公开(公告)号：US20230099060A1

公开(公告)日：2023-03-30

申请号：US18057355

申请日：2022-11-21

申请人： GLYCOM A/S

发明人： Benjámin PODÁNYI ,  Pierre CHASSAGNE ,  Martin MATWIEJUK ,  Markus JONDELIUS HEDEROS

IPC分类号： C07H3/06 ,  C07H1/00 ,  C07H3/02

摘要： It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US20220378809A1

公开(公告)日：2022-12-01

申请号：US17755956

申请日：2020-11-13

申请人： GLYCOM A/S

发明人： Louise Kristine VIGSNÆS ,  Bruce MCCONNELL

IPC分类号： A61K31/702 ,  A61K35/745 ,  A61K9/48 ,  A61K9/16 ,  A61P1/12

摘要： This invention relates to a method and composition for balancing the bile acid profile in the intestine of humans, particularly decreasing primary bile acids and/or increasing production of secondary bile acids.

公开(公告)号：US11505567B2

公开(公告)日：2022-11-22

申请号：US16630372

申请日：2018-07-12

申请人： GLYCOM A/S

发明人： Benjámin Podányi ,  Pierre Chassagne ,  Martin Matwiejuk ,  Markus Jondelius Hederos

IPC分类号： C07H3/06 ,  C07H1/00 ,  C07H3/02 ,  A23L33/00

摘要： It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US20220267782A1

公开(公告)日：2022-08-25

申请号：US17596781

申请日：2020-06-19

申请人： Glycom A/S

发明人： Margit PEDERSEN

IPC分类号： C12N15/70 ,  C12N15/113

摘要： The present invention relates to the field of recombinant production of biological molecules in host cells. The invention provides nucleic acid constructs that allow to modify expression of a desired gene using both in vitro and in vivo gene expression systems with optimized stem-loop structures in the 5′ UTR of said genes. The constructs can advantageously be used to produce a variety of biological molecules recombinantly in industrial scales, e.g. human milk oligosaccharides (HMOs)

公开(公告)号：US11419884B2

公开(公告)日：2022-08-23

申请号：US16312506

申请日：2017-06-23

申请人： GLYCOM A/S

发明人： Nikolay Khanzhin ,  Markus Jondelius Hederos ,  Louise Kristine Vigsnæs ,  Bruce McConnell

IPC分类号： A61K31/702 ,  C12P1/04 ,  A61P31/04 ,  A61K31/7016 ,  C07H1/00 ,  C12P19/04 ,  C12N9/10 ,  A61K31/716 ,  A61K31/7032

摘要： The present disclosure relates to synthetic mixtures of certain human milk oligosaccharides and uses thereof. Particular mixtures provided herein include: lacto-N-triose II, lacto-N-neotetraose, para-lacto-N-neohexaose, and, optionally, lactose; and lacto-N-triose II, lacto-N-tetraose, para-lacto-N-hexaose II, and, optionally, lactose. These mixtures are useful in the prevention and treatment of viral and bacterial infections.

公开(公告)号：US20220119437A1

公开(公告)日：2022-04-21

申请号：US17646093

申请日：2021-12-27

申请人： GLYCOM A/S

发明人： Nikolay KHANZHIN ,  Markus JONDELIUS HEDEROS

IPC分类号： C07H1/06 ,  B01D61/02 ,  B01D61/04 ,  B01D61/58 ,  B01D69/02 ,  B01D69/12 ,  B01D71/56 ,  B01D71/58 ,  C07H3/06 ,  C12P19/04 ,  C08B37/00 ,  C12P19/12 ,  A23L33/00 ,  C12P19/18

摘要： This invention relates to a method for the enzymatic synthesis of oligosaccharides, preferably human milk oligosaccharides (HMOs) The method comprises the enzymatic transfer of a glycosyl moiety and subsequent removal of by-products, such as lactose, by nanofiltration using a membrane comprising an active polyamide layer.

公开(公告)号：US11304966B2

公开(公告)日：2022-04-19

申请号：US16956511

申请日：2018-12-19

申请人： Glycom A/S

发明人： Bruce McConnell ,  Louise Kristine Vigsnæs ,  Sami Damak ,  Norbert Sprenger ,  Francis Foata

IPC分类号： A61K31/702 ,  A61P1/00 ,  A61K31/7016

摘要： The application relates to synthetic compositions and methods for preventing or reducing nociception and/or nociceptive sensitivity in a non-infant human. The human is administered a composition comprising 6′-sialyllactose (6′-SL) and/or lacto-N-tetraose (LNT).

公开(公告)号：US11224605B2

公开(公告)日：2022-01-18

申请号：US16303131

申请日：2017-05-19

申请人： Glycom A/S

发明人： Louise Kristine Vigsnæs ,  Bruce McConnell ,  Emma Elison

IPC分类号： A61K31/702 ,  A61P1/00 ,  A61P25/00

摘要： The application relates to synthetic compositions containing one or more human milk oligosaccharides for treating serotonin and/or tryptophan dysregulation.

公开(公告)号：US11173171B2

公开(公告)日：2021-11-16

申请号：US16820126

申请日：2020-03-16

申请人： Glycom A/S

发明人： Elise Champion ,  Bruce McConnell ,  Gyula Dekany

IPC分类号： A61K31/702 ,  C07H3/06 ,  C12P19/14 ,  C12P19/26 ,  C07H1/00 ,  C12P19/00 ,  C07H5/06 ,  C12P19/18 ,  A61P31/04 ,  A61P31/12 ,  A61K31/7016

摘要： A mixture of human milk oligosaccharides that consists essentially of 3′-O-sialyllactose, a component A which is either 3-O-fucosyllactose or lacto-N-tetraose, a component B which is 3-0-fucosyl-3′-O-sialyllactose when component A is 3-O-fucosyllactose and sialyllacto-N-tetraose a, when component A is lacto-N-tetraose and optionally lactose as a fourth component. The mixtures are made by treating 3′-O-sialyllactose and component A with an α2,3-transsialidase. The mixtures are for use in anti-bacterial and anti-viral compositions, and for promoting the development of Bifidobacterium and Barnesiella.

公开(公告)号：US20210252028A1

公开(公告)日：2021-08-19

申请号：US17114850

申请日：2020-12-08

申请人： Glycom A/S

发明人： Bruce McConnell ,  Louise Kristine Vigsnæs

IPC分类号： A61K31/702 ,  A61K45/06 ,  A61P31/00 ,  A61P3/10 ,  A61P29/00 ,  A61K35/20

摘要： A method and composition including an effective amount of one or more synthetic neutral HMOs are disclosed for modulating the microbiota in the gastro-intestinal tracts of non-infant humans who are carriers of the human fucosyltransferase 2 (FUT2) genetic mutation and for improving one or more gastrointestinal conditions.