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    Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof
    88.
    发明授权
    Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof 失效
    制备硝基氧基烷基取代的羧酸酯的方法，可用于所述方法的中间体及其制备方法

    公开(公告)号：US07723382B2

    公开(公告)日：2010-05-25

    申请号：US10522986

    申请日：2003-08-06

    Applicant: Piero del Soldato ,  Giancarlo Santus ,  Francesca Benedini

    Inventor： Piero del Soldato ,  Giancarlo Santus ,  Francesca Benedini

    IPC: A61K31/21 ,  A61K31/40 ,  C07C203/04 ,  C07C69/00

    CPC classification number: C07C269/06 ,  C07C67/10 ,  C07C69/734 ,  C07C201/02 ,  C07C203/04 ,  C07C271/28 ,  C07C303/28 ,  C07C309/73

    Abstract: The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R—COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.

    Abstract translation: 本发明涉及制备通式（A）化合物的方法，如说明书所述，其中R为药物基团，R 1 -R 12为氢或烷基，m，n，o，q， r和s各自独立地为0〜6的整数，p为0或1，X为O，S，SO，SO 2，NR 13或PR 13或芳基杂芳基，所述方法包括使式 B）R-COOZ（B）其中R如上所定义，Z是氢或选自：Li +，Na +，K +，Ca ++，Mg ++，四烷基铵，四烷基鏻与式（C）化合物的阳离子，如 其描述其中R1-R12和m，n，o，p，q，r，s如上所定义，Y是合适的离去基团。

    PROCESS FOR THE MONONITRATION OF ALKANEDIOLS
    89.
    发明申请
    PROCESS FOR THE MONONITRATION OF ALKANEDIOLS 失效
    阿尔卡尼溶液的制备方法

    公开(公告)号：US20080146830A1

    公开(公告)日：2008-06-19

    申请号：US12036555

    申请日：2008-02-25

    Applicant: Nevio FRANCESCUTTI ,  Tiziano SCUBLA ,  Fausto GORASSINI ,  Graziano CASTALDI

    Inventor： Nevio FRANCESCUTTI ,  Tiziano SCUBLA ,  Fausto GORASSINI ,  Graziano CASTALDI

    IPC: C07C201/00

    CPC classification number: C01B21/46 ,  C07C201/02 ,  C07C203/04

    Abstract: A process for the preparation of compounds of formula HO-A-ONO2   (I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with “stabilised” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.

    Abstract translation: 一种制备式<β的化合物的方法在线式描述=“在线式”中=“铅”→HO-A-ONO 2（I）<α -line-formula description =“In-line Formulas”end =“tail”？>其中A是C 2 -C 6 -C 6亚烷基链，硝化相应的链烷二醇 本文公开了“稳定”硝酸。 该过程对操作员更安全，并允许在工业规模上获得有利的产量。

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