Compositions and methods for diagnosing or treating psoriasis

    公开(公告)号:US07622278B2

    公开(公告)日:2009-11-24

    申请号:US12218033

    申请日:2008-07-09

    CPC classification number: C07K14/4713 C07K14/47

    Abstract: In one aspect, the present invention provides isolated nucleic acid molecules that encode a CAN-1 polypeptide, or an STG polypeptide. In another aspect, the present invention also provides isolated STG polypeptides, isolated CAN-1 polypeptides, and isolated SEEK-1 polypeptides. In another aspect, the present invention provides isolated antibodies that bind specifically to a CAN-1, SEEK-1 or STG polypeptide. In another aspect, the present invention provides methods of diagnosing or predicting the susceptibility to psoriasis of an individual. In another aspect, the present invention provides methods for ameliorating the symptoms and/or progression of psoriasis.

    Method of manufacturing a laminate by means of a solventless adhesive
    8.
    发明授权
    Method of manufacturing a laminate by means of a solventless adhesive 失效
    通过无溶剂粘合剂制造层压板的方法

    公开(公告)号:US3840419A

    公开(公告)日:1974-10-08

    申请号:US20914871

    申请日:1971-12-17

    Applicant: UCB SA

    Abstract: A method of manufacturing a laminate having a width of at least 30 cm. by means of a solventless adhesive, wherein, a first stage, a solventless adhesive is continuously supplied to a distributor means comprising a pre-dosing element and an elasticsurfaced rotating element in such a manner as to coat the surface of the elastic-surfaced rotating element with a layer of solventless adhesive having a thickness of from 5 to 50 microns, the layer then being substantially transferred to a moving film to be laminated, the circumferential speed of the elasticsurfaced rotating element and the speed of linear displacement of the film being in a ratio of from 1:10 to 1:50, so that the film receives a layer of solventless adhesive of a thickness of from 0.5 to 5 microns, and, in a second stage, the film coated in this manner is bonded in known manner to another film to form a laminate.

    Diphenyl-methylene-n-benzyl-piperidines
    9.
    发明授权
    Diphenyl-methylene-n-benzyl-piperidines 失效
    二苯甲基-N-苄基哌啶

    公开(公告)号:US3759928A

    公开(公告)日:1973-09-18

    申请号:US3759928D

    申请日:1970-06-02

    Applicant: UCB SA

    Inventor: ZIVKOVIC D

    CPC classification number: C07D211/70 Y10S514/821 Y10S514/872

    Abstract: WHEREIN A1, A2, A3, A4, A5 and B, taken separately, each represents hydrogen, halogen, halomethyl, alkyl, alkoxy, nitro, cyano or amino, and A5 and B, taken together, represent a bivalent radical selected from the group consisting of alkylene, alkenylene and alkadienylene having 3 to 5 carbon atoms and alkylene dioxy having 1 to 3 carbon atoms, said bivalent radical being connected to two adjacent carbon atoms of the benzene nucleus, WITH THE PROVISO THAT WHEN A1, A2, A3, A4, A5 and B are all hydrogen atoms, the diphenyl-methylene radical is in the ortho or meta position with regard to the nitrogen atom in the piperidine nucleus, AND THE ADDITION SALTS THEREOF WITH PHARMACEUTICALLY ACCEPTABLE INORGANIC OR ORGANIC ACIDS.

    Blood circulation activating, anti-arrhythmic and antihistaminic diphenyl-methylene-N-benzyl-piperidines having the general formula

    Abstract translation: 具有通式为A1,A2,A3,A4,A5和B的血液循环活化,抗心律不齐和抗组胺二苯基 - 亚甲基-N-苄基 - 哌啶分别代表氢,卤素,卤代甲基,烷基,烷氧基, 硝基,氰基或氨基,并且A 5和B一起代表选自具有3至5个碳原子的亚烷基,亚烯基和亚烷基二烯基以及具有1至3个碳原子的亚烷基二氧基的二价基团,所述二价基团连接 对于苯核的两个相邻的碳原子,当A1,A2,A3,A4,A5和B都是氢原子时,二苯基 - 亚甲基相对于氮原子在邻位或间位 哌啶核,以及其与药物接受无机或有机酸的添加剂。

    Process for the manufacture of phosphoric acid in the wet way
    10.
    发明授权
    Process for the manufacture of phosphoric acid in the wet way 失效
    湿法生产磷酸的方法

    公开(公告)号:US3755539A

    公开(公告)日:1973-08-28

    申请号:US3755539D

    申请日:1970-01-02

    Inventor: BIGOT B

    CPC classification number: C01B25/22

    Abstract: A METHOD OF MAKING PHOSPHORIC ACID AND GYPSUM WHICH COMPRISES FORMING A FIRST FLUID REACTION MEDIUM COMPRISING THE PHOSPHORIC ACID PRODUCT OF THE PROCESS, DIVIDING THE PHOSPHATIC RAW MATERIAL, IN POWDER FORM, INTO MAJOR AND MINOR FRACTIONS, MIXING THE MAJOR FRACTION WITH THE FIRST FLUID REACTION MEDIUM, MIXING MORE SULFURIC ACID WITH THE FIRST FLUID REACTION THAN IS REQUIRED TO REACT WITH THE PHOSPHATIC RAW MATERIAL THEREIN TO FORM GYPSUM FORMING A SECOND FLUID REACTION MEDIUM COMPRISING THE PHOSPHORIC ACID PRODUCT OF THE PROCESS, TRANSFERRING PRODUCT FORMED IN THE FIRST REACTION MEDIUM TO THE SECOND REACTION MEDIUM AND MIXING IT THEREWITH, MIXING THE MINOR FRACTION OF PHOSPHATIC RAW MATERIAL WITH THE SECOND FLUID REACTION MEDIUM, AND SEPARATING PHOSPHORIC ACID FROM THE GYPSUM.

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