公开(公告)号：US07929600B2

公开(公告)日：2011-04-19

申请号：US11597905

申请日：2005-06-30

申请人： Takehiro Moriya ,  Yutaka Kamamoto ,  Shigeki Sagayama

发明人： Takehiro Moriya ,  Yutaka Kamamoto ,  Shigeki Sagayama

IPC分类号： H04B1/66

CPC分类号： G10L19/008

摘要： In difference coding, each of a first to M-th channel signals is divided into frames and independent energy of every channel signal and difference energy of difference signals between all channel signals are calculated for each frame. In ascending order of energy, if a signal corresponding to an energy value is independent signal, it is determined that independent coding should be used for the signal. If the signal is a difference signal and the type of coding for one of channel signals has been determined, it is determined that the other should be difference-coded using the former channel signal as a reference signal. If the type of coding for neither of the channel signals has been determined, it is determined that one of them should be independently coded and the other should be difference-coded using the former channel signal as a reference signal.

摘要翻译： 在差分编码中，第一至第M信道信号中的每一个被分成帧和每个信道信号的独立能量，并且针对每个帧计算所有信道信号之间的差分信号的差分能量。 按照能量的升序，如果对应于能量值的信号是独立的信号，则确定信号应该使用独立的编码。 如果信号是差信号，并且已经确定了一个信道信号的编码类型，则确定另一个应当使用前一个信道信号作为参考信号进行差分编码。 如果已经确定了对于两个信道信号的编码类型，则确定它们中的一个应该被独立地编码，而另一个应该使用前一个信道信号作为参考信号进行差分编码。

公开(公告)号：US20100273708A1

公开(公告)日：2010-10-28

申请号：US12762437

申请日：2010-04-19

申请人： Takashi KADOWAKI ,  Toshimasa Yamauchi ,  Shoko Kitajima ,  Yusuke Ito

发明人： Takashi KADOWAKI ,  Toshimasa Yamauchi ,  Shoko Kitajima ,  Yusuke Ito

IPC分类号： A61K38/17 ,  A61P3/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  G01N33/6875 ,  G01N33/74 ,  G01N33/92 ,  G01N2500/10 ,  G01N2800/044

摘要： The present invention provides adiponectin expression-inducing agents, and therapeutic agents using the same for obesity and obesity-related diseases such as cardiovascular diseases or metabolic diseases, as well as methods of searching for adiponectin expression-inducing agents. KLF9, which can bind to the 32-bp fragment of position −188 to position −157 from the adiponectin expression start site, was demonstrated to enhance adiponectin promoter activity. Therefore, the present invention uses KLF9 as an adiponectin expression-inducing agent, and suggests that KLF9 replenishment therapy is useful for preventing and/or treating obesity or obesity-related diseases including metabolic diseases such as insulin resistance and type II diabetes, and cardiovascular diseases.

摘要翻译： 本发明提供了脂联素表达诱导剂和使用其的治疗剂用于肥胖症和肥胖相关疾病如心血管疾病或代谢疾病，以及搜索脂联素表达诱导剂的方法。 KLF9可以结合位点-188的32-bp片段，从脂联素表达起始位点到位置-157，证明增强脂连蛋白启动子活性。 因此，本发明使用KLF9作为脂联素表达诱导剂，并且表明KLF9补充疗法可用于预防和/或治疗肥胖症或肥胖相关疾病，包括诸如胰岛素抵抗和II型糖尿病等代谢疾病和心血管疾病 。

公开(公告)号：US07639865B2

公开(公告)日：2009-12-29

申请号：US10461920

申请日：2003-06-13

申请人： Eisaku Katayama ,  Norio Baba

发明人： Eisaku Katayama ,  Norio Baba

IPC分类号： G06K9/00

CPC分类号： G01N23/046 ,  G01N2223/419 ,  G06T7/55 ,  G06T15/00

摘要： It is an object of the present invention to acquire 3-dimensional image data that correctly express a structural configuration of the subject by processing the projected image data obtained by projecting the subject toward the plural angles . A shape computing unit 260 calculates shape data which represent a outline of the subject, using a plurality of 1st image data of the subject obtained by projecting the subject toward the plural angles. A distributing unit 220 generates gray-scale density-distributions by spreading and distributing densities shown in gray-scale image of the subject respectively within angles along which said gray-scale image was captured. A second integrating unit 240 generates 3-dimensional gray-scale data, which expresses the subject with the 3-dimensional image data, by integrating a plurality of said gray-scale density-distributions generated from a plurality of gray-scale image captured from a plurality of angles. A first integrating unit 280 integrates the shape data and 3-dimensional gray-scale image. A data processing unit 300 generates 3-dimensional image data by extracting only density that exists in perimeter of a shape that the shape data represent, from the 3-dimensional gray-scale data.

摘要翻译： 本发明的目的是通过处理通过将被摄体投影到多个角度而获得的投影图像数据来获取正确表达被摄体的结构构造的3维图像数据。 形状计算单元260使用通过将对象投影到多个角度而获得的被摄体的多个第一图像数据来计算表示被摄体的轮廓的形状数据。 分配单元220通过在被摄体的灰度级图像的角度内分别扩散和分布被摄物体的灰度图像中所示的密度来生成灰度密度分布。 第二积分单元240通过对从多个灰度图像中捕获的多个灰度级图像进行积分而生成多个所述灰度密度分布，生成表示具有3维图像数据的被摄体的三维灰度数据 多个角度 第一积分单元280对形状数据和三维灰度图像进行积分。 数据处理单元300通过从三维灰度数据中仅提取存在于形状数据表示的形状的周边的密度来生成三维图像数据。

公开(公告)号：US20090291461A1

公开(公告)日：2009-11-26

申请号：US12468440

申请日：2009-05-19

申请人： Hiroyuki EBINUMA ,  Hirokazu Yago ,  Yuka Akimoto ,  Osamu Miyazaki ,  Takashi Kadowaki ,  Toshimasa Yamauchi ,  Kazuo Hara

发明人： Hiroyuki EBINUMA ,  Hirokazu Yago ,  Yuka Akimoto ,  Osamu Miyazaki ,  Takashi Kadowaki ,  Toshimasa Yamauchi ,  Kazuo Hara

IPC分类号： G01N33/53

CPC分类号： G01N33/74 ,  G01N2800/042 ,  G01N2800/32

摘要： Kits and methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of adiponectin multimers and provide information that cannot be obtained through measurement of the total amount of adiponectin alone. A method for selectively assaying a target adiponectin multimer in a biological sample comprising distinguishing target adiponectin multimer from the other adiponectin multimers by using a protease and/or an antibody.

摘要翻译： 用于选择性测定生物样品中目标脂联素多聚体的试剂盒和方法。 这种方法通过脂联素多聚体的选择性测定来准确地评估疾病与脂联素之间的关系，并提供通过单独测量脂连蛋白的总量不能获得的信息。 一种用于选择性测定生物样品中的目标脂联素多聚体的方法，包括通过使用蛋白酶和/或抗体将目标脂连蛋白多聚体与其它脂联素多聚体区分开。

公开(公告)号：US07544498B2

公开(公告)日：2009-06-09

申请号：US12106181

申请日：2008-04-18

申请人： Tomohisa Kuzuyama ,  Joseph P. Noel ,  Stephane P. Richard

发明人： Tomohisa Kuzuyama ,  Joseph P. Noel ,  Stephane P. Richard

IPC分类号： G01N33/573 ,  C12N9/10 ,  C12P1/00

CPC分类号： C12N9/1085

摘要： In accordance with the present invention, a novel aromatic prenyltransferase, Orf2 from Streptomyces sp. strain CL190, involved in naphterpin biosynthesis has been identified and the structure thereof elucidated. This prenyltransferase catalyzes the formation of a C—C bond between a prenyl group and a compound containing an aromatic nucleus, and also displays C—O bond formation activity. Numerous crystallographic structures of the prenyltransferase have been solved and refined, e.g., (1) prenyltransferase complexed with a buffer molecule (TAPS), (2) prenyltransferase as a binary complex with geranyl diphosphate (GPP) and Mg2+, and prenyltransferase as ternary complexes with a non-hydrolyzable substrate analogue, geranyl S-thiolodiphosphate (GSPP) and either (3) 1,6-dihydroxynaphthalene (1,6-DHN), or (4) flaviolin (i.e., 2,5,7-trihydroxy-1,4-naphthoquinone, which is the oxidized product of 1,3,6,8-tetrahydroxynaphthalene (THN)). These structures have been solved and refined to 1.5 Å, 2.25 Å, 1.95 Å and 2.02 Å, respectively. This first structure of an aromatic prenyltransferase displays an unexpected and non-canonical (β/α)-barrel architecture. The complexes with both aromatic substrates and prenyl containing substrates and analogs delineate the active site and are consistent with a proposed electrophilic mechanism of prenyl group transfer. These structures also provide a mechanistic basis for understanding prenyl chain length determination and aromatic co-substrate recognition in this structurally unique family of aromatic prenyltransferases. This structural information is useful for predicting the aromatic prenyltransferase activity of proteins.

摘要翻译： 根据本发明，一种新型芳族异戊烯基转移酶，来自链霉菌属的Orf2。 已经鉴定了参与萘普生生物合成的菌株CL190，其结构被阐明。 该异戊烯基转移酶催化异戊烯基和含有芳香核的化合物之间的C-C键的形成，并且还显示C-O键的形成活性。 已经解决和改进了异戊烯基转移酶的许多晶体结构，例如（1）与缓冲分子（TAPS）复合的异戊烯基转移酶，（2）作为二进位配合物的前体甲基转移酶与香叶基二磷酸（GPP）和Mg2 +以及异戊烯基转移酶作为三元复合物 不可水解的底物类似物，香叶基S-硫代双磷酸（GSPP）和（3）1,6-二羟基萘（1,6-DHN）或（4）黄堇素（即2,5,7-三羟基-1， 4-萘醌，其为1,3,6,8-四羟基萘（THN）的氧化产物）。 这些结构分别被解析和精炼成1.5A，2.25，1.95和2.02。 芳族异戊烯基转移酶的这种第一结构显示出意想不到的和非规范（β/α） - 杆状结构。 具有芳香底物和含异戊烯基的底物和类似物的络合物描绘了活性位点，并与提出的异戊烯基转移的亲电子机制一致。 这些结构还提供了在这个结构独特的芳族异戊烯基转移酶家族中了解异戊烯基链长度测定和芳香族共底物识别的机理基础。 该结构信息对于预测蛋白质的芳族异戊烯基转移酶活性是有用的。

公开(公告)号：US07460964B2

公开(公告)日：2008-12-02

申请号：US10571371

申请日：2004-09-10

申请人： Terukazu Mizota ,  Kazuto Kamiyama ,  Hiroyuki Kajimoto ,  Naoki Kawakami ,  Susumu Tachi

发明人： Terukazu Mizota ,  Kazuto Kamiyama ,  Hiroyuki Kajimoto ,  Naoki Kawakami ,  Susumu Tachi

IPC分类号： G01L1/06 ,  G01L7/02 ,  G01L11/02

CPC分类号： G01L1/241 ,  G01L1/247 ,  G01L5/226 ,  G01L5/228

摘要： The invention relates to a technique for reducing computation time for force vector calculation. A force vector reconstruction method that uses an optical tactile sensor, comprises a step for obtaining a marker image by taking an image of behavior of colored markers when an object contacts a contact surface of an elastic body, a step of obtaining information relating to the marker behavior from the marker image, the information being more than the number of force vectors to be obtained, and a step of obtaining force vectors as outputs by inputting information relating to the obtained marker behavior to a transfer function. The step of obtaining force vectors comprises calculating force vectors using only information relating to behavior of markers neighboring region A1 of a position A where it is desired to obtain force vectors.

摘要翻译： 本发明涉及一种用于减少力矢量计算的计算时间的技术。 使用光学触觉传感器的力矢量重建方法包括：当物体接触到弹性体的接触表面时，通过拍摄彩色标记的行为的图像来获得标记图像的步骤，获得与标记相关的信息的步骤 来自标记图像的行为，所述信息大于要获得的力向量的数量;以及通过将与获得的标记行为相关的信息输入到传递函数来获得力向量作为输出的步骤。 获得力矢量的步骤包括使用仅与期望获得力矢量的位置A的相邻区域A1的标记的行为有关的信息来计算力向量。

公开(公告)号：US07379582B2

公开(公告)日：2008-05-27

申请号：US10660464

申请日：2003-09-11

申请人： Eisaku Katayama ,  Norio Baba

发明人： Eisaku Katayama ,  Norio Baba

IPC分类号： G06K9/00

CPC分类号： G06K9/00134 ,  G06T7/0002 ,  G06T7/001 ,  G06T7/564 ,  G06T7/97 ,  G06T2200/04

摘要： A projection image data captured from a plurality of angles is processed, and a three-dimensional image data accurately indicating a three dimensional structure for an object is obtained. A shape computing unit 260 computes shape data indicating an outline of a subject using a plurality of first image data of the subject captured from a plurality of angles. A distributing unit 220 generates a gray-scale density-distribution by extending and distributing density indicated in a gray-scale image of the subject acquired by a projection image capturing apparatus to an angle at which the gray-scale image is captured. The second integrating unit 240 generates a three-dimensional gray-scale data indicating the subject with three-dimensional image data by integrating a plurality of gray-scale images acquired from a plurality of angles and a plurality of gray-scale density-distribution. The first integrating unit 280 integrates the three-dimensional gray-scale image and shape data. The data processing unit 300 generates the three-dimensional image data by extracting only the gray-scale data which exists in the circumference of the shape indicated in the shape data from the three-dimensional gray-scale data.

摘要翻译： 处理从多个角度拍摄的投影图像数据，并且获得准确地指示对象的三维结构的三维图像数据。 形状计算单元260使用从多个角度捕获的对象的多个第一图像数据来计算指示对象的轮廓的形状数据。 分配单元220通过将由投影图像捕获装置获取的被摄体的灰度图像中指示的浓度扩展并分布到捕获灰度图像的角度来生成灰度密度分布。 第二积分单元240通过对从多个角度获得的多个灰度图像和多个灰度密度分布进行积分，生成表示具有三维图像数据的对象的三维灰度数据。 第一积分单元280对三维灰度图像和形状数据进行积分。 数据处理单元300通过从三维灰度数据中仅提取存在于形状数据中指示的形状的圆周中的灰度数据来生成三维图像数据。

公开(公告)号：US07193221B2

公开(公告)日：2007-03-20

申请号：US10516827

申请日：2003-06-10

申请人： Katsuya Okumura ,  Motosuke Miyoshi

发明人： Katsuya Okumura ,  Motosuke Miyoshi

IPC分类号： H01J3/26 ,  H01J3/14 ,  G21K1/08

CPC分类号： H01J37/12 ,  H01J37/147 ,  H01J37/153 ,  H01J2237/1215

摘要： The present invention provides an electron optical lens column suitable for miniaturization, and provides the manufacturing method thereof. The column unit (1) comprises an inner column (11) and an outer column (12). The column unit is, as a whole, structured from a high-resistance electrically conductive ceramic. Electrostatic lenses (21, 22, 23, and 24) are affixed to the inner surface (111) of the inner column using a means such as plating or vapor deposition. Of the electrodes or electrode parts (211–213, 221, 231, 232, and 241–243) from which the lens is structured, those that share the same electric potential are connected by shared interconnections. This makes it possible to connect all of the electrodes or electrode parts with shared electric potentials as a group to the external interconnections.

摘要翻译： 本发明提供一种适用于小型化的电子光学透镜柱，并提供其制造方法。 柱单元（1）包括内柱（11）和外柱（12）。 作为一个整体，柱单元由高电阻导电陶瓷构成。 静电透镜（21,22,23和24）使用电镀或气相沉积等方法固定在内柱的内表面（111）上。 在透镜构成的电极或电极部分（211-213,221,231,232和241-243）中，共享相同电位的电极或电极部分通过共享互连连接。 这使得可以将作为一组的共享电位的所有电极或电极部分连接到外部互连。

公开(公告)号：US20070043508A1

公开(公告)日：2007-02-22

申请号：US10571371

申请日：2004-09-10

申请人： Terukazu Mizota ,  Kazuto Kamiyama ,  Hiroyuki Kajimoto ,  Naoki Kawakami ,  Susumu Tachi

发明人： Terukazu Mizota ,  Kazuto Kamiyama ,  Hiroyuki Kajimoto ,  Naoki Kawakami ,  Susumu Tachi

IPC分类号： G06F19/00

CPC分类号： G01L1/241 ,  G01L1/247 ,  G01L5/226 ,  G01L5/228

摘要： The invention relates to a technique for reducing computation time for force vector calculation. A force vector reconstruction method that uses an optical tactile sensor, comprises a step for obtaining a marker image by taking an image of behavior of colored markers when an object contacts a contact surface of an elastic body, a step of obtaining information relating to the marker behavior from the marker image, the information being more than the number of force vectors to be obtained, and a step of obtaining force vectors as outputs by inputting information relating to the obtained marker behavior to a transfer function. The step of obtaining force vectors comprises calculating force vectors using only information relating to behavior of markers neighboring region A1 of a position A where it is desired to obtain force vectors.

摘要翻译： 本发明涉及一种用于减少力矢量计算的计算时间的技术。 使用光学触觉传感器的力矢量重建方法包括：当物体接触到弹性体的接触表面时，通过拍摄彩色标记的行为的图像来获得标记图像的步骤，获得与标记相关的信息的步骤 来自标记图像的行为，所述信息大于要获得的力向量的数量;以及通过将与获得的标记行为相关的信息输入到传递函数来获得力向量作为输出的步骤。 获得力矢量的步骤包括仅使用与希望获得力矢量的位置A的相邻区域A 1的标记的行为有关的信息来计算力矢量。

公开(公告)号：US20060152735A1

公开(公告)日：2006-07-13

申请号：US10745050

申请日：2003-12-23

申请人： Kazuro Kageyama ,  Isamu Ohsawa ,  Makoto Kanai ,  Yukiya Tsuchida ,  Keiichi Nagata

发明人： Kazuro Kageyama ,  Isamu Ohsawa ,  Makoto Kanai ,  Yukiya Tsuchida ,  Keiichi Nagata

IPC分类号： G01B9/02

CPC分类号： G01H9/004

摘要： This invention provides a device or method for measuring vibration with high sensitivity and over a wide bandwidth. A curved section is formed in an optical fiber. The curved section is disposed on a place to be measured. Light is input in the optical fiber, and then variation of frequency between the input light and the output light is detected. Infinitesimal vibration applied to the curved section can be measured as variation of frequency between the input light and the output light. Further, it is possible to measure vibration over a wide bandwidth.

摘要翻译： 本发明提供一种用于以高灵敏度和宽带宽测量振动的装置或方法。 在光纤中形成弯曲部分。 弯曲部分设置在要测量的地方。 在光纤中输入光，然后检测输入光和输出光之间的频率变化。 可以测量施加到弯曲部分的无穷小振动，作为输入光和输出光之间的频率的变化。 此外，可以在宽带宽上测量振动。