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公开(公告)号：US20150224316A1
公开(公告)日：2015-08-13
申请号：US14696136
申请日：2015-04-24
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/0531 , A61N1/0553 , A61N1/36146 , A61N1/36157 , A61N1/36182 , A61N1/36185
摘要： A neurostimulation device is provided comprising an input, a neurostimulation probe, a stimulation unit and a distribution calculation module. At the input stimulation data is received comprising information relating to a stimulation preferability and an orientation of at least one fiber bundle. The neurostimulation probe comprises an array of stimulation electrodes which are coupled to the stimulation unit. The stimulation unit, in accordance with a specified current distribution, provides currents to the respective stimulation electrodes for generating an electric field gradient. The distribution calculation module is coupled to the input and the stimulation unit for based on the stimulation data determining a preferred position and orientation for the electric field gradient, and based on the preferred position and orientation for the electric field gradient, calculating the specified current distribution.
摘要翻译： 提供神经刺激装置，其包括输入，神经刺激探针，刺激单元和分布计算模块。 在输入刺激数据被接收包括与刺激优选性和至少一个纤维束的取向有关的信息。 神经刺激探针包括耦合到刺激单元的刺激电极的阵列。 刺激单元根据指定的电流分布，向相应的刺激电极提供电流以产生电场梯度。 分布计算模块基于确定电场梯度的优选位置和取向的刺激数据耦合到输入和刺激单元，并且基于电场梯度的优选位置和取向，计算指定的电流分布 。
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2.发明授权Control circuitry and method for controlling a bi-directional switch system, a bi-directional switch, a switching matrix and a medical stimulator 有权用于控制双向开关系统，双向开关，开关矩阵和医疗刺激器的控制电路和方法公开(公告)号：US08937504B2
公开(公告)日：2015-01-20
申请号：US13636137
申请日：2011-04-05
申请人： Pieter Gerrit Blanken , Jeroen Jacob Arnold Tol , Franciscus Adrianus Cornelis Maria Schoofs , Dave Willem van Goor
发明人： Pieter Gerrit Blanken , Jeroen Jacob Arnold Tol , Franciscus Adrianus Cornelis Maria Schoofs , Dave Willem van Goor
IPC分类号： H03K17/687 , H03K17/06 , A61N1/36
CPC分类号： H02J7/008 , A61N1/05 , A61N1/36185 , H02J7/0052 , H02J7/345 , H03K17/063 , H03K17/687
摘要： A control circuitry and a method for controlling a bi-directional switch is provided. The bi-directional switch having a control terminal for receiving a control voltage to control an on state and an off state of the bi-directional switch and at least one semiconductor switch in a bi-directional main current path. The control circuitry comprises an energy storage element, a coupling means to couple the energy storage element to a supply voltage to charge the energy storage element, and a control circuit configured to receive power from the energy storage element and configured to supply the control voltage having a voltage level being independent of the supply voltage when the energy storage element is not coupled to the supply voltage. The coupling means is configured for only coupling the energy storage element to the supply voltage when the bi-directional switch is in the off state.
摘要翻译： 提供了一种用于控制双向开关的控制电路和方法。 双向开关具有用于接收控制电压以控制双向开关的接通状态和断开状态的控制端以及双向主电流路径中的至少一个半导体开关。 控制电路包括能量存储元件，将能量存储元件耦合到电源电压以对能量存储元件充电的耦合装置;以及配置成从能量存储元件接收功率并被配置为提供具有 当能量存储元件没有耦合到电源电压时，电压电平与电源电压无关。 耦合装置被配置为仅当双向开关处于关闭状态时才将能量存储元件耦合到电源电压。
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公开(公告)号：US20140128937A1
公开(公告)日：2014-05-08
申请号：US14070628
申请日：2013-11-04
发明人： Michel Marcel Jose Decré , Jeroen Jacob Arnold Tol , Hubert Cécile François Martens , Franciscus Paulus Maria Budzelaar
CPC分类号： A61N1/3606 , A61N1/0534 , A61N1/36125 , A61N1/36128 , A61N1/375 , A61N1/3752
摘要： An active electronics module for a system for brain applications comprises a lead having a plurality of electrodes at its distal end, at least one main module, and an active electronics module configured such that the active electronics module is connectable or connected to the least one main module on one side and the lead on the other side. The active electronics module includes at least one switch configured such that at least one of the electrodes of the lead can be connected with one or more inputs and/or outputs of the main module.
摘要翻译： 用于大脑应用的系统的有源电子模块包括具有在其远端具有多个电极的引线，至少一个主模块以及有源电子模块，所述有源电子模块被配置为使得所述有源电子模块可连接或连接到所述至少一个主电路 模块在一侧，另一侧的引线。 有源电子模块包括至少一个开关，其被配置为使得引线的至少一个电极可以与主模块的一个或多个输入和/或输出连接。
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公开(公告)号：US20120109599A1
公开(公告)日：2012-05-03
申请号：US13285136
申请日：2011-10-31
IPC分类号： G06F7/60
CPC分类号： A61N1/37247 , A61N1/00
摘要： A system for planning implantation of a neurostimulation probe is provided. The system comprises an input for receiving anatomical data comprising information regarding a position and an orientation of at least one fiber bundle in a target region, an input for receiving therapeutic information comprising information regarding a stimulation preferability of the at least one fiber bundle, an optimization module for based on the position, the orientation and the stimulation preferability of the at least one fiber bundle calculating at least one optimal position and at least one optimal orientation for implantation of the neurostimulation probe at which optimal position and orientation the probe is capable of generating an electric field gradient substantially parallel to at least one fiber bundle with a high stimulation preferability and/or substantially perpendicular to at least one fiber bundle with a low stimulation preferability and an output for providing the optimal position and orientation.
摘要翻译： 提供了一种用于规划神经刺激探针植入的系统。 该系统包括用于接收包括关于目标区域中的至少一个纤维束的位置和取向的信息的解剖数据的输入，用于接收包括关于至少一个纤维束的刺激优选性的信息的治疗信息的输入，优化 模块，用于基于所述至少一个纤维束的位置，方向和刺激优选性计算至少一个最佳位置和至少一个用于植入神经刺激探针的最佳取向，其中探针能够产生最佳位置和取向 基本平行于具有高刺激优选性和/或基本垂直于具有低刺激优选性的至少一个纤维束的至少一个纤维束的电场梯度和用于提供最佳位置和取向的输出。
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公开(公告)号：US20150080987A1
公开(公告)日：2015-03-19
申请号：US14548776
申请日：2014-11-20
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/0526 , A61N1/0529 , A61N1/0534 , A61N1/36021 , A61N1/36025 , A61N1/3605 , A61N1/36067 , A61N1/36082 , A61N2/006
摘要： A neuromimetic device includes a feedforward pathway and a feedback pathway. The device operates in parallel with a suspect neural region, coupled between regions afferent and efferent to the suspect region. The device can be trained to mimic the suspect region while the region is still considered functional; and then replace the region once the region is considered dysfunctional. The device may be particularly useful in treating neuromotor issues such as Parkinson's disease.
摘要翻译： 神经发育装置包括前馈途径和反馈途径。 该装置与怀疑的神经区域并行运行，耦合在传入和传播到可疑区域的区域之间。 该装置可以被训练以模仿可疑区域，同时该区域仍被认为是功能性的; 然后在区域被认为功能失调后更换该区域。 该装置可能特别用于治疗诸如帕金森病的神经运动问题。
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公开(公告)号：US20140172058A1
公开(公告)日：2014-06-19
申请号：US14104212
申请日：2013-12-12
IPC分类号： A61N1/05
CPC分类号： A61N1/0534 , A61B5/04 , A61B5/04001 , A61B5/0478 , A61B5/4064 , A61B5/4082 , A61B5/6868 , A61B2562/18 , A61N1/05 , A61N1/0531 , A61N1/36067 , A61N1/36096 , A61N1/375
摘要： A stimulation probe comprises a lead having a distal end and a proximal end. The distal end of the lead has a plurality of electrodes configured to stimulate tissue. A protective tubing element extends over a portion of the lead proximate the proximal end of the lead. An advanced lead can element includes a switch matrix. The advanced lead can element is coupled to the proximal end of the lead and configured to couple the lead to an implantable pulse generator.
摘要翻译： 刺激探针包括具有远端和近端的引线。 引线的远端具有构造成刺激组织的多个电极。 保护管元件在铅的近端延伸超过导线的一部分。 先进的铅罐元件包括开关矩阵。 先进的铅罐元件耦合到引线的近端，并且被配置为将引线耦合到可植入脉冲发生器。
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公开(公告)号：US08731673B2
公开(公告)日：2014-05-20
申请号：US11932903
申请日：2007-10-31
申请人： Rio Vetter , Daryl Kipke , David Pellinen , David Anderson , Jamille Hetke
发明人： Rio Vetter , Daryl Kipke , David Pellinen , David Anderson , Jamille Hetke
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , A61B5/04001 , A61N1/0539 , A61N1/36082
摘要： The neural interface system of the preferred embodiments includes an electrode array having a plurality of electrode sites and a carrier that supports the electrode array. The electrode array is coupled to the carrier such that the electrode sites are arranged both circumferentially around the carrier and axially along the carrier. A group of the electrode sites may be simultaneously activated to create an activation pattern. The system of the preferred embodiment is preferably designed for deep brain stimulation, and, more specifically, for deep brain stimulation with fine electrode site positioning, selectivity, tunability, and precise activation patterning. The system of the preferred embodiments, however, may be alternatively used in any suitable environment (such as the spinal cord, peripheral nerve, muscle, or any other suitable anatomical location) and for any suitable reason.
摘要翻译： 优选实施例的神经接口系统包括具有多个电极位置的电极阵列和支撑电极阵列的载体。 电极阵列耦合到载体，使得电极位置沿着载体周向布置并且沿着载体轴向布置。 可以同时激活一组电极部位以产生激活模式。 优选实施例的系统优选地设计用于深部脑刺激，更具体地，针对具有精细电极位置定位，选择性，可调性和精确激活图案化的深部脑刺激。 然而，优选实施例的系统可以替代地在任何合适的环境（例如脊髓，周围神经，肌肉或任何其他合适的解剖学位置）中以及出于任何合适的原因使用。
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8.发明申请Control Circuitry And Method For Controlling A Bi-Directional Switch System, A Bi-Directional Switch, A Switching Matrix And A Medical Stimulator 有权用于控制双向开关系统的控制电路和方法，双向开关，开关矩阵和医疗刺激器公开(公告)号：US20130009691A1
公开(公告)日：2013-01-10
申请号：US13636137
申请日：2011-04-05
申请人： Pieter Gerrit Blanken , Jeroen Jacob Arnold Tol , Franciscus Adrianus Cornelis Maria Schoofs , Dave Willem Van Goor
发明人： Pieter Gerrit Blanken , Jeroen Jacob Arnold Tol , Franciscus Adrianus Cornelis Maria Schoofs , Dave Willem Van Goor
IPC分类号： H03K17/66
CPC分类号： H02J7/008 , A61N1/05 , A61N1/36185 , H02J7/0052 , H02J7/345 , H03K17/063 , H03K17/687
摘要： A control circuitry (134) and a method for controlling a bi-directional switch (132) is provided. The bi-directional switch (132) having a control terminal (130) for receiving a control voltage (124) to control an on state and an off state of the bi-directional switch (132) and at least one semiconductor switch in a bi-directional main current path. The control circuitry (134) comprises an energy storage element (102), a coupling means (101) to couple the energy storage element (102) to a supply voltage to charge the energy storage element (102), and a control circuit (108) configured to receive power from the energy storage element (102) and configured to supply the control voltage having a voltage level being independent of the supply voltage when the energy storage element (102) is not coupled to the supply voltage. The coupling means (101) is configured for only coupling the 132 energy storage element (102) to the supply voltage when the bi-directional switch (132) is in the off state.
摘要翻译： 提供了控制电路（134）和用于控制双向开关（132）的方法。 双向开关（132）具有用于接收控制电压（124）以控制双向开关（132）的导通状态和断开状态的控制端子（130）和双向开关（132）中的至少一个半导体开关 双向主电流路径。 控制电路（134）包括能量存储元件（102），将能量存储元件（102）耦合到电源电压以对能量存储元件（102）充电的耦合装置（101）和控制电路（108） ），其被配置为从所述能量存储元件（102）接收电力，并且被配置为当所述能量存储元件（102）未耦合到所述电源电压时，提供具有与所述电源电压无关的电压电平的所述控制电压。 耦合装置（101）被配置为当双向开关（132）处于关闭状态时，仅将132能量存储元件（102）耦合到电源电压。
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公开(公告)号：US20120303107A1
公开(公告)日：2012-11-29
申请号：US13574803
申请日：2011-01-20
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61M25/0102 , A61N1/0551
摘要： The invention relates a system (302) for medical stimulation. The system (302) comprises an implantable probe (304) bifurcated into a primary branch (306) and a secondary branch (308) at a bifurcation (310), wherein the probe is provided at its distal end (112, 312) with an electrode (114) for delivering electrical stimulation to tissue. Herein, the primary branch (306) is configured for at least temporarily mechanically co-operating with a guide wire (316) configured for guiding the probe (304) into said tissue whereas the secondary branch (308) is configured for electrically connecting said electrode to a device for generating the electrical stimulation.
摘要翻译： 本发明涉及用于医疗刺激的系统（302）。 系统（302）包括在分叉（310）处分叉成主分支（306）和次分支（308）的可植入探针（304），其中探针在其远端（112,312）处设置有 用于向组织递送电刺激的电极（114）。 这里，主分支（306）被配置为至少与被配置为将探针（304）引导到所述组织中的导丝（316）临时机械地协作，而辅助分支（308）构造成电连接所述电极 涉及用于产生电刺激的装置。
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公开(公告)号：US20120150256A1
公开(公告)日：2012-06-14
申请号：US13321190
申请日：2010-07-23
IPC分类号： A61N1/36
CPC分类号： A61B5/04004 , A61B5/04001 , A61B5/7239 , A61B2562/0209 , A61B2562/046 , A61N1/0534 , A61N1/36182
摘要： A system (10) and a method for deep brain stimulation are provided. The system (10) comprises a probe (11) and a processor (14). The probe (11) comprises an array of sensing electrodes (12) for acquiring signals representing neuronal activity at corresponding positions in a brain and an array of stimulation electrodes (12) for applying stimulation amplitudes to corresponding brain regions. The processor (14) is operably coupled to the sensing electrodes (12) and the stimulation electrodes (12) and is arranged for performing the method according to the invention. The method comprises receiving (21) the acquired signals from the sensing electrodes (12), processing (22) the acquired signals to find at least one brain region with atypical neuronal activity, based on the acquired signals determining (23) a spatial distribution of stimulation amplitudes over the array of stimulation electrodes (12), and applying (24) the spatial distribution of stimulation amplitudes to the array of stimulation electrodes (12) in order to stimulate the at least one region with atypical neuronal activity.
摘要翻译： 提供一种系统（10）和深脑刺激的方法。 系统（10）包括探针（11）和处理器（14）。 探针（11）包括用于获取表示脑中对应位置的神经元活动的信号的感测电极阵列（12），以及用于对相应的脑区域施加刺激振幅的刺激电极阵列（12）。 处理器（14）可操作地耦合到感测电极（12）和刺激电极（12），并被布置用于执行根据本发明的方法。 该方法包括从所述感测电极（12）接收（21）获取的信号，处理（22）所获取的信号，以基于所获取的信号确定（23）空间分布，以获得具有非典型神经元活动的至少一个脑区域 在刺激电极阵列上的刺激幅度，以及将刺激幅度的空间分布应用于刺激电极阵列（12），以刺激具有非典型神经元活动的至少一个区域。
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