公开(公告)号：US20050267556A1

公开(公告)日：2005-12-01

申请号：US10856201

申请日：2004-05-28

申请人： Allan Shuros ,  Avram Scheiner ,  Rodney Salo

发明人： Allan Shuros ,  Avram Scheiner ,  Rodney Salo

IPC分类号： A61L31/16 ,  A61N1/05 ,  A61K9/22 ,  A61N1/362

CPC分类号： A61L31/16 ,  A61L2300/40 ,  D04C1/06 ,  D10B2509/00

摘要： Implantable devices are configured to be positioned in or near the heart and to carry and deliver an anti-apoptotic drug to a treatment site in or near the heart. The implantable devices include, but are not limited to, leads, stents, heart valves, atrial septal defect devices, cardiac patches and ventricular restraint devices. Depending on the composition of the device, the drug may be carried by the device through a coating applied to the device, or may be included in the device during the device manufacturing process. The drug may also be included in microparticles, such a microspheres, that are delivered locally through a conduit, such as a catheter.

摘要翻译： 可植入装置被配置为定位在心脏中或附近，并将抗细胞凋亡药物携带并递送至心脏内或附近的治疗部位。 可植入装置包括但不限于引线，支架，心脏瓣膜，心房间隔缺损装置，心脏贴片和心室约束装置。 根据装置的组成，药物可以由装置通过施加到装置的涂层携带，或者可以在装置制造过程中包括在装置中。 药物也可以包括在通过导管（例如导管）局部递送的微粒（例如微球体）中。

公开(公告)号：US20070043393A1

公开(公告)日：2007-02-22

申请号：US11207251

申请日：2005-08-19

申请人： Marina Brockway ,  Joseph Pastore ,  Yi Zhang ,  Carlos Ricci ,  Allan Shuros ,  Rodney Salo

发明人： Marina Brockway ,  Joseph Pastore ,  Yi Zhang ,  Carlos Ricci ,  Allan Shuros ,  Rodney Salo

IPC分类号： A61N1/02

CPC分类号： A61N1/36585 ,  A61N1/056 ,  A61N1/36114 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/36557

摘要： An implantable cardiac rhythm management (CRM) device delivers a chronic therapy while detecting an ischemic state. When the ischemic state indicates the occurrence of an ischemic event, the implantable CRM device delivers a post-ischemia therapy. The post-ischemia therapy and the chronic therapy are adjusted using feedback control with the ischemic state and parameters indicative of the effectiveness of the post-ischemic therapy and the effectiveness of the chronic therapy as inputs.

摘要翻译： 植入式心律管理（CRM）装置在检测缺血状态时进行慢性治疗。 当缺血状态表明发生缺血事件时，可植入的CRM装置传递缺血后的治疗。 使用具有缺血状态的反馈控制和指示缺血后治疗的有效性和作为输入的慢性治疗的有效性的参数来调整局部后缺血治疗和慢性治疗。

公开(公告)号：US20060173504A1

公开(公告)日：2006-08-03

申请号：US11046215

申请日：2005-01-28

申请人： Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

发明人： Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A method and apparatus are disclosed for treating mitral or tricuspid regurgitation with electrical stimulation. By providing pacing stimulation to a selected region of the left ventricle, such as one in proximity to the mitral valve apparatus in a manner which pre-excites the region during early ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.

摘要翻译： 公开了一种用于用电刺激治疗二尖瓣或三尖瓣反流的方法和装置。 通过以在早期心室收缩期间预激活该区域的方式向左心室的选定区域（例如二尖瓣装置附近的一个）提供起搏刺激，可获得有益效果，其可以防止或减少 二尖瓣反流。

公开(公告)号：US20080091138A1

公开(公告)日：2008-04-17

申请号：US11998969

申请日：2007-12-03

申请人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

发明人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

IPC分类号： A61M31/00

CPC分类号： A61M5/1723 ,  A61B5/0031 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61M5/14244 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/3627

摘要： A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

摘要翻译： 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。

公开(公告)号：US20060173505A1

公开(公告)日：2006-08-03

申请号：US11116955

申请日：2005-04-28

申请人： Rodney Salo ,  Allan Shuros ,  Joseph Pastore ,  Qingsheng Zhu

发明人： Rodney Salo ,  Allan Shuros ,  Joseph Pastore ,  Qingsheng Zhu

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A method and apparatus are disclosed for treating mitral or tricuspid regurgitation with electrical stimulation. By providing pacing stimulation to a selected region of the left ventricle, such as one in proximity to the mitral valve apparatus or papillary muscles in a manner that pre-excites the region during early ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.

摘要翻译： 公开了一种用于用电刺激治疗二尖瓣或三尖瓣反流的方法和装置。 通过在左心室的选定区域（例如在二尖瓣装置或乳头肌附近的区域）以在早期心室收缩期间预激活该区域的方式提供起搏刺激，可以获得有益效果，其可以预防或减少 二尖瓣反流的程度。

公开(公告)号：US20070088214A1

公开(公告)日：2007-04-19

申请号：US11250928

申请日：2005-10-14

申请人： Allan Shuros ,  Rodney Salo ,  Michael Kane

发明人： Allan Shuros ,  Rodney Salo ,  Michael Kane

IPC分类号： A61B8/00

CPC分类号： A61B8/065 ,  A61B5/076 ,  A61B5/1076 ,  A61B5/6876 ,  A61B5/6884 ,  A61B8/02 ,  A61B8/06 ,  A61B8/12 ,  A61B8/4483

摘要： An ultrasonic implantable device includes an ultrasonic sensor having a plurality of transducers. The sensor is configured for mounting to a vessel wall. A first of the transducers directs sound waves in a direction at least partially upstream or downstream in the vessel. A second of the transducers directs sound waves in a radial direction through an interior of the vessel against a sidewall of the vessel. The sensor monitors a change in frequency of the sound waves from the first transducer to determine a fluid velocity in the vessel. The sensor also monitors a reflection time of the sound waves from the second transducer that return from the sidewall to determine an internal diameter of the vessel. The determined fluid velocity and vessel diameter can be used to determine a volumetric flow rate of the fluid in the vessel.

摘要翻译： 超声波可植入装置包括具有多个换能器的超声波传感器。 传感器被配置为安装到血管壁。 换能器中的第一个将声波沿至少部分在容器的上游或下游的方向引导。 传感器中的第二个将声波沿径向引导通过容器的内部抵靠容器的侧壁。 传感器监测来自第一换能器的声波的频率变化以确定容器中的流体速度。 传感器还监测来自第二换能器的声波的反射时间，其从侧壁返回以确定容器的内径。 确定的流体速度和容器直径可用于确定容器中流体的体积流量。

公开(公告)号：US20050043675A1

公开(公告)日：2005-02-24

申请号：US10645823

申请日：2003-08-21

申请人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

发明人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

IPC分类号： A61B5/00 ,  A61B5/11 ,  A61M5/142 ,  A61M5/172 ,  A61M31/00 ,  A61N1/362

CPC分类号： A61M5/1723 ,  A61B5/0031 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61M5/14244 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/3627

摘要： A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

摘要翻译： 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。

公开(公告)号：US07725185B2

公开(公告)日：2010-05-25

申请号：US12070080

申请日：2008-02-15

申请人： Lili Liu ,  Rodney Salo

发明人： Lili Liu ,  Rodney Salo

IPC分类号： A61N1/365 ,  A61N1/05

CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

摘要翻译： 用电刺激治疗逆转心室重构的装置和方法。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

公开(公告)号：US20080097541A1

公开(公告)日：2008-04-24

申请号：US11931718

申请日：2007-10-31

申请人： Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

发明人： Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

IPC分类号： A61N1/368

CPC分类号： A61N1/368 ,  A61N1/3622 ,  A61N1/3627

摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.

公开(公告)号：US20070100383A1

公开(公告)日：2007-05-03

申请号：US11261202

申请日：2005-10-28

申请人： Joseph Pastore ,  Rodney Salo ,  Ronald Heil ,  Randy Westlund

发明人： Joseph Pastore ,  Rodney Salo ,  Ronald Heil ,  Randy Westlund

IPC分类号： A61N1/36

CPC分类号： A61N1/0587 ,  A61N1/059 ,  A61N1/3627

摘要： A method includes mounting an anchor member to a surface of a heart, the anchor member having a tension member coupled to the anchor member, advancing a lead body along the tension member, the lead body including a plurality of electrodes disposed along the lead body, identifying an MI region of the heart, positioning the plurality of electrodes at or near the MI region, affixing the tension member to the lead body to hold the electrodes in position, and delivering pulses through the plurality of electrodes to the heart.

摘要翻译： 一种方法包括将锚定构件安装到心脏的表面，所述锚定构件具有联接到所述锚定构件的张紧构件，使所述引线体沿着所述张紧构件前进，所述引线主体包括沿着所述引线主体设置的多个电极， 识别心脏的MI区域，将多个电极定位在MI区域处或附近，将张紧构件固定到引线体以将电极保持在适当位置，并且将脉冲通过多个电极传递到心脏。