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公开(公告)号：US10794861B2
公开(公告)日：2020-10-06
申请号：US16262224
申请日：2019-01-30
摘要： The invention proposes a methods and devices for tandem ion mobility spectrometry using at least one TIMS analyzers (TIMS=trapping ion mobility spectrometry), in particular in the field of structural biology.
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公开(公告)号：US20190265195A1
公开(公告)日：2019-08-29
申请号：US16262224
申请日：2019-01-30
摘要： The invention proposes a methods and devices for tandem ion mobility spectrometry using at least one TIMS analyzers (TIMS=trapping ion mobility spectrometry), in particular in the field of structural biology.
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公开(公告)号：US11854778B2
公开(公告)日：2023-12-26
申请号：US18149189
申请日：2023-01-03
发明人： Michael Easterling
IPC分类号： H01J49/00 , G01N27/622 , G01N30/72 , G01N33/50 , G01N33/68 , H01J49/16 , G01N33/483
CPC分类号： H01J49/0004 , G01N27/622 , G01N30/7233 , G01N33/50 , G01N33/6848 , H01J49/0031 , H01J49/164 , H01J49/165 , G01N33/4833 , G01N2560/00
摘要： A method for the identification and localization of small molecule species in a histologic thin tissue section comprises the steps of: a) acquiring a mass/mobility image of the tissue section and generating a mass/mobility map of the small molecule species of interest for each pixel of the image; b) providing a second sample of the same tissue and extracting the small molecules of interest, separating them, and acquiring mass and ion mobility spectra from the separated small molecules; c) identifying the small molecules of interest using corresponding reference databases; and d) assigning identified small molecules to entries in the mass/mobility maps of the first tissue section by comparison of ion masses and mobilities of the identified species to those of the second thin tissue section.
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公开(公告)号：US20230411137A1
公开(公告)日：2023-12-21
申请号：US18459616
申请日：2023-09-01
发明人： Anil MAVANUR , Felician MUNTEAN
IPC分类号： H01J49/16 , G01N27/623
CPC分类号： H01J49/167 , G01N27/623
摘要： The invention relates to the generation of desolvated ions by electrospraying to be investigated analytically, e.g. according to the charge-related mass m/z and/or ion mobility. The cloud of highly charged droplets drawn from the spray capillary by a high voltage is usually focused and stabilized by a beam of nebulizing gas surrounding the cloud of tiny droplets. For a fast drying of the droplets, an additional desolvation gas is usually heated to a temperature of up to several hundred degrees centigrade and blown into the cloud of droplets. The invention particularly relates to the heating of the gas which is instrumental in the generation of desolvated ions as part of the electrospraying process without any mechanical or electrical contact between the heating power supply and the heater itself, but rather by heating the heater for the gas using electromagnetic induction.
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公开(公告)号：US11315779B1
公开(公告)日：2022-04-26
申请号：US17208705
申请日：2021-03-22
发明人： Melvin Andrew Park
IPC分类号： H01J49/42 , G01N27/623 , H01J49/40 , H01J49/06
摘要： A mass spectrometric system comprises an RF-device for transversely confining ions in an ion region using: (a) a first set of electrodes arranged parallel to one another along a direction of ion travel to define a first transverse boundary of the ion region, and that are supplied with a first RF-voltage such that opposite phases of the first RF-voltage are applied to adjacent electrodes of the first set; and (b) a second set of electrodes arranged parallel to one another along said direction of ion travel to define a second transverse boundary of the ion region, and that are supplied with a second RF-voltage such that opposite phases of the second RF-voltage are applied to adjacent electrodes of the second set, the first and second transverse boundaries being opposite each other in a transverse direction of the ion region and the first and second RF voltages having different frequencies.
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公开(公告)号：US11676808B2
公开(公告)日：2023-06-13
申请号：US17713550
申请日：2022-04-05
发明人： Melvin Andrew Park
IPC分类号： H01J49/42 , G01N27/623 , H01J49/40 , H01J49/06
CPC分类号： H01J49/422 , G01N27/623 , H01J49/065 , H01J49/40 , H01J49/4235
摘要： An ion mobility separator comprises an RF-device for transversely confining ions in an ion region using: (a) a first set of electrodes arranged parallel to one another along a direction of ion travel to define a first transverse boundary of the ion region, and that are supplied with a first RF-voltage such that different phases of the first RF-voltage are applied to adjacent electrodes of the first set; and (b) a second set of electrodes arranged parallel to one another along said direction of ion travel to define a second transverse boundary of the ion region, and that are supplied with a second RF-voltage such that different phases of the second RF-voltage are applied to adjacent electrodes of the second set, the first and second transverse boundaries being substantially opposite each other in a transverse direction of the ion region and the first and second RF voltages having different frequencies.
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公开(公告)号：US11569078B2
公开(公告)日：2023-01-31
申请号：US16705403
申请日：2019-12-06
发明人： Michael Easterling
IPC分类号： H01J49/00 , G01N27/622 , G01N30/72 , G01N33/50 , G01N33/68 , H01J49/16 , G01N33/483
摘要： A method for the identification and localization of small molecule species in a histologic thin tissue section comprises the steps of: a) acquiring a mass/mobility image of the tissue section and generating a mass/mobility map of the small molecule species of interest for each pixel of the image; b) providing a second sample of the same tissue and extracting the small molecules of interest, separating them, and acquiring mass and ion mobility spectra from the separated small molecules; c) identifying the small molecules of interest using corresponding reference databases; and d) assigning identified small molecules to entries in the mass/mobility maps of the first tissue section by comparison of ion masses and mobilities of the identified species to those of the second thin tissue section.
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公开(公告)号：US20220301845A1
公开(公告)日：2022-09-22
申请号：US17713550
申请日：2022-04-05
发明人： Melvin Andrew PARK
IPC分类号： H01J49/42 , H01J49/06 , H01J49/40 , G01N27/623
摘要： An ion mobility separator comprises an RF-device for transversely confining ions in an ion region using: (a) a first set of electrodes arranged parallel to one another along a direction of ion travel to define a first transverse boundary of the ion region, and that are supplied with a first RF-voltage such that different phases of the first RF-voltage are applied to adjacent electrodes of the first set; and (b) a second set of electrodes arranged parallel to one another along said direction of ion travel to define a second transverse boundary of the ion region, and that are supplied with a second RF-voltage such that different phases of the second RF-voltage are applied to adjacent electrodes of the second set, the first and second transverse boundaries being substantially opposite each other in a transverse direction of the ion region and the first and second RF voltages having different frequencies.
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公开(公告)号：US20220277949A1
公开(公告)日：2022-09-01
申请号：US17737622
申请日：2022-05-05
发明人： Melvin Andrew PARK
摘要： The invention provides hybrid mass spectrometric systems which comprise an ion source, a first trapped ion mobility spectrometry (TIMS) analyzer and a mass analyzer, wherein the TIMS analyzer is located and operated in a first vacuum chamber at an elevated pressure above 500 Pa, and methods for operating the hybrid mass spectrometric systems.
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公开(公告)号：US20210375610A1
公开(公告)日：2021-12-02
申请号：US17313131
申请日：2021-05-06
发明人： Anil MAVANUR , Felician MUNTEAN
IPC分类号： H01J49/16 , G01N27/623
摘要： The invention relates to the generation of desolvated ions by electrospraying to be investigated analytically, e.g. according to the charge-related mass m/z and/or ion mobility. The cloud of highly charged. droplets drawn from the spray capillary by a high voltage is usually focused and stabilized by a beam of nebulizing gas surrounding the cloud of tiny droplets. For a fast drying of the droplets, an additional desolvation gas is usually heated to a temperature of up to several hundred degrees centigrade and blown into the cloud of droplets. The invention particularly relates to the heating of the gas which is instrumental in the generation of desolvated ions as part of the electrospraying process without any mechanical or electrical contact between the heating power supply and the heater itself, but rather by heating the heater for the gas using electromagnetic induction.
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