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公开(公告)号：US20230340028A1
公开(公告)日：2023-10-26
申请号：US18059171
申请日：2022-11-28
IPC分类号： C07K14/005 , C12N7/00 , C12N15/85 , A61P31/14 , A61K39/215
CPC分类号： C07K14/005 , C12N7/00 , C12N15/85 , A61P31/14 , A61K39/215 , C12N2770/20023 , C12N2770/20022 , C12N2800/10
摘要： The present invention relates i.a. to a recombinant avian coronavirus spike protein or fragment thereof comprising a mutation at amino acid position 267 to Cysteine. Further, the present invention relates to an immunogenic composition comprising an avian coronavirus with such spike protein.
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82.发明公开公开(公告)号：US20230277648A1
公开(公告)日：2023-09-07
申请号：US18067614
申请日：2022-12-16
发明人： Veljko NIKOLIN , Egbert Siegfried MUNDT , Fernando Rodriguez GONZALEZ , Laia Bosch CAMOS , Javier Alonso COLLADO MIGUENS
CPC分类号： A61K39/12 , C12N15/746 , C12N15/86 , A61K2039/552
摘要： The present invention relates to African swine fever virus (ASFV) peptides and/or polypeptides as well as immunogenic fragments thereof, corresponding encoding AFSV oligonucleotides and/or polynucleotides as well as immunogenic fragments thereof, immunogenic compositions, vaccines and uses thereof.
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公开(公告)号：US20230210394A1
公开(公告)日：2023-07-06
申请号：US18159241
申请日：2023-01-25
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. , Boehringer Ingelheim Vetmedica GmbH
IPC分类号： A61B5/0255 , A61B5/00 , A61B7/04
CPC分类号： A61B5/0255 , A61B5/7264 , A61B7/04 , A61B2503/40
摘要： A method for analyzing an acoustic signal having a time period and having a plurality of repeated audio patterns, has the following steps: receiving an audio signal having the acoustic signal; determining the audio patterns repeated within the acoustic signal; determining a window length for a plurality of windows, wherein the window length divides the time period of the acoustic signal into the plurality of windows; and windowing the acoustic signal to obtain the plurality of windows.
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公开(公告)号：US11679212B2
公开(公告)日：2023-06-20
申请号：US16101617
申请日：2018-08-13
发明人： Marcus Knell , Michael Aven , Benjamin Franzmann , Steffen Schuy , Herbert Wachtel , Guido Endert , Alexander Christ , Horst Wergen
CPC分类号： A61M15/08 , A61D7/04 , A61M15/009 , A61M15/0013 , A61M15/0073 , A61M15/0086 , A61M15/0093 , A61M15/0096 , B05B11/1056 , A61M15/0018 , A61M2205/581 , A61M2205/583 , A61M2250/00 , B05B7/0012 , B05B11/0038 , B05B11/1091
摘要： An inhaler, preferably for insertion into a nostril, in particular a horse's nostril, with a pressure generator, which has a tensioning device for the drive, and with a tensioning mechanism for tensioning the tensioning device, whereby the tensioning mechanism has a lever gear for tensioning the tensioning device.
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公开(公告)号：US20230159543A1
公开(公告)日：2023-05-25
申请号：US18050567
申请日：2022-10-28
发明人： Hannes Fiepko KOOLMAN , Bart HERLÉ
IPC分类号： C07D487/04 , C07D513/04 , C07D491/052
CPC分类号： C07D487/04 , C07D513/04 , C07D491/052
摘要： This invention provides for compounds of the formula:
wherein the variables are defined herein, or salt thereof, compositions comprising these compounds, and methods for the treatment, control and/or prevention of a parasitic infestation and/or infection in an animal in need thereof by administering an effective amount of these compounds to said animal.-
公开(公告)号：US11649104B2
公开(公告)日：2023-05-16
申请号：US17308099
申请日：2021-05-05
发明人： Marcus Rainer Rahmel , Guido Endert , Jonas Ruf , Horst Wergen
CPC分类号： B65D81/3211 , A61J1/2089 , B65D21/0231 , B65D43/02 , A61J1/2027 , A61J1/2065
摘要： A connecting system for providing a fluidic connection, preferably between containers, wherein the connecting system has at least two connecting arrangements configured to provide the fluidic connection, namely a first connecting arrangement and a second connecting arrangement, each of which is fluidically sealed in an initial state, wherein the first connecting arrangement has, in particular, an opening region that is deformable outside the opening region and is configured such that deformation causes the first connecting arrangement to open in the opening region.
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公开(公告)号：US11596681B2
公开(公告)日：2023-03-07
申请号：US16980723
申请日：2019-03-19
发明人： Alice Mundt , Andreas Gallei , Kristina Rehmet
摘要： The present invention relates to the field of (vector) vaccines, and especially to the novel EHV insertion site UL43. The present invention further concerns related expression cassettes and vectors, which are suitable to express genes of interest, especially antigen encoding sequences. The viral vectors of the present invention are useful for producing an immunogenic composition or vaccine.
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公开(公告)号：US20230054761A1
公开(公告)日：2023-02-23
申请号：US17759132
申请日：2021-01-19
发明人： Michael A. FOLAN , David J. FOLAN
摘要： The present disclosure provides delivery systems for functional ingredients, such as drugs, nutritional supplements, botanicals, and vitamins. The delivery systems comprise an ingestible matrix within which the functional ingredient(s) are substantially uniformly and completely dispersed. The matrix comprises foams derived by physical shear of egg white to achieve amplified available dose and improved release characteristics of functional ingredients at skin and mucosal surfaces for healthcare purposes. The disclosure also provides methods of preparing and using the delivery systems.
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公开(公告)号：US20220378737A1
公开(公告)日：2022-12-01
申请号：US17873638
申请日：2022-07-26
发明人： Saskia KLEY , Dania REICHE
IPC分类号： A61K31/351 , A61K38/28 , A61K9/20 , A61K9/48 , A61K9/02 , A61K31/7034 , A61K45/06 , A61K9/08 , A61K31/00 , C07D309/10 , A61P5/50 , A61P27/12 , A61K47/22 , A61K31/352 , A61P9/12 , A61K9/14 , A61P3/00 , A61P3/06 , C07D493/08 , A61P3/10 , A61P3/04 , A61P31/12 , A61P29/00 , A61K9/00 , A61K31/401
摘要： One or more SGLT2 inhibitors or pharmaceutically acceptable forms thereof are provided for use in the treatment and/or prevention of a metabolic disorder in a canine animal, preferably where the metabolic disorder is one or more selected from ketoacidosis, pre-diabetes, insulin dependent diabetes mellitus, insulin resistance diabetes, insulin resistance, obesity, hyperglycemia, hyperglycemia induced cataract formation, impaired glucose tolerance, hyperinsulinemia, dyslipidemia, dysadipokinemia, subclinical inflammation, systemic inflammation, low grade systemic inflammation, hepatic lipidosis, inflammation of the pancreas, metabolic disorder consequences, such as hypertension, renal dysfunction and/or musculoskeletal disorders, and/or Syndrome X (metabolic syndrome), wherein preferably the development of hyperglycemia induced cataract formation is prevented or remission is achieved and/or wherein preferably the development of metabolic disorder consequences, such as hypertension, renal dysfunction and/or musculoskeletal disorders, is prevented or progression is slowed or remission is achieved.
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公开(公告)号：US11512115B2
公开(公告)日：2022-11-29
申请号：US16867650
申请日：2020-05-06
IPC分类号： A61K39/00 , A61K39/215 , C12N7/00 , A61K39/12 , C07K14/165 , C07K14/005 , C12N15/85 , A61P31/14
摘要： The present invention relates i.a. to a recombinant avian coronavirus spike protein or fragment thereof comprising a mutation at amino acid position 267 to Cysteine. Further, the present invention relates to an immunogenic composition comprising an avian coronavirus with such spike protein.
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