Methods and kits for testing the efficacy of therapeutic compounds and other therapies in a three-dimensional matrix with respect to tumorous cells and tissue
    2.
    发明授权
    Methods and kits for testing the efficacy of therapeutic compounds and other therapies in a three-dimensional matrix with respect to tumorous cells and tissue 失效
    用于测试相对于肿瘤细胞和组织的三维基质中治疗化合物和其它疗法的疗效的方法和试剂盒

    公开(公告)号:US07977041B2

    公开(公告)日:2011-07-12

    申请号:US11812152

    申请日:2007-06-15

    IPC分类号: C12N5/071 C12N5/09

    摘要: Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiological fibers, which are adapted and arranged to provide conditions which permit behaviors, such as the movement of cells away from the margins of samples of target tissue through the matrix, to be evaluated in a manner that produces data useful for evaluating the oncological status and characteristics of the cells. In a further key aspect, the invention permits the in vitro testing and analyses of one or more conventional, experimental or theoretical therapies with respect to specific target tissues or cells. Among such therapies are therapeutic compounds and combinations thereof, radiation therapies, combinations of therapeutic compound and radiation and numerous other possible therapies.

    摘要翻译: 提供了用于加速设计,测试和评估肿瘤治疗的三维生理基质,方法,仪器和试剂盒。 本发明的关键方面包括基质,特别是凝胶基质,其包含一种或多种生理纤维,其适于和布置成提供允许行为的条件,例如细胞从目标组织的样品的边缘移动通过基质 ,以产生可用于评估细胞的肿瘤状态和特征的数据的方式进行评估。 在另一关键方面,本发明允许对特定靶组织或细胞的一种或多种常规,实验或理论疗法的体外测试和分析。 在这些疗法中,治疗化合物及其组合,放射疗法,治疗化合物和辐射的组合以及许多其它可能的疗法。

    Energy pack and individual battery cell cartridge
    3.
    发明授权
    Energy pack and individual battery cell cartridge 失效
    能量包和单个电池盒

    公开(公告)号:US5212021A

    公开(公告)日:1993-05-18

    申请号:US839415

    申请日:1992-02-21

    IPC分类号: H01M2/10 H01M10/46 H04N5/225

    CPC分类号: H04N5/2251 H01M2/1022

    摘要: The present invention is directed to a cartridge comprising a rectangular base and four side walls which form a cavity into which an energy pack or a plurality of individual battery cells, either primary or secondary, are locatable. The cartridge is securable to an electrical apparatus by a latching mechanism. Alternatively, the cartridge can be integral therewith. In a first embodiment, a plurality of cells are locatable such that their positive and negative contacts are positioned against a set of positive and negative contact areas located along the first and second side walls. The first embodiment optionally comprises a contact arm, locatable substantially parallel to the second side wall, which includes a plurality of positive contact areas corresponding to and across from the negative contact areas located on the second side wall. A plurality of cells, having a shorter length than the battery cells locatable between the first and second side walls, are locatable between the contact arm and the second side wall. In a second embodiment, the cartridge includes first and second contact arms positionable substantially parallel to the third and fourth side walls, between the first and the second side walls. The plurality of battery cells are locatable between the third side wall and the first contact arm, between the first and the second contact arm, and between the second contact arm and the fourth side wall. The cartridge also provides circuitry to recharge the energy pack and/or secondary cells located therein.

    摘要翻译: 本发明涉及一种包括矩形基座和四个侧壁的盒,其形成空腔,能量包或多个单独的电池单元可以是主要的或次要的。 盒通过锁定机构固定到电气设备上。 或者,盒可与其成一体。 在第一实施例中,多个单元可定位成使得它们的正和负触点抵靠沿着第一和第二侧壁定位的一组正和负接触区域定位。 第一实施例可选地包括可定位成基本上平行于第二侧壁的接触臂,该接触臂包括对应于位于第二侧壁上的负接触区域并跨过第二侧壁的负接触区域的多个正接触区域。 具有比位于第一和第二侧壁之间的电池单元更短的长度的多个电池可位于接触臂和第二侧壁之间。 在第二实施例中,盒包括在第一和第二侧壁之间基本上平行于第三和第四侧壁定位的第一和第二接触臂。 多个电池单元可定位在第三侧壁和第一接触臂之间,第一和第二接触臂之间以及第二接触臂和第四侧壁之间。 墨盒还提供用于为位于其中的能量包和/或二次电池再充电的电路。

    Drain line cleaning system
    4.
    发明授权

    公开(公告)号:US11285520B2

    公开(公告)日:2022-03-29

    申请号:US16885847

    申请日:2020-05-28

    IPC分类号: B08B9/032 E03C1/304

    摘要: A drain line cleaning system including a housing, a pump carried by the housing, a line cleaning agent carrying tube in communication with the pump, a controller in communication with the pump, and a power supply carried by the housing and connected to the pump and the controller. The line cleaning agent carrying tube includes an intake that is connectable to a reservoir that carries line cleaning agent and an output that is connectable to a drain line. The controller controls the pump to function to withdraw the line cleaning agent from the reservoir and causes the line cleaning agent to be expelled through the output.

    METHOD AND APPARATUS FOR PERFORMING A NEAR-INSTANTANEOUS RESTORE OF A DATABASE
    5.
    发明申请
    METHOD AND APPARATUS FOR PERFORMING A NEAR-INSTANTANEOUS RESTORE OF A DATABASE 有权
    用于执行数据库近似恢复的方法和设备

    公开(公告)号:US20120117033A1

    公开(公告)日:2012-05-10

    申请号:US12975035

    申请日:2010-12-21

    IPC分类号: G06F17/30

    摘要: Some embodiments provide methods and apparatuses for performing a near-instantaneous restore of a database. During operation, the system intercepts a database management system restore request to restore a database from a backup file to a data file, wherein the backup file comprises a first number (e.g., N1) of data pages. Next, in response to intercepting the database management system restore request, the system sends information to the database management system indicating that the backup file comprises a second number (e.g., N2) of data pages, wherein the second number of data pages is less than the first number of data pages (e.g., N2

    摘要翻译: 一些实施例提供了用于执行数据库的近瞬时恢复的方法和装置。 在操作期间,系统拦截数据库管理系统恢复请求以将数据库从备份文件恢复到数据文件,其中备份文件包括第一数量(例如,N1)的数据页。 接下来,响应于拦截数据库管理系统恢复请求,系统向数据库管理系统发送指示备份文件包括数据页的第二数量(例如N2)的信息,其中第二数量的数据页小于 第一个数据页数(例如,N2

    DRAIN LINE CLEANING SYSTEM
    7.
    发明申请

    公开(公告)号:US20210370361A1

    公开(公告)日:2021-12-02

    申请号:US16885847

    申请日:2020-05-28

    IPC分类号: B08B9/032 E03C1/304

    摘要: A drain line cleaning system including a housing, a pump carried by the housing, a line cleaning agent carrying tube in communication with the pump, a controller in communication with the pump, and a power supply carried by the housing and connected to the pump and the controller. The line cleaning agent carrying tube includes an intake that is connectable to a reservoir that carries line cleaning agent and an output that is connectable to a drain line. The controller controls the pump to function to withdraw the line cleaning agent from the reservoir and causes the line cleaning agent to be expelled through the output.

    Method and apparatus for performing a near-instantaneous restore of a database
    8.
    发明授权
    Method and apparatus for performing a near-instantaneous restore of a database 有权
    用于执行数据库的近即时恢复的方法和装置

    公开(公告)号:US08433688B2

    公开(公告)日:2013-04-30

    申请号:US12975035

    申请日:2010-12-21

    IPC分类号: G06F7/00 G06F17/00

    摘要: Some embodiments provide methods and apparatuses for performing a near-instantaneous restore of a database. During operation, the system intercepts a database management system restore request to restore a database from a backup file to a data file, wherein the backup file comprises a first number (e.g., N1) of data pages. Next, in response to intercepting the database management system restore request, the system sends information to the database management system indicating that the backup file comprises a second number (e.g., N2) of data pages, wherein the second number of data pages is less than the first number of data pages (e.g., N2

    摘要翻译: 一些实施例提供了用于执行数据库的近瞬时恢复的方法和装置。 在操作期间,系统拦截数据库管理系统恢复请求以将数据库从备份文件恢复到数据文件,其中备份文件包括第一数量(例如,N1)的数据页。 接下来,响应于拦截数据库管理系统恢复请求,系统向数据库管理系统发送指示备份文件包括数据页的第二数量(例如N2)的信息,其中第二数量的数据页小于 第一个数据页数(例如,N2

    Methods and kits for testing the efficacy of therapeutic compounds and other therapies in a three-dimensional matrix with respect to tumorous cells and tissue

    公开(公告)号:US07883841B2

    公开(公告)日:2011-02-08

    申请号:US11812152

    申请日:2007-06-15

    IPC分类号: C12N5/071 C12N5/09

    摘要: Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiological fibers, which are adapted and arranged to provide conditions which permit behaviors, such as the movement of cells away from the margins of samples of target tissue through the matrix, to be evaluated in a manner that produces data useful for evaluating the oncological status and characteristics of the cells. In a further key aspect, the invention permits the in vitro testing and analyses of one or more conventional, experimental or theoretical therapies with respect to specific target tissues or cells. Among such therapies are therapeutic compounds and combinations thereof, radiation therapies, combinations of therapeutic compound and radiation and numerous other possible therapies.

    Three-dimensional physiological matrices for oncological testing, and methods for their production and use
    10.
    发明授权
    Three-dimensional physiological matrices for oncological testing, and methods for their production and use 失效
    用于肿瘤检测的三维生理基质及其生产和使用方法

    公开(公告)号:US08007991B2

    公开(公告)日:2011-08-30

    申请号:US11812128

    申请日:2007-06-15

    IPC分类号: C12N5/071 C12N5/09

    CPC分类号: G01N33/5088 G01N2800/52

    摘要: Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiological fibers, which are adapted and arranged to provide conditions which permit behaviors, such as the movement of cells away from the margins of samples of target tissue through the matrix, to be evaluated in a manner that produces data useful for evaluating the oncological status and characteristics of the cells. In a further key aspect, the invention permits the in vitro testing and analysis of one or more conventional, experimental or theoretical therapies with respect to specific target tissues or cells. Among such therapies are therapeutic compounds and combinations thereof, radiation therapies, combinations of therapeutic compounds and radiation and numerous other possible therapies.

    摘要翻译: 提供了用于加速设计,测试和评估肿瘤治疗的三维生理基质,方法,仪器和试剂盒。 本发明的关键方面包括基质,特别是凝胶基质,其包含一种或多种生理纤维,其适于和布置成提供允许行为的条件,例如细胞从目标组织的样品的边缘移动通过基质 ,以产生可用于评估细胞的肿瘤状态和特征的数据的方式进行评估。 在另一个关键方面,本发明允许体外测试和分析关于特定靶组织或细胞的一种或多种常规的实验或理论疗法。 在这些疗法中,治疗化合物及其组合,放射疗法,治疗化合物和辐射的组合以及许多其它可能的疗法。