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    Extra-corporeal Dual Stage Blood Processing Method and Apparatus
    81.
    发明申请
    Extra-corporeal Dual Stage Blood Processing Method and Apparatus 有权
    超身体双阶段血液处理方法和装置

    公开(公告)号：US20040249332A1

    公开(公告)日：2004-12-09

    申请号：US10709194

    申请日：2004-04-20

    申请人： GAMBRO, INC.

    发明人： Marlene Bainbridge ,  Muriel Keller ,  Timothy M. Gordon ,  Michael J. McAteer ,  Scott D. Butzke

    IPC分类号： A61M037/00 ,  B01D033/15

    CPC分类号： A61M1/3693 ,  A61M1/30 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3692 ,  A61M1/3696 ,  G06F19/00

    摘要： Methods and apparatus particularly involving the separation of blood into blood components and the collection of such components are disclosed. In one aspect, an extra-corporeal method for the collection of plasma and red blood cells is provided, wherein the collection of plasma and red blood cells may occur simultaneously or subsequently utilizing the same dual stage blood processing vessel. The flow of blood to the blood processing vessel and return of uncollected blood components may be provided via a single needle, wherein blood is removed from and returned to a donor/patient during alternating blood removal and blood return submodes. Platelet separation and collection options are also described. In either case, prior to red blood cell collection, a set-up phase may be carried out to set a predetermined hematocrit and AC ratio. Replacement fluid delivery may optionally also be provided either substantially continuously during any collection phase(s) and/or in a bolus mode.

    摘要翻译： 公开了特别涉及将血液分离成血液成分并收集这些组分的方法和装置。 一方面，提供了用于收集血浆和红细胞的额外体外方法，其中血浆和红细胞的收集可以同时发生或随后使用相同的双级血液处理容器。 可以经由单个针提供血液加工血液到血液处理容器的流动和未收集的血液成分的返回，其中在交替的血液清除和血液返回子模式期间从血液中取出血液并返回给供体/患者。 还描述了血小板分离和收集选项。 在任一种情况下，在红细胞收集之前，可以进行设置阶段以设定预定的血细胞比容和AC比。 替代流体输送可以任选地在任何收集阶段和/或以推注模式中基本连续地提供。

    Purified Water Supply System for High Demand Devices and Applications
    82.
    发明申请
    Purified Water Supply System for High Demand Devices and Applications 有权
    用于高需求设备和应用的净化供水系统

    公开(公告)号：US20040195157A1

    公开(公告)日：2004-10-07

    申请号：US10709530

    申请日：2004-05-12

    申请人： GAMBRO, INC.

    发明人： Stephen M. Mullins ,  Douglas A. Luehmann ,  John D. Bielefeld

    IPC分类号： B01D035/14

    CPC分类号： B01D61/145 ,  A61M1/1656 ,  A61M1/1668 ,  A61M2205/84 ,  B01D61/02 ,  B01D61/025 ,  B01D61/08 ,  B01D61/10 ,  B01D61/58 ,  C02F1/44 ,  C02F1/441 ,  C02F1/444 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T137/0402 ,  Y10T137/85954 ,  Y10T137/86035

    摘要： A water supply sub-system for connection to a main water supply system includes a storage tank having an inlet with a flow control valve for connection to the main water supply system. The sub-system may be disconnected from the main system and configured as a closed system for disinfecting the sub-system. An outlet line connects the storage tank to a pump that pumps water from the tank to a sub-system supply line. One or more branch connections may connect the sub-system supply line to high-demand water using devices, such as dialysis machines. The supply line may be a feedback loop. A shunt feedback loop parallel to the feedback loop of the supply line has a pressure control valve that regulates pressure in the supply line feedback loop. A filtration device may also be included to ensure the purity of the water circulating through the sub-system.

    摘要翻译： 用于连接到主供水系统的供水子系统包括具有入口的储罐，该入口具有用于连接到主供水系统的流量控制阀。 子系统可能与主系统断开连接，并配置为用于对子系统进行消毒的封闭系统。 出口管路将储罐连接到将水从水箱泵送到子系统供水管线的泵。 一个或多个分支连接可以将子系统供应管线连接到高需求用水的设备，例如透析机。 电源线可以是反馈回路。 与供电线路的反馈环路并联的分流反馈回路具有调节供应线路反馈回路中的压力的​​压力控制阀。 还可以包括过滤装置以确保通过子系统循环的水的纯度。

    Centrifuge for processing blood and blood components in ring-type blood processing bags
    83.
    发明申请
    Centrifuge for processing blood and blood components in ring-type blood processing bags 有权
    离心机用于处理环型血液处理袋中的血液和血液成分

    公开(公告)号：US20040162209A1

    公开(公告)日：2004-08-19

    申请号：US10627029

    申请日：2003-07-24

    申请人： Gambro, Inc.

    发明人： Niclas Hogberg ,  Emanuel Hallgren ,  Peter Pihlstedt

    IPC分类号： B04B011/00

    CPC分类号： A61M1/3693 ,  A61M1/0209 ,  A61M1/3696 ,  B04B5/0428 ,  B04B2013/006

    摘要： The claimed invention refers to a centrifuge intended for processing blood and blood components and with its function based on the effective utilisation of ring type blood processing bags with associated secondary bags and other accessories. The most outstanding feature of the centrifuge, in accordance with the claimed invention, is that its rotor, at the same intended height of the ring bag (22) inner periphery, shows at least three supports (9-11) arranged along this periphery and intended to locate the ring bag's inner strengthened periphery edge on guide holes at the same time as the centrifuge and its rotor is equipped with a joint rotating inner lid (6) which includes a clamp function (7) that clamps ring bag (22) securely along and between supports (9-11). Furthermore, in the invention these supports (9-11) have, on the one hand, built-in valve functions for communication between the ring bag and the respective secondary bags can be actively controlled and, on the other hand, sterile welding functions for communication between ring bag (22) and the respective secondary bags when interruption and blocking is required.

    摘要翻译： 所要求保护的发明是指旨在用于处理血液和血液成分的离心机，并且其功能基于有效利用具有相关次级袋和其它附件的环型血液处理袋。 根据要求保护的发明，离心机的最突出的特征是其在环袋（22）内周边的相同预期高度处的转子显示出沿着这个周边布置的至少三个支撑件（9-11） 旨在将离心机和其转子配备有接合旋转内盖（6）的同时定位在引导孔上的环袋的内部加强的周边边缘，其包括夹紧功能（7），该夹紧功能（7）牢固地夹紧环形袋（22） 在支撑（9-11）之间和之间。 此外，在本发明中，这些支撑件（9-11）一方面可以主动地控制环袋和相应的次级袋之间的连通的内置阀功能，另一方面，用于 当需要中断和阻塞时，环袋（22）和各个次级袋之间的通信。

    Centrifuge and container system for treatment of blood and blood components
    84.
    发明申请
    Centrifuge and container system for treatment of blood and blood components 有权
    离心机和集装箱系统用于治疗血液和血液成分

    公开(公告)号：US20040147387A1

    公开(公告)日：2004-07-29

    申请号：US10759767

    申请日：2004-01-16

    申请人： Gambro, Inc.

    发明人： Peter Unger ,  Eric Westberg

    IPC分类号： B04B007/12

    CPC分类号： B04B5/0428

    摘要： A Centrifuge for the separation and/or treatment of cells in a substantially annular or partially annular separation bag having a rotor with rotor shaft with a hollow upper portion defining a central compartment and a rotor bowl for the separation bag and a container system including the separation bag for use therewith.

    Apparatus for producing blood component products
    85.
    发明申请
    Apparatus for producing blood component products 有权
    用于生产血液成分产品的装置

    公开(公告)号：US20040096814A1

    公开(公告)日：2004-05-20

    申请号：US10699358

    申请日：2003-10-30

    申请人： Gambro, Inc.

    发明人： Robert Warner Langley ,  Larry Joe Dumont

    IPC分类号： A01N001/02 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50

    CPC分类号： A61M1/385 ,  A61M1/02 ,  A61M1/30 ,  A61M1/303 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2205/50 ,  Y10T436/101666 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/25375

    摘要： A method and apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield for the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield for the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield my be associated therewith, thereby providing a blood component product.

    摘要翻译： 用于生产血液成分产品的方法和装置。 在一个实施例中，从全血源收集多个预定类型的血液成分。 使用至少两种在线产量测定技术来确定收获的血液成分的产量。 一种是预定的产量预测技术，第二种是预定的产量监测技术，每种都是相对于预定的离线产量确定技术单独校准的。 预定的产量预测和监测技术各自提供收获的血液成分的产量，然后利用每个产量来提供确定的产量。 因此，当收集的血液成分被包装时，确定的产量与之相关联，从而提供血液成分产品。

    Fluid mixing and irradiation device and method especially for biological fluids
    86.
    发明申请
    Fluid mixing and irradiation device and method especially for biological fluids 审中-公开
    流体混合和照射装置和方法特别适用于生物流体

    公开(公告)号：US20030205454A1

    公开(公告)日：2003-11-06

    申请号：US10427260

    申请日：2003-04-30

    申请人： Gambro, Inc.

    发明人： Dennis Hlavinka ,  Michael A. Martinez

    IPC分类号： B01J019/08 ,  C07C001/00

    CPC分类号： B01F5/0615 ,  A61K41/0019 ,  A61L2/0005 ,  A61L2/0011 ,  A61L2/0047 ,  A61L2/0052 ,  A61L2/0064 ,  A61L2/0082 ,  A61L2/08 ,  A61L2/084 ,  A61L2/10 ,  A61L2/12 ,  A61M1/32 ,  A61M1/3681 ,  A61M1/3683 ,  A61M2202/0208 ,  A61M2202/0275 ,  A61M2206/14 ,  B01F3/22 ,  B01F3/2292 ,  B01F15/00857 ,  H05B3/0085

    摘要： The present invention relates to a method and/or apparatus suitable for use in reduction of any pathogens in a fluid such as a biological fluid, or a fraction or component thereof, which may contain pathogens. The device may include a vessel having an inlet and an outlet and a passage which extends therebetween. The passage may have a wall which is substantially transparent to a pathogen reduction radiation. The passage contains a static mixer system which is formed and arranged for thoroughly mixing the fluid in use of the device so as to bring substantially the whole of the fluid into an irradiation zone extending along and in substantially direct proximity to the passage walls during passage between the inlet and the outlet to be expose the fluid to a similar substantial level of irradiation. The static mixer may include light transmissive blades.

    摘要翻译： 本发明涉及适用于减少可能含有病原体的流体如生物流体或其部分或组分中的任何病原体的方法和/或装置。 该装置可以包括具有入口和出口的容器以及在它们之间延伸的通道。 通道可具有对病原体还原辐射基本透明的壁。 该通道包含静态混合器系统，其形成并布置成在使用该装置时使流体充分混合，从而使整个流体进入沿着通道壁延伸并基本上直接接近通道壁的照射区域 入口和出口将液体暴露于类似的显着水平的照射。 静态混合器可以包括透光叶片。

    Purified water supply system for high demand devices and applications
    88.
    发明申请
    Purified water supply system for high demand devices and applications 审中-公开
    净化水供应系统，用于高需求装置和应用

    公开(公告)号：US20030034305A1

    公开(公告)日：2003-02-20

    申请号：US10041898

    申请日：2002-01-07

    申请人： Gambro, Inc.

    发明人： Douglas A. Luehmann ,  Johnny W. Hannah ,  Stephen M. Mullins ,  John D. Bielefeld

    IPC分类号： B01D061/26

    CPC分类号： B01D61/145 ,  A61M1/1656 ,  A61M1/1668 ,  A61M2205/84 ,  B01D61/02 ,  B01D61/025 ,  B01D61/08 ,  B01D61/10 ,  B01D61/58 ,  C02F1/44 ,  C02F1/441 ,  C02F1/444 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T137/0402 ,  Y10T137/85954 ,  Y10T137/86035

    摘要： A water supply sub-system for connection to a main water supply system, in which the sub-system includes: a storage tank having an inlet for connection to the main water supply system, an outlet and an outlet line connecting the outlet of the storage tank to a pump which pumps water from the tank to a sub-system supply line. One or more branch connections are connected to the sub-system supply line. Connectable to the one or more branch connections are one or more high-demand water using devices, such as dialyzer re-use machines. The subsystem may feed water to these high demand devices, and the sub-system and the one or more high demand devices may thus be substantially isolated from the main water supply system so that the high demands thereof will not adversely impact the water supply parameters. Thus, one or more lower demand machines, such as dialysis machines, may be connected to the main line without supply parameter disruption thereto. The sub-system preferably further includes a feedback loop and the storage tank preferably has a spray head disposed therein, the spray head being disposed to spray inlet and/or recirculated feed back water into said storage tank. Among other alternative options, an ultrafiltration device may also be included in the sub-system supply line to ensure the purity of the water circulating through the sub-system.

    摘要翻译： 一种用于连接到主供水系统的供水子系统，其中所述子系统包括：具有用于连接到所述主供水系统的入口的储罐，连接所述储存器的出口的出口和出口管线 罐将其从水箱泵送到子系统供应管线。 一个或多个分支连接连接到子系统电源线。 可连接到一个或多个分支连接件是一个或多个高需求用水装置，例如透析器再利用机器。 子系统可以向这些高要求装置供水，并且子系统和一个或多个高要求装置因此可以与主供水系统基本隔离，因此其高要求不会不利地影响供水参数。 因此，一个或多个下层需求机器（例如透析机）可以连接到主线路而没有供应参数中断。 子系统优选地还包括反馈回路，并且存储罐优选地具有设置在其中的喷头，喷头设置成将进水和/或再循环的反馈水喷射到所述储罐中。 在其他替代方案中，超滤装置也可以包括在子系统供应管线中，以确保通过子系统循环的水的纯度。

    Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced approach
    89.
    发明申请
    Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced approach 有权

    公开(公告)号：US20020068675A1

    公开(公告)日：2002-06-06

    申请号：US10008989

    申请日：2001-11-02

    申请人： Gambro, Inc.

    发明人： Thomas J. Felt ,  Dennis J. Hlavinka

    IPC分类号： B04B007/12 ,  B04B009/00

    CPC分类号： B04B5/0442 ,  A61M1/0231 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  B04B5/0428 ,  B04B7/08 ,  B04B9/08 ,  B04B2005/045 ,  B04B2005/0464 ,  B04B2009/143

    摘要： A centrifugal separation device for use in a fluid separation system to centrifugally separate a composite fluid into the composite components thereof. This centrifugal separation device includes a centrifugal rotor housing and a rotor which is disposed in a freely rotatable disposition within the housing, the rotor having a fluid receiving area and several fluid flow channels defined therein. A composite fluid to be separated is delivered to the fluid receiving area from which it travels through a radial fluid transport channel to a circumferential fluid separation channel where it is subjected to substantial centrifugal forces which separate the composite fluid into components which each then travel to distinct first and second separated fluid outlet channels. The separated fluids then exit from these outlet channels and are then moved from the separation device to a collection bag for storage or may then be returned to the donor. The first and second fluid outlet channels also have respective first and second lengths which are related to each other so as to provide a substantial hydraulic pressure balance for the respective separated fluids flowing therethrough. Such a pressure balance controls the interface of the separated fluid components within the circumferential separation channel. The preferred relationship of the respective first and second lengths of said first and second separated fluid outlet channels to each other which provides the hydraulic balance is null3gh3nullnull3gh3 wherein the first length of the first outlet channel is h3, and the second length of the second outlet channel is h3, wherein g is a gravitational acceleration value and null3 represents the density of the fluids in the first outlet channel and null3 represents the density of the fluids in the second outlet channel. The preferred centrifugal drive motor used here produces a rotating magnetic field, which co-acts with a magnetically reactive material disposed in the rotor to rotate the rotor with the rotating magnetic field. A loopless, sealless continuous flow centrifuge is thus useful herein.