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    Anchorage devices comprising an active pharmaceutical ingredient
    1.
    发明授权
    Anchorage devices comprising an active pharmaceutical ingredient 有权

    公开(公告)号：US10086115B2

    公开(公告)日：2018-10-02

    申请号：US14045991

    申请日：2013-10-04

    申请人： TYRX, Inc.

    发明人： William McJames ,  Frank Do ,  Satish Pulapura ,  Qing Ge

    IPC分类号： A61L31/00 ,  A61L31/08 ,  A61L31/10 ,  A61L31/16 ,  A61N1/05

    摘要： An anchorage device comprising a mesh substrate coupled to an implantable medical device is disclosed, where the mesh substrate has a coating comprising a polymer, and the mesh further comprises at least one active pharmaceutical ingredient. The active pharmaceutical agent is designed to elute from the mesh over time. The mesh substrate can be configured to reduce the mass of the anchorage device such that tissue in-growth and/or scar tissue formation at the treatment site is reduced. In some embodiments, the mesh substrate can be formed with a mesh having a low areal density. In some embodiments, the mesh substrate can include one or more apertures or pores to reduce the mass of the substrate.

    Temporarily Stiffened Mesh Prostheses
    2.
    发明申请
    Temporarily Stiffened Mesh Prostheses 有权
    临时加强网状假肢

    公开(公告)号：US20140046350A1

    公开(公告)日：2014-02-13

    申请号：US14033979

    申请日：2013-09-23

    申请人： TYRX Pharma, Inc. ,  Silicon Valley Bank ,  TYRX, Inc.

    发明人： Fatima Buevich ,  Frank Do ,  William McJames ,  Satish Pulapura ,  William Edelman ,  Arikha Moses ,  Mason Diamond ,  Shari Timothy

    IPC分类号： A61L27/34 ,  A61F2/00

    CPC分类号： A61F2/0063 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61F2310/0097 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/10 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/606 ,  A61L2430/02

    摘要： The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.

    摘要翻译： 本发明涉及医用假体及其制造方法。 特别地，假体是具有特定涂层的临时硬化网，以提供初始刚度，从而允许更容易的手术处理以用于治疗或重建软组织缺陷。 优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网，所述可生物降解的聚合物可以通过涂覆网状物的细丝或纤维来临时固定那些丝或纤维的接触点和/或通过增加网状物的刚度 至少是原始刚度的1.1倍。 本发明的装置还可以提供与其植入，插入或手术使用相关的各种术后并发症的缓解。 通过将生物活性剂和/或药物包括在涂层中，这些装置通常提供与手术或使用假体相关的副作用或并发症的预防和可以减轻。

    Mesh pouches for implantable medical devices
    3.
    发明授权
    Mesh pouches for implantable medical devices 有权
    用于可植入医疗器械的网袋

    公开(公告)号：US08591531B2

    公开(公告)日：2013-11-26

    申请号：US11936054

    申请日：2007-11-06

    申请人： Fatima Buevich ,  Arikha Moses ,  Frank Do ,  William McJames ,  William Edelman ,  Mason Diamond ,  Satish Pulapura

    发明人： Fatima Buevich ,  Arikha Moses ,  Frank Do ,  William McJames ,  William Edelman ,  Mason Diamond ,  Satish Pulapura

    IPC分类号： A61B17/08 ,  B65D69/00

    CPC分类号： A61L31/10 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2090/0815 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  A61N1/375

    摘要： Biodegradable polymer-coated surgical meshes formed into pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices. Such meshes are formed into a receptacle, e.g., a pouch or other covering, capable of encasing, surrounding and/or holding the cardiac rhythm management device or other implantable medical device for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other implantable medical device. Preferred embodiments include surgical mesh pouches coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The pouches of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use, and, optionally, include one or more drugs in the polymer matrix of the coating to provide prophylactic effects and/or alleviate side effects or complications associated with the surgery or implantation of the CRM or other implantable medical device.

    摘要翻译： 描述形成袋的可生物降解的聚合物涂覆的手术网与心律管理装置（CRM）和其他可植入医疗装置一起使用。 这样的网状物形成为能够包围，围绕和/或保持心律管理装置或其它可植入医疗装置的容器，例如袋或其它覆盖物，以确保其在适当位置，抑制或减少细菌生长， 在CRM或其他可植入医疗设备上或周围提供疼痛缓解和/或抑制瘢痕形成或纤维化。 优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网袋，其可以通过涂覆网的细丝或纤维来暂时固定那些丝或纤维的接触点和/或通过增加网的刚度而充当硬化剂 至少是其原始刚度的1.1倍。 本发明的小袋还可以缓解与其植入，插入或手术使用相关的各种术后并发症，并且任选地在包衣的聚合物基质中包括一种或多种药物以提供预防效果和/或缓解侧 与手术或植入CRM或其他可植入医疗器械相关的影响或并发症。

    SYNTHESIS OF TYROSINE DERIVED POLYARYLATES
    7.
    发明申请
    SYNTHESIS OF TYROSINE DERIVED POLYARYLATES 审中-公开

    公开(公告)号：US20180355103A1

    公开(公告)日：2018-12-13

    申请号：US15972836

    申请日：2018-05-07

    申请人： TYRX, Inc.

    发明人： SATISH PULAPURA ,  FATIMA BUEVICH ,  XIANGJI CHEN ,  SUPING LYU

    IPC分类号： C08G63/81

    摘要： A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.