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公开(公告)号：US10132340B2
公开(公告)日：2018-11-20
申请号：US14771674
申请日：2014-03-14
申请人： Apple Inc.
IPC分类号： F16B1/00 , A45C13/30 , A44B11/00 , A44B17/00 , A44B99/00 , A44B13/00 , A41F1/00 , A43B1/00 , A45C13/10 , A43C11/14 , A45F5/00 , F16B2/08 , H05K5/02
摘要： A system for carrying or using a device includes the device and at least one attachment apparatus. The device may include at least one attachment element. The attachment apparatus may include a length of material and at least one attachment point arranged on an end of the length of material. The at least one attachment point may include at least one magnetic feature configured to attach and detach the device and the length of material. The material can include but is not limited to cloth, metallic (magnetic and non-magnetic), fibrous material, and so forth.
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2.发明授权Compositions and methods for double-targeting virus infections and targeting cancer cells 有权用于双向靶向病毒感染和靶向癌细胞的组合物和方法公开(公告)号：US08138200B2
公开(公告)日：2012-03-20
申请号：US12629387
申请日：2009-12-02
申请人： Louis S. Kucera , Ronald A. Fleming , Khalid S. Ishaq , Gregory L. Kucera , Susan L. Morris-Natschke
发明人： Louis S. Kucera , Ronald A. Fleming , Khalid S. Ishaq , Gregory L. Kucera , Susan L. Morris-Natschke
CPC分类号： C07H19/06 , A61K31/66 , A61K31/675 , C07F9/10 , C07H19/10 , C07H19/16 , Y02A50/463
摘要： The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at more than one stage of the virus life cycle) and thereby inhibiting virus replication. The compositions of the invention include compounds which comprise a phosphocholine moiety covalently conjugated with one or more antiviral agents (e.g. nucleoside analogue, protease inhibitor, etc.) to a lipid backbone. The invention also includes pharmaceutical compositions and kits for use in treatment of a virus infection in mammals. The methods of the invention comprise administering a compound of the invention, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of the invention, in an amount effective to treat the infection, to a mammal infected with a virus. Additionally, the invention includes compositions and methods useful for combating a cancer in a mammal and for facilitating delivery of a therapeutic agent to a mammalian cell. The compositions of the invention include compounds which comprise an alkyl lipid or phospholipid moiety covalently conjugated with an anticancer agent (e.g. a nucleoside analogue). The invention also includes pharmaceutical compositions and kits for combating a cancer and for facilitating delivery of a therapeutic agent to a mammalian cell. The methods of the invention comprise administering a compound of the invention, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of the invention, in an amount effective to combat a cancer or to facilitate delivery of a therapeutic agent to a mammalian cell.
摘要翻译： 本发明包括通过双重靶向病毒（即在病毒生命周期的多于一个阶段靶向病毒）并因此抑制病毒复制而用于治疗哺乳动物病毒感染的组合物和方法。 本发明的组合物包括包含与一种或多种抗病毒剂（例如核苷类似物，蛋白酶抑制剂等）共价结合到脂质主链的磷酸胆碱部分的化合物。 本发明还包括用于治疗哺乳动物病毒感染的药物组合物和试剂盒。 本发明的方法包括将治疗感染的本发明化合物，其药学上可接受的盐或本发明的药物组合物给予感染病毒的哺乳动物。 另外，本发明包括可用于对抗哺乳动物中的癌症并促进治疗剂递送至哺乳动物细胞的组合物和方法。 本发明的组合物包括包含与抗癌剂（例如核苷类似物）共价缀合的烷基脂质或磷脂部分的化合物。 本发明还包括用于对抗癌症并促进治疗剂递送至哺乳动物细胞的药物组合物和试剂盒。 本发明的方法包括给予本发明的化合物，其药学上可接受的盐或本发明的药物组合物，其量有效地抵抗癌症或促进治疗剂递送至哺乳动物细胞。
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公开(公告)号：US10279695B2
公开(公告)日：2019-05-07
申请号：US15657776
申请日：2017-07-24
发明人： Jin Su Jang , Taek Hyun Jung , Zeung Il Kim , Jae Yong Seong
摘要： An electric vehicle (EV) parallel charging method may comprise determining whether a parallel charging input is detected or not, the parallel charging input being an input that both a conductive charging input and an inductive charging input are sensed; in response to determining that the parallel charging input is detected, comparing a power of the conductive charging input with a power of the inductive charging input; selecting an input applied to a high-voltage battery and an input applied to at least one of an auxiliary battery and a load based on a result of the comparison; and performing a parallel charging operation for the high-voltage battery and at least one of the auxiliary battery and the load by using powers supplied from the selected inputs.
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公开(公告)号：US07708799B2
公开(公告)日：2010-05-04
申请号：US11440164
申请日：2006-05-23
申请人： Nigel Grech , John L. Peterson
发明人： Nigel Grech , John L. Peterson
IPC分类号： C05D9/00
摘要： Dithiocarbamate and phosphite containing fertilizers, as well as methods of making and methods of using these fertilizers, are disclosed.
摘要翻译： 公开了含有二硫代氨基甲酸盐和亚磷酸盐的肥料，以及制备方法和使用这些肥料的方法。
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公开(公告)号：US07439043B2
公开(公告)日：2008-10-21
申请号：US10411043
申请日：2003-04-09
申请人： Shawn DeFrees , David Zopf , Robert Bayer , Caryn Bowe , David Hakes , Xi Chen
发明人： Shawn DeFrees , David Zopf , Robert Bayer , Caryn Bowe , David Hakes , Xi Chen
摘要： The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
摘要翻译： 本发明包括用于重组肽分子的方法和组合物，包括向肽添加或缺失一个或多个糖基，和/或向肽中加入修饰基团。
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公开(公告)号：US10149521B2
公开(公告)日：2018-12-11
申请号：US15728349
申请日：2017-10-09
申请人： Apple Inc.
发明人： Andrzej T. Baranski , Serhan O. Isikman , Tyler S. Bushnell , Steven J. Martisauskas , David I. Nazzaro
摘要： Systems and methods for dynamically adjusting the fit of a wearable electronic device are disclosed. In many embodiments, a tensioner associated with a wearable electronic device can control one or more actuators that are mechanically coupled to either the housing or to a band attached to the wearable electronic device. In one example, in response to a signal to increase the tightness of the band, the tensioner can cause the actuator(s) to increase the tension within the band.
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公开(公告)号：US07582279B2
公开(公告)日：2009-09-01
申请号：US10692311
申请日：2003-10-23
CPC分类号： A61K49/0461 , A61K9/1075 , A61K9/1275 , A61K49/0433 , A61K49/1806 , A61K51/0406 , A61K51/0478 , A61K51/1217 , B82Y5/00 , Y10S514/938 , Y10S977/829 , Y10S977/905 , Y10S977/927 , Y10S977/93
摘要： A surface-modified lipoprotein-like oil-in-water emulsion useful as a blood-pool selective delivery vehicle for lipophilic imaging agents or lipophilic derivatives of water-soluble imaging agents. The blood-pool selective delivery vehicle remains in the blood for several hours, shows very little early hepatic sequestration, and is cleared from the blood within 24 hours. The mean diameter of the oil phase is less than 150 nm which minimizes sequestration by the reticuloendothelial system. The surface of the oil phase is modified with a polyethyl glycol-modified phospholipid to prevent normal interactions with the receptor sites of the hepatocytes. In radiographic imaging, radioactive or stable, synthetic or semi-synthetic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bis[7-(3-amino-2,4,6-triiodophenyl)heptanoate], or lipid soluble derivatives of traditional water-soluble contrast agents, such as aliphatic esters of iopanoic, diatrizoic, and acetrizoic acid, may be incorporated into the lipophilic core of a lipoprotein-like emulsion particle.
摘要翻译： 用作脂溶性成像剂或水溶性成像剂的亲脂性衍生物的血液池选择性递送载体的表面改性脂蛋白样水包油乳液。 血液池选择性输送载体在血液中保持数小时，显示出非常少的早期肝脏螯合，并在24小时内从血液中清除。 油相的平均直径小于150nm，其最小化网状内皮系统的螯合。 用聚乙二醇修饰的磷脂修饰油相的表面以防止与肝细胞的受体位点的正常相互作用。 放射摄影成像中，放射性或稳定的合成或半合成多卤甘油三酸酯如2-油酰甘油-1,3-双[7-（3-氨基-2,4,6-三碘苯基）庚酸酯]或脂溶性衍生物 的传统的水溶性造影剂，如碘，脂肪族和代谢酸的脂肪族酯可以并入脂蛋白样乳液颗粒的亲脂性核心中。
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公开(公告)号：US11533566B2
公开(公告)日：2022-12-20
申请号：US17180560
申请日：2021-02-19
申请人： LG Display Co., Ltd.
发明人： YongWoo Lee , Yong-Su Ham , Taeheon Kim , Sung-Eui Shin
IPC分类号： H04R17/00 , H01L41/047 , H01L41/08 , H01L41/37 , H01L41/083 , H01L41/09
摘要： A flexible vibration module is disclosed. The flexible vibration module includes a piezoelectric composite layer, including: a plurality of piezoelectric portions each having a piezoelectric characteristic, where at least two of the plurality of piezoelectric portions have different sizes; and a flexible portion between the plurality of piezoelectric portions.
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公开(公告)号：US10197839B2
公开(公告)日：2019-02-05
申请号：US15363014
申请日：2016-11-29
申请人： LG Display Co., Ltd.
发明人： Sang-Wook Lee
IPC分类号： G02F1/1345 , G02F1/1334 , G02F1/1333 , G02F1/1335 , G02F1/1343 , G02F1/1362 , G02F1/1368
摘要： Provided is a liquid crystal display (LCD) device. An LCD device includes: a gate line on a substrate; first and second data lines crossing the gate line to respectively define first and second pixel regions; and a plurality of electrodes at each of the first and second pixel regions and including a plurality of bars, the plurality of electrodes including a first and a second outermost electrode, wherein the first data line overlaps an upper portion of the first outermost electrode of the first pixel region, and is spaced apart from a lower portion of the first outermost electrode of the first pixel region, and wherein the second data line is spaced apart from an upper portion of the second outermost electrode of the first pixel region, and overlaps a lower portion of the second outermost electrode of the first pixel region.
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公开(公告)号：US07428746B2
公开(公告)日：2008-09-23
申请号：US11516930
申请日：2006-09-06
CPC分类号： H04L63/0272 , H04L63/102 , H04L63/105 , H04L63/108 , H04L63/1433 , H04L63/20
摘要： A system and method to ensure that a remote computer making a VPN connection complies with network security policies. Server-driven security checks may be configured to verify compliance with each access level before access is granted at that level. The security checks may be selected based at least according to the information received from the remote computer. After the server determines that the remote computer complies with the security policy for the requested access level, the server may pass a token to the remote computer, or may grant VPN access to the remote computer. If the remote computer does not comply with the security policy associated with the requested access level but is in compliance with a security policy corresponding to a lower access level, the server may grant the remote computer access to the lower access level.
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