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公开(公告)号：US08986702B2
公开(公告)日：2015-03-24
申请号：US12467957
申请日：2009-05-18
申请人： Yosef Refaeli , Brian Curtis Turner
发明人： Yosef Refaeli , Brian Curtis Turner
IPC分类号： C12N5/24 , C12N5/16 , C12N5/0781 , C12N15/13 , C07K14/005 , C07K14/82 , C07K16/00 , C12N15/62 , C07K16/10 , C07K16/40 , C12N15/113 , A61K39/00
CPC分类号： C07K14/82 , A61K39/00 , A61K2039/505 , A61K2039/53 , A61K2039/55516 , C07K16/00 , C07K16/1018 , C07K16/40 , C07K2319/10 , C07K2319/20 , C07K2319/21 , C12N15/113 , C12N2310/14
摘要： Provided herein are various processes for the improved production of antibody producing organisms, antibody producing tissues, antibody producing cells and antibodies. In certain embodiments, provided herein are methods for rapidly producing antibody producing organisms, tissues, cells and antibodies derived from humans, organisms, plants or cells that are genetically altered to over-express certain proteins.
摘要翻译： 本文提供了用于改进产生抗体的生物体，产生抗体的组织，产生抗体的细胞和抗体的各种方法。 在某些实施方案中，本文提供了用于快速产生产生抗体的生物，组织，细胞和源自人，生物，植物或细胞的抗体的方法，其被遗传改变以过度表达某些蛋白质。
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公开(公告)号：US08551968B2
公开(公告)日：2013-10-08
申请号：US12048148
申请日：2008-03-13
申请人： Yosef Refaeli , Brian Curtis Turner
发明人： Yosef Refaeli , Brian Curtis Turner
CPC分类号： C07K16/1018 , A01K2217/05 , A01K2267/02 , A61K39/00 , A61K39/12 , A61K39/21 , C07K16/00 , C07K16/1045 , C07K16/18 , C07K16/32 , C12N15/85 , C12N2710/16734 , C12N2740/12034 , C12N2740/12043 , C12N2760/16134
摘要： This invention generally relates to methods for the production of antibody producing cells and antibodies in protooncogene expressing animals. The invention also relates to methods for the efficient production of antibodies specific for antigens that are normally subject to immunological constraints such as self tolerance. The invention further relates to the production of antibody producing cells and antibodies without the need for the conventional fusing of antibody producing B cells with a myeloma fusion partner.
摘要翻译： 本发明一般涉及在表达动物的原癌基因中产生产生抗体的细胞和抗体的方法。 本发明还涉及有效制备抗原特异性抗体的方法，所述抗体通常受到诸如自身耐受之类的免疫学限制。 本发明还涉及产生抗体的细胞和抗体，而不需要常规融合产生抗体的B细胞与骨髓瘤融合配偶体。
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公开(公告)号：US20130045370A1
公开(公告)日：2013-02-21
申请号：US13332456
申请日：2011-12-21
申请人： Eric Joseph Aho , Curt Brian Curtis , Scott Alan Garten , Randall Maurice Prather , James Timothy Sanchez , Michael Dominic Schulte , Brian Dominic Stephens
发明人： Eric Joseph Aho , Curt Brian Curtis , Scott Alan Garten , Randall Maurice Prather , James Timothy Sanchez , Michael Dominic Schulte , Brian Dominic Stephens
CPC分类号： B29C44/06 , B29C35/0266 , B29C70/04 , F01D11/122 , Y02T50/672 , Y10T29/49297 , Y10T428/2495 , Y10T428/249953
摘要： Processes for producing near net-shape panels and panels formed thereby. The processes include forming a preform to comprise a stack of multiple plies that contain an uncured expandable foam material. The preform has regions that differ from each other by the number and/or volume of the plies therein. The preform and its plies are then cured within a restricted volume to produce a near net-shape panel. The curing step causes the expandable foam material to expand, and the restricted volume is sized so that the number and volume of the plies within the regions of the preform cause zones within the panel to have different densities and/or thicknesses.
摘要翻译： 用于生产由此形成的近网状面板和面板的方法。 所述方法包括形成预制件以包括含有未固化的可膨胀泡沫材料的多层叠层。 预型件具有彼此不同的区域的数量和/或体积。 然后将预成型件及其层叠体在受限制的体积内固化以产生接近网状的面板。 固化步骤使可膨胀泡沫材料膨胀，并且限制体积的尺寸使得预成型体区域内的层的数量和体积使得面板内的区域具有不同的密度和/或厚度。
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公开(公告)号：US20130001942A1
公开(公告)日：2013-01-03
申请号：US13173135
申请日：2011-06-30
申请人： Bryan Fulmer , Brian Curtis , Christopher R. Poquette , William Boppre , Steve Twining , Samuel D. McCarley , Dean Lax
发明人： Bryan Fulmer , Brian Curtis , Christopher R. Poquette , William Boppre , Steve Twining , Samuel D. McCarley , Dean Lax
IPC分类号： F16L55/00
CPC分类号： F16L41/005 , B60T8/3685 , B60T17/043
摘要： A hydraulic manifold assembly having a block including a plurality of fluid ports provided on a common surface of the block, and a set of hydraulic fittings. Each fitting is assigned to a prescribed one of the ports. Each fitting includes a hollow bolt insertable into the prescribed fluid port, and a banjo block having a first aperture for receiving the hollow bolt and a second aperture intersecting the first aperture. The second aperture provides an external fluid port for fluidly coupling a remote device. The plurality of banjo blocks includes at least one adjacent pair of banjo blocks that are unique from each other and have exterior shapes complementary to each other to control the relative orientation therebetween when coupled to the prescribed fluid ports. The exterior shapes of the adjacent banjo blocks cooperate to prevent misassembly.
摘要翻译： 一种液压歧管组件，其具有包括设置在所述块的公共表面上的多个流体端口的块和一组液压配件。 每个配件被分配到规定的一个端口。 每个配件包括可插入规定流体端口的中空螺栓，以及具有用于接收中空螺栓的第一孔和具有与第一孔相交的第二孔的班卓琴座。 第二孔提供用于流体连接远程装置的外部流体端口。 多个班卓琴块包括彼此独特的至少一个相邻的一对班卓琴座，并且具有彼此互补的外部形状，以在连接到规定的流体端口时控制它们之间的相对定向。 相邻的班卓琴座的外形相配合，以防止错误组装。
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公开(公告)号：US20110263820A1
公开(公告)日：2011-10-27
申请号：US12962197
申请日：2010-12-07
申请人： Yosef Refaeli , Brian Curtis Turner
发明人： Yosef Refaeli , Brian Curtis Turner
IPC分类号： C07K14/00
CPC分类号： C07K14/82 , A61K39/00 , A61K2039/505 , A61K2039/53 , A61K2039/55516 , C07K16/00 , C07K16/1018 , C07K16/40 , C07K2319/10 , C07K2319/20 , C07K2319/21 , C12N15/113 , C12N2310/14
摘要： Provided herein are various processes for the improved production of antibody producing organisms, antibody producing tissues, antibody producing cells and antibodies. In certain embodiments, provided herein are methods for rapidly producing antibody producing organisms, tissues, cells and antibodies derived from humans, organisms, plants or cells that are genetically altered to over-express certain proteins.
摘要翻译： 本文提供了用于改进产生抗体的生物体，产生抗体的组织，产生抗体的细胞和抗体的各种方法。 在某些实施方案中，本文提供了用于快速产生产生抗体的生物，组织，细胞和源自人，生物，植物或细胞的抗体的方法，其被遗传改变以过度表达某些蛋白质。
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公开(公告)号：US20110071309A1
公开(公告)日：2011-03-24
申请号：US12888613
申请日：2010-09-23
申请人： Brent R. CONSTANTZ , Brian Curtis
发明人： Brent R. CONSTANTZ , Brian Curtis
摘要： Systems and methods are disclosed for generating a proton removing agent and an acidic solution in a low voltage electrochemical system and utilizing the proton removing agent to sequester carbon dioxide from a waste gas in a carbon dioxide sequestration system and utilizing the acidic solution to catalyze at least one step of a chemical syntheses in combination with a plant based material.
摘要翻译： 公开了用于在低压电化学系统中产生质子去除剂和酸性溶液的系统和方法，并利用质子去除剂从二氧化碳封存系统中的废气中除去二氧化碳，并利用酸性溶液至少催化 化学合成与植物基材料结合的一步。
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7.发明申请CONDITIONALLY IMMORTALIZED LONG-TERM STEM CELLS AND METHODS OF MAKING AND USING SUCH CELLS 有权有条件地永久化长期干细胞以及制备和使用这种细胞的方法公开(公告)号：US20100297763A1
公开(公告)日：2010-11-25
申请号：US12701383
申请日：2010-02-05
IPC分类号： C12N5/02 , C12N5/0789
CPC分类号： C12N5/0647 , C07K14/005 , C07K14/4738 , C07K14/4747 , C07K14/82 , C07K2319/10 , C07K2319/50 , C12N5/0635 , C12N5/0636 , C12N5/0646 , C12N15/62 , C12N2501/105 , C12N2501/113 , C12N2501/125 , C12N2501/145 , C12N2501/2303 , C12N2501/2306 , C12N2501/48 , C12N2501/606 , C12N2510/04 , C12N2740/16322
摘要： Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.
摘要翻译： 公开了用于有条件永生化干细胞的方法，包括成体和胚胎干细胞，通过这些方法产生的细胞，使用这种细胞的治疗和实验室或研究方法，以及鉴定与细胞分化和发育相关的化合物或治疗疾病的方法， 使用这样的细胞。 还描述了急性骨髓性白血病（AML）的小鼠模型和与这种小鼠模型相关的细胞和方法。
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公开(公告)号：US20100279351A1
公开(公告)日：2010-11-04
申请号：US12048148
申请日：2008-03-13
申请人： Yosef Refaeli , Brian Curtis Turner
发明人： Yosef Refaeli , Brian Curtis Turner
IPC分类号： C12P21/00 , C12N5/0781
CPC分类号： C07K16/1018 , A01K2217/05 , A01K2267/02 , A61K39/00 , A61K39/12 , A61K39/21 , C07K16/00 , C07K16/1045 , C07K16/18 , C07K16/32 , C12N15/85 , C12N2710/16734 , C12N2740/12034 , C12N2740/12043 , C12N2760/16134
摘要： This invention generally relates to methods for the production of antibody producing cells and antibodies in protooncogene expressing animals. The invention also relates to methods for the efficient production of antibodies specific for antigens that are normally subject to immunological constraints such as self tolerance. The invention further relates to the production of antibody producing cells and antibodies without the need for the conventional fusing of antibody producing B cells with a myeloma fusion partner.
摘要翻译： 本发明一般涉及在表达动物的原癌基因中产生产生抗体的细胞和抗体的方法。 本发明还涉及有效制备抗原特异性抗体的方法，所述抗体通常受到诸如自身耐受之类的免疫学限制。 本发明还涉及产生抗体的细胞和抗体，而不需要常规融合产生抗体的B细胞与骨髓瘤融合配偶体。
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公开(公告)号：US07749927B2
公开(公告)日：2010-07-06
申请号：US11646024
申请日：2006-12-27
IPC分类号： B32B5/26
CPC分类号： F16L23/032 , Y10T428/249924 , Y10T428/31504 , Y10T442/659 , Y10T442/697
摘要： Tethered flange corners including at least one ply of barrier fibers and at least one fiber tow wrapped about the barrier fibers. Also included are flanges having a tethered corner containing at least one ply of barrier fibers, at least one fiber tow wrapped about the barrier fibers, at least one ply of filler fibers applied over the fiber tow, and at least one ply of flange fibers applied over the filler fibers. Additionally included are articles incorporating a composite structure having a flange with a tethered corner containing at least one ply of barrier fibers and at least one fiber tow wrapped about the barrier fibers.
摘要翻译： 连接的法兰角包括至少一层屏障纤维和至少一条围绕阻挡纤维缠绕的纤维束。 还包括具有包含至少一层屏障纤维的系绳角的凸缘，围绕阻挡纤维缠绕的至少一根纤维丝束，施加在纤维丝束上的至少一层填料纤维，以及施加至少一层法兰纤维 在填料纤维上。 另外包括具有复合结构的制品，该复合结构具有凸缘，该凸缘具有包含至少一层屏障纤维的束缚角和围绕阻挡纤维缠绕的至少一根纤维束。
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公开(公告)号：US20080156419A1
公开(公告)日：2008-07-03
申请号：US11646796
申请日：2006-12-28
IPC分类号： C03C25/10
CPC分类号： B29C70/32 , B29C35/02 , B29C35/16 , B29C53/562 , B29C53/566 , B29C53/585 , B29C53/8075 , B29K2063/00 , B29K2079/08
摘要： Continuous debulking methods involving providing a spool of fabric, heating the fabric to produce a heated fabric while concurrently transferring the heated fabric to a composite structure forming tool, wrapping the heated fabric about the composite structure forming tool, applying resin to the heated fabric to obtain a resin rich fabric surface, applying a subsequent ply of heated fabric to the resin rich fabric surface to obtain an impregnated composite material, and debulking and cooling the impregnated composite to obtain a composite structure preform.
摘要翻译： 连续减粘方法包括提供织物卷轴，加热织物以产生加热的织物，同时将加热的织物转移到复合结构形成工具，将加热的织物缠绕在复合结构形成工具上，将树脂施加到加热的织物上以获得 树脂丰富的织物表面，将随后的加热织物层施加到富含树脂的织物表面上，以获得浸渍的复合材料，并对浸渍的复合材料进行减压和冷却以获得复合结构预制件。
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