摘要:
Disclosed herein are a lightweight silicone implant which is manufactured by filling a foamed silicone sponge and/or vacant silicone capsules in a silicone bag or a cohesive gel bag and sealing the bag, and a method for manufacturing the same.
摘要:
The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same.Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be effectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.
摘要:
The present invention is directed to a novel imidazole derivative having an aryl piperidine substituent of formula (I) and a method for preparation thereof, and a pharmaceutical composition containing said imidazole derivative as an active ingredient for preventing or treating a MCH (melanine-concentrating hormone)-related disease.
摘要:
A hydraulic circuit is provided, which can prevent the bucket from being separated from the bucket rest by preventing a change of stroke of a boom cylinder or an arm cylinder during long traveling of wheel type heavy equipment, and can secure safety since it is not required for an operator to adjust the position of a working device like boom and arm. The hydraulic circuit includes first and second hydraulic pumps, a boom cylinder, an arm cylinder, a boom confluence logic valve, a first port formed to connect with a large chamber of the boom cylinder in a housing in which a spool for the boom cylinder is shiftably installed, a second port formed to connect with a hydraulic tank in the housing, and a first orifice formed between the housing and a land part of the spool for the boom cylinder located between the first port and the second port. During long traveling of the heavy equipment, a very small amount of hydraulic fluid fed from the second hydraulic pump to the large chamber of the boom cylinder drains to the hydraulic tank through the first orifice to prevent a change of stroke of the boom cylinder.
摘要:
The present invention relates to novel benzopyranyl guanidine derivatives of the formula 1, process for preparation therof and pharmaceutical use of the benzopyranyl guanidine derivatives. The benzopyranyl guanidine derivatives of the present invention can be used for protecting heart, neuronal cell or brain damage, preserving organs, and also the benzopyranyl guanidine derivatives are pharmacologically useful for inhibiting NO generation, and for suppressing lipid peroxidation, angiogenesis or restenosis. Wherein R1, R2, R3, R4, R5, R6, n and * are each defined in specification.
摘要:
A hydraulic circuit for preventing a change of stroke of a boom cylinder or an arm cylinder during transportation. The hydraulic circuit includes first and second hydraulic pumps, a boom cylinder, an arm cylinder, a boom confluence logic valve, a first port connected with a chamber of the boom cylinder in a housing in which a spool for the boom cylinder is shiftably installed, a second port connected with a hydraulic tank in the housing, and a first orifice formed between the housing and a land part of the spool for the boom cylinder located between the first port and the second port. During transportation, a small amount of hydraulic fluid fed from the second hydraulic pump to the large chamber of the boom cylinder drains to the hydraulic tank through the first orifice to prevent a change of stroke of the boom cylinder.
摘要:
The present invention relates to benzopyran derivatives substituted with a benzimidazole derivative, or pharmaceutically acceptable salts thereof, a preparation method of the same and pharmarceutical compositions containing them. Benzopyran derivatives substituted with a benzimidazole derivative, represented in Formula (1), have the function of protecting heart from ischemia-reperfusion without side effect like vasodilation, so that a pharmaceutical composition containing benzopyran derivatives substituted with a benzimidazole derivative or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc. and for the treatment of diseases caused by ischemia-reperfusion.
摘要:
The present invention relates to novel benzopyranyl heterocycle derivatives of the formula 1, process for preparation thereof and pharmaceutical use of the benzopyranyl heterocycle derivatives. The benzopyranyl heterocycle derivatives of the present invention can be used for protecting heart, brain, retina and neuronal cell from “ischemia-reperfusion” injury, treatment for diseases related to it and suppressing lipid peroxidation. Wherein R1, R2, R3, R4, n and * are each defined in specification.
摘要:
The present invention is directed to a novel imidazole derivative having an aryl piperidine substituent of formula (I) and a method for preparation thereof, and a pharmaceutical composition containing said imidazole derivative as an active ingredient for preventing or treating a MCH (melanine-concentrating hormone)-related disease.
摘要:
The present invention relates to benzopyran derivatives substituted with a thioxobenzoxazole derivative, or pharmaceutically acceptable salts thereof, processes for preparing the same and a pharmaceutical composition containing the above as an effective ingredient Benzopyran derivatives substituted with thioxobenzoxazole derivatives, represented in , have the function of protecting heart from ischemia-reperfusion both in vivo and in vitro, so that a pharmaceutical composition containing benzopyran derivatives substituted with thioxobenzoxoazole derivatives or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc, and for the treatment of diseases caused by ischemia-reperfusion.