公开(公告)号：US20130046356A1

公开(公告)日：2013-02-21

申请号：US13658538

申请日：2012-10-23

申请人： Proteus Biomedical, Inc.

发明人： Marc Jensen ,  Benedict James Costello ,  Todd Thompson ,  Mark J. Zdeblick ,  Olivier Colliou ,  George M. Savage

IPC分类号： A61N1/37

CPC分类号： A61N1/3627

摘要： Methods of highly selective cardiac tissue stimulation and devices for practicing the same, e.g., implantable segmented electrode devices, are provided. The methods and devices provide a previously unavailable high phrenic nerve capture voltage paired with a low pacing capture voltage threshold. The subject methods and devices provide a number of benefits. For example, patients who previously would have been required to have their resynchronization device turned off due to phrenic nerve capture will now be able to reap the benefits of resynchronization therapy.

摘要翻译： 提供了高选择性心脏组织刺激的方法和用于实施该方法的装置，例如可植入分段的电极装置。 这些方法和装置提供了与低起搏捕获电压阈值配对的先前不可用的高膈神经捕获电压。 主题方法和设备提供了许多好处。 例如，以前由于膈神经捕获而被关闭的再同步装置的患者现在将能够获得再同步治疗的好处。

公开(公告)号：US08204586B2

公开(公告)日：2012-06-19

申请号：US11562690

申请日：2006-11-22

申请人： Mark Zdeblick

发明人： Mark Zdeblick

IPC分类号： A61B5/04

CPC分类号： A61B5/05 ,  A61B5/11 ,  A61N1/3627 ,  A61N1/36542

摘要： Methods for evaluating tissue motion of a tissue location, e.g., a cardiac location, via external continuous field tomography are provided. Aspects of the methods include generating at least one substantially linear continuous field gradient across the tissue location of interest, and using a resultant signal from a sensing element stably associated with the tissue location to evaluate motion of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.

摘要翻译： 提供了通过外部连续场断层摄影术来评估组织位置例如心脏位置的组织运动的方法。 方法的方面包括跨越感兴趣的组织位置生成至少一个基本上线性的连续场梯度，以及使用来自与组织位置稳定相关联的感测元件的合成信号来评估组织位置的运动。 还提供了用于实践主题方法的系统，装置和相关组合物。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

公开(公告)号：US08187161B2

公开(公告)日：2012-05-29

申请号：US12202143

申请日：2008-08-29

申请人： Haifeng Li ,  Mark Zdeblick ,  Lawrence Arne ,  Yafei Bi ,  Nilay Jani ,  Jonathan Withrington

发明人： Haifeng Li ,  Mark Zdeblick ,  Lawrence Arne ,  Yafei Bi ,  Nilay Jani ,  Jonathan Withrington

IPC分类号： A61F2/02

CPC分类号： A61N1/37288 ,  A61N1/025

摘要： Various aspects of the present invention enable robust, reliable control functionality for effectors present on intraluminal, e.g., vascular leads, as well as other types of implantable devices. Aspects of the invention include implantable integrated circuits that have self-referencing and self-clocking signal encoding, and are capable of bidirectional communication. Also provided by the invention are effector assemblies that include the integrated circuits, as well as implantable medical devices, e.g., pulse generators that include the same, as well as systems and kits thereof and methods of using the same, e.g., in pacing applications, including cardiac resynchronization therapy (CRT) applications.

摘要翻译： 本发明的各个方面对存在于管腔内（例如血管引线）以及其它类型的可植入装置的效果器提供了鲁棒且可靠的控制功能。 本发明的方面包括具有自参考和自时钟信号编码并且能够进行双向通信的可植入集成电路。 本发明还提供了包括集成电路的效应器组件以及可植入的医疗装置，例如包括其的脉冲发生器，以及其系统和套件，以及使用该装置的方法，例如在起搏应用中， 包括心脏再同步治疗（CRT）应用。

公开(公告)号：US20120116188A1

公开(公告)日：2012-05-10

申请号：US13180525

申请日：2011-07-11

申请人： Jeremy Frank ,  Peter Bjeletich ,  Hooman Hafezi ,  Robert Azevedo ,  Robert Duck ,  Iliya Pesic ,  Benedict Costello ,  Eric Snyder

发明人： Jeremy Frank ,  Peter Bjeletich ,  Hooman Hafezi ,  Robert Azevedo ,  Robert Duck ,  Iliya Pesic ,  Benedict Costello ,  Eric Snyder

IPC分类号： A61B5/07 ,  B05D5/12 ,  B32B38/04

CPC分类号： A61B5/073 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/14539 ,  A61B5/4839 ,  A61B5/6861 ,  A61B2560/0214 ,  A61B2562/12 ,  A61B2562/125 ,  A61B2562/162 ,  A61J3/007 ,  H01M4/0402 ,  H01M4/06 ,  H01M4/08 ,  H01M4/366 ,  H01M4/381 ,  H01M4/582 ,  H01M4/66 ,  H01M6/34 ,  H01M2220/30 ,  H01Q1/273 ,  Y10T29/49002 ,  Y10T29/49117 ,  Y10T156/1056

摘要： The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.

摘要翻译： 本发明的系统包括不同材料形式的导电元件，电子元件和部分电源。 当与导电流体接触时，产生电压电位并且电源完成，这激活了系统。 电子部件控制不同材料之间的电导，以产生独特的当前签名。 该系统还可以测量系统周围环境的状况。

公开(公告)号：US08172762B2

公开(公告)日：2012-05-08

申请号：US11897942

申请日：2007-08-31

申请人： Timothy L. Robertson

发明人： Timothy L. Robertson

IPC分类号： A61B5/02

CPC分类号： A61B5/026 ,  A61B5/0031 ,  A61B5/14535 ,  G06F19/00

摘要： Embodiments of the present invention provide blood flow sensors that can be used for measurement of various physiological parameters under a wide array of conditions. In some embodiments, the blood flow sensor can be implanted into a blood vessel and left in place indefinitely and will unobtrusively measure and record data as the patient engages in regular daily activities. The data can later be read out by a clinician using a suitable interface. In other embodiments, the data is collected and analyzed within a data collection device implanted in or attached to the patient's body, and the collection device can report to the patient on an ongoing basis or in the form of alerts issued when conditions requiring medical intervention are detected.

摘要翻译： 本发明的实施例提供可用于在广泛条件下测量各种生理参数的血液流量传感器。 在一些实施例中，血液流量传感器可以被植入血管并且无限期地保持在适当的位置，并且将随着患者进行常规的日常活动而不经意地地测量和记录数据。 数据随后可以由临床医生使用合适的界面读出。 在其他实施例中，在植入或附接到患者身体的数据收集装置内收集和分析数据，并且收集装置可以持续基础或以需要医疗干预的条件发出的警报的形式向患者报告 检测到。

公开(公告)号：US08123684B2

公开(公告)日：2012-02-28

申请号：US12624241

申请日：2009-11-23

申请人： Mark J. Zdeblick

发明人： Mark J. Zdeblick

IPC分类号： A61N1/00

CPC分类号： A61N1/372 ,  A61B5/04011 ,  A61B5/0422 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/37211 ,  A61N1/37276 ,  A61N1/37288 ,  A61N2001/0585

摘要： Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.

摘要翻译： 用于控制用于放置在受检者体内的一个或多个模块化电路（“卫星”）的技术。 通过在包括第一和第二导电路径的总线上发送信号来控制一个或多个卫星。 在系统实施例中还耦合到总线的是诸如提供电力并包括控制电路的起搏器的装置。 每个卫星包括卫星电路和与组织相互作用的一个或多个效应器。 卫星电路耦合到总线，并且因此使控制器与一个或多个效应器接合，这些效应器可以用作致动器，传感器或两者。 效应器可以是用于将模拟电信号（例如，一个或多个起搏脉冲）引入电极定位的局部区域（例如，心脏肌肉）中的组织中或用于感测模拟信号（例如，传播 去极化信号）。

公开(公告)号：US20110130809A1

公开(公告)日：2011-06-02

申请号：US12600586

申请日：2009-11-13

申请人： Mark Zdeblick

发明人： Mark Zdeblick

IPC分类号： A61N1/36

CPC分类号： A61N1/36146 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/3686

摘要： System, device and method of variable pacing and stimulation are provided. In one example device, one or more lead integrated circuits may programmably control one or more variability parameters. One or more electrodes may provide electrical stimulation. Each electrode may be individually addressable by at least one of the lead integrated circuits and controlled by at least one variability parameter. Electrodes may be intentionally shorted together during time intervals that fall between times of stimulus, so as to dissipate potentials that might otherwise persist and cause electrode degradation.

摘要翻译： 提供可变起搏和刺激的系统，装置和方法。 在一个示例性设备中，一个或多个引线集成电路可编程地控制一个或多个可变性参数。 一个或多个电极可以提供电刺激。 每个电极可以由至少一个引线集成电路单独寻址并由至少一个可变性参数控制。 在刺激时间之间的时间间隔内，电极可能被故意地短路在一起，以消散可能会持续并导致电极降解的电位。

公开(公告)号：US07925329B2

公开(公告)日：2011-04-12

申请号：US11249152

申请日：2005-10-11

申请人： Mark Zdeblick ,  George M. Savage

发明人： Mark Zdeblick ,  George M. Savage

IPC分类号： A61B5/05

CPC分类号： A61N1/36528 ,  A61B5/05 ,  A61B5/1107

摘要： The inventive implantable Doppler tomography system allows, for the first time, the use of Doppler shift for purposes of tracking cardiac wall motion. The present inventive Doppler tomography system methods and devices provide a critical new tool in the physician's armamentarium which provides accurate, real time monitoring of the mechanical performance of the heart.

摘要翻译： 本发明的可植入多普勒层析成像系统首次允许使用多普勒频移来跟踪心脏壁运动。 本发明的多普勒层析成像系统方法和装置在医师装置中提供关键的新工具，其提供对心脏的机械性能的准确的实时监测。

公开(公告)号：US07771363B2

公开(公告)日：2010-08-10

申请号：US11316615

申请日：2005-12-21

申请人： Todd Thompson

发明人： Todd Thompson

IPC分类号： A61B5/02

CPC分类号： A61B5/026 ,  A61B1/00147

摘要： The present invention provides a new mechanical sensor approach to maneuvering catheters and other cardiac devices into blood outlets, with particular application to maneuvering cardiac devices into the coronary sinus and beyond. Additionally, the inventive sensing device provides assessment of the viability of branching veins and other potential device sites, such as within the coronary venous system.

摘要翻译： 本发明提供了一种用于将导管和其他心脏装置操纵到血液出口中的新的机械传感器方法，其特别适用于将心脏装置操纵到冠状窦及其以外。 另外，本发明的感测装置提供了分支静脉和其它潜在装置部位如冠状静脉系统内存活能力的评估。

公开(公告)号：US07713195B2

公开(公告)日：2010-05-11

申请号：US11731090

申请日：2007-03-29

申请人： Mark J. Zdeblick

发明人： Mark J. Zdeblick

IPC分类号： A61N1/08

CPC分类号： A61N1/372 ,  A61B5/04011 ,  A61B5/0422 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/37211 ,  A61N1/37276 ,  A61N1/37288 ,  A61N2001/0585

摘要： Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.

摘要翻译： 用于控制用于放置在受检者体内的一个或多个模块化电路（“卫星”）的技术。 通过在包括第一和第二导电路径的总线上发送信号来控制一个或多个卫星。 在系统实施例中还耦合到总线的是诸如提供电力并包括控制电路的起搏器的装置。 每个卫星包括卫星电路和与组织相互作用的一个或多个效应器。 卫星电路耦合到总线，并且因此使控制器与一个或多个效应器接合，这些效应器可以用作致动器，传感器或两者。 效应器可以是用于将模拟电信号（例如，一个或多个起搏脉冲）引入电极定位的局部区域（例如，心脏肌肉）中的组织中或用于感测模拟信号（例如，传播 去极化信号）。