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    Methods and device for biomolecule characterization
    2.
    发明授权
    Methods and device for biomolecule characterization 有权
    生物分子表征的方法和装置

    公开(公告)号：US07744816B2

    公开(公告)日：2010-06-29

    申请号：US10138157

    申请日：2002-05-01

    申请人： Xing Su ,  Andrew A. Berlin

    发明人： Xing Su ,  Andrew A. Berlin

    IPC分类号： G01N33/48

    CPC分类号： G01N33/48721 ,  C12Q2563/179 ,  C12Q2565/631 ,  G01N33/6803

    摘要： The methods and apparatus 100, disclosed herein are of use for sequencing 150 and/or identifying 160 proteins 230, 310, polypeptides 230, 310 or peptides 230, 310. Proteins 230, 310 containing labeled amino acid residues may be synthesized and passed through nanopores 255, 330. A detector 257, 345 operably coupled to a nanopore 255, 330 may detect labeled amino acid residues as they pass through the nanopore 255, 330. Distance maps 140 for each type of labeled amino acid residue may be compiled. The distance maps 140 may be used to sequence 150 and/or identify 160 the protein 230, 310. In different embodiments of the invention, amino acid residues labeled with luminescent labels 235, 245 or nanoparticles 315 may be detected using photodetectors 257 or electrical detectors 345. Apparatus 100 of use for protein 230, 310 sequencing 150 and/or identification 160 are also disclosed herein.

    摘要翻译： 本文公开的方法和装置100可用于测序150和/或鉴定160个蛋白质230,310，多肽230,310或肽230,310。可以合成含有标记的氨基酸残基的蛋白质230,310并通过纳米孔 可操作地耦合到纳米孔255,330的检测器257,345可以在标记的氨基酸残基通过纳米孔255,330时检测标记的氨基酸残基。可以编译每种类型的标记的氨基酸残基的距离图140。 距离图140可以用于序列150和/或识别160蛋白230,310。在本发明的不同实施方案中，用发光标记235,245或纳米颗粒315标记的氨基酸残基可以使用光电检测器257或电检测器 本文还公开了用于蛋白质230,3001测序150和/或鉴定物160的装置100。

    Methods to increase nucleotide signals by Raman scattering
    4.
    发明授权
    Methods to increase nucleotide signals by Raman scattering 有权
    通过拉曼散射增加核苷酸信号的方法

    公开(公告)号：US07238477B2

    公开(公告)日：2007-07-03

    申请号：US10660902

    申请日：2003-09-12

    申请人： Xing Su ,  Andrew A. Berlin ,  Selena Chan ,  Steven J. Kirch ,  Tac-Woong Koo ,  Gabi Neubauer ,  Valluri Rao ,  Narayanan Sundararajan ,  Mineo Yamakawa

    发明人： Xing Su ,  Andrew A. Berlin ,  Selena Chan ,  Steven J. Kirch ,  Tac-Woong Koo ,  Gabi Neubauer ,  Valluri Rao ,  Narayanan Sundararajan ,  Mineo Yamakawa

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  G01N21/63

    CPC分类号： C12Q1/6869 ,  C12Q2565/632 ,  C12Q2563/155 ,  C12Q2521/319

    摘要： The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman labels before incorporation into a nucleic acid. In other embodiments, unlabeled nucleic acids are used. Exonuclease treatment of the nucleic acid results in the release of labeled or unlabeled nucleotides that are detected by Raman spectroscopy. In alternative embodiments of the invention, nucleotides released from a nucleic acid by exonuclease treatment are covalently cross-linked to nanoparticles and detected by surface enhanced Raman spectroscopy (SERS), surface enhanced resonance Raman spectroscopy (SERRS) and/or coherent anti-Stokes Raman spectroscopy (CARS). Other embodiments of the invention concern apparatus for nucleic acid sequencing.

    摘要翻译： 本文公开的方法和装置涉及通过增强拉曼光谱进行的核酸测序。 在本发明的某些实施方案中，在掺入核酸之前，核苷酸与拉曼标记物共价连接。 在其它实施方案中，使用未标记的核酸。 核酸外切核酸处理导致通过拉曼光谱法检测的标记或未标记的核苷酸的释放。 在本发明的替代实施方案中，通过外切核酸酶处理从核酸释放的核苷酸与纳米颗粒共价交联，并通过表面增强拉曼光谱（SERS），表面增强共振拉曼光谱（SERRS）和/或相干反斯托克斯拉曼 光谱学（CARS）。 本发明的其它实施方案涉及用于核酸测序的装置。

    Distribution of partitionable physical properties for market based control of actuators and sensors
    6.
    发明授权
    Distribution of partitionable physical properties for market based control of actuators and sensors 有权
    可分配物理特性的分布，用于执行器和传感器的市场控制

    公开(公告)号：US06568592B1

    公开(公告)日：2003-05-27

    申请号：US09406391

    申请日：1999-09-27

    申请人： Warren B. Jackson ,  David K. Biegelsen ,  Tad H. Hogg ,  Andrew A. Berlin

    发明人： Warren B. Jackson ,  David K. Biegelsen ,  Tad H. Hogg ,  Andrew A. Berlin

    IPC分类号： G06F1700

    CPC分类号： G06Q10/04

    摘要： Distributed market based analog control of a system of actuators and sensors. The system is comprised of one or more producing units having an output responsive to a market price and one or more input units having an input responsive to a market price. Market price information is communicated through an information channel that is encoded as measurable changes in non-electrical partitionable physical properties. Such partitionable physical properties include pressure, thermal, chemical or acoustic properties.

    摘要翻译： 基于分布式市场的模拟控制系统的执行器和传感器。 该系统包括一个或多个具有响应于市场价格的输出的生产单元和具有响应于市场价格的输入的一个或多个输入单元。 市场价格信息通过编码为非电可分割物理性质的可测量变化的信息通道来传达。 这种可分离的物理性质包括压力，热，化学或声学性质。

    Microsensor including a VCSEL and method for electro-mechanical coupling of microsensors
    7.
    发明授权
    Microsensor including a VCSEL and method for electro-mechanical coupling of microsensors 有权
    微传感器包括VCSEL和微传感器的机电耦合方法

    公开(公告)号：US06552328B1

    公开(公告)日：2003-04-22

    申请号：US09510357

    申请日：2000-02-22

    申请人： Andrew A. Berlin ,  Elmer S. Hung

    发明人： Andrew A. Berlin ,  Elmer S. Hung

    IPC分类号： H01J4014

    CPC分类号： H01S5/183 ,  G02B26/001 ,  H01S5/02248 ,  H01S5/14

    摘要： A microsensor including a VCSEL for use in a MEMS. By coupling the top mirror of the VCSEL to the micromechanical structure, either directly or indirectly, the motion of the micromechanical structure in response to a physical phenomenon can directly modulate the wavelength of the light emitted from the VCSEL. Also, a method for sensing and transmitting information about the configuration or motion of a mechanical structure. The method includes coupling the top mirror of a VCSEL to the mechanical structure that directly encodes information about the motion into the frequency of light emitted by the VCSEL.

    摘要翻译： 包括用于MEMS的VCSEL的微传感器。 通过将VCSEL的上反射镜直接或间接地耦合到微机械结构，响应于物理现象的微机械结构的运动可以直接调制从VCSEL发射的光的波长。 而且，一种用于感测和传送关于机械结构的构造或运动的信息的方法。 该方法包括将VCSEL的上反射镜耦合到直接将关于运动的信息编码成由VCSEL发射的光的频率的机械结构。

    Paper handling flap valve array system
    8.
    发明授权
    Paper handling flap valve array system 失效
    纸张处理瓣阀阵列系统

    公开(公告)号：US6004395A

    公开(公告)日：1999-12-21

    申请号：US994138

    申请日：1997-12-19

    申请人： Mark H. Yim ,  Warren B. Jackson ,  James G. Chase ,  David K. Biegelsen ,  Patrick C. P. Cheung ,  Andrew A. Berlin ,  Kenneth N. Horne

    发明人： Mark H. Yim ,  Warren B. Jackson ,  James G. Chase ,  David K. Biegelsen ,  Patrick C. P. Cheung ,  Andrew A. Berlin ,  Kenneth N. Horne

    IPC分类号： B65H5/22 ,  B05C11/00

    CPC分类号： B65H5/228 ,  Y10T137/87812

    摘要： A valve array for supporting objects such as paper with controlled fluid flow is disclosed. Optional valve arrays can be used to controllably eject marking agents for marking or coating a paper or other suitable substrate. Each valve in the valve array has one or more flap elements positioned in a valve chamber. These flap elements are movable to alternatively block the fluid flow through valve chamber outlets with the aid of various catch mechanisms for controllably latching the flap elements. The catch mechanisms have a disabled state and an activated state for holding and allowing release of the flap elements. Once the catch mechanism are disabled, the flap elements are free to move to another position, provided they can overcome the mechanical fluid flow forces that tend to hold it in position. To counter and utilize such forces for moving the flap elements, an impulse mechanism kicks the flap element into the valve chamber, away from the catch mechanisms. Since the position of the flap elements is unstable, oscillations of the flap elements in the fluid flow will eventually bring the flap element into catchment range of another catch mechanism in an activated state.

    摘要翻译： 公开了一种用于支撑诸如具有受控流体流动的纸张的物体的阀阵列。 可选的阀阵列可用于可控地排出用于标记或涂覆纸张或其它合适基底的标记剂。 阀阵列中的每个阀具有位于阀室中的一个或多个挡板元件。 这些翼片元件可移动以借助于用于可控制地闩锁翼片元件的各种捕捉机构交替地阻挡通过阀室出口的流体流动。 捕捉机构具有禁用状态和用于保持并允许释放襟翼元件的激活状态。 一旦锁定机构被禁用，则翼片元件可自由地移动到另一位置，只要它们能够克服倾向于将其保持在适当位置的机械流体流动力即可。 为了抵抗和利用这种力来移动翼片元件，脉冲机构将翼片元件踢向阀室，远离捕捉机构。 由于襟翼元件的位置不稳定，因此流体流中的襟翼元件的振荡将最终使襟翼元件进入处于活动状态的另一掣子机构的集水区。