公开(公告)号：US20040219028A1

公开(公告)日：2004-11-04

申请号：US10797482

申请日：2004-03-09

申请人： BACCHUS VASCULAR INC., A Delaware Corporation

发明人： Denise M. Demarais ,  Stephen A. Leeflang ,  Michael A. Evans ,  Gwendolyn A. Watanabe ,  John C. Tanner III ,  Christian S. Eversull

IPC分类号： F04B001/00 ,  F04B035/04

CPC分类号： A61M25/0023 ,  A61B17/320725 ,  A61B2017/00685 ,  A61B2017/320775 ,  A61M29/02

摘要： Material transport catheters and methods for their use rely on rotation of an impeller within a catheter body and a clearing element for preventing buildup of materials at the opening of the catheter body. The impeller preferably comprises an inner tube or shaft having a helical rotor formed over an outer surface thereof. The clearing element may comprise a free end of a structure near the distal end of the catheter body for disrupting clot, wherein the free end of the structure extends into the distal opening of the catheter body to break up materials as the impeller is rotated. Alternatively, the clearing element may comprise a cutting member disposed at the distal opening of the catheter body.

公开(公告)号：US20040006306A1

公开(公告)日：2004-01-08

申请号：US10438266

申请日：2003-05-13

申请人： BACCHUS VASCULAR INC.

发明人： Michael A. Evans ,  Denise Demarais ,  Alexander Khairkhahan ,  Dino Decicco

IPC分类号： A61M029/00

CPC分类号： A61M25/1011 ,  A61B17/22 ,  A61B17/3207 ,  A61B17/320708 ,  A61B17/320725 ,  A61B2017/22038 ,  A61B2017/22039 ,  A61B2017/22042 ,  A61B2017/22061 ,  A61B2017/22067 ,  A61B2017/22084 ,  A61B2017/320733 ,  A61B2217/005 ,  A61M25/007 ,  A61M25/1002 ,  A61M2025/018 ,  A61M2025/1052

摘要： An apparatus for treating an occlusive region of a blood vessel includes a catheter including a first lumen extending from an end port to a first side port, and a second lumen extending from a proximal end of the catheter to a second side port. A balloon is mounted on the catheter between the first and second side ports. During use, a guidewire is placed into an occlusive region, and the guidewire is backloaded through the first and second lumens. The catheter is advanced over the guidewire, and the balloon is expanded to isolate the occlusive region. The guidewire is removed, and an agitator is advanced through the second lumen. After the agitator is agitated to dislodge occlusive material from the occlusive region, the agitator is removed, and the loose occlusive material is aspirated via the second side port.

摘要翻译： 用于治疗血管闭塞区域的装置包括导管，其包括从端口延伸到第一侧端口的第一腔，以及从导管的近端延伸到第二侧端口的第二腔。 气囊安装在第一和第二侧面之间的导管上。 在使用期间，将导丝放置在闭塞区域中，并且导丝通过第一和第二腔管被后加载。 导管在导线上前进，并且气囊膨胀以隔离闭塞区域。 引导线被移除，并且搅拌器前进通过第二管腔。 在搅动器搅动以从闭塞区域移除闭塞性材料之后，移除搅拌器，经由第二侧端口吸出松弛的封闭材料。

公开(公告)号：US20030083608A1

公开(公告)日：2003-05-01

申请号：US10187492

申请日：2002-07-01

申请人： Bacchus Vascular, Inc.

发明人： Michael Evans ,  Will R. DuBrul

IPC分类号： A61B017/20

CPC分类号： A61M25/104 ,  A61B17/22 ,  A61B17/22012 ,  A61B90/39 ,  A61B2017/22067 ,  A61B2017/22084 ,  A61F2/958 ,  A61M2025/1052 ,  A61M2025/1093

摘要： The present invention describes a catheter suitable for introduction into a tubular tissue for dissolving blockages in such tissue. The catheter is particularly useful for removing thrombi within blood vessels. In accordance with the preferred embodiments, a combination of vibrating motion and injection of a lysing agent is utilized to break up blockages in vessels. The vessels may be veins, arteries, ducts, intestines, or any lumen within the body that may become blocked from the material that flows through it. As a particular example, dissolution of vascular thrombi facilitated by advancing a catheter through the occluded vessel, the catheter causing a vibrating, stirring action in and around the thrombus usually in combination with the dispensing of a thrombolytic agent such as urokinase into the thrombus. The catheter has an inflatable or expandable member near the distal tip which, when inflated or expanded, prevents the passage of dislodged thrombus around the catheter. The dislodged portions of thrombus are directed through a perfusion channel in the catheter, where they are removed by filtration means housed within the perfusion channel before the blood exists the tip of the catheter. Catheters that allow both low frequency (1-100 Hz) vibratory motion and delivery of such agents to a blockage and a method for using such catheters are disclosed. A distal protection system comprising a braided structure capable of moving from a contracted condition to an expanded condition and adapted to inhibit particles from moving completely through the braided structure when expanded is also disclosed.

摘要翻译： 本发明描述了一种适于引入管状组织中以将阻塞物溶解在这种组织中的导管。 导管特别适用于去除血管内的血栓。 根据优选实施方案，利用振动运动和裂解剂注射的组合来分解血管中的阻塞。 血管可以是静脉，动脉，管道，肠道或身体内可能被流过其的物质阻塞的任何内腔。 作为一个具体实例，通过使导管穿过闭塞的血管促进血管血栓的溶解，导管在血栓内和周围引起振动，搅动作用，通常与分泌溶血栓剂如尿激酶一起进入血栓。 导管在远侧末端附近具有可膨胀或可扩张的构件，当充气或膨胀时，其可以防止移位的血栓在导管周围通过。 血栓的移出部分被引导通过导管中的灌注通道，在血液存在于导管尖端之前，通过过滤装置将其置于灌注通道内。 公开了允许低频（1-100Hz）振动运动和这种试剂输送到阻塞的导管，以及使用这种导管的方法。 还公开了一种远端保护系统，其包括能够从收缩状态移动到膨胀状态并且适于在膨胀时抑制颗粒完全移动通过编织结构的编织结构。

公开(公告)号：US20020173819A1

公开(公告)日：2002-11-21

申请号：US09862174

申请日：2001-05-21

申请人： BACCHUS VASCULAR, INC.

发明人： Stephen Leeflang ,  Denlse DeMarais ,  Michael Evans

IPC分类号： A61M029/00

CPC分类号： A61B17/22 ,  A61B17/32037 ,  A61B2017/22084 ,  A61B2217/005 ,  A61B2217/007 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0076 ,  A61F2230/008 ,  A61F2230/0093 ,  A61F2250/0003

摘要： An apparatus includes a jet housing including an inlet and an outlet, and a nozzle within the jet housing for injecting fluid towards the outlet. A filter element is disposed on the inlet, the filter element including openings for preventing particulate larger than a predetermined size from entering the inlet. The jet housing is positioned within a blood vessel, and fluid is injected from the nozzle towards the outlet to create a vacuum at the inlet, thereby causing fluid downstream of the outlet to flow retrograde through the vessel around the jet housing into the inlet. The filter element prevents particulate from entering the inlet, thereby effectively capturing the particulate, which may be aspirated. Alternatively, a filter element is used to filter particulate during a procedure. The filter element everts from a tubular to an everted configuration for capturing particulate.

摘要翻译： 一种装置包括一个包括一个入口和一个出口的喷气式外壳，以及一个用于将流体喷射到出口的射流壳体内的喷嘴。 过滤元件设置在入口上，过滤元件包括用于防止大于预定尺寸的颗粒进入入口的开口。 射流壳体位于血管内，并且流体从喷嘴朝向出口注入以在入口处产生真空，从而使出口下游的流体逆流地流过穿过射流壳体的容器进入入口。 过滤元件防止颗粒进入入口，从而有效地捕获可被吸入的颗粒。 或者，过滤元件用于过滤颗粒物。 过滤器元件从管状件脱离到用于捕获颗粒物的脱开构造。

公开(公告)号：US20020029052A1

公开(公告)日：2002-03-07

申请号：US09820084

申请日：2001-03-27

申请人： BACCHUS Vascular, Inc.

发明人： Michael A. Evans ,  Denise M. Demarais ,  Gwendolyn A. Watanabe ,  Stephen A. Leeflang

IPC分类号： A61B017/22

CPC分类号： A61B17/3207 ,  A61B17/22 ,  A61B17/221 ,  A61B17/32002 ,  A61B17/320725 ,  A61B17/32075 ,  A61B17/320783 ,  A61B2017/00287 ,  A61B2017/00362 ,  A61B2017/320004 ,  A61B2017/320044 ,  A61B2017/320741 ,  A61M25/1002 ,  A61M25/1027 ,  A61M29/02 ,  A61M2025/1015 ,  A61M2025/1088 ,  A61M2025/109

摘要： The present invention provides devices, systems, methods and kits for the percutaneous removal of unwanted tissue or obstructive matter from body cavities or lumens, particularly from the vasculature. Blood vessels, including the coronary, peripheral and neurovascular circulation, which are narrowed or blocked by atheromatous material or plaque are often treated with traditional endarterectomy procedures. The present invention allows the benefits of such a procedure with an intraluminal approach, particularly a percutaneous approach. Generally, the present invention provides a set of catheters or tools which are percutaneously introduceable to the site of the blockage or occlusion. The tools dissect or cut through the innermost tissue layer of the lumen to an underlying tissue layer. The innermost tissue layer is then stripped away from the underlying layer with the occlusive material thereattached. The detached tissue layer and occlusive material is then removed from the lumen; this may include additional cutting, maceration and removal through mechanical aspiration. In any case, the resulting lumen is free of obstruction.

摘要翻译： 本发明提供用于经皮去除不想要的组织或阻塞物质的装置，系统，方法和试剂盒，所述装置，系统，方法和试剂盒用于从体腔或腔，特别是脉管系统中去除。 通常使用传统的内膜切除手术治疗包括动脉粥样硬化材料或斑块变窄或阻塞的冠状动脉，周围和神经血管循环的血管。 本发明允许使用腔内方法，特别是经皮方法的这种手术的益处。 通常，本发明提供一组导管或工具，其经皮可引入阻塞部位或闭塞部位。 该工具将内腔的最内层组织切割或切割到下面的组织层。 然后将最内侧的组织层从附近的闭塞材料剥离下来的层。 然后从管腔移除脱离的组织层和封闭材料; 这可能包括通过机械抽吸进行额外的切割，浸渍和去除。 在任何情况下，所得到的内腔没有阻塞。

公开(公告)号：US07517352B2

公开(公告)日：2009-04-14

申请号：US09820084

申请日：2001-03-27

申请人： Michael Evans ,  Denise Demarais ,  Gwendolyn Watanabe ,  Stephen Leeflang

发明人： Michael Evans ,  Denise Demarais ,  Gwendolyn Watanabe ,  Stephen Leeflang

IPC分类号： A61M29/00

CPC分类号： A61B17/3207 ,  A61B17/22 ,  A61B17/221 ,  A61B17/32002 ,  A61B17/320725 ,  A61B17/32075 ,  A61B17/320783 ,  A61B2017/00287 ,  A61B2017/00362 ,  A61B2017/320004 ,  A61B2017/320044 ,  A61B2017/320741 ,  A61M25/1002 ,  A61M25/1027 ,  A61M29/02 ,  A61M2025/1015 ,  A61M2025/1088 ,  A61M2025/109

摘要： The present invention provides devices, systems, methods and kits for the percutaneous removal of unwanted tissue or obstructive matter from body cavities or lumens, particularly from the vasculature. Blood vessels, including the coronary, peripheral and neurovascular circulation, which are narrowed or blocked by atheromatous material or plaque are often treated with traditional endarterectomy procedures. The present invention allows the benefits of such a procedure with an intraluminal approach, particularly a percutaneous approach. Generally, the present invention provides a set of catheters or tools which are percutaneously introduceable to the site of the blockage or occlusion. The tools dissect or cut through the innermost tissue layer of the lumen to an underlying tissue layer. The innermost tissue layer is then stripped away from the underlying layer with the occlusive material thereattached. The detached tissue layer and occlusive material is then removed from the lumen; this may include additional cutting, maceration and removal through mechanical aspiration. In any case, the resulting lumen is free of obstruction.

摘要翻译： 本发明提供用于经皮去除不想要的组织或阻塞物质的装置，系统，方法和试剂盒，所述装置，系统，方法和试剂盒用于从体腔或腔，特别是脉管系统中去除。 通常使用传统的内膜切除手术治疗包括动脉粥样硬化材料或斑块变窄或阻塞的冠状动脉，周围和神经血管循环的血管。 本发明允许使用腔内方法，特别是经皮方法的这种手术的益处。 通常，本发明提供一组导管或工具，其经皮可引入阻塞部位或闭塞部位。 该工具将内腔的最内层组织切割或切割到下面的组织层。 然后将最内侧的组织层从附近的闭塞材料剥离下来的层。 然后从管腔移除脱离的组织层和封闭材料; 这可能包括通过机械抽吸进行额外的切割，浸渍和去除。 在任何情况下，所得到的内腔没有阻塞。

公开(公告)号：US06936025B1

公开(公告)日：2005-08-30

申请号：US09704967

申请日：2000-11-01

申请人： Michael Evans ,  Will R. Dubrul

发明人： Michael Evans ,  Will R. Dubrul

IPC分类号： A61B17/22 ,  A61B19/00 ,  A61F2/06 ,  A61F2/84 ,  A61M29/02 ,  A61B17/20 ,  A61M25/00 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61M25/104 ,  A61B17/22 ,  A61B17/22012 ,  A61B90/39 ,  A61B2017/22067 ,  A61B2017/22084 ,  A61F2/958 ,  A61M2025/1052 ,  A61M2025/1093

摘要： A catheter suitable for dissolving blockages in tubular tissue provides a combination of low frequency (1–100 Hz) vibratory motion and injection of a lysing agent. The tubular tissue may be veins, arteries, ducts, intestines, or any other blocked body lumen. For vascular thrombi, the catheter may induce a vibrating, stirring action in and around the thrombus in combination with dispensing of a thrombolytic agent, such as urokinase, into the thrombus. An inflatable or expandable member may be provided near a distal tip of the catheter to prevent release of dislodged thrombus.

摘要翻译： 适合于将阻塞物溶解在管状组织中的导管提供低频（1-100Hz）振动运动和裂解剂的注射的组合。 管状组织可以是静脉，动脉，导管，肠或任何其它阻塞的体腔。 对于血管血栓，导管可以在血栓内和周围引起振动，搅动作用，并结合血栓溶解剂（例如尿激酶）分配到血栓中。 可以在导管的远侧末端附近设置可膨胀或可扩张的构件，以防止脱落的血栓的释放。

公开(公告)号：US20040181150A1

公开(公告)日：2004-09-16

申请号：US10812536

申请日：2004-03-29

申请人： BACCHUS VASCULAR, INC.

发明人： Michael A. Evans ,  Denise M. Demarais

IPC分类号： A61B006/00

CPC分类号： A61M25/0102 ,  A61B17/3207 ,  A61B2017/00252 ,  A61B2017/22077 ,  A61M25/0606

摘要： Access to blood vessels and other body lumens is provided from spaced-apart access penetrations. A penetrating device is introduced through a first access penetration to a target site within the body lumen and then used to penetrate outwardly from the body lumen to an external surface on an organ or the patient's skin. A guidewire may then be deployed through the penetrating device, and the penetrating device removed to leave the guidewire in place. Catheters and other interventional and diagnostic devices may then be introduced to the target site from either or both of the first and second access penetrations over the same guidewire.

摘要翻译： 通过间隔开的通道穿透提供进入血管和其他体腔。 穿透装置通过第一进入穿透被引入到体腔内的目标部位，然后用于从体腔向外穿透到器官或患者皮肤上的外表面。 然后可以通过穿透装置部署导丝，并且移除穿透装置以将导丝放置就位。 然后可以通过相同导丝上的第一和第二进入穿透中的任一个或两者将导管和其它介入和诊断装置引入目标部位。

公开(公告)号：US20030055445A1

公开(公告)日：2003-03-20

申请号：US10285843

申请日：2002-10-31

申请人： Bacchus Vascular, Inc.

发明人： Michael A. Evans ,  Denise M. Demarais ,  Stephen A. Leeflang ,  Christian S. Eversull

IPC分类号： A61D001/02

CPC分类号： A61B17/320725 ,  A61B17/221 ,  A61B17/320758 ,  A61B17/320783 ,  A61B2017/00685 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61B2090/08021

摘要： Devices, methods, kits, and methods remove obstructive material from the vasculature and other body lumens. Expansible baskets may be used as cooperating radially expansible shearing members. Helically oriented struts of each basket may wind in a uniform circumferential direction. The struts can be independently flexible, allowing the shearing members to flex axially together. The inner basket may be rotatably driven and may use an axial pump extending proximally from the shearing members and/or a distal penetrator for advancing into an occlusion which inhibits guidewire access. The struts may slide substantially continuously across each other, and may be sufficiently aggressive for highly effective thrombectomy. A rotationally static and axially flexible outer basket may provide a safe, limited atherectomy treatment.

公开(公告)号：US20110046542A1

公开(公告)日：2011-02-24

申请号：US12816347

申请日：2010-06-15

申请人： Michael A. Evans ,  Denise Demarias ,  Dino De Cicco ,  Kelvin Ning ,  Alexander Khairkhahan ,  Tyler Jon Strang

发明人： Michael A. Evans ,  Denise Demarias ,  Dino De Cicco ,  Kelvin Ning ,  Alexander Khairkhahan ,  Tyler Jon Strang

IPC分类号： A61B17/22 ,  A61M25/00 ,  A61M25/10 ,  A61M25/09

CPC分类号： A61M25/0021 ,  A61B17/22 ,  A61B17/320725 ,  A61B17/320758 ,  A61B2017/22067 ,  A61B2017/22084 ,  A61M25/007 ,  A61M25/0105

摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.

摘要翻译： 使用具有注入溶栓剂，抽吸凝块和流体并允许导丝通过的能力的导管实现凝块破裂和溶解。 任选地，导管还可以包括用于在溶栓剂存在下进一步破坏凝块的机械搅拌器。 导管中的流阻器提供输注和/或抽吸主要集中在血管中的凝块治疗区域，同时还提供可选的输液和/或远离治疗区域的抽吸。 在一些实施例中，输注，抽吸和导丝通过共同内腔。 血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。 以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。