公开(公告)号：US11370930B2

公开(公告)日：2022-06-28

申请号：US16477037

申请日：2017-12-25

申请人： Seiko Epson Corporation

发明人： Hiroshi Takiguchi ,  Hiroaki Kida ,  Masaru Terada ,  Naoyuki Toyoda ,  Atsushi Denda

IPC分类号： C09D11/322 ,  C09D11/102 ,  C09D167/02 ,  C09D171/02 ,  C09D11/38 ,  B41J2/01 ,  C08G65/335 ,  C09D11/36 ,  B41M5/00 ,  C08K5/521 ,  C08K7/00 ,  C08K9/04 ,  C08K3/08

摘要： A solvent-based ink composition is provided that includes: an organic solvent; a surface-treated metal powder; and a polyoxyethylene alkyl ether phosphoric acid compound, the content of the polyoxyethylene alkyl ether phosphoric acid compound with respect to the total mass of an ink is 0.1 to 10.0 percent by mass, and the surface-treated metal powder contains aluminum or an aluminum alloy and is surface-treated by a surface treating agent of a fluorine-based compound.

公开(公告)号：US11370863B2

公开(公告)日：2022-06-28

申请号：US17087651

申请日：2020-11-03

申请人： The Procter & Gamble Company

发明人： Ryan Michael West ,  Scott Leroy Cron ,  Yingkun Jin ,  William Michael Glandorf

IPC分类号： A61K8/81 ,  A61Q11/00 ,  C08F8/40 ,  C08F30/02 ,  C08F230/02 ,  C08F220/38 ,  C08G79/04 ,  C08F220/56 ,  C07F9/38 ,  C08F290/06 ,  C08F8/14 ,  C08F220/06 ,  C08F299/02 ,  C08F6/04 ,  C08F8/26 ,  C08F8/48 ,  C08F130/02 ,  C08G65/26 ,  C08F8/02 ,  C07F9/6571 ,  C08F228/02 ,  C08F8/44 ,  C08F8/12 ,  C07F9/6587 ,  A61K8/91 ,  C08G65/335 ,  C08F220/58 ,  C08G81/02

摘要： Disclosed are oral care compositions of novel phosphono-phosphate and anionic group containing polymer compositions that have targeted uses with divalent cations and surfaces having divalent cations. These compounds can be used to deliver anionic character to surfaces such as calcium hydroxyapatite for use in oral care applications.

公开(公告)号：US11110175B2

公开(公告)日：2021-09-07

申请号：US15749951

申请日：2016-08-05

申请人： Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： Daniel S. Kohane ,  Rong Yang ,  Lily Yun Lin

IPC分类号： A61K47/34 ,  A61K9/46 ,  A61K9/06 ,  A61K31/407 ,  A61K31/424 ,  A61K31/431 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5383 ,  A61K31/573 ,  A61K45/06 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/22 ,  A61P27/16 ,  A61P31/04 ,  C08G79/04 ,  A61K31/445 ,  A61K9/00 ,  A61K38/12 ,  A61K47/26 ,  C08G65/335

摘要： The present invention provides compositions and methods for delivery of therapeutic agents across an barrier. The compositions include a therapeutic agent (e.g., antimicrobial agent, antibiotic, or anesthetic agent), a permeation enhancer which increases the flux of the therapeutic agent across the barrier, and a matrix forming agent. The matrix forming agent forms a gel at a suitable gelation temperature and rheological properties for use in drug delivery, and in some cases, the gelation temperature and rheological properties are not significantly changed from those of the composition without the permeation enhancer. The invention also provides a matrix forming agent and compositions thereof. Such compositions are particularly useful in the treatment of otitis media. Methods of treatment, methods of delivery, and kits for the compositions described herein are also provided.

公开(公告)号：US10808075B2

公开(公告)日：2020-10-20

申请号：US16062149

申请日：2016-12-08

申请人： BASF SE

发明人： Bjoern Ludolph ,  Steffen Maas ,  Sophia Ebert ,  Patrick Delplancke ,  Frank Huelskoetter

IPC分类号： C08G65/26 ,  C08G65/326 ,  C08G65/327 ,  C08G73/02 ,  C08G65/334 ,  C08G65/333 ,  C08G65/335 ,  C11D1/00 ,  C10M133/08 ,  C10N20/00

摘要： Provided herein are polymers obtainable by a process including the steps a) and b) described below. In Step a) at least one component a1) is condensed to obtain a polyether having remaining hydroxyl groups. Component a1) is at least one component selected from N-(hydroxyalkyl) amins according to formula (Ia) and/or (Ib) as defined below. Besides component a1), further components can be present in the condensation step a). In step b) a part of the remaining hydroxyl groups are reacted with at least one alkylene oxide. The alkoxylation according to step b) is carried out in a substoichiometric way. The ratio of i) the alkylene oxide versus ii) the sum of the amount of the remaining hydroxyl groups is >0:1 to

公开(公告)号：US20200271642A1

公开(公告)日：2020-08-27

申请号：US16645862

申请日：2018-08-28

申请人： NOF Corporartion

发明人： Akane Katori ,  Masaru Matsuda ,  Tomozumi Noda ,  Takashi Sasaki ,  Hirotaka Suzuki ,  Nobuyuki Sakamoto

IPC分类号： G01N33/531 ,  C08G65/335 ,  G01N33/53

摘要： A compound is provided which is effectively adsorbed to a substrate surface, such as an immune reaction vessel, has extremely high protein adsorption inhibitory effect that inhibits non-specific adsorption of protein or the like, and has excellent washability to retain the inhibitory effect before and after washing operation of the substrate. Also provided are a protein adsorption inhibitor using the compound, a phosphorylcholine-modified substrate, and a method for inhibiting protein adsorption. The compound is a phosphorylcholine group-containing polyethylene glycol derivative represented by formula (1). The method for inhibiting protein adsorption of the present invention includes the step of forming an adsorbed layer of the derivative on a substrate surface.

公开(公告)号：US20200206362A1

公开(公告)日：2020-07-02

申请号：US16599661

申请日：2019-10-11

申请人： Moderna TX, Inc.

发明人： Gilles Besin ,  Stephen Hoge ,  Joseph Senn ,  Kerry Benenato ,  Staci Sabnis

IPC分类号： A61K48/00 ,  A61K9/127 ,  C12N15/88 ,  A61K31/7115 ,  A61K47/14 ,  A61K47/18 ,  A61K47/54 ,  A61K47/69 ,  A61K47/60 ,  A61K31/713 ,  A61K39/39 ,  A61K47/10 ,  C08G65/332 ,  C08G65/333 ,  C08G65/334 ,  C08G65/335 ,  C12N15/117

摘要： This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

公开(公告)号：US20190151339A1

公开(公告)日：2019-05-23

申请号：US16259732

申请日：2019-01-28

申请人： Nektar Therapeutics

发明人： Timothy A. Riley ,  Lin Cheng

IPC分类号： A61K31/662 ,  C08G65/335 ,  A61K47/60 ,  C07F9/40

摘要： The invention relates to (among other things) oligomer-foscarnet conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated foscarnet compounds.

公开(公告)号：US20190106538A1

公开(公告)日：2019-04-11

申请号：US15743139

申请日：2016-07-07

申请人： SOLVAY SPECIALTY POLYMERS ITALY S.P.A.

发明人： Roberto VALSECCHI ,  Rosaldo PICOZZI ,  Giovanni SIMEONE

IPC分类号： C08G65/00 ,  C08G65/333 ,  C08G65/335 ,  G11B5/725

CPC分类号： C08G65/007 ,  C08G65/33306 ,  C08G65/335 ,  C08G65/3351 ,  C10M107/38 ,  G11B5/725

摘要： The present invention relates to novel (per)fluoropolyether polymers and their use as lubricants, in particular for Magnetic Recording Media (MRM).

公开(公告)号：US20190010286A1

公开(公告)日：2019-01-10

申请号：US16067015

申请日：2016-11-07

申请人： SOBUTE NEW MATERIALS CO., LTD. ,  BOTE BUILDING MATERIALS (TIANJIN) CO., LTD.

发明人： Qianping RAN ,  Jiaping LIU ,  Tao WANG ,  Jianfeng MA ,  Shuai Qi ,  Shimin FAN ,  Yong YANG

IPC分类号： C08G65/335 ,  C08G65/331 ,  C08G65/332 ,  C04B24/24 ,  C04B28/02

CPC分类号： C08G65/3355 ,  C04B24/22 ,  C04B24/243 ,  C04B24/246 ,  C04B28/02 ,  C04B2103/408 ,  C08G65/331 ,  C08G65/332 ,  C08G65/3322 ,  C08G65/334 ,  C08G65/335 ,  C04B18/08 ,  C04B18/141 ,  C04B2103/0088

摘要： The present invention provides a method for preparing a polymer and a use of the polymer. The resulting polymer is used as a dispersant for an aqueous dispersion of a hydraulic binder and/or a latent hydraulic binder, such that water-reducing rate is improved, and suitable control of air content can be achieved, thereby improving the strength of concrete. The method for preparing a polymer includes polycondensation of a polyether macromonomer A of a specific structure, a monomer B and an aldehyde C to obtain the polymer. The monomer B is phenylsulfonic acid, p-/o-aminophenylsulfonic acid, p-/o-hydroxylbenzoic acid, p-/o-aminobenzoic acid, p-/o-hydroxylphenylsulfonic acid, or a phosphoric acid group or phosphorous acid group-containing monomer of a specific structure. A molar ratio of the polyether macromonomer A and the monomer B is 1:(0.5 to 12).

公开(公告)号：US20180043039A1

公开(公告)日：2018-02-15

申请号：US15797816

申请日：2017-10-30

申请人： BOARD OF REGENTS OF THE UNIVERSITY OF HOUSTON SYSTEM ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  ALZECA BIOSCIENCES, LLC

发明人： Ananth V. Annapragada ,  Jason L. Eriksen ,  Eric A. Tanifum ,  Indrani Dasgupta ,  Stephen C. Cook

IPC分类号： A61K49/18 ,  C08G65/335 ,  A61K9/127

CPC分类号： A61K49/1812 ,  A61K9/1273 ,  A61K47/6911 ,  A61K49/0466 ,  C08G65/3353

摘要： Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease.