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1.发明授权Inducing cellular immune responses to Plasmodium falciparum using peptide and nucleic acid compositions 有权使用肽和核酸组合物诱导恶性疟原虫的细胞免疫应答公开(公告)号：US09266930B1
公开(公告)日：2016-02-23
申请号：US09390061
申请日：1999-09-03
申请人： Alessandro Sette , John Sidney , Scott Southwood , Brian D. Livingston , Robert Chestnut , Denise Marie Baker , Esteban Celis , Ralph T. Kubo , Howard M. Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Brian D. Livingston , Robert Chestnut , Denise Marie Baker , Esteban Celis , Ralph T. Kubo , Howard M. Grey
IPC分类号： A61K39/002 , A61K39/015 , C07K14/44 , C07K14/445 , A61K39/00
CPC分类号： A61K39/015 , A61K39/0011 , A61K39/002 , A61K2039/5154 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/605 , C07K7/08 , C07K14/005 , C07K14/445 , C07K14/70539 , C07K2319/00 , C07K2319/01 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , Y02A50/412
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare Plasmodium falciparum epitopes, and to develop epitope-based vaccines directed towards malaria. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of malaria. In particular, this application discloses isolated peptides comprising oligopeptides, for example the oligopeptide GVSENIFLK, or isolated peptides conjugated with T helper peptides that are used as antigens in epitope-based vaccines to prevent and/or treat malaria.
摘要翻译： 本发明使用我们对抗原被T细胞识别和制备恶性疟原虫表位的机制的知识，并开发针对疟疾的基于表位的疫苗。 更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗疟疾。 特别地，本申请公开了分离的肽，其包含寡肽，例如寡肽GVSENIFLK，或与T辅助肽缀合的分离肽，其用作基于表位的疫苗中的抗原以预防和/或治疗疟疾。
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公开(公告)号：US20100068218A1
公开(公告)日：2010-03-18
申请号：US12408472
申请日：2009-03-20
申请人： Alessandro SETTE , Robert Chesnut , Mark J. Newman , Brian D. Livingston , Lilia Marie Babe , Yiyou Chen , Lawrence M. Deyoung , Manley T.F. Huang , Scott D. Power
发明人： Alessandro SETTE , Robert Chesnut , Mark J. Newman , Brian D. Livingston , Lilia Marie Babe , Yiyou Chen , Lawrence M. Deyoung , Manley T.F. Huang , Scott D. Power
CPC分类号： A61K39/292 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/6031 , A61K2039/605 , A61K2039/645 , C07K14/005 , C12N2730/10122 , C12N2730/10134
摘要： The invention relates to the field of biology. In particular, it relates to multi-epitope nucleic acid and peptide vaccines and methods of designing such vaccines to provide increased immunogenicity.
摘要翻译： 本发明涉及生物学领域。 特别地，其涉及多表位核酸和肽疫苗以及设计这种疫苗以提供增加的免疫原性的方法。
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3.发明申请公开(公告)号：US20100049491A1
公开(公告)日：2010-02-25
申请号：US12330079
申请日：2008-12-08
申请人： Alessandro SETTE , Robert Chestnut , Brian D. Livingston , Denise Marie Baker , Mark J. Newman , David H. Brown
发明人： Alessandro SETTE , Robert Chestnut , Brian D. Livingston , Denise Marie Baker , Mark J. Newman , David H. Brown
CPC分类号： A61K39/29 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/292 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2730/10122 , C12N2730/10134 , C12N2740/16022 , C12N2740/16034 , G16B15/00 , G16B20/00 , G16B30/00 , G16B40/00
摘要： The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of amino acid insertions at the junctions of the multi-epitope constructs so as to minimize the number of junctional epitopes and provide vaccines with increased immunogenicity.
摘要翻译： 本发明涉及生物学领域。 特别地，本发明涉及一种用于设计优化的多表位疫苗的方法和系统，其具有在多表位构建体的连接处具有氨基酸插入的选择的组合，以便最小化连接表位的数目并提供具有增加的免疫原性的疫苗。
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公开(公告)号：US20190282679A1
公开(公告)日：2019-09-19
申请号：US16094394
申请日：2017-04-14
申请人： Rima MCLEOD , Kamal EL BISSATI , Ying ZHOU , Jeff ALEXANDER , Lo VANG , Steve REED , Sara M. PAULILLO , Senthil K. RAMAN , Peter BURKHARD , Mariane MELO , Darrel IRVINE , Ron WEISS , Yuan ZHANG , Alessandro SETTE , John SIDNEY , Brian D. LIVINGSTON , Hernan LORENZI
发明人： Rima MCLEOD , Kamal EL BISSATI , Ying ZHOU , Jeff ALEXANDER , Lo VANG , Steve REED , Sara M. PAULILLO , Senthil K. RAMAN , Peter BURKHARD , Mariane MELO , Darrel IRVINE , Ron WEISS , Yuan ZHANG , Alessandro SETTE , John SIDNEY , Brian D. LIVINGSTON , Hernan LORENZI
IPC分类号： A61K39/002 , A61K9/00 , A61P33/02
摘要： Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.
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5.发明申请Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US20090311283A1
公开(公告)日：2009-12-17
申请号：US11976998
申请日：2007-10-30
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
CPC分类号： C07K14/005 , A61K31/7088 , A61K2039/53 , A61K2039/55516 , A61K2039/6031 , A61K2039/70 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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6.发明授权公开(公告)号：US07462354B2
公开(公告)日：2008-12-09
申请号：US09894018
申请日：2001-06-27
CPC分类号： A61K39/29 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/292 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2730/10122 , C12N2730/10134 , C12N2740/16022 , C12N2740/16034 , G06F19/16 , G06F19/18 , G06F19/22 , G06F19/24
摘要： The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of amino acid insertions at the junctions of the multi-epitope constructs so as to minimize the number of junctional epitopes and provide vaccines with increased immunogenicity.
摘要翻译： 本发明涉及生物学领域。 特别地，本发明涉及一种用于设计优化的多表位疫苗的方法和系统，其具有在多表位构建体的连接处具有氨基酸插入的选择的组合，以便最小化连接表位的数目并提供具有增加的免疫原性的疫苗。
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公开(公告)号：US20200289629A1
公开(公告)日：2020-09-17
申请号：US16892083
申请日：2020-06-03
申请人： Rima MCLEOD , Kamal EL BISSATI , Ying ZHOU , Jeff ALEXANDER , Lo VANG , Steve REED , Sara M. PAULILLO , Senthil K. RAMAN , Peter BURKHARD , Mariane MELO , Darrel IRVINE , Ron WEISS , Yuan ZHANG , Alessandro SETTE , John SIDNEY , Brian D. LIVINGSTON , Hernan LORENZI
发明人： Rima MCLEOD , Kamal EL BISSATI , Ying ZHOU , Jeff ALEXANDER , Lo VANG , Steve REED , Sara M. PAULILLO , Senthil K. RAMAN , Peter BURKHARD , Mariane MELO , Darrel IRVINE , Ron WEISS , Yuan ZHANG , Alessandro SETTE , John SIDNEY , Brian D. LIVINGSTON , Hernan LORENZI
IPC分类号： A61K39/002 , A61P33/02 , A61K9/00 , A61K39/012
摘要： Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.
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公开(公告)号：US20090196915A1
公开(公告)日：2009-08-06
申请号：US12196015
申请日：2008-08-21
IPC分类号： A61K9/127 , A61K9/14 , A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6025 , A61K2039/622 , A61K2039/70 , C07K14/005 , C07K2319/00 , C07K2319/21 , C12N2760/16022 , C12N2760/16034
摘要： The invention provides compositions of influenza proteins, such as matrix and nucleoprotein, that are presented to an individual's immune system as multimeric displays to induce an immune response. The compositions are optionally associated with any type of immunomodulatory compound (IMC) comprising an immunostimulatory sequences (ISS). The invention further provides compositions of influenza matrix and nucleoproteins that can induce cellular and/or humoral immune response. The invention also provides methods of making and using these compositions, e.g., as a vaccine, for ameliorating symptoms associated with infection with influenza virus or for reducing the risk of infection with influenza virus.
摘要翻译： 本发明提供了作为多聚体显示物呈递给个体的免疫系统以诱导免疫应答的流感蛋白（例如基质和核蛋白）的组合物。 组合物任选地与包含免疫刺激序列（ISS）的任何类型的免疫调节化合物（IMC）相关联。 本发明还提供可诱导细胞和/或体液免疫应答的流感基因和核蛋白的组合物。 本发明还提供了制备和使用这些组合物例如疫苗用于改善与流感病毒感染相关的症状或降低流感病毒感染风险的方法。
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公开(公告)号：US07507803B2
公开(公告)日：2009-03-24
申请号：US10677754
申请日：2003-10-03
申请人： Alessandro Sette , Robert Chesnut , Mark J. Newman , Brian D. Livingston , Lilia Maria Babe , Yiyou Chen , Lawrence M. Deyoung , Manley T. F. Huang , Scott D. Power
发明人： Alessandro Sette , Robert Chesnut , Mark J. Newman , Brian D. Livingston , Lilia Maria Babe , Yiyou Chen , Lawrence M. Deyoung , Manley T. F. Huang , Scott D. Power
IPC分类号： C07H21/04
CPC分类号： A61K39/292 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/6031 , A61K2039/605 , A61K2039/645 , C07K14/005 , C12N2730/10122 , C12N2730/10134
摘要： The invention relates to the field of biology. In particular, it relates to multi-epitope nucleic acid and peptide vaccines and methods of designing such vaccines to provide increased immunogenicity.
摘要翻译： 本发明涉及生物学领域。 特别地，其涉及多表位核酸和肽疫苗以及设计这种疫苗以提供增加的免疫原性的方法。
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10.发明授权Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 失效使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US06689363B1
公开(公告)日：2004-02-10
申请号：US09239043
申请日：1999-01-27
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
IPC分类号： A61K3800
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , A61K2039/70 , C07K14/005 , C07K14/33 , C07K14/4746 , C07K14/705 , C07K14/70539 , C07K14/82 , C12N2730/10122 , C12N2740/16022 , C12N2760/16122 , C12N2770/24222
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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