公开(公告)号：US20030194421A1

公开(公告)日：2003-10-16

申请号：US10331126

申请日：2002-12-27

Applicant: Angiotech Pharmaceuticals, Inc.

Inventor： Pierre E. Signore

IPC: A61K031/4745 ,  A61K031/337

CPC classification number: A61K9/0024 ,  A61K9/0051 ,  A61K9/1075 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1658 ,  A61K9/5146 ,  A61K9/5153 ,  A61K9/5161 ,  A61K9/5192 ,  A61K31/337 ,  A61K31/4375 ,  A61K31/4745 ,  A61K31/475

Abstract: Compositions, methods and devices are provided for treating and/or preventing uveitis.

Abstract translation: 提供用于治疗和/或预防葡萄膜炎的组合物，方法和装置。

公开(公告)号：US20030181371A1

公开(公告)日：2003-09-25

申请号：US10331125

申请日：2002-12-27

Applicant: Angiotech Pharmaceuticals, Inc.

Inventor： William L. Hunter ,  David M. Gravett ,  Philip M. Toleikis ,  Arpita Maiti

IPC: A61K038/39 ,  A61K031/65 ,  A61K031/19

CPC classification number: A61L31/044 ,  A61L27/24 ,  A61L27/58 ,  A61L31/16

Abstract: Compositions comprising collagen and at least one metalloprotease inhibitor, and methods of making and using same are provided.

Abstract translation: 提供了包含胶原蛋白和至少一种金属蛋白酶抑制剂的组合物，以及制备和使用它们的方法。

公开(公告)号：US20030157187A1

公开(公告)日：2003-08-21

申请号：US10172737

申请日：2002-06-13

Applicant: Angiotech Pharmaceuticals, Inc.

Inventor： William L. Hunter

IPC: A61K033/00 ,  A61K033/14 ,  A61K031/7048 ,  A61K031/427 ,  A61K031/4025

CPC classification number: A61K9/0019 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/0043 ,  A61K9/0048 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/12 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1658 ,  A61K9/5015 ,  A61K9/5052 ,  A61K9/5073 ,  A61K9/51 ,  A61K9/7007 ,  A61K31/047 ,  A61K31/08 ,  A61K31/138 ,  A61K31/16 ,  A61K31/17 ,  A61K31/22 ,  A61K31/223 ,  A61K31/28 ,  A61K31/335 ,  A61K31/337 ,  A61K31/352 ,  A61K31/36 ,  A61K31/366 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/519 ,  A61K31/70 ,  A61K31/7064 ,  A61K33/00 ,  A61K33/06 ,  A61K33/16 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/34 ,  A61K47/40 ,  A61K47/6951 ,  A61K47/6957 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/43 ,  A61L2300/606 ,  B82Y5/00

Abstract: Methods and compositions for treating or preventing inflammatory diseases such as psoriasis or multiple sclerosis are provided, comprising the step of delivering to the site of inflammation an anti-microtubule agent, or analogue or derivative thereof.

公开(公告)号：US20030144570A1

公开(公告)日：2003-07-31

申请号：US10155868

申请日：2002-05-24

Applicant: Angiotech Pharmaceuticals, Inc.

Inventor： William L. Hunter ,  David M. Gravett ,  Richard T. Liggins ,  Troy A.E. Loss ,  Arpita Maiti ,  Philip M. Toleikis

IPC: A61N005/00

CPC classification number: A61N5/1027 ,  A61K41/0038 ,  A61K49/0002 ,  A61K49/222 ,  A61K51/1282 ,  A61L31/18 ,  A61N2005/1019 ,  A61N2005/1023 ,  A61K2300/00

Abstract: Disclosed herein are therapeutic devices, compositions and methods for treating proliferative diseases. For example, within one aspect of the invention therapeutic devices are provided, comprising a device that locally administers radiation and a cell-cycle inhibitor

公开(公告)号：US20040224023A1

公开(公告)日：2004-11-11

申请号：US10671327

申请日：2003-09-25

Applicant: ANGIOTECH PHARMACEUTICALS, INC. ,  THE UNIVERSITY OF BRITISH COLUMBIA

Inventor： William L. Hunter ,  Lindsay S. Machan

IPC: A61K009/14

CPC classification number: A61K9/0024 ,  A61K9/10 ,  A61K9/1075 ,  A61K9/12 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/167 ,  A61K9/5031 ,  A61K9/5138 ,  A61K9/5146 ,  A61K9/5153 ,  A61K9/5192 ,  A61K9/70 ,  A61K9/7007 ,  A61K31/00 ,  A61K31/28 ,  A61K31/335 ,  A61K31/337 ,  A61K33/24 ,  A61K47/34

Abstract: The present invention provides methods for treating or preventing diseases associated with body passageways, comprising the step of delivering to an external portion of the body passageway a therapeutic agent. Representative examples of therapeutic agents include anti-angiogenic factors, anti-proliferative agents, anti-inflammatory agents, and antibiotics.

Abstract translation: 本发明提供了治疗或预防与身体通道相关的疾病的方法，包括向人体通道的外部部分递送治疗剂的步骤。 治疗剂的代表性实例包括抗血管生成因子，抗增殖剂，抗炎剂和抗生素。

公开(公告)号：US20030039675A1

公开(公告)日：2003-02-27

申请号：US09995490

申请日：2001-11-27

Applicant: Angiotech Pharmaceuticals, Inc.

Inventor： Lawrence L. Kunz ,  John M. Reno

IPC: A61K031/337 ,  A61K031/075 ,  A61F002/00

CPC classification number: A61K9/0024 ,  A61K31/04 ,  A61K31/131 ,  A61K31/135 ,  A61K31/138 ,  A61K31/165 ,  A61K31/17 ,  A61K31/337 ,  A61K31/352 ,  A61K31/365 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/519 ,  A61K31/551 ,  A61K31/704 ,  A61K47/51 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6817 ,  A61K47/6831 ,  A61K47/6843 ,  A61K47/6927 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  G01N2800/323 ,  Y10S435/975

Abstract: Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.

公开(公告)号：US20030004209A1

公开(公告)日：2003-01-02

申请号：US10112921

申请日：2002-03-28

Applicant: Angiotech Pharmaceuticals, Inc.

Inventor： William L. Hunter ,  Lindsay S. Machan ,  A. Larry Arsenault

IPC: A61K031/337 ,  A61K009/14

CPC classification number: A61K9/5153 ,  A61K9/0019 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/1658 ,  A61K9/167 ,  A61K9/7007 ,  A61K31/122 ,  A61K31/136 ,  A61K31/185 ,  A61K31/203 ,  A61K31/335 ,  A61K31/337 ,  A61K31/519 ,  A61K31/57 ,  A61K33/24 ,  A61K45/06 ,  A61K47/32 ,  A61K47/34 ,  A61K47/50 ,  A61K47/6925 ,  A61L31/10 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/622 ,  A61L2430/36 ,  C07K14/811 ,  C08L23/0815 ,  C08L23/0853 ,  C08L67/04 ,  C08L2203/02 ,  C08L2312/00 ,  Y10S514/825 ,  Y10S514/826 ,  A61K2300/00 ,  C08L23/08 ,  C08L2666/18 ,  C08L2666/06

Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.

公开(公告)号：US20040146546A1

公开(公告)日：2004-07-29

申请号：US10673046

申请日：2003-09-26

Applicant: Angiotech Pharmaceuticals, Inc.

Inventor： David M. Gravett ,  Philip M. Toleikis ,  Dechi Guan ,  Pierre E. Signore ,  Thomas S. Spencer ,  William L. Hunter ,  Kaiyue Wang

IPC: A61L015/00

CPC classification number: A61L31/16 ,  A61F2/06 ,  A61F2/90 ,  A61F2250/0067 ,  A61L27/14 ,  A61L27/54 ,  A61L27/58 ,  A61L31/06 ,  A61L31/10 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/43 ,  Y10T442/2525 ,  C08L67/04

Abstract: The present invention provides compositions, devices, and methods for maintaining or improving the integrity of body passageways following surgery, such as at a graft site, or injury. Delivery devices including one or more therapeutic agents and a mesh are described. Representative examples of therapeutic agents include microtubule stabilizing agents, anti-angiogenic factors, inhibitors of smooth muscle cell growth or proliferation, non-steroidal anti-inflammaory drugs, and other factors useful preventing and/or reducing a proliferative biological response that may obstruct or hinder the optimal functioning of the passageway or cavity.

Abstract translation: 本发明提供了用于维持或改善手术后的身体通道的完整性（例如在移植部位或损伤）的组合物，装置和方法。 描述包括一种或多种治疗剂和网状物的输送装置。 治疗剂的代表性实例包括微管稳定剂，抗血管生成因子，平滑肌细胞生长或增殖的抑制剂，非甾体抗炎症药物和用于预防和/或降低可能阻碍或阻碍的增殖性生物反应的其它因素 通道或腔体的最佳功能。

公开(公告)号：US20020192280A1

公开(公告)日：2002-12-19

申请号：US10137736

申请日：2002-05-01

Applicant: Angiotech Pharmaceuticals, Inc.

Inventor： William L. Hunter ,  David M. Gravett ,  Richard T. Liggins ,  Philip M. Toleikis

IPC: A61K009/20 ,  A61K031/728 ,  A61K031/721 ,  A61K031/717

CPC classification number: A61K9/5153 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/5161 ,  A61K9/7007 ,  A61K31/337 ,  A61K31/717 ,  A61K31/721 ,  A61K31/728 ,  A61K47/36 ,  A61K47/42 ,  A61K2300/00

Abstract: Disclosed herein are compositions and methods for treating a variety of inflammatory conditions (e.g., inflammatory arthritis, adhesions, tumor excision sites, and fibroproliferative diseases of the eye). For example, there is provided a composition comprising a protein or polysaccharide containing dispersed (e.g., in micelle or liposome form) anti-microtubule agent, which may be formulated for administration to a patient in need thereof.

Abstract translation: 本文公开了用于治疗各种炎性病症（例如炎症性关节炎，粘连，肿瘤切除部位和眼睛的纤维增生性疾病）的组合物和方法。 例如，提供了包含含有分散（例如胶束或脂质体形式）抗微管剂的蛋白质或多糖的组合物，其可以配制用于给予有需要的患者。

公开(公告)号：US20130115263A1

公开(公告)日：2013-05-09

申请号：US13663254

申请日：2012-10-29

Applicant: Angiotech Pharmaceuticals, Inc.

Inventor： William L. Hunter ,  David M. Gravett ,  Philip M. Toleikis ,  Richard T. Liggins ,  Troy A.E. Loss

IPC: A01N43/54

CPC classification number: A61L29/08 ,  A01N43/54 ,  A61L27/54 ,  A61L29/16 ,  A61L2300/204 ,  A61L2300/404

Abstract: Medical implants are provided which release a fluoropyrimidine or an analog thereof, thereby inhibiting or reducing the incidence of infection associated with the implant.