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    CELL-MATRIX MICROSPHERES, METHODS FOR PREPARATION AND APPLICATIONS
    2.
    发明申请
    CELL-MATRIX MICROSPHERES, METHODS FOR PREPARATION AND APPLICATIONS 有权
    细胞基质微球，制备和应用方法

    公开(公告)号：US20080031858A1

    公开(公告)日：2008-02-07

    申请号：US11750863

    申请日：2007-05-18

    申请人： Barbara Chan ,  Godfrey Chan ,  Hoi Wong ,  Pik Cheung ,  Song-Eng Cheah ,  Danny Chan

    发明人： Barbara Chan ,  Godfrey Chan ,  Hoi Wong ,  Pik Cheung ,  Song-Eng Cheah ,  Danny Chan

    IPC分类号： A61K35/00 ,  A61P43/00 ,  C12M1/00 ,  C12N5/06 ,  C12P1/00

    CPC分类号： C12N5/0602 ,  A61K35/12 ,  C12M25/14 ,  C12N5/0012 ,  C12N5/0655 ,  C12N5/0663 ,  C12N2510/02 ,  C12N2533/54 ,  C12N2533/90

    摘要： A method has been developed to produce stable cell-matrix microspheres with up to 100% encapsulation efficiency and high cell viability, using matrix or biomaterial systems with poor shape and mechanical stability for applications including cell therapeutics via microinjection or surgical implantation, 3D culture for in vitro expansion without repeated cell splitting using enzymatic digestion or mechanical dissociation and for enhanced production of therapeutic biomolecules, and in vitro modeling for morphogenesis studies. The modified droplet generation method is simple and scalable and enables the production of cell-matrix microspheres when the matrix or biomaterial system used has low concentration, with slow phase transition, with poor shape and mechanical stability.

    摘要翻译： 已经开发了一种方法来生产具有高达100％包封效率和高细胞活力的稳定的细胞基质微球，使用具有差的形状和机械稳定性的基质或生物材料体系，包括通过显微注射或手术植入的细胞治疗剂，3D培养物 使用酶消化或机械解离并且用于增强治疗性生物分子的产生的体外扩增而不重复细胞分裂，以及用于形态发生研究的体外模拟。 改进的液滴生成方法简单可伸缩，当使用的基质或生物材料系统具有低浓度，缓慢的相变，形状和机械稳定性差时，能够生产细胞基质微球。

    Photochemically crosslinked collagen scaffolds and methods for their preparation
    3.
    发明申请
    Photochemically crosslinked collagen scaffolds and methods for their preparation 有权
    光化学交联的胶原支架及其制备方法

    公开(公告)号：US20060099268A1

    公开(公告)日：2006-05-11

    申请号：US11225108

    申请日：2005-09-14

    申请人： Barbara Chan ,  Kwok So

    发明人： Barbara Chan ,  Kwok So

    IPC分类号： A61K9/14 ,  A61K38/17 ,  C07K14/78

    CPC分类号： A61L27/24 ,  A61L27/50 ,  C07K14/78 ,  C07K19/00 ,  C12N5/0068 ,  C12N2533/54

    摘要： A method for producing collagen-based scaffolds with improved characteristics, which broadens the usage of collagen in tissue engineering and the products so produced are described. The method comprises reconstitution of three-dimensional collagen matrices from collagen monomer solution and crosslinking the matrix with a light source in the presence of a photosensitizing reagent. The crosslinked products can be in any shape and form and used in the dry or wet state, for applications including but not limited to tissue engineering and controlled drug delivery.

    摘要翻译： 描述了具有改进特征的胶原蛋白类支架的制造方法，其增加了组织工程中胶原蛋白的使用和所制造的产品。 该方法包括从胶原单体溶液中重构三维胶原基质，并在光敏试剂存在下用光源交联基质。 交联产物可以是任何形状和形式，并且在干或湿状态下使用，用于包括但不限于组织工程和受控药物递送的应用。