摘要:
Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.
摘要:
Detailed is electricity generation for powering devices associated with swimming pools or other structures utilizing recirculating fluid. The recirculating fluid is used to produce electricity for direct or indirect supply to electrical devices. Turbines may be placed in by-pass channels so as to have access to some fluid flow yet not unduly disrupt main flow of the recirculating fluid.
摘要:
The invention relates to a method for purifying water by forming in an electrolytic cell molecular halogen, hypohalic acid, hypohalite ions or combinations thereof, from halide ions dissolved in the water; and dissolving one or more soluble metal salts in the water to provide corresponding metal ions. The invention also relates to a system for purifying water, having an electrolytic cell comprising a plurality of electrodes sufficient to electrolytically convert halide ion in the water into molecular halogen, hypohalic acid, or hypohalite ions, or combinations thereof; and a metal generator, which provides concentrations of one or more metals to the water.
摘要:
The disclosed technology can execute a sequence of transactions to process a request associated with a health care company and/or other entities interacting in a health care industry. Execution of at least some of the transaction sequence can result in the formation of an instance of a semantic network that can be used to support such processing. The request can correspond to a change in a relationship associated with such entities, where such request corresponds to an electronic document exhibiting a structured natural language format with a fixed context and a fixed grammar.
摘要:
The disclosed technology can identify indicia associated with different entity types that interact within an industry, identify one or more relationships (e.g., contractual provisions) that can affect interactions between such entity types, and identify transactions associated with one or more of the interactions. Further, the identified transactions can be organized into one or more transaction sequences. The identified indicia, the one or more identified relationships, and the one or more transaction sequences can then be associated to form a semantic network. An instance of the semantic network can be formed in response to the execution of at least some of the transaction sequence and can serve, at least in part, as the basis for processing requests associated with the entities. The requests can correspond to interactions associated with the entities and may be represented in a natural language format, exhibiting a fixed context and a fixed grammar.
摘要:
Provided herein is a DNA analysis method for detecting a presence or absence of a DNA molecule that comprises a structural variation, comprising contacting the DNA with at least two primers that anneal in a parallel orientation to a target region and contacting the primer-annealed DNA with a 5′ to 3′ exonuclease negative, strand displacement negative DNA polymerase.
摘要:
A succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof, for use in treating pulmonary disorders.
摘要:
The disclosed technology can identify indicia associated with different entity types (e.g., health care companies, health care suppliers, health care practitioners, etc.) that interact within a health care industry, identify one or more relationships (e.g., contractual provisions) that can affect interactions between such entity types, and identify transactions associated with one or more of the interactions. Further, the identified transactions can be organized into one or more transaction sequences. The identified indicia, the one or more identified relationships, and the one or more transaction sequences can then be associated to form a semantic network. An instance of the semantic network can be formed based, at least in part, on a detection of at least one interaction associated with the entities.
摘要:
The present invention provides processes useful for preparing 5-lipoxygenase activating protein (FLAP) inhibitors and their intermediates. In particular, processes for preparing 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, the anhydrous Form C polymorph of sodium 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionate, and intermediates useful in said processes are provided.