公开(公告)号：US20070225781A1

公开(公告)日：2007-09-27

申请号：US11386239

申请日：2006-03-21

申请人： Vahid Saadat ,  Lorns G. Eltherington

发明人： Vahid Saadat ,  Lorns G. Eltherington

IPC分类号： A61F7/00

CPC分类号： A61F7/12 ,  A61B2017/00084 ,  A61F2007/0056 ,  A61F2007/0076 ,  A61F2007/0094

摘要： Apparatus and methods for cooling and/or heating selected regions within a body are described herein. An implantable system is used to cool or heat nerve bodies down to about 15° C. to diminish nerve impulses. In one embodiment, the system can include an implantable unit containing a pumping mechanism and/or various control electronics. The system has a cooling element. The cooling element can be a Peltier junction or a catheter through which hot or cold fluid flows. The heated portion of the Peltier junction can be cooled by a liquid heat transfer medium which absorbs the heat from the junction and dissipates the heat elsewhere.

摘要翻译： 本文描述了用于冷却和/或加热体内所选区域的装置和方法。 使用可植入系统将神经体冷却或加热至约15℃，以减少神经冲动。 在一个实施例中，系统可以包括含有泵送机构和/或各种控制电子装置的可植入单元。 该系统具有冷却元件。 冷却元件可以是热或冷流体流过的珀尔帖接头或导管。 珀尔帖接头的加热部分可以通过液体传热介质进行冷却，液体传热介质吸收来自接头的热量，并将热量散发到别处。

公开(公告)号：US20150164571A1

公开(公告)日：2015-06-18

申请号：US14503060

申请日：2014-09-30

申请人： Nidus Medical, LLC

发明人： Vahid SAADAT

IPC分类号： A61B18/02 ,  A61B1/04 ,  A61B1/233

CPC分类号： A61B18/02 ,  A61B1/04 ,  A61B1/233 ,  A61B17/24 ,  A61B18/1485 ,  A61B2018/0022 ,  A61B2018/00327 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/00714 ,  A61B2018/00791 ,  A61B2018/00982 ,  A61B2018/0212 ,  A61B2018/0268 ,  A61B2018/143 ,  A61B2018/1475 ,  A61B2090/378 ,  A61B2218/002 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/003

摘要： Apparatus and methods for treating conditions such as rhinitis are disclosed herein where a distal end of a probe shaft is introduced through the nasal cavity where the distal end has an end effector with a first configuration having a low-profile which is shaped to manipulate tissue within the nasal cavity. The distal end may be positioned into proximity of a tissue region having a post nasal nerve associated with a middle or inferior nasal turbinate. Once suitably positioned, the distal end may be reconfigured from the first configuration to a second configuration which is shaped to contact and follow the tissue region and the post nasal nerve may then be ablated via the distal end. Ablation may be performed using various mechanisms, such as cryotherapy, and optionally under direct visualization.

摘要翻译： 本文公开了用于治疗诸如鼻炎的病症的装置和方法，其中探针轴的远端通过鼻腔引入，其中远端具有末端执行器，其具有低轮廓的第一构造，其具有被成形为操纵组织内的组织 鼻腔。 远端可以定位在具有与中鼻甲或下鼻甲相连的鼻后神经的组织区域附近。 一旦适当地定位，远端可以从第一构型重新配置到第二构型，其被成形为接触和跟随组织区域，并且鼻后神经可以经由远端被烧蚀。 可以使用诸如冷冻治疗的各种机制进行消融，并且可选地直接观察。

公开(公告)号：US20080058590A1

公开(公告)日：2008-03-06

申请号：US11848193

申请日：2007-08-30

申请人： Vahid Saadat ,  Ruey-Feng Peh ,  Edmund Tam

发明人： Vahid Saadat ,  Ruey-Feng Peh ,  Edmund Tam

IPC分类号： A61B1/32

CPC分类号： A61B1/32 ,  A61B1/00085 ,  A61B1/005 ,  A61B1/041

摘要： Tissue visualization devices having multi-segmented frame are described herein where such devices may utilize multiple expanding frame members coupled to a flexible deployment catheter shaft or rigid shaft. The multiple frame members may extend distally to collapse into a low-profile configuration and may further expand or open radially to create a working field between the frame members. Moreover, the distal ends of each frame member may be tapered such that the frame members may close tightly relative to one another forming an atraumatic end. Additionally, any number of therapeutic tools can also be passed through the catheter or shaft for performing any number of procedures on the tissue for identifying, locating, and/or treating tissue.

摘要翻译： 本文描述了具有多分段框架的组织可视化装置，其中这种装置可以利用联接到柔性展开导管轴或刚性轴的多个扩展框架构件。 多个框架构件可以向远侧延伸以折叠成低轮廓构造，并且可以进一步扩展或径向地开放以在框架构件之间形成工作区域。 此外，每个框架构件的远端可以是锥形的，使得框架构件可以相对于彼此紧密地紧密地形成形成无伤痕的端部。 此外，任何数量的治疗工具也可以通过导管或轴，用于在组织上执行任何数量的程序以识别，定位和/或治疗组织。

公开(公告)号：US07758571B2

公开(公告)日：2010-07-20

申请号：US10494487

申请日：2002-11-01

申请人： Vahid Saadat

发明人： Vahid Saadat

IPC分类号： A61B18/02 ,  A61F7/12

CPC分类号： A61B18/02 ,  A61B2017/00292 ,  A61B2017/00867 ,  A61B2017/22001 ,  A61B2017/22038 ,  A61B2017/22051 ,  A61B2018/00101 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Methods and apparatus for cryo-therapy are disclosed herein. This includes a hollow guidewire disposed within a catheter having helical loops contacting tissue. A coolant delivery tube disposed within can have a coolant delivered from a proximal end into the guidewire lumen. The coolant flows back proximally through the guidewire while cooling the guidewire surface and cooling or cryogenically ablating the contacting tissue. To minimize guidewire exposure to surrounding fluids or tissue, insulative barriers can be attached to the guidewire. A coolant delivery tube and return lumen can be integrated from a single extrusion in various configurations. Expandable balloons can also be used to expand the loops of the guidewire to contact the tissue. Also, helical loops with a coolant delivery tube or stem disposed longitudinally within the loops can be used and the loops can also have a variable collapsible cooling region.

摘要翻译： 本文公开了用于冷冻治疗的方法和装置。 这包括设置在具有螺旋环接触组织的导管内的中空导丝。 设置在其内的冷却剂输送管可以具有从近端输送到导丝管内腔的冷却剂。 冷却剂通过导丝向后流回，同时冷却导丝表面并冷却或低温地消融接触组织。 为了尽量减少对周围流体或组织的导线暴露，绝缘屏障可以附着在导丝上。 冷却剂输送管和返回腔可以以各种配置从单个挤出机集成。 也可以使用可膨胀气球来扩展导丝的环以接触组织。 此外，可以使用具有纵向设置在环内的冷却剂输送管或杆的螺旋环，并且环也可以具有可变的可折叠冷却区域。

公开(公告)号：US20090187074A1

公开(公告)日：2009-07-23

申请号：US12355378

申请日：2009-01-16

申请人： Vahid SAADAT ,  Ruey-Feng PEH ,  Edmund TAM

发明人： Vahid SAADAT ,  Ruey-Feng PEH ,  Edmund TAM

IPC分类号： A61B1/00

CPC分类号： A61B1/3132 ,  A61B1/00085 ,  A61B1/00094 ,  A61B1/00179 ,  A61B1/0125 ,  A61B1/018 ,  A61B1/05 ,  A61B1/32 ,  A61B17/0218 ,  A61B17/3478 ,  A61B2017/00243 ,  A61B2017/003 ,  A61B2017/320044 ,  A61B2017/3488 ,  A61M25/0068 ,  A61M25/0074 ,  A61M25/0082 ,  A61M29/02

摘要： Epicardial access and treatment systems are described herein where such devices may utilize multiple expanding frame members coupled to a flexible or rigid deployment catheter shaft. The multiple frame members may extend distally to collapse into a low-profile configuration and may further expand or open radially to create a working or surgical field under direct visualization and defined by the frame members and surrounding membrane while retracting any surrounding tissue. Moreover, the distal ends of each frame member may be tapered such that the frame members may close tightly relative to one another forming an atraumatic end. Any number of therapeutic tools can be passed through the catheter for performing any number of procedures on the tissue.

摘要翻译： 本文描述了心外膜通路和治疗系统，其中这种装置可以利用联接到柔性或刚性展开导管轴的多个扩张框架构件。 多个框架构件可以向远侧延伸以塌陷成低轮廓构造，并且可以进一步在径向上扩张或开放以在直接可视化下产生工作或外科手术领域，并且由框架构件和周围膜定义，同时缩回任何周围组织。 此外，每个框架构件的远端可以是锥形的，使得框架构件可以相对于彼此紧密地紧密地形成形成无伤痕的端部。 任何数量的治疗工具可以通过导管，用于在组织上执行任何数量的程序。

公开(公告)号：US20090005674A1

公开(公告)日：2009-01-01

申请号：US12109175

申请日：2008-04-24

申请人： Vahid SAADAT ,  Zachary J. MALCHANO

发明人： Vahid SAADAT ,  Zachary J. MALCHANO

IPC分类号： A61B6/12

CPC分类号： A61B5/1076 ,  A61B5/1077 ,  A61B5/435 ,  A61B2562/0209 ,  A61B2562/046 ,  A61B2562/164 ,  A61B2562/168

摘要： An expandable member for characterizing a three-dimensional space within a mammalian body is described. The expandable member is delivered to a target region in a deflated state where it is expanded by inflation of the member. Sensory transducers that contact the member relay sensory information generated when the member is in an expanded state to a microprocessor located outside the body. Using the sensory information, a data-driven picture that characterizes the three-dimensional space within the body is created with a microprocessor. The apparatus is useful in preparation for minimally invasive surgical therapy.

摘要翻译： 描述了用于表征哺乳动物体内的三维空间的可扩展构件。 可膨胀构件以放气状态被输送到目标区域，在膨胀状态下，膨胀构件通过构件的膨胀膨胀。 感测传感器，其将当构件处于展开状态时产生的构件继电器感测信息接触位于身体外部的微处理器。 使用感官信息，用微处理器创建表征身体内的三维空间的数据驱动画面。 该装置可用于微创手术治疗的准备。

公开(公告)号：US20140012180A1

公开(公告)日：2014-01-09

申请号：US13858403

申请日：2013-04-08

申请人： Nidus Medical, LLC

发明人： Howard LEVIN ,  Mark GELFAND

IPC分类号： A61M27/00

CPC分类号： A61M27/002 ,  A61M1/28 ,  A61M1/285 ,  A61M2210/1085

摘要： A method to remove ascites from a mammalian body including: draining ascites from the peritoneal cavity to the bladder of the mammalian body, and evacuating the drained ascites out of the bladder. The method may be practiced with a valved fistula implanted into the bladder to form a passage between the peritoneal cavity and the bladder.

摘要翻译： 一种从哺乳动物体内除去腹水的方法，包括：将腹水从腹膜腔排出到哺乳动物体内，将排出的腹水排出膀胱。 该方法可以用植入膀胱中的带阀的瘘来实现，以在腹腔和膀胱之间形成通道。

公开(公告)号：US08463359B2

公开(公告)日：2013-06-11

申请号：US12109175

申请日：2008-04-24

申请人： Vahid Saadat ,  Zachary J. Malchano

发明人： Vahid Saadat ,  Zachary J. Malchano

IPC分类号： A61B5/055 ,  A61B8/14 ,  A61M29/00

CPC分类号： A61B5/1076 ,  A61B5/1077 ,  A61B5/435 ,  A61B2562/0209 ,  A61B2562/046 ,  A61B2562/164 ,  A61B2562/168

摘要： An expandable member for characterizing a three-dimensional space within a mammalian body is described. The expandable member is delivered to a target region in a deflated state where it is expanded by inflation of the member. Sensory transducers that contact the member relay sensory information generated when the member is in an expanded state to a microprocessor located outside the body. Using the sensory information, a data-driven picture that characterizes the three-dimensional space within the body is created with a microprocessor. The apparatus is useful in preparation for minimally invasive surgical therapy.

摘要翻译： 描述了用于表征哺乳动物体内的三维空间的可扩展构件。 可膨胀构件以放气状态被输送到目标区域，在膨胀状态下，膨胀构件通过构件的膨胀膨胀。 感测传感器，其将当构件处于展开状态时产生的构件继电器感测信息接触位于身体外部的微处理器。 使用感官信息，用微处理器创建表征身体内的三维空间的数据驱动画面。 该装置可用于微创手术治疗的准备。

公开(公告)号：US07500985B2

公开(公告)日：2009-03-10

申请号：US11096980

申请日：2005-04-01

申请人： Vahid Saadat

发明人： Vahid Saadat

IPC分类号： A61F7/00

CPC分类号： A61F7/12 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/126

摘要： Apparatus and methods for cooling selected regions within a body are described herein. An implantable cooling system is used to cool regions of the brain, spinal cord, fibrous nerve bodies, e.g., vagus nerve, etc. down to about 30° C. to diminish nerve impulses which control seizures or chronic pain. The system includes an implantable unit containing a pumping mechanism and/or various control electronics. It also has a heat exchanger attachable to a tubular body organ, such as the superior vena cava or the inferior vena cava, through which the heat is effectively dissipated. Also included is a heat pump such as a Peltier junction configured to be placed into contact with the region of tissue to be cooled. The heated portion of the Peltier junction is cooled by a liquid heat transfer medium which absorbs the heat from the junction and dissipates it into the tubular body organ.

摘要翻译： 本文描述了用于冷却体内所选区域的装置和方法。 植入式冷却系统用于将大脑，脊髓，纤维神经体（例如迷走神经等）的区域冷却至约30℃，以减少控制癫痫发作或慢性疼痛的神经冲动。 该系统包括含有泵送机构和/或各种控制电子装置的可植入单元。 它还具有可连接到诸如上腔静脉或下腔静脉的管状体器官的热交换器，热量被有效地消散通过该热交换器。 还包括一个热泵，例如珀尔帖接头，被配置为与要冷却的组织区域接触。 珀尔帖接头的加热部分由液体传热介质冷却，液体传热介质从接合处吸收热量并将其散发到管状体脏器中。

公开(公告)号：US07232458B2

公开(公告)日：2007-06-19

申请号：US10841160

申请日：2004-05-07

申请人： Vahid Saadat

发明人： Vahid Saadat

IPC分类号： A61F7/00

CPC分类号： A61F7/12 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/126

摘要： Apparatus and methods for cooling selected regions within a body are described herein. An implantable cooling system is used to cool regions of the brain, spinal cord, fibrous nerve bodies, e.g., vagus nerve, etc. down to about 30° C. to diminish nerve impulses which control seizures or chronic pain. The system includes an implantable unit containing a pumping mechanism and/or various control electronics. It also has a heat exchanger attachable to a tubular body organ, such as the superior vena cava or the inferior vena cava, through which the heat is effectively dissipated. Also included is a heat pump such as a Peltier junction configured to be placed into contact with the region of tissue to be cooled. The heated portion of the Peltier junction is cooled by a liquid heat transfer medium which absorbs the heat from the junction and dissipates it into the tubular body organ.

摘要翻译： 本文描述了用于冷却体内所选区域的装置和方法。 植入式冷却系统用于将大脑，脊髓，纤维神经体（例如迷走神经等）的区域冷却至约30℃，以减少控制癫痫发作或慢性疼痛的神经冲动。 该系统包括含有泵送机构和/或各种控制电子装置的可植入单元。 它还具有可连接到诸如上腔静脉或下腔静脉的管状体器官的热交换器，热量被有效地消散通过该热交换器。 还包括一个热泵，例如珀尔帖接头，被配置为与要冷却的组织区域接触。 珀尔帖接头的加热部分由液体传热介质冷却，液体传热介质从接合处吸收热量并将其散发到管状体脏器中。