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公开(公告)号：US20110172163A1
公开(公告)日：2011-07-14
申请号：US13058325
申请日：2009-08-11
Applicant: Jonathan M. Harris , Joakim E. Swedberg
Inventor： Jonathan M. Harris , Joakim E. Swedberg
Abstract: The invention relates to KLK protease inhibitors. In particular, the invention is directed to KLK4 protease inhibitors and their uses in the treatment of a cancer, such as prostate cancer.
Abstract translation: 本发明涉及KLK蛋白酶抑制剂。 特别地，本发明涉及KLK4蛋白酶抑制剂及其在治疗癌症例如前列腺癌中的用途。
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82.发明申请CONSTRUCT CAPABLE OF RELEASE IN CLOSED CIRCULAR FORM FROM A LARGER NUCLEOTIDE SEQUENCE PERMITTING SITE SPECIFIC EXPRESSION AND/OR DEVELOPMENTALLY REGULATED EXPRESSION OF SELECTED GENETIC SEQUENCES 有权从大型核素序列允许位置封闭的通用形式释放的构建体特异性表达和/或开发的所选择的遗传序列的调控表达公开(公告)号：US20110119782A1
公开(公告)日：2011-05-19
申请号：US12948005
申请日：2010-11-17
Applicant: James Langham Dale , Benjamin Dugdale , Greg John Hafner , Scott Richard Hermann , Douglas Kenneth Becker , Robert Maxwell Harding , Srimek Chowpongpang
Inventor： James Langham Dale , Benjamin Dugdale , Greg John Hafner , Scott Richard Hermann , Douglas Kenneth Becker , Robert Maxwell Harding , Srimek Chowpongpang
IPC: C12N15/63 , C12N15/82 , A01H5/00 , A01K67/027
CPC classification number: C12N15/8282 , C12N15/79 , C12N15/8203 , C12N15/8216 , C12N15/8257 , C12N15/8263 , C12N15/8283
Abstract: The present invention relates generally to constructs and in particular genetic constructs comprising polynucleotide sequences capable of release in covalently closed, circular form from a larger nucleotide sequence such as, but not limited to, a genome of a eukaryotic cell. Preferably, once released, a polynucleotide sequence is reconstituted in a form which permits expression of the polynucleotide sequence. In one embodiment, the reconstituted polynucleotide sequence comprises a coding sequence with all or part of an extraneous nucleotide such as, but not limited to, an intronic sequence or other splice signal inserted therein. Expression and in particular transcription of the coding sequence involves splicing out the extraneous sequence. The release and circularization is generally in response to a stimulus such as a protein-mediated stimulus. More particularly, the protein is a viral or prokaryotic or eukaryotic derived protein or developmentally and/or tissue specific regulated protein.
Abstract translation: 本发明一般涉及构建体，特别是包含能够以较大核苷酸序列（例如但不限于真核细胞的基因组）以共价闭合的环形形式释放的多核苷酸序列的遗传构建体。 优选地，一旦释放，以允许多核苷酸序列表达的形式重构多核苷酸序列。 在一个实施方案中，重构的多核苷酸序列包含具有全部或部分外来核苷酸的编码序列，例如但不限于插入其中的内含子序列或其他剪接信号。 表达，特别是编码序列的转录涉及剪接外来序列。 释放和环化通常响应于诸如蛋白质介导的刺激的刺激。 更具体地，蛋白质是病毒或原核或真核衍生的蛋白质或发育和/或组织特异性调节蛋白。
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83.发明申请公开(公告)号：US20100281566A1
公开(公告)日：2010-11-04
申请号：US12570431
申请日：2009-09-30
Applicant: James Langham Dale , Robert Maxwell Harding , Douglas Kenneth Becker , Gregory John Hafner , Ilin Yang
Inventor： James Langham Dale , Robert Maxwell Harding , Douglas Kenneth Becker , Gregory John Hafner , Ilin Yang
IPC: C12N15/82 , C12Q1/70 , C12Q1/02 , C12N5/10 , C12N15/63 , A61K38/16 , C07K7/08 , C07K7/06 , C07K14/005 , A01H5/00 , A61P31/12
CPC classification number: C12N15/8216 , C07K14/005 , C12N15/8222 , C12N15/8223 , C12N2730/00022
Abstract: This invention discloses a constitutive promoter for expression of foreign or endogenous coding sequences in plants, including dicotyledonous and monocotyledonous plants. The invention also discloses a chimeric nucleic acid construct comprising the promoter of the invention operably linked to a foreign or endogenous polynucleotide that codes for a protein of interest or a transcript capable of modulating expression of a target gene. The invention further discloses transformed plant cells, as well as differentiated plants and plant parts, containing the construct. Methods for diagnosis and treatment of viral infections, especially badnaviral infections, are also disclosed.
Abstract translation: 本发明公开了一种用于在植物中表达外源或内源编码序列的组成型启动子，包括双子叶植物和单子叶植物。 本发明还公开了一种嵌合核酸构建体，其包含可操作地连接到编码目标蛋白质的外源或内源多核苷酸的本发明启动子或能够调节靶基因表达的转录物。 本发明还公开了转化的植物细胞，以及含有该构建体的分化植物和植物部分。 还公开了用于诊断和治疗病毒感染，特别是恶毒病毒感染的方法。
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公开(公告)号：US20100279927A1
公开(公告)日：2010-11-04
申请号：US12837992
申请日：2010-07-16
Applicant: Zee Upton , Jennifer Ann Kricker
Inventor： Zee Upton , Jennifer Ann Kricker
IPC: A61K38/30 , C07K14/65 , C07K14/485 , C07K14/50 , C07K14/51 , C07K14/81 , C07K14/79 , C07K14/00 , C07K14/78 , A61K38/02 , A61P35/00 , A61P17/06 , A61P9/10 , A61P35/04
CPC classification number: A61K47/48246 , A61K38/1709 , A61K38/30 , A61K38/39 , C07K14/71 , C07K14/78 , A61K2300/00
Abstract: An isolated protein complex is provided which includes a growth factor, growth factor binding protein and vitronectin. Preferably, the isolated protein complex includes an insulin-like growth factor-I, insulin-like growth factor binding protein-3 or insulin-like growth factor binding protein-5 and vitronectin. Also provided are methods of modulating cell proliferation and/or migration by administering said protein complex for the purposes of wound healing, skin repair and tissue replacement therapy. Conversely, by using agents that disrupt growth factor protein complexes formed in vivo, growth factor-driven cell proliferation and/or migration may be suppressed such as for the purposes of treating cancers, psoriasis, atherosclerosis and wounds prone to hypertrophic scarring.
Abstract translation: 提供了分离的蛋白质复合物，其包括生长因子，生长因子结合蛋白和玻连蛋白。 优选地，分离的蛋白质复合物包括胰岛素样生长因子-I，胰岛素样生长因子结合蛋白-3或胰岛素样生长因子结合蛋白-5和玻连蛋白。 还提供了通过对于伤口愈合，皮肤修复和组织置换治疗的目的施用所述蛋白质复合物来调节细胞增殖和/或迁移的方法。 相反，通过使用破坏体内形成的生长因子蛋白复合物的试剂，可以抑制生长因子驱动的细胞增殖和/或迁移，例如用于治疗癌症，牛皮癣，动脉粥样硬化和容易发生肥大性瘢痕形成的伤口。
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公开(公告)号：US20100276955A1
公开(公告)日：2010-11-04
申请号：US12665288
申请日：2008-06-19
Applicant: Bernard Chen , Timothy Robert Constable , Hung Nien Kha
Inventor： Bernard Chen , Timothy Robert Constable , Hung Nien Kha
CPC classification number: C21D9/34 , C21D1/667 , C21D9/04 , C21D2211/002 , C21D2211/008
Abstract: A method of treating a steel railway wheels to form a required distribution of compressive residual stress in the rim. In general terms the wheel heated and then quenched from the plate towards the rim. The wheel is first heated to form austenite throughout the plate and rim portions. The wheel is then cooled to form bainite/martensite in the plate portion. The wheel is cooled to form bainite/martensite in an inner portion of the rim. The wheel is cooled to form bainite/martensite in an outer portion of the rim.
Abstract translation: 一种处理钢铁车轮以在轮辋中形成压缩残余应力所需分布的方法。 一般来说，车轮被加热，然后从板向边缘淬火。 首先将轮子加热以在整个板和边缘部分形成奥氏体。 然后将车轮冷却以在板部分中形成贝氏体/马氏体。 轮子被冷却以在边缘的内部部分中形成贝氏体/马氏体。 将轮子冷却以在边缘的外部部分形成贝氏体/马氏体。
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Patent Agency Ranking
公开(公告)号：US07785835B2
公开(公告)日：2010-08-31
申请号：US11807476
申请日：2007-05-29
Applicant: Zee Upton , Jennifer Ann Kricker
Inventor： Zee Upton , Jennifer Ann Kricker
CPC classification number: A61K47/48246 , A61K38/1709 , A61K38/30 , A61K38/39 , C07K14/71 , C07K14/78 , A61K2300/00
Abstract: An isolated protein complex is provided which includes a growth factor, growth factor binding protein and vitronectin. Preferably, the isolated protein complex includes an insulin-like growth factor-I, insulin-like growth factor binding protein-3 or insulin-like growth factor binding protein-5 and vitronectin. Also provided are methods of modulating cell proliferation and/or migration by administering said protein complex for the purposes of wound healing, skin repair and tissue replacement therapy. Conversely, by using agents that disrupt growth factor protein complexes formed in vivo, growth factor-driven cell proliferation and/or migration may be suppressed such as for the purposes of treating cancers, psoriasis, atherosclerosis and wounds prone to hypertrophic scarring.
Abstract translation: 提供了分离的蛋白质复合物，其包括生长因子，生长因子结合蛋白和玻连蛋白。 优选地，分离的蛋白质复合物包括胰岛素样生长因子-I，胰岛素样生长因子结合蛋白-3或胰岛素样生长因子结合蛋白-5和玻连蛋白。 还提供了通过对于伤口愈合，皮肤修复和组织置换治疗的目的施用所述蛋白质复合物来调节细胞增殖和/或迁移的方法。 相反，通过使用破坏体内形成的生长因子蛋白复合物的试剂，可以抑制生长因子驱动的细胞增殖和/或迁移，例如用于治疗癌症，牛皮癣，动脉粥样硬化和容易发生肥大性瘢痕形成的伤口。
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公开(公告)号：US07730493B2
公开(公告)日：2010-06-01
申请号：US11024919
申请日：2004-12-29
Applicant: Kim Elms , Stephen Milliner , Julien J. P. Vayssiere
Inventor： Kim Elms , Stephen Milliner , Julien J. P. Vayssiere
CPC classification number: G06F9/544 , G06F9/465 , G06F2209/461
Abstract: A technique for facilitating coordination of actions by multiple programs involves providing an execution environment for active objects. The execution environment may be an object space. Client programs may write active objects to the object space, which execute on behalf of the client programs. The client programs may obtain the results of the executed active objects, even if the client program is disconnected from the object space while the active object is executing.
Abstract translation: 用于促进多个程序的动作协调的技术涉及为活动对象提供执行环境。 执行环境可以是对象空间。 客户端程序可以将活动对象写入到代表客户端程序执行的对象空间中。 即使在活动对象正在执行时客户端程序与对象空间断开连接，客户机程序也可以获得执行的活动对象的结果。
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公开(公告)号：US20090311303A1
公开(公告)日：2009-12-17
申请号：US12298481
申请日：2007-04-27
Applicant: Cameron Lutton , Ben Goss
Inventor： Cameron Lutton , Ben Goss
CPC classification number: C08F283/00 , A61F2/30965 , A61F2/447 , A61F2002/2817 , A61F2002/30062 , A61F2002/3008 , A61F2002/30677 , A61F2002/30785 , A61F2002/30904 , A61F2002/4475 , A61F2210/0004 , A61F2250/0098 , A61F2310/00023 , A61F2310/00353 , A61L27/14 , A61L27/18 , A61L27/46 , A61L27/58 , A61L31/06 , A61L31/148 , C08F220/06 , C08F222/1006 , C08L67/04
Abstract: A biodegradable copolymer network, which is particularly suited for use in applications such as interbody implants for bone fusion, is provided. The biodegradable copolymer network of the present invention is biodegradable yet provides sufficient mechanical strength for use in procedures such as spinal fusion. Also provided are methods of producing said biodegradable copolymer network, methods of delivery of biologically active substances, implants comprising said biodegradable copolymer network and methods of administering bioactive and in particular, osteoinductive, substances.
Abstract translation: 提供了一种特别适用于诸如用于骨融合的椎间植入物的应用中的可生物降解的共聚物网络。 本发明的可生物降解的共聚物网络是可生物降解的，但提供足够的机械强度用于诸如脊柱融合的过程中。 还提供了生产所述可生物降解的共聚物网络的方法，递送生物活性物质的方法，包含所述可生物降解的共聚物网络的植入物和施用生物活性的，特别是骨诱导的物质的方法。
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公开(公告)号：US20090141235A1
公开(公告)日：2009-06-04
申请号：US11884425
申请日：2006-02-14
Applicant: Michael Collins , Tobias Buehren , Leo Carney , Brett Davis , D. Robert Iskander , Ross Franklin , Stephanie Buehren
Inventor： Michael Collins , Tobias Buehren , Leo Carney , Brett Davis , D. Robert Iskander , Ross Franklin , Stephanie Buehren
IPC: G02C7/04
CPC classification number: G02C7/044 , G02C7/04 , G02C7/048 , G02C2202/24
Abstract: Devices and methods for controlling myopia are provided. The devices and methods relate to the inventors discovery of the relationship between near work, the forces applied to the eye by the eyelids and myopia. The devices include a contact lens comprising a region that disperses force applied to the eye by an eyelid. The devices also include a device designed by measuring first wavefront aberrations of an eye before pre-near work and measuring second measured wavefront aberrations of the eye post-near work. The methods include a method for controlling myopia including identifying optical changes associated with near work and correcting the optical changes with an optical device.
Abstract translation: 提供了用于控制近视的装置和方法。 这些装置和方法涉及发明人发现近距离工作，由眼睑和近视眼施加的力之间的关系。 这些装置包括隐形眼镜，其包括通过眼睑分散施加到眼睛的力的区域。 这些装置还包括通过在预接近工作之前测量眼睛的第一波前像差而设计的装置，并测量眼睛后附近工作的第二测量波前像差。 这些方法包括一种用于控制近视的方法，包括识别与近距离工作相关联的光学变化并用光学装置校正光学变化。
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公开(公告)号：US07514398B2
公开(公告)日：2009-04-07
申请号：US10380892
申请日：2001-09-24
Applicant: Zee Upton , Jennifer Ann Kricker
Inventor： Zee Upton , Jennifer Ann Kricker
CPC classification number: A61K47/48246 , A61K38/1709 , A61K38/30 , A61K38/39 , C07K14/71 , C07K14/78 , A61K2300/00
Abstract: An isolated protein complex is provided which includes a growth factor, growth factor binding protein and vitronectin. Preferably, the isolated protein complex includes an insulin-like growth factor-I, insulin-like growth factor binding protein-3 or insulin-like growth factor binding protein-5 and vitronectin. Also provided are methods of modulating cell proliferation and/or migration by administering said protein complex for the purposes of wound healing, skin repair and tissue replacement therapy. Conversely, by using agents that disrupt growth factor protein complexes formed in vivo, growth factor-driven cell proliferation and/or migration may be suppressed such as for the purposes of treating cancers, psoriasis, atherosclerosis and wounds prone to hypertrophic scarring.
Abstract translation: 提供了分离的蛋白质复合物，其包括生长因子，生长因子结合蛋白和玻连蛋白。 优选地，分离的蛋白质复合物包括胰岛素样生长因子-I，胰岛素样生长因子结合蛋白-3或胰岛素样生长因子结合蛋白-5和玻连蛋白。 还提供了通过对于伤口愈合，皮肤修复和组织置换治疗的目的施用所述蛋白质复合物来调节细胞增殖和/或迁移的方法。 相反，通过使用破坏体内形成的生长因子蛋白复合物的试剂，可以抑制生长因子驱动的细胞增殖和/或迁移，例如用于治疗癌症，牛皮癣，动脉粥样硬化和容易发生肥大性瘢痕形成的伤口。
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