摘要:
The present invention provides devices, systems, methods and kits for the percutaneous removal of unwanted tissue or obstructive matter from body cavities or lumens, particularly from the vasculature. Blood vessels, including the coronary, peripheral and neurovascular circulation, which are narrowed or blocked by atheromatous material or plaque are often treated with traditional endarterectomy procedures. The present invention allows the benefits of such a procedure with an intraluminal approach, particularly a percutaneous approach. Generally, the present invention provides a set of catheters or tools which are percutaneously introduceable to the site of the blockage or occlusion. The tools dissect or cut through the innermost tissue layer of the lumen to an underlying tissue layer. The innermost tissue layer is then stripped away from the underlying layer with the occlusive material thereattached. The detached tissue layer and occlusive material is then removed from the lumen; this may include additional cutting, maceration and removal through mechanical aspiration. In any case, the resulting lumen is free of obstruction.
摘要:
An apparatus includes a jet housing including an inlet and an outlet, and a nozzle within the jet housing for injecting fluid towards the outlet. A filter element is disposed on the inlet, the filter element including openings for preventing particulate larger than a predetermined size from entering the inlet. The jet housing is positioned within a blood vessel, and fluid is injected from the nozzle towards the outlet to create a vacuum at the inlet, thereby causing fluid downstream of the outlet to flow retrograde through the vessel around the jet housing into the inlet. The filter element prevents particulate from entering the inlet, thereby effectively capturing the particulate, which may be aspirated. Alternatively, a filter element is used to filter particulate during a procedure. The filter element everts from a tubular to an everted configuration for capturing particulate.
摘要:
Embodiments provide methods and systems for treating aneurysms using filling structures filled with a curable medium. An embodiment of a method comprises positioning at least one double-walled filling structure across the aneurysm and filling the structure(s) with a filling medium so that an outer wall conforms to the inside of the aneurysm and an inner wall forms a generally tubular lumen to provide for blood flow. The lumen is supported with a balloon or other expandable device while and/or after filling. The pressure within the structure and/or in the space between an external wall of the structure and the aneurysm wall is monitored and a flow of the medium into the structure is controlled responsive to the pressure. The pressure can also be used to determine a filling endpoint. The medium is hardened while the lumen remains supported by the balloon. The balloon is then removed after the medium hardens.
摘要:
Aneurysms are treated by placing a scaffold across an aneurysmal sac to provide a blood flow lumen therethrough. An aneurysmal space surrounding the scaffold is filled with one or more expandable structures which are simultaneously or sequentially expanded to fill the aneurysmal space and reduce the risk of endoluminal leaks and scaffold migration. The expandable structures are typically inflatable and delivered by delivery catheter, optionally with an inflation tube or structure attached to the expandable structure.
摘要:
Aneurysms are treated by filling at least one double-walled filling structure with a curable medium within the aneurysm. The filling structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. Scaffolds are placed into the tubular lumens in order to help maintain the shape, anchor the filling structures in place, and provide improved blood flow transition into and out of the tubular lumens.
摘要:
Aneurysms are treated by filling a double-walled filling structure with a curable medium. The structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. The filling structures are preferably used in pairs for providing flow into the iliac arteries when treating abdominal aortic aneurysm.
摘要:
A method of forming an aggregate. The method comprising forming a green pellet including waste glass and additive(s). The unfired pellets are coated with a refractory material and sintered such that some of the additive/additives breaks down to generate gas which is at least partially retained in the microstructure of the mixture to form pores, the additive/additives so being that upon heating the additive/additives and glass combine to produce glass ceramics.
摘要:
Compounds that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods to inhibit the DNA-PK biological activity, methods to sensitize cells the agents that cause DNA lesions, and methods to potentiate cancer treatment are disclosed.
摘要:
A method of determining the density of an underground formation surrounding a borehole from measurement of gamma rays arising from irradiation of the formation by a nuclear source in a tool body located in the borehole, and measurement of gamma-ray flux in the tool body at two different detector spacings from the source, the method comprising determining a substantially straight-line relationship between gamma-ray flux measurements at each different spacing with respect to the density of the formation for a tool body with no standoff; determining a relationship defining the deviation with respect to tool standoff of the density determined from the measured gamma-ray flux measurements at the two different detector spacings from the density calculated from the straight line relationships; and for a given pair of gamma-ray flux measurements at the different detector spacings, determining the intersection of the relationship defining the deviation with the straight line relationship so as to indicate the density of the formation surrounding the bore-hole; wherein the source is a neutron source and the gamma rays measured in the too! body are neutron-induced gamma rays resulting from neutron irradiation of the formation.
摘要:
A method of changing from a first gear position to a second gear position of a transmission arrangement is disclosed. The arrangement includes a rotatable transmission member, a hydrostatic continuously variable transmission coupled to the transmission member and operable to rotate the transmission member at a first speed, a controller configured to control operation of the hydrostatic continuously variable transmission, and a gear apparatus coupled to the transmission member and configured to be shiftable between at least the first gear position and the second gear position. The method includes controlling the hydrostatic continuously variable transmission, using the controller, to rotate the transmission member at the first speed, and shifting the gear apparatus from the first gear position to the second gear position while the transmission member is rotating at, or converging with, the first speed.