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1.
公开(公告)号:US20080226645A1
公开(公告)日:2008-09-18
申请号:US12008691
申请日:2008-01-10
申请人: Margot Mary O'Toole , Frederick William Immermann , Andrew Arthur Hill , Padmalatha Sunkara Reddy , Michael Edward Burczynski , Douglas Kenneth Miller , Karl Henry Nocka , Stanley Francis Wolf , Michael Ronald Bowman , Andrew Joseph Dorner , I-Ming Wang
发明人: Margot Mary O'Toole , Frederick William Immermann , Andrew Arthur Hill , Padmalatha Sunkara Reddy , Michael Edward Burczynski , Douglas Kenneth Miller , Karl Henry Nocka , Stanley Francis Wolf , Michael Ronald Bowman , Andrew Joseph Dorner , I-Ming Wang
IPC分类号: A61K31/7088 , C40B40/06 , A61K39/395 , C07K16/00 , A61K31/7105 , C07H21/00 , A61K38/02 , C40B30/00
CPC分类号: C12Q1/6883 , C12Q1/6837 , C12Q2600/136 , C12Q2600/158
摘要: The present invention provides methods and compositions for the assessment and treatment of asthma and other inflammatory diseases, particularly those mediated by interleukin-13 (IL-13). The present invention also provides arrays comprising markers for asthma as well as IL-13 responsiveness. The markers of the present invention can be used in methods to diagnose a patient as having asthma or an IL-13-mediated condition, to evaluate the effectiveness of potential therapeutic agents, to identify or evaluate agents capable of modulating marker expression levels, and to select a treatment for a patient suffering from asthma or an IL-13-mediated condition.
摘要翻译: 本发明提供了用于评估和治疗哮喘和其它炎性疾病的方法和组合物,特别是由白细胞介素-13(IL-13)介导的那些。 本发明还提供了包含哮喘标志物以及IL-13反应性的阵列。 本发明的标记可以用于诊断患有哮喘或IL-13介导的病症的患者的方法,以评估潜在治疗剂的有效性,鉴定或评估能够调节标记物表达水平的药剂,以及 选择治疗患有哮喘或IL-13介导病症的患者。
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公开(公告)号:US06918917B1
公开(公告)日:2005-07-19
申请号:US09686729
申请日:2000-10-10
申请人: John D. Nguyen , Arthur Hill , Laurent Schaller
发明人: John D. Nguyen , Arthur Hill , Laurent Schaller
CPC分类号: A61B17/064 , A61B17/0469 , A61B17/06 , A61B2017/0472 , A61B2017/06009 , A61B2017/06057 , A61B2017/081 , A61F2/2445 , A61F2/2466
摘要: Clips of a self-closing type are used in annuloplasty procedures. Each clip is generally U-shaped with two end points separated from each other when it is constrained to be in an open configuration, but tends to coil up to assume its naturally closed configuration if the constraint is removed. A plurality of such clips in open configurations penetrate the tissue around the annulus circumferentially and then the constraint keeping them in the open configuration is removed such that they pull the tissue together between their two end points and this tends to reduce the diameter of the annulus. Such clips may be deployed each in the form of a clip assembly, having at least one of its end points connected to a needle through a flexible member and a release mechanism by which the clip can be easily released. The needle is caused to penetrate the tissue at one position and to come out therefrom at another circumferentially separated positions. Alternatively, a clip delivery device may be used with a plurality of such clips loaded to a clip-holder serving to keep them in open configurations. A pusher pushes the loaded clips out of the device one at a time. Self-closing clips can be used efficiently also in ring annuloplasty and valve replacement procedures.
摘要翻译: 自闭型的夹子用于瓣环成形术。 每个夹子通常是U形的,当限制为处于打开构型时,两个端点彼此分开,但是如果约束被去除,则趋于线圈化以呈现其自然关闭的构造。 多个这样的打开构型的夹子沿圆周方向穿过环带周围的组织,然后去除保持它们处于打开构型的约束,使得它们将组织拉在它们的两个端点之间,这倾向于减小环的直径。 这样的夹子可以以夹子组件的形式展开,夹具组件的至少一个端点通过柔性构件连接到针头,释放机构通过该释放机构可以容易地释放夹子。 引导针在一个位置穿透组织,并在另一个周向分开的位置从其中脱出。 或者,剪辑传送设备可以与多个这样的夹子一起使用,这些夹子被加载到夹持器,用于使它们保持打开的配置。 一个推动器一次将装载的夹子推出设备。 自闭合夹可以有效地用于环瓣成形术和瓣膜置换手术。
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公开(公告)号:US2022543A
公开(公告)日:1935-11-26
申请号:US2448135
申请日:1935-06-01
申请人: ARTHUR HILL
发明人: ARTHUR HILL
IPC分类号: H04B1/08
CPC分类号: H04B1/08
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公开(公告)号:US1769026A
公开(公告)日:1930-07-01
申请号:US26935528
申请日:1928-04-12
申请人: ARTHUR HILL
发明人: ARTHUR HILL
IPC分类号: G05D16/10
CPC分类号: G05D16/10 , Y10T137/7809
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公开(公告)号:US869274A
公开(公告)日:1907-10-29
申请号:US1907357068
申请日:1907-02-12
申请人: STOKES ARTHUR HILL
发明人: STOKES ARTHUR HILL
CPC分类号: E02B13/02
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公开(公告)号:US756803A
公开(公告)日:1904-04-05
申请号:US1903162663
申请日:1903-06-22
申请人: ARTHUR HILL , ROGERS CHRISTOPHER L
发明人: ROGERS CHRISTOPHER L
CPC分类号: A01G25/023 , B26D7/015
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公开(公告)号:US07744611B2
公开(公告)日:2010-06-29
申请号:US10718236
申请日:2003-11-19
申请人: John D. Nguyen , Laurent Schaller , Arthur Hill
发明人: John D. Nguyen , Laurent Schaller , Arthur Hill
CPC分类号: A61B17/064 , A61B17/0469 , A61B17/06 , A61B2017/0472 , A61B2017/06009 , A61B2017/06057 , A61B2017/081 , A61F2/2442
摘要: A clip of a self-closing type is used for valve repair. The clip is generally U-shaped with two end points separated from each other when it is constrained to be in an open configuration, but tends to coil up to assume its natural closed configuration if the constraint is removed. At least one end point is connected through a suture to a tissue-penetrating needle. A needle holder has an outer tube and an inner member which has a slit at the front and is slidable inside the outer tube. They are designed such that the slit can grab the needle tightly or release it as the inner member is moved backward or forward with respect to the outer tube. With the needle secured at the front, the needle holder is passed through a cannula inserted through an incision and the needle penetrates the leaflets such that the clip can be positioned with its end points hooked to the pair of leaflets to be stitched together. If the clip is released from the suture thereafter, it tends to coil up, reducing the distance between the end points and pulling the leaflets together. A double-arm clip assembly with each of the end points of the clip attached through a suture to a separate needle may be similarly used for valve repair. Such a double-arm clip assembly may contain two of such clips mutually connected by means of a flexible connector such that two leaflets are held together by the connector, with the two clips each anchored to a corresponding one of the leaflets.
摘要翻译: 自动关闭型的夹子用于阀门修理。 夹子通常为U形,当限制为处于打开构型时,两个端点彼此分离,但是如果约束被去除,则趋向于卷起以呈现其自然闭合构型。 至少一个端点通过缝合线连接到组织穿透针。 针保持器具有外管和内部构件,其在前部具有狭缝并且可在外管内滑动。 它们被设计成使得当内部构件相对于外管向后或向前移动时,狭缝可以紧紧地抓住针或释放针。 当针固定在前面时,针保持器穿过插入穿过切口的套管,并且针穿透小叶,使得夹子可以定位成其端点钩在一对传单上以缝合在一起。 如果夹子此后从缝合线中释放出来,则往往卷起,减少端点之间的距离并将传单拉到一起。 通过缝合线将夹子的每个端点附接到单独的针的双臂夹子组件可以类似地用于阀门修复。 这种双臂夹子组件可以包含两个这样的夹子,这些夹子通过柔性连接器相互连接,使得两个传单由连接器保持在一起,其中两个夹子各自固定到相应的一个传单中。
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公开(公告)号:US3936181A
公开(公告)日:1976-02-03
申请号:US405081
申请日:1973-10-10
申请人: Frank Arthur Hill
发明人: Frank Arthur Hill
摘要: A photocopying machine including a device for reorientating an original circulating through the machine for multiple copying. The device consists of a row of microswitches extending transversely to the direction of travel of the original, each microswitch being arranged, when contacted by the sheet before another sheet, to apply a brake to the sheet at a location behind it until the sheet has been reorientated sufficiently to contact other microswitches.
摘要翻译: 一种复印机,包括用于重新定向循环通过机器的原件进行多次复印的装置。 该装置由一排横向于原件行进方向延伸的微动开关组成,每个微动开关被布置成在另一张纸张之前被片材接触时,在其后面的位置向片材施加制动器,直到片材已经被 重新定位以接触其他微动开关。
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9.
公开(公告)号:US1890220A
公开(公告)日:1932-12-06
申请号:US45281630
申请日:1930-05-15
IPC分类号: B27K3/50
CPC分类号: B27K3/50 , B27K3/0242 , B27K3/38 , B27K3/44 , Y10S428/907 , Y10T428/24545 , Y10T428/31815
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公开(公告)号:US20210174647A1
公开(公告)日:2021-06-10
申请号:US16706690
申请日:2019-12-07
申请人: Scott Arthur Hill
发明人: Scott Arthur Hill
IPC分类号: G07F17/32
摘要: An innovative method of playing a modified poker game with seven related variations featuring a novel method of tournament mechanics, through an electronic device or in a casino, known as “Tennessee Hold 'Em® Tournaments”, which promotes strategic decision making and greater player participation is defined. Three to nine players are permitted per table. Three players sitting to the left of the Dealer (Button) furnish blind bets. Five phases of card distribution and progressively increasing betting rounds are defined. After the third card distribution, players decide whether to hold all hole cards, or discard one or two hole cards. Next, all discards are revealed, giving players insight into opponents' hands. Players choosing to hold 4 hole cards are excluded from using the fourth, final community card. Players choosing to hold 5 hole cards are excluded from using the third and fourth community cards. Eliminating complex ‘side pots’, an innovative method of “loaning” additional chips, known as ‘overdrawn chips’ (ODC) allows players who do not have enough chips to continue betting and complete in that hand, providing a last chance to recover or be eliminated. The Tournament is finished when 2 players remain. Winner and runner up chip counts are totalled, and the winner's chip count is divided by the total chip count to determine the percentage of the Tournament Pot awarded to the winner. Remainder of the Tournament Pot is awarded the runner up.
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