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公开(公告)号：US10696732B2
公开(公告)日：2020-06-30
申请号：US15979319
申请日：2018-05-14
申请人： Albumedix Ltd
发明人： Darrell Sleep , Andrew Plumridge , Jason Cameron , Inger Sandlie , Jan Terje Andersen , Esben Peter Friis
IPC分类号： A61K38/38 , A61K47/48 , C07K14/76 , C12P21/06 , C12P21/04 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07H21/04 , C07K14/765 , C07K14/54 , A61K45/06
摘要： The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.
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公开(公告)号：US20230039076A1
公开(公告)日：2023-02-09
申请号：US17656728
申请日：2022-03-28
申请人： Albumedix Ltd
IPC分类号： C07K14/765 , A61K47/64 , A61K38/38 , A61K47/42
摘要： The present invention relates to conjugation-competent albumins and albumin-related polypeptides, and their conjugates with at least one moiety, and to polynucleotides encoding them.
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公开(公告)号：US11555061B2
公开(公告)日：2023-01-17
申请号：US16827356
申请日：2020-03-23
申请人： Albumedix Ltd
发明人： Christopher John Arthur Finnis , Joanna Mary Hay , Esben Peter Friis , Jason Cameron , Darrell Sleep
IPC分类号： C07K14/765 , G16B5/00 , C07K14/76
摘要： Based on the three-dimensional structure of albumin, the inventors have designed variant polypeptides (muteins) which have one or more cysteine residues with a free thiol group (hereinafter referred to as “thio-albumin”). The variant polypeptide may be conjugated through the sulphur atom of the cysteine residue to a conjugation partner such as a bioactive compound.
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公开(公告)号：US10711050B2
公开(公告)日：2020-07-14
申请号：US15989985
申请日：2018-05-25
申请人： Albumedix LTD
IPC分类号： C07K14/765 , A61K38/38 , C07K14/55 , C07K14/755 , C07K16/18 , C12N9/64
摘要： The invention provides methods and materials for making and using variant serum albumin amino acid sequences which exhibit improved properties compared to wild type serum albumin sequences. The invention further provides methods and materials for making and using fusion proteins in which the variant serum albumin amino acid sequences are fused to a therapeutic or diagnostic agent, such as a therapeutic protein, or a functional fragment or variant thereof that maintains activity, and exhibits improved properties.
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公开(公告)号：US20200157155A1
公开(公告)日：2020-05-21
申请号：US16415187
申请日：2019-05-17
申请人： Albumedix LTD.
发明人： Christopher John Arthur Finnis , Jennifer Mary Mclaughlan , Per Kristoffer Nordeide , Preethi Ramaiya
IPC分类号： C07K14/395 , C12R1/865 , C12N15/04 , C07K1/14 , C12N15/63 , C12N1/14 , C12N15/81 , C12N9/10 , C12P21/02 , C12N9/00 , C12N15/80
摘要： The invention provides an improved host strain for production of desired protein.
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公开(公告)号：US20190216079A1
公开(公告)日：2019-07-18
申请号：US16372581
申请日：2019-04-02
申请人： ALBUMEDIX LTD
IPC分类号： A01N1/02 , C12N5/074 , C07K14/765 , C12N5/0735 , C12N5/00 , C12N1/04
CPC分类号： A01N1/0221 , A01N1/0284 , C07K14/765 , C12N1/04 , C12N5/0018 , C12N5/0606 , C12N5/0607 , C12N2500/24 , C12N2500/34 , C12N2500/38
摘要： The invention relates to a methods and uses for the preservation of stem cells, by a method comprising the steps of combining the stem cells with a cryopreservation medium to produce a mixture, and freezing the mixture to produce a frozen stem cell product, optionally, wherein the method further comprises the steps of thawing the frozen stem cell product, transferring the thawed cells to a storage medium, and storing stem cells in the storage medium, wherein the cryopreservation medium and/or the storage medium comprises a recombinant yeast-derived serum albumin preparation, more preferably wherein the recombinant yeast-derived serum albumin preparation is present in the cryopreservation medium and is also present in the storage medium. The invention also relates to methods and uses for the preservation of stem cells, by a method comprising storing stem cells in a storage medium, wherein the stem cells have been frozen in a cryopreservation medium, thawed, and then transferred to the storage medium prior to storage; and wherein the cryopreservation medium and/or the storage medium comprises a recombinant yeast-derived serum albumin preparation, more preferably wherein the recombinant yeast-derived serum albumin preparation is present in the cryopreservation medium and is also present in the storage medium.
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公开(公告)号：US10329340B2
公开(公告)日：2019-06-25
申请号：US15915977
申请日：2018-03-08
申请人： Albumedix Ltd
发明人： Karen Ann Delahay
IPC分类号： C07K14/765
摘要： The present invention relates to variants of a parent albumin, the variants having altered plasma half-life compared with the parent albumin. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
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公开(公告)号：US20220090159A1
公开(公告)日：2022-03-24
申请号：US17464991
申请日：2021-09-02
申请人： Albumedix Ltd
摘要： The invention provides an improved host strain for production of desired protein.
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公开(公告)号：US20210070839A1
公开(公告)日：2021-03-11
申请号：US16820421
申请日：2020-03-16
申请人： Albumedix Ltd
IPC分类号： C07K14/765 , A61K47/64 , A61K38/38 , A61K47/42
摘要： The present invention relates to conjugation-competent albumins and albumin-related polypeptides, and their conjugates with at least one moiety, and to polynucleotides encoding them.
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公开(公告)号：US10233228B2
公开(公告)日：2019-03-19
申请号：US13640235
申请日：2011-04-08
申请人： Andrew Plumridge , Darrell Sleep , Inger Sandlie , Jan Terje Andersen , Jason Cameron , Leslie Evans , Steven Athwal , Elizabeth Allan , Esben Peter Friis
发明人： Andrew Plumridge , Darrell Sleep , Inger Sandlie , Jan Terje Andersen , Jason Cameron , Leslie Evans , Steven Athwal , Elizabeth Allan , Esben Peter Friis
IPC分类号： C07K14/765
摘要： The application discloses albumin derivatives comprising or consisting of domain III and at least one further domain wherein the derivative or variant is not a naturally occurring albumin derivative or variant. The derivatives may be used in conjugates and fusion polypeptides.
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