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121 条记录 (耗时 0.037 秒)

    Synergistic genome-nonintegrating reprogramming by microRNAs and transcription factors
    1.
    发明授权
    Synergistic genome-nonintegrating reprogramming by microRNAs and transcription factors 有权

    公开(公告)号：US11001809B2

    公开(公告)日：2021-05-11

    申请号：US15036235

    申请日：2014-11-13

    申请人： THE MCLEAN HOSPITAL CORPORATION

    发明人： Kwang-Soo Kim ,  Young Cha

    IPC分类号： C12N5/074 ,  C12N15/113 ,  A61K35/12

    摘要： Disclosed herein are methods of generating induced pluripotent stem cells. The method involves providing a quantity of somatic or non-embryonic cells, contacting the contacting the somatic or non-embryonic cells with a quantity of one or more reprogramming factors and one or more RNA molecules, and culturing the somatic or non-embryonic cells for a period of time sufficient to generate at least one induced pluripotent stem cell. Various reprogramming factors and RNA molecules for use in the methods are disclosed herein. Also disclosed are cell lines and pharmaceutical compositions generated by use of the methods.

    Methods for measuring the magnitude of attention and motor activity disturbance in a subject
    4.
    发明授权
    Methods for measuring the magnitude of attention and motor activity disturbance in a subject 有权
    测量受试者的注意力和运动活动障碍的程度的方法

    公开(公告)号：US09050032B2

    公开(公告)日：2015-06-09

    申请号：US13122805

    申请日：2009-10-08

    申请人： Martin Teicher

    发明人： Martin Teicher

    IPC分类号： G01N33/48 ,  G01N33/50 ,  A61B5/11 ,  A61B5/16

    CPC分类号： A61B5/168 ,  A61B5/1114 ,  A61B5/1118 ,  A61B5/1127 ,  A61B5/165 ,  A61B5/4848 ,  A61B5/7275 ,  A61B5/7278 ,  A61B5/7282

    摘要： The invention features methods and systems to monitor changes in the magnitude of attentional disturbance and the magnitude of motor activity disturbance in a subject. The invention also features methods and systems for determining a subject's degree of concordance with individuals having an attentional disorder versus individuals not having an attentional disorder. The methods and systems of the invention can enable clinicians and consumers to ascertain both the severity of an attentional disorder as well as how much an individual changes over time, or with therapy.

    摘要翻译： 本发明的特征在于监测受试者的注意障碍的大小和运动活动干扰的大小的变化的方法和系统。 本发明还涉及用于确定受试者与注意障碍的个体与不具有注意障碍的个体的一致程度的方法和系统。 本发明的方法和系统可以使临床医生和消费者能够确定注意障碍的严重程度以及个体随时间改变或治疗的程度。

    METHODS FOR THE TREATMENT OF PSYCHIATRIC DISORDERS
    6.
    发明申请
    METHODS FOR THE TREATMENT OF PSYCHIATRIC DISORDERS 审中-公开
    治疗心理障碍的方法

    公开(公告)号：US20130281410A1

    公开(公告)日：2013-10-24

    申请号：US13697674

    申请日：2011-05-13

    申请人： Perry F. Renshaw

    发明人： Perry F. Renshaw

    IPC分类号： A61K31/198 ,  A61K45/06

    CPC分类号： A61K31/198 ,  A61K31/155 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention provides methods for the treatment of major depressive disorder in male subjects and methods for the treatment of psychiatric disorders at high altitudes by administering one or more creatine-containing compounds.

    摘要翻译： 本发明提供了通过给予一种或多种含肌酸的化合物来治疗男性受试者的重度抑郁障碍的方法和用于治疗高海拔地区精神病的方法。

    Magnetic Field Treatment Techniques
    9.
    发明申请
    Magnetic Field Treatment Techniques 有权
    磁场处理技术

    公开(公告)号：US20130066138A1

    公开(公告)日：2013-03-14

    申请号：US13669128

    申请日：2012-11-05

    申请人： The McLean Hospital Corporation

    发明人： Michael L. Rohan ,  Perry Renshaw ,  Aimee Parow

    IPC分类号： A61N2/02

    CPC分类号： A61N1/36025 ,  A61N1/0484 ,  A61N2/006 ,  A61N2/008 ,  A61N2/02

    摘要： The invention involves enhancing brain function by stimulating the brain using magnetic fields. Applications of the new methods include improving the condition of individuals with cognitive disorders, such as depression, and studying the effects of neural stimulation using induced electric fields. These techniques can avoid deleterious effects of psychotropic pharmaceutical treatments, and provide a relatively safe, comfortable, inexpensive means of direct cranial stimulation.

    摘要翻译： 本发明涉及通过使用磁场刺激大脑来增强脑功能。 新方法的应用包括改善患有认知障碍（如抑郁症）的个体的状况，并研究使用诱导电场的神经刺激的影响。 这些技术可以避免精神药物治疗的有害影响，并提供相对安全，舒适，便宜的直接颅刺激手段。

    Methods for diagnosis and prognosis of psychotic disorders
    10.
    发明授权
    Methods for diagnosis and prognosis of psychotic disorders 有权
    精神障碍的诊断和预后方法

    公开(公告)号：US08163475B2

    公开(公告)日：2012-04-24

    申请号：US11804461

    申请日：2007-05-18

    申请人： Christine Konradi

    发明人： Christine Konradi

    IPC分类号： C12Q1/68 ,  C12Q1/00 ,  G01N33/566 ,  G01N33/567

    CPC分类号： G01N33/6896 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2800/304 ,  G01N2800/7004

    摘要： The invention features methods diagnostic of a psychotic disorder such as bipolar disorder or schizophrenia. The methods include obtaining a cell sample from a subject, subjecting a cell from the sample to stress (e.g., nutrient stress), and measuring nucleic acid or polypeptide expression in the cell, where an alteration in expression is indicative of the subject having or being at increased risk of developing a psychotic disorder. The invention also features prognostic monitoring methods for subjects having a psychotic disorder, useful in determining the progression of a psychotic disorder in a subject or the effectiveness of a therapy.

    摘要翻译： 本发明的特征在于诊断精神病如双相性精神障碍或精神分裂症的方法。 所述方法包括从受试者获得细胞样品，使来自样品的细胞受压（例如，营养应激），以及测量细胞中的核酸或多肽表达，其中表达改变指示受试者具有或正在 发展为精神障碍的风险增加。 本发明还具有用于确定受试者中精神病症进展或治疗有效性的精神障碍患者的预后监测方法。