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公开(公告)号:US11967435B2
公开(公告)日:2024-04-23
申请号:US17434497
申请日:2020-02-28
IPC分类号: A61M60/178 , A61B8/06 , A61M60/216 , A61M60/232 , A61M60/515 , A61M60/562 , A61M60/857 , G06F30/28 , G16H10/60 , G16H20/40 , G16H30/20 , G16H50/30 , G16H50/70 , G06F113/08 , G16H40/40 , G16H40/67
CPC分类号: G16H50/70 , A61B8/06 , A61M60/178 , A61M60/216 , A61M60/232 , A61M60/515 , A61M60/562 , A61M60/857 , G06F30/28 , G16H10/60 , G16H20/40 , G16H30/20 , G16H50/30 , G06F2113/08 , G16H40/40 , G16H40/67
摘要: A model of flow through a left ventricular assist device (LVAD) can be used for preoperative planning of implantation of the LVAD into a patient and/or optimization of the LVAD after implantation into the patient are described. At least one imaging data set related to a patient and at least one physiological data set related to the patient can be received. An ideal parameter related to the LVAD can be determined based on the at least one imaging data set related to the patient, the at least one physiological data set related to the patient using a model of circulation in a large spatial region of the patient's body and a three-dimensional anatomical model of at least one component of the region of the patient's body and at least one component of the LVAD. Flow patterns within the three-dimensional anatomical model are calculated using computational fluid dynamics.
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公开(公告)号:US20230192821A1
公开(公告)日:2023-06-22
申请号:US17926549
申请日:2021-05-20
发明人: Jane Osbourn , Ralph Minter , Jacob Galson
摘要: There is provided inter alia a polypeptide comprising a CDRH1 sequence comprising or consisting of a sequence sharing 80% or greater sequence identity with a CDRH1 sequence as shown in Table 1 and/or a CDRH2 sequence comprising or consisting of a sequence sharing 80% or greater sequence identity with a CDRH2 sequence as shown in Table 1 and/or a CDRH3 sequence comprising or consisting of a sequence sharing 80% or greater sequence identity with a CDRH3 sequence as shown in Table 1.
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公开(公告)号:US10912472B2
公开(公告)日:2021-02-09
申请号:US16891661
申请日:2020-06-03
IPC分类号: A61B5/00 , A61B5/04 , A61B5/02 , A61B5/046 , A61B5/0432 , A61B5/0408
摘要: A computer implemented method and system for identifying one or more areas of the heart muscle responsible for supporting or initiating abnormal heart rhythms using electrogram data recorded from a plurality of electrodes obtained from a corresponding series of sensing locations on the heart over a recording time period; the method including the steps of: setting a pre-defined geodesic distance, dividing the recording time period into several analysis time periods, and pairing each sensing location with a plurality of other sensing locations from within the defined geodesic distance, thus forming a plurality of location pairings; for each of the analysis time periods, defining the relative timing of each activation signal for each location within each pairing, determining whether the relative timing of activation signals falls within plausible biological parameters, defining the leading signal of the pair for each electrogram activation within the respective analysis time period; and assigning a series of lead signal scores to each electrogram pairing acquired within each analysis time period based on the proportion of time within the respective analysis time period that each activation signal is leading within each pairing; repeating the analysis at the same location at least once whilst varying the analysis time period; combining each analysis time period for each signal location to provide a statistical measure of the proportion that each signal location tends to lead relative to other locations within the defined geodesic area; and relating lead signal scores from overlapping geodesic areas to provide relative combined lead signal scores; to provide an indication of the relative likelihood that each sensing location is generally preceding other areas and is therefore at or adjacent to a driver area of the abnormal heart rhythm.
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公开(公告)号:US20190139452A1
公开(公告)日:2019-05-09
申请号:US16095418
申请日:2017-04-20
摘要: A simulation manikin (1) for central venous cannulation comprises a first tube (3) for simulating a vein, a simulated clavicle (4), a first member (2) to which the tube (3) and simulated clavicle (4) are removeably affixed to in a position which is anatomically correct with respect to each other and a second member (11) having a surface which simulates the contours of half a neck to the clavicle. The manikin (1) is useful for teaching students identification of key anatomic landmarks, navigation of needle under ultrasound, recognition of correct blood vessels, and avoiding and managing potential complications.
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公开(公告)号:US20170119849A1
公开(公告)日:2017-05-04
申请号:US15317833
申请日:2015-06-10
CPC分类号: A61K38/193 , A61B5/4887 , A61K9/0019 , A61K35/28 , A61K2035/124
摘要: The present invention provides a composition comprising cells obtainable by bone marrow aspiration, or multipotent or pluripotent progenitor cells, and granulocyte-colony stimulating factor (G-CSF), as a combined preparation for simultaneous, separate or sequential use in the therapy of cardiomyopathy in a subject, wherein the cells are administered directly to the myocardium of the subject.
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公开(公告)号:US20150297813A1
公开(公告)日:2015-10-22
申请号:US14440848
申请日:2013-11-05
CPC分类号: A61M1/122 , A61M1/1005 , A61M1/101 , A61M1/1086 , A61M1/1098 , A61M1/12 , A61M1/125 , A61M1/127
摘要: Mechanical circulatory supports configured to operate in series with the native heart are disclosed. In an embodiment, a centrifugal pump is used. In an embodiment, inlet and outlet ports are connected into the aorta and blood flow is diverted through a lumen and a centrifugal pump between the inlet and outlet ports.
摘要翻译: 公开了配置成与天然心脏串联操作的机械循环支撑件。 在一个实施例中,使用离心泵。 在一个实施例中,入口和出口连接到主动脉中,并且血流通过入口和出口之间的内腔和离心泵转向。
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