公开(公告)号：US08384027B2

公开(公告)日：2013-02-26

申请号：US13119264

申请日：2009-09-17

Applicant: John B. Hoyes ,  David Langridge

Inventor： John B. Hoyes ,  David Langridge

IPC: H01J49/42

CPC classification number: H01J49/062 ,  G01N27/622 ,  H01J49/02 ,  H01J49/065

Abstract: An ion guide array is disclosed comprising a first ion guide section and a second ion guide section and optionally further ion guide sections. Each ion guide section may comprise a plurality of electrodes having an aperture through which ions are transmitted in use. A transfer section is arranged at the exit of the first ion guide section and ions are transmitted radially from the first ion guide section into the second ion guide section. The electrodes in the transfer section may have a radial aperture enabling ions to be transmitted radially from the first ion guide section to the second ion guide section.

Abstract translation: 公开了一种离子导向阵列，其包括第一离子引导部分和第二离子引导部分以及任选的其它离子引导部分。 每个离子引导部分可以包括具有孔的多个电极，在使用中离子通过该孔传播。 在第一离子引导部的出口设置有转印部，离子从第一离子引导部径向地传递到第二离子引导部。 转印部分中的电极可以具有使得离子能够从第一离子导向部径向地传递到第二离子引导部的径向孔。

公开(公告)号：US20110042560A1

公开(公告)日：2011-02-24

申请号：US12863801

申请日：2009-02-11

Applicant: Zheng Ouyang ,  Jason Harper ,  Nicholas Charipar ,  Robert Graham Cooks

Inventor： Zheng Ouyang ,  Jason Harper ,  Nicholas Charipar ,  Robert Graham Cooks

IPC: H01J49/26

CPC classification number: H01J37/32009 ,  H01J27/022 ,  H01J37/00 ,  H01J37/32348 ,  H01J49/02 ,  H01J49/105 ,  H01J49/142 ,  H01J2237/0044 ,  H05H1/24 ,  H05H1/2406 ,  H05H1/30 ,  H05H2001/2412 ,  H05H2001/2443 ,  H05H2240/10 ,  H05H2240/20 ,  Y10T436/145555 ,  Y10T436/147777 ,  Y10T436/173076 ,  Y10T436/203332 ,  Y10T436/24

Abstract: The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.

Abstract translation: 本发明一般涉及用于解吸和电离样品中至少一种分析物的低温等离子体探针及其使用方法。 在一个实施方案中，本发明一般涉及一种低温等离子体探针，其包括：壳体，其具有放电气体入口端口，探针尖端，两个电极和介电屏障，其中两个电极由电介质屏障隔开， 来自电源的电压的施加产生低温等离子体，其中通过电场和/或放电气体流将低温等离子体推出排出区域。

公开(公告)号：US07667193B2

公开(公告)日：2010-02-23

申请号：US11711142

申请日：2007-02-26

Applicant: Alan Finlay

Inventor： Alan Finlay

IPC: H01J49/00 ,  H01J49/02

CPC classification number: H01J49/02

Abstract: A personalized mass spectrometer system is described. By fabricating analyzer components on a module and including with that module an identifier for that module, it is possible to uniquely associate a user or task with one or more modules. The module is removably receivable within a housing and can be replaced with another module if so required.

Abstract translation: 描述了一种个性化的质谱仪系统。 通过在模块上制造分析器组件，并且在该模块中包括该模块的标识符，可以将用户或任务与一个或多个模块唯一地相关联。 模块可拆卸地接收在外壳内，如果需要，可以用其他模块更换。

公开(公告)号：US07476853B2

公开(公告)日：2009-01-13

申请号：US11349551

申请日：2006-02-07

Applicant: Roman Zubarev ,  Alexander Misharin ,  Oleg Silivra ,  Frank Kjeldsen

Inventor： Roman Zubarev ,  Alexander Misharin ,  Oleg Silivra ,  Frank Kjeldsen

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/005 ,  G01N33/6848 ,  H01J49/02 ,  Y10S250/91 ,  Y10T436/17

Abstract: The invention relates to a method and apparatus for the fragmentation of large molecules, especially biopolymers. The invention consists in reacting analyte ions with excited or radical neutral particles, whereby, at least in the case of bombardment of analyte ions with helium atoms from an FAB generator, a new type of fragmentation occurs which strongly resembles fragmentation by electron capture (ECD). The reactions may be performed in magnetic ion traps (ion cyclotron resonance cells, ICR), in RF ion traps according to Wolfgang Paul, in RF ion guides, or in free beams of analyte ions or neutral particles.

Abstract translation: 本发明涉及一种用于大分子，特别是生物聚合物破碎的方法和装置。 本发明包括使分析物离子与激发或自由基中性颗粒反应，由此，至少在从FAB发生器轰击具有氦原子的分析物离子的情况下，发生类似于通过电子捕获（ECD）破碎的新型碎裂， 。 反应可以在磁离子阱（离子回旋共振池，ICR），RF离子阱中根据Wolfgang Paul，RF离子导向器或分析离子或中性粒子的自由光束进行。

公开(公告)号：US20080315080A1

公开(公告)日：2008-12-25

申请号：US10587478

申请日：2006-06-05

Applicant: Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

Inventor： Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

IPC: B01D59/46

CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r,φ,z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ,z) is the result of a perturbation W to an ideal field U(r, φ,z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ,z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than about 2π radians over an ion detection period Tm.

Abstract translation: 公开了诸如轨道捕获器的静电捕获器，具有电极结构。 产生U'（r，phi，z）形式的静电捕获场，以捕获陷阱内的离子，使它们经历同步振荡。 捕获场U'（r，phi，z）是对于理想场U（r，phi，z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。 扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，phi，z）的等电位，或者通过添加失真场（电或 磁性）。 扰动的幅度使得至少一些捕获的离子在离子检测周期Tm之后具有大于零但小于约2pi弧度的绝对相位扩展。

公开(公告)号：US20080073510A1

公开(公告)日：2008-03-27

申请号：US11711142

申请日：2007-02-26

Applicant: Alan Finlay

Inventor： Alan Finlay

IPC: H01J49/00

CPC classification number: H01J49/02

Abstract: A personalised mass spectrometer system is described. By fabricating analyser components on a module and including with that module an identifier for that module, it is possible to uniquely associate a user or task with one or more modules. The module is removably receivable within a housing and can be replaced with another module if so required.

Abstract translation: 描述了一种个性化的质谱仪系统。 通过在模块上制造分析器组件，并且在该模块中包括该模块的标识符，可以将用户或任务与一个或多个模块唯一地相关联。 模块可拆卸地接收在外壳内，如果需要，可以用其他模块更换。

公开(公告)号：US20070152149A1

公开(公告)日：2007-07-05

申请号：US11619858

申请日：2007-01-04

Applicant: Gordana Ivosev ,  Nic Bloomfield

Inventor： Gordana Ivosev ,  Nic Bloomfield

IPC: B01D59/44

CPC classification number: H01J49/40 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/02 ,  H01J49/025

Abstract: Systems and methods for calculating ion flux. In one embodiment, a mass spectrometer includes an ion source for emitting a beam of ions from a sample through a plurality of pulses during an analysis period, and a detector positioned downstream of said ion source. A clock is provided which is configured to determine a repeatable series of bins, wherein each bin in the repeatable series will correspond to a corresponding pulse time segment in every pulse. Additionally a controller is provided which is operatively coupled to the detector and to the clock and configured to determine the total number of pulses during the analysis period. The controller is further configured to determine for at least one bin in the repeatable series, the number of corresponding pulse time segments in which no ion impact was detected during the analysis period. The controller is also configured to calculate the ion flux corresponding to the at least one bin and wherein said ion flux is calculated to be correlated to the probability of not detecting an ion impact during pulse time segments which correspond to the at least one bin in the repeatable series.

Abstract translation: 用于计算离子通量的系统和方法。 在一个实施例中，质谱仪包括离子源，用于在分析周期期间通过多个脉冲从样品发射离子束，以及位于所述离子源下游的检测器。 提供时钟，其被配置为确定可重复的一系列存储区，其中可重复序列中的每个仓对应于每个脉冲中的相应脉冲时间段。 另外，提供控制器，其可操作地耦合到检测器和时钟并且被配置为在分析周期期间确定总脉冲数。 控制器还被配置为确定可重复序列中的至少一个箱，在分析周期期间没有检测到离子冲击的相应脉冲时间段的数量。 控制器还被配置为计算对应于至少一个仓的离子通量，并且其中计算所述离子通量与在脉冲时间段期间不检测离子冲击的概率相关联，所述脉冲时间段对应于所述至少一个仓 可重复系列。

公开(公告)号：US20070045529A1

公开(公告)日：2007-03-01

申请号：US11329536

申请日：2006-01-11

Applicant: Libo Cao ,  Christopher Janko ,  Guoxiang Chen

Inventor： Libo Cao ,  Christopher Janko ,  Guoxiang Chen

IPC: H01J49/26

CPC classification number: H01J49/02 ,  H01J49/0009

Abstract: A data processing engine for an automated mass spectrometry system is provided that identifies analyte and spike peak locations in spectral data based upon mass spectrometer tunings and solution identities. The data processing engine calculates analyte concentrations based upon spectral responses at the identified peak locations.

Abstract translation: 提供了一种用于自动质谱系统的数据处理引擎，其基于质谱仪调谐和溶液特性来识别光谱数据中的分析物和尖峰位置。 数据处理引擎基于所识别的峰位置处的光谱响应来计算分析物浓度。

公开(公告)号：US20060076483A1

公开(公告)日：2006-04-13

申请号：US11205758

申请日：2005-08-16

Applicant: Adi Scheidemann ,  Mark McGraw ,  Clare Long ,  Gottfried Kibelka

Inventor： Adi Scheidemann ,  Mark McGraw ,  Clare Long ,  Gottfried Kibelka

IPC: B01D59/44

CPC classification number: H01J49/02 ,  H01J49/28 ,  H05K1/0271 ,  H05K1/0284 ,  H05K2201/2009

Abstract: Mass spectrometer systems for measuring mass/charge ratios of analytes are described. A mass spectrometer system includes a vacuum flange, a PCB base plate coupled to the vacuum flange, and an ion optic assembly coupled to the PCB base plate. The PCB base plate may include signal-processing electronics. The system may include an electrical cable coupled to the PCB base plate for supplying power, control, and I/O to the ion optic assembly and the signal processing electronics. Alternatively, a mass spectrometer system includes a PCB base plate and an ion optic assembly. The PCB base plate has a sealant portion and an electrical portion. The ion optic assembly is coupled to the electrical portion. The system may include a vacuum housing for enclosing the ion optic assembly. The vacuum housing is coupled to the sealant portion of the PCB base plate for sustaining a vacuum while the system is in operation.

Abstract translation: 描述了用于测量分析物质量/电荷比的质谱仪系统。 质谱仪系统包括真空法兰，联接到真空法兰的PCB基板和耦合到PCB基板的离子光学组件。 PCB基板可以包括信号处理电子器件。 该系统可以包括耦合到PCB基板的电缆，用于向离子光学组件和信号处理电子器件供电，控制和I / O。 或者，质谱仪系统包括PCB基板和离子光学组件。 PCB基板具有密封剂部分和电气部分。 离子光学组件耦合到电气部分。 该系统可以包括用于封闭离子光学组件的真空壳体。 真空壳体联接到PCB基板的密封剂部分，以在系统运行时维持真空。

公开(公告)号：US20030193021A1

公开(公告)日：2003-10-16

申请号：US10437142

申请日：2003-05-13

Inventor： Philip S. Berger ,  W. Ronald Gentry ,  Henry W. Rohrs

IPC: H01J049/32

CPC classification number: G06Q20/00 ,  H01J49/02 ,  H01J49/288 ,  H04L67/10 ,  H04L69/329

Abstract: A mass sensor, in an exemplary embodiment, includes a housing that includes a first plate, a second plate, and a center portion positioned between the first and second plates. The mass analyzer also includes an ionizer a double focusing mass spectrometer, and an ion detector. The ionizer, the double focusing mass spectrometer, and the ion detector are located in a cavity in the housing. The double focusing mass spectrometer includes an electric sector energy analyzer that includes a first element located on an inside surface of the first plate, and a second element located on an inside surface of the second plate. The first and second elements are substantially concentric and congruent and have a circular arc shape. Each first and second element include a first boundary electrode, a second boundary electrode, and a continuous resistive material extending between the first and second boundary electrodes.

Abstract translation: 在示例性实施例中，质量传感器包括壳体，该壳体包括第一板，第二板和位于第一板和第二板之间的中心部分。 质量分析仪还包括电离器，双重聚焦质谱仪和离子检测器。 离子发生器，双重聚焦质谱仪和离子检测器位于壳体中的空腔中。 双重聚焦质谱仪包括电扇区能量分析仪，其包括位于第一板的内表面上的第一元件和位于第二板的内表面上的第二元件。 第一和第二元件基本上是同心的和一致的并且具有圆弧形状。 每个第一和第二元件包括第一边界电极，第二边界电极和在第一和第二边界电极之间延伸的连续电阻材料。