速，提取和/或靶向方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了转动磁体，边缘聚焦磁体，集中磁场磁体，绕组和控制线圈，平面入射磁场表面和提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接减少 即使在从同步加速器提取质子的过程中，所需磁场的尺寸也能直接降低所需的工作功率，并允许同步加速器中质子的持续加速。