Abstract:
In one aspect, the present invention provides isolated nucleic acid molecules that encode a CAN-1 polypeptide, or an STG polypeptide. In another aspect, the present invention also provides isolated STG polypeptides, isolated CAN-1 polypeptides, and isolated SEEK-1 polypeptides. In another aspect, the present invention provides isolated antibodies that bind specifically to a CAN-1, SEEK-1 or STG polypeptide. In another aspect, the present invention provides methods of diagnosing or predicting the susceptibility to psoriasis of an individual. In another aspect, the present invention provides methods for ameliorating the symptoms and/or progression of psoriasis.
Abstract:
Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
Abstract:
In one aspect, the present invention provides isolated nucleic acid molecules that encode a CAN-1 polypeptide, or an STG polypeptide. In another aspect, the present invention also provides isolated STG polypeptides, isolated CAN-1 polypeptides, and isolated SEEK-1 polypeptides. In another aspect, the present invention provides isolated antibodies that bind specifically to a CAN-1, SEEK-1 or STG polypeptide. In another aspect, the present invention provides methods of diagnosing or predicting the susceptibility to psoriasis of an individual. In another aspect, the present invention provides methods for ameliorating the symptoms and/or progression of psoriasis.
Abstract:
Disclosed are nicotinanilide-N-oxide compounds, methods for their production, pharmaceutical compositions which include these compounds, and methods for their use in various therapies.
Abstract:
Isolated nucleic acid molecules are provided which encode Fkhsf, as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and host cells containing such expression vectors. Utilizing assays based upon the nucleic acid sequences disclosed herein (as well as mutant forms thereof), numerous molecules may be identified which modulate the immune system.
Abstract:
1. A COMPOUND SELECTED FROM THE GROUP CONSISTING OF THOSE OF THE FORMULA:
1-R3,5-R1,7-R2-THIENO(3,4-D)PYRIMIDINE
WHEREIN: R1 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF CHLORO AND PROPYL, R2 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF MORPHOLINO, 2-METHYL-MORPHOLINO AND 3-METHYLMORPHOLINO, AND R3 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND METHYL, AND THE ADDITION SALTS THEREOF WITH PHARMACEUTICALLY ACCEPTABLE ACIDS.
Abstract:
A method of manufacturing a laminate having a width of at least 30 cm. by means of a solventless adhesive, wherein, a first stage, a solventless adhesive is continuously supplied to a distributor means comprising a pre-dosing element and an elasticsurfaced rotating element in such a manner as to coat the surface of the elastic-surfaced rotating element with a layer of solventless adhesive having a thickness of from 5 to 50 microns, the layer then being substantially transferred to a moving film to be laminated, the circumferential speed of the elasticsurfaced rotating element and the speed of linear displacement of the film being in a ratio of from 1:10 to 1:50, so that the film receives a layer of solventless adhesive of a thickness of from 0.5 to 5 microns, and, in a second stage, the film coated in this manner is bonded in known manner to another film to form a laminate.
Abstract:
WHEREIN A1, A2, A3, A4, A5 and B, taken separately, each represents hydrogen, halogen, halomethyl, alkyl, alkoxy, nitro, cyano or amino, and A5 and B, taken together, represent a bivalent radical selected from the group consisting of alkylene, alkenylene and alkadienylene having 3 to 5 carbon atoms and alkylene dioxy having 1 to 3 carbon atoms, said bivalent radical being connected to two adjacent carbon atoms of the benzene nucleus, WITH THE PROVISO THAT WHEN A1, A2, A3, A4, A5 and B are all hydrogen atoms, the diphenyl-methylene radical is in the ortho or meta position with regard to the nitrogen atom in the piperidine nucleus, AND THE ADDITION SALTS THEREOF WITH PHARMACEUTICALLY ACCEPTABLE INORGANIC OR ORGANIC ACIDS.
Blood circulation activating, anti-arrhythmic and antihistaminic diphenyl-methylene-N-benzyl-piperidines having the general formula
Abstract:
A METHOD OF MAKING PHOSPHORIC ACID AND GYPSUM WHICH COMPRISES FORMING A FIRST FLUID REACTION MEDIUM COMPRISING THE PHOSPHORIC ACID PRODUCT OF THE PROCESS, DIVIDING THE PHOSPHATIC RAW MATERIAL, IN POWDER FORM, INTO MAJOR AND MINOR FRACTIONS, MIXING THE MAJOR FRACTION WITH THE FIRST FLUID REACTION MEDIUM, MIXING MORE SULFURIC ACID WITH THE FIRST FLUID REACTION THAN IS REQUIRED TO REACT WITH THE PHOSPHATIC RAW MATERIAL THEREIN TO FORM GYPSUM FORMING A SECOND FLUID REACTION MEDIUM COMPRISING THE PHOSPHORIC ACID PRODUCT OF THE PROCESS, TRANSFERRING PRODUCT FORMED IN THE FIRST REACTION MEDIUM TO THE SECOND REACTION MEDIUM AND MIXING IT THEREWITH, MIXING THE MINOR FRACTION OF PHOSPHATIC RAW MATERIAL WITH THE SECOND FLUID REACTION MEDIUM, AND SEPARATING PHOSPHORIC ACID FROM THE GYPSUM.