公开(公告)号：US09562911B2

公开(公告)日：2017-02-07

申请号：US14609865

申请日：2015-01-30

申请人： Aristo Vojdani

发明人： Aristo Vojdani

IPC分类号： G01N33/68 ,  G01N33/544

CPC分类号： G01N33/6854 ,  G01N33/543 ,  G01N33/544 ,  G01N33/564 ,  G01N2800/24

摘要： Compositions and methods for accurately characterizing immune reactivity to food allergens have been developed, in which test surfaces that incorporate different food antigen preparations derived from the same food into individual test sites are provided. Such coated surfaces can be produced using raw and cooked foods. The use of a panel of such test surfaces to characterize specific IgG, IgA, and/or C1q binding provides improved sensitivity and accuracy in determining immune reactivity and response to specific foods.

摘要翻译： 已经开发了用于准确表征对食物过敏原的免疫反应性的组合物和方法，其中将从相同食物衍生的不同食品抗原制剂的试验表面提供到各个测试部位。 这样的涂覆表面可以使用生的和熟的食物来生产。 使用一组这样的测试表面来表征特异性IgG，IgA和/或C1q结合提供了确定免疫反应性和对特定食物的反应的改进的灵敏度和准确性。

公开(公告)号：US20120196299A1

公开(公告)日：2012-08-02

申请号：US13359007

申请日：2012-01-26

申请人： Aristo Vojdani

发明人： Aristo Vojdani

IPC分类号： G01N33/573 ,  G01N33/566

CPC分类号： G01N33/564 ,  G01N33/6893 ,  G01N2333/195 ,  G01N2800/06 ,  G01N2800/709

摘要： Methods, assays, and apparatus are disclosed for testing of antigens associated with intestinal and/or blood-brain barrier permeability. For example, blood, saliva or other bodily fluid can be tested for binding (1) to a bacterial toxin (preferably a lipopolysaccharide), and (2) binding to tissue antigens selected from at least one of (a) a gut-related antigen and (b) a blood brain barrier-related antigen. Analysis of test results can be used to assist in detecting and diagnosing diseases associated with leaky gut syndrome (whether due to paracellular or transcellular pathways, and whether due to bacterial toxins or some other cause) and/or to diseases associated with excessive blood brain barrier permeability, which are contemplated herein to include both neuroinflammation and/or neuroautoimmunity conditions, and especially amyotrophic lateral sclerosis, Parkinsons disease, multiple sclerosis, Alzheimer's, or peripheral neuropathy, and major depression.

摘要翻译： 公开了用于测试与肠和/或血脑屏障通透性相关的抗原的方法，测定和装置。 例如，可以测试血液，唾液或其他体液与细菌毒素（优选脂多糖）的结合（1），和（2）结合选自以下的至少一种的组织抗原：（a）肠相关抗原 和（b）血脑屏障相关抗原。 测试结果的分析可用于帮助检测和诊断与肠道综合征相关的疾病（无论是由于细胞外或跨细胞途径引起的，以及是否由于细菌毒素或其他原因）和/或与血脑屏障过度相关的疾病 本文考虑的渗透性包括神经炎症和/或神经自身免疫性疾病，特别是肌萎缩性侧索硬化，帕金森病，多发性硬化，阿尔茨海默病或周围神经病变以及重度抑郁症。

公开(公告)号：US20060094073A1

公开(公告)日：2006-05-04

申请号：US11328963

申请日：2006-01-09

申请人： Aristo Vojdani

发明人： Aristo Vojdani

IPC分类号： G01N33/537 ,  G01N33/53 ,  G01N33/543

CPC分类号： G01N33/6893 ,  G01N33/564 ,  G01N2800/32 ,  Y10S436/811

摘要： A method for diagnosing the likelihood and severity of cardiovascular disease in a patient is disclosed. The method determines the levels of antibodies against autoantigens, including myosin, oxidized LDL, β-2-glycoprotein, heat shock protein-60, platelet glycoprotein, and immune complexes. It then compares the results to normal levels to determine the likelihood and severity of cardiovascular disease.

公开(公告)号：US20090253154A1

公开(公告)日：2009-10-08

申请号：US12061314

申请日：2008-04-02

申请人： Aristo Vojdani

发明人： Aristo Vojdani

IPC分类号： G01N33/53 ,  G01N33/563

CPC分类号： G01N33/6854

摘要： A method for determining the presence of delayed food allergy and intolerance against antigens extracted from modified foods. The method includes determining a level of antibodies against a modified dietary food antigen in blood and mucosal samples from the patient and comparing the level with normal levels of the antibodies. Dietary antigens that were tested include milk and modified milk products; eggs and modified egg products; meat and modified meat products; fish, mollusks, and crustaceans and their modified products; oils, fats and their modified products; grains and modified grain products; pulses, seeds kernels, nuts and their modified products; vegetables and modified vegetable products; fruits and modified fruit products; sugar, modified sugar products, modified chocolate products and confectionery; and spices and their modified forms.

摘要翻译： 一种确定延迟食物过敏的存在的方法和对从改良食品中提取的抗原的不耐受性。 该方法包括确定来自患者的血液和粘膜样品中抗体与修饰的膳食食物抗原的抗体水平，并将该水平与正常水平的抗体进行比较。 测试的膳食抗原包括牛奶和改性乳制品; 鸡蛋和改性蛋制品; 肉类和改性肉制品; 鱼，软体动物和甲壳类动物及其改良产品; 油，脂肪及其改性产品; 谷物和改性谷物制品; 豆类，种子仁，坚果及其改性产品; 蔬菜和改良蔬菜制品; 水果和改良水果制品; 糖，改性糖制品，改性巧克力制品和糖果; 香料及其改性剂。

公开(公告)号：US06815161B1

公开(公告)日：2004-11-09

申请号：US09283655

申请日：1999-04-01

申请人： Aristo Vojdani

发明人： Aristo Vojdani

IPC分类号： C07H2104

CPC分类号： C12Q1/6883 ,  C12Q1/6895 ,  C12Q2600/16

摘要： A method for determining an increased likelihood of the presence of chronic fatigue syndrome (CFS), fibromyalgia (FMS), or rheumatoid arthritis (RA) in an individual, comprising isolating blood cells from the individual and determining the presence of one or more Mycoplasma species present in the blood cells, wherein the presence of one or more Mycoplasma species indicates an increased likelihood of the presence of CFS, FMS, RA or GWS.

公开(公告)号：US5853996A

公开(公告)日：1998-12-29

申请号：US843951

申请日：1997-04-17

申请人： Eli Mordechai ,  Aristo Vojdani

发明人： Eli Mordechai ,  Aristo Vojdani

IPC分类号： C12Q1/48 ,  C12Q1/68 ,  G01N1/30 ,  G01N33/50 ,  G01N33/573 ,  G01N33/53

CPC分类号： G01N33/573 ,  C12Q1/48 ,  G01N1/30 ,  G01N33/5091

摘要： A method for diagnosing chronic fatigue syndrome in an individual. Peripheral blood monocytes are isolated and p68 kinase activity, mRNA levels, protein levels, apoptosis and cell cycle analysis are measured. Significantly increased levels of any of these compared to healthy control individuals indicates the presence of chronic fatigue syndrome.

摘要翻译： 一种诊断个体慢性疲劳综合征的方法。 分离外周血单核细胞，测定p68激酶活性，mRNA水平，蛋白水平，细胞凋亡和细胞周期分析。 与健康对照个体相比，任何这些相比显着增加，表明存在慢性疲劳综合征。

公开(公告)号：US5707816A

公开(公告)日：1998-01-13

申请号：US796411

申请日：1997-02-06

申请人： Aristo Vojdani

发明人： Aristo Vojdani

IPC分类号： G01N33/53 ,  G01N33/569 ,  G01N33/542 ,  G01N33/554 ,  G01N33/567

CPC分类号： G01N33/56961 ,  G01N33/5308 ,  Y10T436/25

摘要： A method of determining immunological cross reactivity between Candida and human tissue or food antigens. Tissue antigen preparations or food extracts are analyzed by electrophoresis. Cross reacting antigens are identified by immunoblotting using anti-Candida antisera.

摘要翻译： 测定假丝酵母与人体组织或食物抗原之间的免疫交叉反应性的方法。 通过电泳分析组织抗原制剂或食品提取物。 通过使用抗念珠菌抗血清的免疫印迹来鉴定交叉反应抗原。

公开(公告)号：US20080014600A1

公开(公告)日：2008-01-17

申请号：US11780447

申请日：2007-07-19

申请人： Aristo VOJDANI

发明人： Aristo VOJDANI

IPC分类号： G01N33/00

CPC分类号： G01N33/6896 ,  G01N2800/285

摘要： A method of diagnosing multiple sclerosis and other demyelinating diseases or predicting a predisposition to multiple sclerosis and other demyelinating diseases. The method utilizes detection of increased amounts of memory lymphocytes reacting to MS antigens, proinflammatory cytokines, and antibodies against MS antigens.

摘要翻译： 诊断多发性硬化症和其他脱髓鞘疾病或预测多发性硬化症和其他脱髓鞘疾病的倾向的方法。 该方法利用检测增加量的与MS抗原反应的淋巴细胞，促炎细胞因子和针对MS抗原的抗体。

公开(公告)号：US07252957B2

公开(公告)日：2007-08-07

申请号：US10770712

申请日：2004-02-03

申请人： Aristo Vojdani

发明人： Aristo Vojdani

IPC分类号： G01N33/53

CPC分类号： C12Q1/6883 ,  C07K16/2851 ,  C07K16/2896 ,  C07K16/40 ,  C07K2317/34 ,  C12Q1/701 ,  C12Q1/705 ,  G01N33/6896

摘要： Disclosed herein is a method for following up a prognosis of children with autism before and after treatment with different modalities administered by their clinicians, confirming the involvement of infectious agents, dietary proteins, and toxic chemicals in development of autism. The method utilizes detection of increased amounts of antibodies against an antigen based on infectious agent, toxic chemicals, or dietary proteins. Another method utilizes detection of antibodies to a self-tissue or peptide.

摘要翻译： 本文公开了一种用于在治疗之前和之后用其临床医生施用的不同方式跟踪自闭症患儿的预后的方法，证实感染因子，膳食蛋白质和有毒化学物质参与发展自闭症。 该方法利用基于感染剂，有毒化学物质或膳食蛋白质的抗原检测增加抗体的量。 另一种方法利用对自身组织或肽的抗体的检测。

公开(公告)号：US20060194267A1

公开(公告)日：2006-08-31

申请号：US11066399

申请日：2005-02-25

申请人： Aristo Vojdani

发明人： Aristo Vojdani

IPC分类号： G01N33/554 ,  C07K14/195 ,  G01N33/569 ,  C07K16/12

CPC分类号： G01N33/56905 ,  G01N33/53 ,  G01N33/56911 ,  G01N33/6893 ,  G01N2333/20 ,  G01N2333/29 ,  G01N2333/43556 ,  G01N2333/44 ,  G01N2800/42 ,  Y02A50/57 ,  Y10T436/25

摘要： ELISA, Western Blot, and a peptide-based ELISA were applied to clinical specimens from patients with clinical symptoms of tick borne diseases, including Lyme disease. Peptides from different components of Borrelia during different cycles, including peptides from outer surface protein, leukocyte function associated antigens, immunodominant antigens, variable major proteins, and peptides from decorin-binding proteins of Borrelial subspecies (B. sensu stricto. B. afzelii, B. garinii) were used. Antibodies against specific peptides from Babesia and Ehrlichia were also measured.

摘要翻译： ELISA，Western Blot和基于肽的ELISA应用于患有蜱传播疾病（包括莱姆病）的临床症状患者的临床标本。 来自不同周期的疏螺旋体不同组分的肽，包括来自外表面蛋白的肽，白细胞功能相关抗原，免疫显性抗原，可变主要蛋白质和来自双侧亚种（B. sensu stricto B.afzelii，B 使用garinii）。 还测定了来自巴贝虫和埃里巴马的特异性肽的抗体。