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公开(公告)号：US5763608A
公开(公告)日：1998-06-09
申请号：US595885
申请日：1996-02-05
IPC分类号： C07D239/22 , C07D239/70 , C07D239/90 , C07D239/34 , C07D239/88
CPC分类号： C07D239/22 , C07D239/70 , C07D239/90
摘要： The present invention provides a process for preparing a 5,6-dihydro-3H-pyrimidin-4-one derivatives which comprises the steps of (a) dehydrating a N-acyl beta amino acid in the presence of a dehydration agent and an organic solvent for a sufficient period of time and under suitable temperature and pressure conditions to form an oxazone (b) adding a carboxylic acid and a primary amine salt of a carboxylic acid to said oxazone to form a mixture, (c) distilling azeotropically said mixture for a suitable period of time and under suitable temperature and pressure conditions to substantially remove said dehydration agent and said organic solvent, and (d) heating the product of step (c) for a sufficient period of time and under suitable temperature and pressure conditions to form said pyrimidin derivatives.
摘要翻译： 本发明提供一种制备5,6-二氢-3H-嘧啶-4-酮衍生物的方法，其包括以下步骤：（a）在脱水剂和有机溶剂存在下使N-酰基β氨基酸脱水 （b）向所述恶唑酮中加入羧酸和羧酸的伯胺盐以形成混合物，（c）将共沸蒸馏所述混合物用于 适当的时间段和在合适的温度和压力条件下，以基本上除去所述脱水剂和所述有机溶剂，和（d）在合适的温度和压力条件下加热步骤（c）的产物足够的时间以形成所述 嘧啶衍生物。
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公开(公告)号：US5116983A
公开(公告)日：1992-05-26
申请号：US520991
申请日：1990-05-08
CPC分类号： C07J73/003 , C07J51/00 , C07J73/005
摘要： A process for dehydrogenating a compound of the formula ##STR1## which comprises reacting the compound with a silylating agent in the presence of a quinone to introduce a .DELTA..sup.1 double bond.
摘要翻译： （III）的化合物的脱氢方法，其包括使化合物与甲硅烷基化剂在醌存在下反应以引入DELTA 1双键。
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公开(公告)号：US07173152B2
公开(公告)日：2007-02-06
申请号：US11208474
申请日：2005-08-19
申请人： Apurba Bhattacharya , Victor Suarez
发明人： Apurba Bhattacharya , Victor Suarez
IPC分类号： C07C233/05
CPC分类号： C07C231/10 , C07C231/02 , C07C2603/18 , C07C233/15 , C07C233/25 , C07C233/33 , C07C233/54 , C07C233/07
摘要： The present invention provides a method for the reductive acetamidation of an aryl nitro compound by reacting a substituted acid with an aryl nitro compound and adding a catalytic amount of a base with the substituted acid and the aryl nitro compound to form an acetamidation aryl nitro compound. The acetamidation aryl nitro compound is then purified.
摘要翻译： 本发明提供了通过使取代的酸与芳基硝基化合物反应并将催化量的碱与取代的酸和芳基硝基化合物反应以形成乙酰胺基芳基硝基化合物来还原芳基硝基化合物的方法。 然后纯化乙酰胺基芳基硝基化合物。
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公开(公告)号：US5489712A
公开(公告)日：1996-02-06
申请号：US334822
申请日：1994-11-04
申请人： Apurba Bhattacharya
发明人： Apurba Bhattacharya
IPC分类号： C07C45/67 , C07C45/68 , C07C49/623 , C07C45/45
摘要： The present invention provides a novel process for preparing cyclic ketones, such as indanones, which comprises the steps of (a) subjecting a substituted ketone to suitable methylenation conditions in the presence of a methylene transfer agent and an acylating agent for a sufficient period of time and under suitable conditions of temperature and pressure to form the corresponding alpha, beta unsaturated ketone, and (b) subjecting said unsaturated ketone to suitable cyclization conditions in the presence of a suitable acid or base for a sufficient period of time and under suitable conditions of temperature and pressure to form said cyclic ketones.
摘要翻译： 本发明提供了一种制备环酮的新方法，如茚满酮，其包括以下步骤：（a）在亚甲基转移剂和酰化剂的存在下使取代的酮进行合适的亚甲基化条件足够的时间 并在适当的温度和压力条件下形成相应的α，β不饱和酮，和（b）在合适的酸或碱存在下将所述不饱和酮在适当的环化条件下充分足够的时间和在适当的条件下 温度和压力以形成所述环酮。
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公开(公告)号：US5399707A
公开(公告)日：1995-03-21
申请号：US257412
申请日：1994-06-10
IPC分类号： C07D333/24 , C07B55/00 , C07B57/00 , C07C51/43 , C07C51/487 , C07C57/30 , C07C227/42 , C07C229/26 , C07D209/28 , C07D233/64 , C07D263/56 , C07D491/052
CPC分类号： C07C51/43 , C07C51/487
摘要： A process is provided whereby S(+)-ibuprofen or R(-)-ibuprofen L-lysinate salt is produced by selective precipitation from a mixture containing enantiomers of ibuprofen and L-lysine. The quantity of L-lysine is not more than about a molar equivalent of the quantity of one of the enantiomers in the ibuprofen enantiomeric mixture. Upon precipitation of one ibuprofen enantiomer from the mixture, the overall precipitate and reaction mixture can be held for a sufficient period of time at a second temperature to allow the first precipitate to redissolve into the reaction mixture and the other ibuprofen enantiomer to precipitate out of the mixture in the salt form. Optically active ibuprofen is racemized by being heated at 100.degree. C. to 300.degree. C. in the substantial absence of other materials.
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6.发明授权
公开(公告)号：US5304610A
公开(公告)日：1994-04-19
申请号：US42358
申请日：1993-04-02
IPC分类号： G03F7/033 , A61K8/00 , A61K8/37 , A61K8/49 , A61K47/30 , A61Q5/02 , A61Q5/12 , B01F17/40 , B01F17/52 , C08F8/12 , C08F12/00 , C08F26/06 , C08F212/14 , C08F226/06 , C08L39/00 , C08L39/04 , C08L101/00 , C09D5/00 , C09K17/20 , C11D3/37
CPC分类号： C08F226/06 , C08F212/14 , C08F8/12 , G03C2001/0471
摘要： A unique polymer was synthesized via copolymerization of vinylpyridine and acetoxystyrene under radical-initiated conditions followed by acidic or basic hydrolysis of the acetoxy group to afford the corresponding hydroxy group. The built-in acid-base dual functionality (phenolic and pyridyl units) in this polymer backbone gives rise to its unique solubility properties over a wide pH range in both aqueous and non-aqueous media. Due to its amphoteric nature, this polymer finds application as an anti-stat, viscosity modifier, and/or ion-exchange resin.
摘要翻译： 通过乙烯基吡啶和乙酰氧基苯乙烯在自由基引发条件下的共聚合，然后酸性或碱性水解乙酰氧基来合成独特的聚合物，得到相应的羟基。 该聚合物骨架中的内置酸碱双官能团（酚类和吡啶基单元）在水性和非水性介质中都能在宽的pH范围内产生独特的溶解性。 由于其两性性质，该聚合物可用作抗静电，粘度调节剂和/或离子交换树脂。
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公开(公告)号：US4605760A
公开(公告)日：1986-08-12
申请号：US766376
申请日：1985-08-16
申请人： Apurba Bhattacharya
发明人： Apurba Bhattacharya
CPC分类号： C07C45/68 , C07C45/673 , C07C45/81 , C07C2103/18
摘要： A process for direct preparation of an enantiomer of a substituted fluorenyloxyacetic acid is disclosed. The acetic acid derivative is useful for treating brain edema.
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公开(公告)号：US20070249563A1
公开(公告)日：2007-10-25
申请号：US11737783
申请日：2007-04-20
申请人： Apurba Bhattacharya , Vijayabhaskar Bolugoddu , Pravinchandra Vankawala , Chandrasekhar Elati , Srinivas Gangula , Amarnath Lekkala , Ramakrishna Mallemula , Anitha Naredla , Ashok Sigala
发明人： Apurba Bhattacharya , Vijayabhaskar Bolugoddu , Pravinchandra Vankawala , Chandrasekhar Elati , Srinivas Gangula , Amarnath Lekkala , Ramakrishna Mallemula , Anitha Naredla , Ashok Sigala
IPC分类号： A61K31/675 , C07F9/6506
CPC分类号： C07D233/74 , C07F9/6506
摘要： Processes for preparing fosphenytoin.
摘要翻译： 制备芬太尼的方法
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公开(公告)号：US20060052638A1
公开(公告)日：2006-03-09
申请号：US11208474
申请日：2005-08-19
申请人： Apurba Bhattacharya , Victor Suarez
发明人： Apurba Bhattacharya , Victor Suarez
IPC分类号： C07C231/02
CPC分类号： C07C231/10 , C07C231/02 , C07C2603/18 , C07C233/15 , C07C233/25 , C07C233/33 , C07C233/54 , C07C233/07
摘要： The present invention provides a method for the reductive acetamidation of an aryl nitro compound by reacting a substituted acid with an aryl nitro compound and adding a catalytic amount of a base with the substituted acid and the aryl nitro compound to form an acetamidation aryl nitro compound. The acetamidation aryl nitro compound is then purified.
摘要翻译： 本发明提供了通过使取代的酸与芳基硝基化合物反应并将催化量的碱与取代的酸和芳基硝基化合物反应以形成乙酰胺基芳基硝基化合物来还原芳基硝基化合物的方法。 然后纯化乙酰胺基芳基硝基化合物。
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10.发明授权
公开(公告)号：US5210149A
公开(公告)日：1993-05-11
申请号：US968741
申请日：1992-10-30
IPC分类号： B01J43/00 , B01J45/00 , C08F8/12 , C08F212/14 , H01B1/12
CPC分类号： H01B1/122 , B01J43/00 , B01J45/00 , C08F212/14 , C08F8/12 , C08F2810/50 , G03C2001/0471
摘要： A unique polymer was synthesized via copolymerization of vinylpyridine and acetoxystyrene under radical-initiated conditions followed by acidic or basic hydrolysis of the acetoxy group to afford the corresponding hydroxy group. The built-in acid-base dual functionality (phenolic and pyridyl units) in this polymer backbone gives rise to its unique solubility properties over a wide pH range in both aqueous and non-aqueous media. Due to its amphoteric nature, this polymer finds application as an anti-stat, viscosity modifier, and/or ion-exchange resin.
摘要翻译： 通过乙烯基吡啶和乙酰氧基苯乙烯在自由基引发条件下的共聚合，然后酸性或碱性水解乙酰氧基来合成独特的聚合物，得到相应的羟基。 该聚合物骨架中的内置酸碱双官能团（酚类和吡啶基单元）在水性和非水性介质中都能在宽的pH范围内产生独特的溶解性。 由于其两性性质，该聚合物可用作抗静电，粘度调节剂和/或离子交换树脂。
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