利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

32 条记录 (耗时 0.03 秒)

    Substrates and compounds bonded thereto
    4.
    发明授权
    Substrates and compounds bonded thereto 失效
    底物和与之结合的化合物

    公开(公告)号：US07658994B2

    公开(公告)日：2010-02-09

    申请号：US10896392

    申请日：2004-07-22

    申请人： Brinda B. Lakshmi

    发明人： Brinda B. Lakshmi

    IPC分类号： B32B7/12 ,  B32B15/04 ,  B32B3/26

    CPC分类号： G01N33/54353 ,  Y10T428/249953 ,  Y10T428/28 ,  Y10T428/2804 ,  Y10T428/2852

    摘要： Articles and methods for the use of such articles are described for use in immobilizing nucleophile-containing materials. In one aspect, the invention provides an article comprising: a substrate having a first surface and a second surface; and a phosphonitrilic tethering group affixed to the first surface of the substrate, the phosphonitrilic tethering group comprising a reaction product of a complementary functional group on the first surface of the substrate with a phosphonitrilic tethering compound. A method of immobilizing a nucleophile-containing material to a substrate is also described, the method comprising: providing a phosphonitrilic tethering compound; providing a substrate having a complementary functional group capable of reacting with phosphonitrilic tethering compound; preparing a substrate-attached phosphonitrilic tethering group by reacting the phosphonitrilic tethering compound with the complementary functional group on the substrate resulting in an ionic bond, covalent bond, or combinations thereof; and reacting the substrate-attached phosphonitrilic tethering group with a nucleophile-containing material to immobilize the nucleophile-containing material.

    摘要翻译： 描述了使用这些制品的制品和方法用于固定含亲核试剂的材料。 一方面，本发明提供了一种制品，其包括：具有第一表面和第二表面的基底; 以及固定在基材的第一表面上的膦酸性束缚基团，所述膦酸性束缚基包含在底物的第一表面上的互补官能团的反应产物和磷酸三苯酯系链化合物。 还描述了将含亲核试剂的材料固定到基底的方法，所述方法包括：提供磷酸三苯酯键合化合物; 提供具有能够与膦腈键合化合物反应的互补官能团的底物; 通过使磷腈络合的化合物与底物上的互补官能团反应制备底物连接的磷腈键合基团，得到离子键，共价键或其组合; 并使与底物连接的磷酸盐系链基团与含有亲核试剂的材料反应以固定含有亲核试剂的材料。

    Method for laser desorption mass spectrometry using porous polymeric substrates with particle fillers
    6.
    发明授权
    Method for laser desorption mass spectrometry using porous polymeric substrates with particle fillers 有权
    使用具有颗粒填料的多孔聚合物基质的激光解吸质谱法

    公开(公告)号：US07462494B2

    公开(公告)日：2008-12-09

    申请号：US10457651

    申请日：2003-06-09

    申请人： Brinda B. Lakshmi ,  Bathsheba E. Chong Conklin

    发明人： Brinda B. Lakshmi ,  Bathsheba E. Chong Conklin

    IPC分类号： G01N24/00

    CPC分类号： H01J49/0418 ,  Y10T428/249953 ,  Y10T436/24

    摘要： Articles and methods for the high-energy desorption/ionization of various compositions are disclosed. Methods of the invention utilize porous substrates, optionally in combination with one or more surface coatings and fillers, to provide enhanced desorption of analytes. Such enhanced desorption is particularly useful in fields of analysis such as mass spectrometry. This enhanced desorption has various utilities. For example, use of the porous substrate may allow desorption to be performed without the use of chemical matrices.

    摘要翻译： 公开了各种组合物的高能解吸/电离的制品和方法。 本发明的方法利用多孔基材，任选地与一种或多种表面涂层和填料组合，以提供分析物的增强的解吸附。 这种增强解吸在分析领域尤其有用，例如质谱法。 这种增强的解吸具有各种效用。 例如，使用多孔基材可以允许在不使用化学基质的情况下进行解吸。