公开(公告)号：US20200018748A1

公开(公告)日：2020-01-16

申请号：US16496971

申请日：2018-03-23

Applicant: CHARITÉ-UNIVERSITÄTSMEDIZIN BERLIN

Inventor： Philipp ENGHARD ,  Nina GÖRLICH ,  Hannah Antonia BRAND ,  Valerie LANGHANS ,  Petra REINKE

IPC: G01N33/50 ,  G01N33/493 ,  G01N15/14

Abstract: The invention provides a method of assigning to a patient a likelihood of having a kidney disease, or a likelihood of undergoing kidney transplant rejection, comprising the steps of providing a urine sample from the patient and determining the concentration of T cells, podocytes and proximal tubular epithelial cells. The ratios of these cell types are used for determining the risk of a kidney disease or transplant rejection.

公开(公告)号：US20200011778A1

公开(公告)日：2020-01-09

申请号：US16482661

申请日：2018-02-07

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  ADVANCED TEAR DIAGNOSTICS

Inventor： Mackenzie Honikel ,  Chi Lin ,  Andrew Penman ,  Brittney Cardinell ,  Jeffrey LaBelle ,  Pierce Youngbar ,  Marcus Smith

IPC: G01N13/04 ,  G01N33/487 ,  G01N33/493 ,  G01N33/49

Abstract: Osmolality and osmolality sensors and methods utilizing electrochemical impedance to detect changes in impedance to varying salinity concentrations. By way of example, the impedance reported at the specified frequency varies logarithmically with the concentration of sodium chloride subject to the sensor surface. Measurements obtained by the sensors and methods herein are utilized, for example, to differentiate between the clinical stages of dry eye disease (290-316 mOsm/L) to complement the current diagnostic procedures. Blood serum, urinalysis, and saliva also may be tested and the corresponding osmolarity or osmolality level evaluated for indications of a disease or condition.

公开(公告)号：US20190339284A1

公开(公告)日：2019-11-07

申请号：US16308591

申请日：2017-06-12

Applicant: WARSZAWSKI UNIWERSYTET MEDYCZNY ,  INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK

Inventor： Krzysztof MUCHA ,  Leszek PACZEK ,  Radoslaw ZAGOZDZON ,  Bartosz FORONCEWICZ ,  Michal DADLEZ ,  Magdalena BAKUN ,  Jan PIWOWARSKI ,  Tomas PILZYS ,  Michal MARCINKOWSKI ,  Damian GARBICZ ,  Elzbieta GRZESIUK ,  Michal FLORCZAK

IPC: G01N33/68 ,  G01N33/493

Abstract: The present invention relates to use of markers selected from a group consisting of alpha-IB-glycoprotein (A1BG), alpha-1-acid glycoprotein 1 (ORM1), Ig lambda-2 chain C regions (IGLC2) and serotransferrin (TF) in methods for diagnosis, monitoring and differentiation of IgA nephropathy. In addition corresponding diagnostic kits are provided.

公开(公告)号：US20190323880A1

公开(公告)日：2019-10-24

申请号：US16475977

申请日：2018-01-04

Applicant: LIXIL Corporation

Inventor： Hirokazu SHIMASAKI ,  Hiroaki WATANABE ,  Tsunaki ITOU ,  Tomoya SASAKI ,  Hideya KOIKE

IPC: G01G19/52 ,  A47K13/24 ,  G01G19/50 ,  G01N33/493 ,  G01N33/487

Abstract: The present invention provides a measuring device which is configured to measure a body weight of a user sitting on a toilet seat, which is installed on a toilet bowl, and on which the toilet seat is installed, the device including a plurality of load measuring units that are configured to measure a load of the user acting on the toilet seat and that are disposed to protrude upward from an upper surface. The toilet seat includes a plurality of leg portions disposed to protrude downward from a lower surface, a height from the upper surface to upper ends of the load measuring units is greater than a height from the lower surface of the toilet seat to lower ends of the leg portions, and the load measuring units are disposed at different positions from the leg portions as seen in plan view.

公开(公告)号：US20190301988A1

公开(公告)日：2019-10-03

申请号：US16462693

申请日：2017-11-23

Applicant: AMAN SHARMA

Inventor： AMAN SHARMA

IPC: G01N1/40 ,  G01N1/34 ,  G01N1/38 ,  C07K1/14 ,  C12N15/10 ,  G01N33/49 ,  G01N33/493 ,  B01D21/26

Abstract: The present invention relates to methods and kits for isolation of cell-derived vesicles and their associated macromolecules like nucleic acids, proteins, lipids metabolites etc. from one or more blood, serum, plasma, saliva, urine, cerebrospinal fluid, breast milk, tear, conditioned culture media etc. to assist detection, prevention, and understanding of disease biology. The invention offers various advantages including simple technical solutions which are cost-effective, time-saving and scalable for large industrial outputs.

公开(公告)号：US20190298317A1

公开(公告)日：2019-10-03

申请号：US15943031

申请日：2018-04-02

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Evan G. Colgan ,  Minhua Lu ,  Vince S. Siu

IPC: A61B10/00 ,  A61B5/145 ,  A61B5/20 ,  G01N33/493

Abstract: A health analysis fixture includes a receptacle. A volume of water and a body fluid sample form a water line within the receptacle. A light-emitting device and a light-sensing device are disposed within the receptacle. A measurement device determines a height of the water line before and after an introduction of the body fluid sample. A computer processor is configured to receive sensor data from the light-sensing device, receive the determined height of the water line before and after the introduction of the body fluid sample from the measurement device, calculate a dilution factor for the body fluid sample from the received height of the water line before and after the introduction of the body fluid sample, receive sensor data from the light-sensing device, and interpret the received sensor data based on the dilution factor to generate health information therefrom.

公开(公告)号：US20190285535A1

公开(公告)日：2019-09-19

申请号：US16421054

申请日：2019-05-23

Applicant: IDEXX Laboratories, Inc.

Inventor： Jeremy Hammond ,  James Russell

IPC: G01N15/14 ,  C12Q1/06 ,  G01N33/493 ,  B01L3/00

Abstract: A method for detecting bacteria and determining the concentration thereof in a liquid sample includes the steps of taking an optical section through a container holding a volume of the liquid sample at a predetermined field of view and at a predetermined focal plane depth or angle and after a period of time has elapsed to allow non-bacteria in the sample to settle to the bottom of the container. Since bacteria auto arranges in the liquid sample, forming a lattice-like grid pattern, an optical section through the volume of auto-arranged bacteria may be used to measure the quantity of bacteria residing in that section. A container for holding the liquid sample has particular structure which aids in separating the non-bacteria from the bacteria.

公开(公告)号：US10383606B1

公开(公告)日：2019-08-20

申请号：US16036621

申请日：2018-07-16

Applicant: Bloom Health, Inc.

Inventor： Matthew McCord ,  Jon Carder ,  Sergio Alvarez ,  Jesus Gonzalez

IPC: A61B10/00 ,  G01N33/52 ,  G01N1/20 ,  E03D11/13 ,  G01N33/543 ,  G01N33/493 ,  A61B5/00 ,  G08C17/02 ,  C12Q1/54 ,  C12Q1/00

Abstract: Urine analysis system that couples or integrates with a toilet. Wirelessly links to a computer, such as a user's mobile device to accept control inputs and report urine test results. Accepts user input to initiate testing and deploys a urine collector into the toilet bowl above the water to collect a urine sample. The collected urine sample is dispensed onto multiple regions of a test matrix that may perform many urine tests simultaneously. A single test matrix may include multiple types of tests, such as immunochromatography and colorimetric assays. An optical imaging system detects reaction of the urine with reagents integrated into the test matrix. Analysis of images may be performed locally or on a remote server. The system may store an inventory of test matrices to support daily testing for long durations, for example 6 months or more before refilling.

公开(公告)号：US10330621B1

公开(公告)日：2019-06-25

申请号：US15638339

申请日：2017-06-29

Applicant: Theos Medical Systems

Inventor： Saket Bhatia ,  Ankush Bhatia

IPC: G01N27/30 ,  G01N27/07 ,  G01N27/403 ,  G01N27/327 ,  G01N33/493 ,  A61B5/00 ,  A61B5/20

Abstract: Provided is an electrolyte sensor that uses conductive elastomer electrodes. Examples of the intended analytes for sensor use include those found in urine, saliva, blood, feces, and spinal fluid, although other analytes exist for electrolyte detection. Conductive elastomer trace electrodes are separated by a channel or gap which can be bridged by an electrolyte and thereby complete an electrical circuit to an alarm or other circuitry. Channel or gap distances vary the level of electrical resistance associated with detecting certain analytes.

公开(公告)号：US20190187124A1

公开(公告)日：2019-06-20

申请号：US16099640

申请日：2016-10-25

Applicant: Shanghai Kohler Electronics, Ltd.

Inventor： Zhiyu Qin

IPC: G01N33/487 ,  B65D83/08 ,  G01N33/493

CPC classification number: G01N33/48757 ,  B65D83/08 ,  G01N33/48 ,  G01N33/493

Abstract: A test paper box and a smart toilet containing same are provided. The test paper box has a support and a housing arranged at the outside of the support. The support has a base and an elongated cavity arranged at the base for storing test paper. The base is provided with a through hole arranged at a location corresponding to a bottom surface of the elongated cavity. A paper-receiving slot is arranged below the through hole. The paper-receiving slot is fixed to the bottom of the base to receive the bottommost piece of test paper exposed from the elongated cavity, and the paper-receiving slot is provided with a paper outlet. The test paper box can be attached and detached conveniently, delivers test paper smoothly, can be replaced easily, has low costs, and is suitable for smart toilets.