公开(公告)号：US20230366671A1

公开(公告)日：2023-11-16

申请号：US18134929

申请日：2023-04-14

申请人： Miami University

发明人： Hui Wang

IPC分类号： G01B9/02091 ,  A61B3/10 ,  A61B3/00 ,  A61B5/00

CPC分类号： G01B9/02091 ,  A61B3/102 ,  A61B3/0025 ,  A61B5/0066

摘要： A Field Scanning OCT (FSOCT) system that overcomes the bottleneck of imaging speed through simultaneous (parallel) detection of photons from a sample. This provides phase stability during imaging. The herein-disclosed FSOCT methods and devices detect backscattered photons in parallel simultaneously from multiple locations without relying on mechanical motion to capture them at offset positions at different times. This significantly improves the performance of OCT imaging.

公开(公告)号：US09909106B2

公开(公告)日：2018-03-06

申请号：US14766777

申请日：2014-02-14

申请人： Miami University

发明人： Xiao-Wen Cheng ,  Xin-Hua Cheng ,  Tyler A. Garretson

IPC分类号： C12N7/00 ,  C07K14/005 ,  C12N15/86

CPC分类号： C12N7/00 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/14022 ,  C12N2710/14043 ,  C12N2710/14122 ,  C12N2710/14143 ,  C12N2710/14152

摘要： A recombinant baculovirus expression vector or cell comprising an engineered baculovirus fp25k gene with one to three modified or mutated spots, the modified spots comprise the two 7-adenine mononucleotide repeats (MNR) and the 10th TTAA site. The invention also provides the method of making the vector and baculovirus.

公开(公告)号：US08835112B2

公开(公告)日：2014-09-16

申请号：US13898293

申请日：2013-05-20

申请人： Miami University

发明人： Paul Anthony Harding ,  Zhenqing Zhou

IPC分类号： C12Q1/68 ,  C07H21/02 ,  A61K48/00 ,  C12N15/85 ,  C12N15/86

CPC分类号： C12N15/85 ,  A61K48/005 ,  C12N15/86 ,  C12N2799/022 ,  C12N2799/027

摘要： A method for converting animal cells into brown adipose tissue cells is provided that includes transforming the animal cells using an expression vector. The expression vector includes a nucleotide sequence encoding HB-EGF operatively linked to a promoter and a nucleotide sequence encoding ADAM 12 operatively linked to a promoter. Converting animal cells to brown adipose tissue cells can be used to treat obesity or to treat cancer by converting target cells to brown adipose tissue cells.

摘要翻译： 提供了将动物细胞转化为棕色脂肪组织细胞的方法，其包括使用表达载体转化动物细胞。 表达载体包括编码与启动子有效连接的HB-EGF的核苷酸序列和与启动子有效连接的编码ADAM12的核苷酸序列。 将动物细胞转化为棕色脂肪组织细胞可用于治疗肥胖症或通过将靶细胞转化为棕色脂肪组织细胞来治疗癌症。

公开(公告)号：US20090292228A1

公开(公告)日：2009-11-26

申请号：US12471857

申请日：2009-05-26

申请人： Michael Bailey Van Kuren ,  Donna Scarborough

发明人： Michael Bailey Van Kuren ,  Donna Scarborough

IPC分类号： A61H7/00

CPC分类号： A61H39/00 ,  A61B17/1325 ,  A61H7/001 ,  A61H39/04 ,  A61H2201/165 ,  A61H2205/065

摘要： A method and device for reducing gag reflex by applying pressure to a pressure point in the palm of the hand. A splint that holds the hand relatively immobile has a rigid member and an actuating pressure system, such as a solenoid, at the pressure point. The rigid member at least partially immobilizes the human user's palm and fingers. The actuating pressure system is mounted at an inner side of the volar side of the enclosure adjacent to a pressure region of the palm. A power supply is connected to the actuating pressure system to apply an electrical current to the pressure system, which exerts pressure to the pressure region of the user's palm in order to diminish or normalize the user's gag reflex response.

摘要翻译： 一种用于通过向手掌中的压力点施加压力来减少反射的方法和装置。 夹持手相对不动的夹板在压力点具有刚性构件和诸如螺线管的致动压力系统。 刚性构件至少部分地固定人类用户的手掌和手指。 致动压力系统安装在与手掌的压力区域相邻的外壳的容积侧的内侧。 电源连接到致动压力系统以将电流施加到压力系统，该压力系统对用户手掌的压力区域施加压力，以便减少或规范使用者的反射反射响应。

公开(公告)号：US20080184881A1

公开(公告)日：2008-08-07

申请号：US12025167

申请日：2008-02-04

申请人： Hong-Cai Zhou ,  Shengqian Ma

发明人： Hong-Cai Zhou ,  Shengqian Ma

IPC分类号： B01D53/22 ,  C07C63/15 ,  B01J20/22 ,  B01J20/02

CPC分类号： C07F15/065 ,  B01D2253/204 ,  B01J20/226 ,  B01J20/28078 ,  C07C51/09 ,  C07C63/331 ,  C07F1/005 ,  C07F3/003 ,  C07F15/045 ,  Y10S95/902

摘要： Metal-organic framework-based molecular sieves comprising pores with a temperature-adjustable pore opening. The temperature-adjustable pore size molecular sieves comprise a plurality of metal clusters bound with a plurality of amphiphilic ligands, each ligand comprising a functionalized hydrophobic moiety and a functionalized hydrophilic moiety, and wherein the metal clusters and amphiphilic ligand hydrophilic moieties form a metal cluster layer, the metal cluster layer forming at least one hydrophilic pore. On each side of the metal cluster layer, a plurality of associated amphiphilic ligand hydrophobic moieties cooperate with the metal cluster layer to form a tri-layer and a plurality of tri-layers are held in proximity with each other to form at least one hydrophobic chamber. The hydrophobic moieties form temperature-adjustable pore size hydrophobic pores. When adjusted to a pre-selected temperature the temperature-adjustable pore openings allow for the passage of molecules having a size less than the size of the pre-selected temperature-adjustable pore opening.

摘要翻译： 基于金属 - 有机骨架的分子筛包括具有温度可调开孔的孔。 温度可调的孔径分子筛包括与多个两亲性配体结合的多个金属簇，每个配体包含官能化的疏水部分和官能化的亲水部分，并且其中金属簇和两亲性配位体亲水部分形成金属簇层 形成至少一个亲水孔的金属簇层。 在金属簇层的每一侧上，多个相关联的两亲性配体疏水部分与金属簇层配合形成三层，并且多个三层保持彼此接近以形成至少一个疏水室 。 疏水部分形成温度可调孔径的疏水孔。 当调节到预先选定的温度时，温度可调节的孔隙允许具有小于预先选择的温度可调开孔的尺寸的分子通过。

公开(公告)号：US5919617A

公开(公告)日：1999-07-06

申请号：US360606

申请日：1994-12-21

申请人： Jnanendra K. Bhattacharjee ,  Richard C. Garrad ,  Paul L. Skatrud ,  Robert B. Peery

发明人： Jnanendra K. Bhattacharjee ,  Richard C. Garrad ,  Paul L. Skatrud ,  Robert B. Peery

IPC分类号： C07K16/14 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

CPC分类号： C12Q1/6895 ,  C07K16/14

摘要： The present invention provides novel methods and materials for detecting the presence of a fungus in a biological sample. The inventive methods and materials exploit the fact that the amino acid sequence of the saccharopine dehydrogenase molecule is highly conserved in fungi. Inventive hybridization probes, nucleic acids, PCR primers, antibodies, epitopes, reagents and methods are provided.

摘要翻译： 本发明提供用于检测生物样品中真菌存在的新方法和材料。 本发明的方法和材料利用了这样一个事实，即酵母脱氢酶分子的氨基酸序列在真菌中是高度保守的。 提供了本发明的杂交探针，核酸，PCR引物，抗体，表位，试剂和方法。

公开(公告)号：US5622698A

公开(公告)日：1997-04-22

申请号：US499122

申请日：1995-07-06

申请人： Richard E. Lee, Jr.

发明人： Richard E. Lee, Jr.

IPC分类号： A01N63/00 ,  C12N1/20

CPC分类号： A01N63/00 ,  Y10S435/847 ,  Y10S435/874

摘要： Ice nucleating agents are introduced into or on invertebrates. They elevate the supercooling point of such invertebrates. Where such invertebrates are freeze-intolerant, they may be killed or made susceptible to freezing by subjecting them to temperatures at or below the elevated supercooling point. Food sources treated with ice nucleating agents can be used to introduce the agents effectively to the invertebrate.

摘要翻译： 冰成核剂被引入无脊椎动物或其中。 它们提高了这种无脊椎动物的过冷点。 当这种无脊椎动物是不耐冷冻的时候，它们可能被处死或者容易受到冻结的影响，使其处于升高的过冷点或低于升高的过冷点的温度。 可以使用用冰成核剂处理的食物来有效地将药剂引入无脊椎动物。

公开(公告)号：US4734376A

公开(公告)日：1988-03-29

申请号：US921459

申请日：1986-10-22

申请人： Gilbert E. Pacey ,  Ken-ichi Sasaki

发明人： Gilbert E. Pacey ,  Ken-ichi Sasaki

IPC分类号： C07D273/00 ,  G01N21/75 ,  G01N33/20 ,  G01N33/50

CPC分类号： C07D273/00 ,  Y10T436/255

摘要： Chromogenic aza-12-crown-4 ethers which can be used for the spectrophotometric determination of lithium ion in aqueous solutions are disclosed. The compounds of the invention are particularly useful for the analysis of Li.sup.+ in the presence of Na.sup.+, a situation common in biological and geological systems. The compounds [e.g., 1-(2-oxy-5-nitrobenzyl)-1-hydro-1-aza-4,7,10-trioxacyclododecane], their methods of manufacture, and methods of utilizing the compounds for the analysis of lithium are disclosed.

摘要翻译： 公开了可用于水溶液中锂离子的分光光度测定的显色氮杂-12-冠醚4。 本发明的化合物特别可用于在Na +存在下分析Li +，这在生物学和地质学系统中是常见的。 化合物[例如1-（2-氧-5-硝基苄基）-1-氢-1-氮杂-4,7,10-三氧杂环十二烷]，其制备方法和利用该化合物分析锂的方法 被披露。

公开(公告)号：US4659815A

公开(公告)日：1987-04-21

申请号：US698019

申请日：1985-02-04

申请人： Gilbert E. Pacey ,  Ken-ichi Sasaki

发明人： Gilbert E. Pacey ,  Ken-ichi Sasaki

IPC分类号： C07D273/00 ,  C07D273/01

CPC分类号： C07D273/00

摘要： Chromogenic aza-12-crown-4 ethers which can be used for the spectrophotometric determination of lithium ion in aqueous solutions are disclosed. The compounds of the invention are particularly useful for the analysis of Li.sup.30 in the presence of Na.sup.+, a situation common in biological and geological systems. The compounds [e.g., 1-(2-oxy-5-nitrobenzyl)-1-hydro-1-aza-4,7,10-trioxacylclododecane], their methods of manufacture, and methods of utilizing the compounds for the analysis of lithium are disclosed and claimed.

摘要翻译： 公开了可用于水溶液中锂离子的分光光度测定的显色氮杂-12-冠醚4。 本发明的化合物特别可用于在Na +存在下分析Li30，这在生物学和地质学系统中是常见的。 化合物[例如1-（2-氧-5-硝基苄基）-1-氢-1-氮杂-4,7,10-三氧杂环十二烷]，其制备方法和利用该化合物分析锂的方法 被公开和要求保护。

公开(公告)号：US4414671A

公开(公告)日：1983-11-08

申请号：US308714

申请日：1981-10-05

申请人： William E. Wells, Jr. ,  S. Douglas Marcum ,  Lawrence W. Downes ,  Richard A. Tilton

发明人： William E. Wells, Jr. ,  S. Douglas Marcum ,  Lawrence W. Downes ,  Richard A. Tilton

IPC分类号： H01S3/09 ,  H01S3/097 ,  H01S3/22 ,  H01S3/223

CPC分类号： H01S3/223 ,  H01S3/09 ,  H01S3/09707

摘要： Electromagnetic radiation (10) is provided in a gas mixture (12) including helium in the X(1) state and nitrogen in the Y(1) state. The helium is pumped to excite a high population density of its atoms from the X(1) state to the X(2) state; and photons (15) of suitable frequency are injected into the mixture (12) to excite, via a three-body radiative collision of an atom of X(2) with a molecule of Y(1) and a photon (15): a high population density of molecules of the nitrogen from the Y(1) state to the Y(3) state, followed by a substantially simultaneous return of a substantial portion of the excited helium atoms to the X(1) state and a substantial depopulation of the Y(3) state of the nitrogen, causing the molecules thereof to drop to the lower energy Y(2) state, thereby stimulating the emission from the nitrogen of two photons (10) at the same wavelength for each absorbed photon (15), and thus providing a total quantity of photon emission (10) with sufficient gain for amplification of electromagnetic radiation (10), and finally resulting in the depopulation of the molecules in the Y(2) state by autoionization.

摘要翻译： 在包括X（1）中的氦和Y（1）状态的氮气的气体混合物（12）中提供电磁辐射（10）。 泵送氦气以将其原子的高人口密度从X（1）状态激发到X（2）状态; 并且将适当频率的光子（15）注入到混合物（12）中，以通过X（2）的原子与Y（1）的分子和光子（15）的三体辐射碰撞来激发： 从Y（1）状态到Y（3）状态的氮的分子的高人口密度，随后大部分激发的氦原子的大部分同时返回到X（1）状态，并且实质上减少 氮的Y（3）状态，使其分子下降到较低的能量Y（2）状态，由此针对每个吸收的光子（15）刺激相同波长的两个光子（10）的氮的发射， ，从而提供具有足够增益用于放大电磁辐射（10）的光子发射总量（10），并且最终导致通过自动离子化分解为Y（2）状态的分子。