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公开(公告)号：US20240092716A1
公开(公告)日：2024-03-21
申请号：US18265865
申请日：2021-12-09
发明人： Jamal-Eddine OUAZZANI CHAHDI , Géraldine LE GOFF , Jean-Félix DALLERY , Jean-François BETZER , Arnaud VOITURIEZ , Angela MARINETTI , Fanny CACHEUX
IPC分类号： C07C49/747 , A61P31/04 , C07C45/59 , C07C49/753 , C07C69/738 , C07D317/54
CPC分类号： C07C49/747 , A61P31/04 , C07C45/59 , C07C49/753 , C07C69/738 , C07D317/54 , C07C2601/10
摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as a drug, especially as an antibiotic. The present invention also relates to a pharmaceutical composition comprising said compound of formula (I) and at least one pharmaceutically acceptable excipient. The present invention further concerns a method of preparation of a compound of formula (I′).
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公开(公告)号：US20240085598A1
公开(公告)日：2024-03-14
申请号：US18263620
申请日：2022-01-24
申请人： UNIVERSITE DE BORDEAUX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS , INSTITUT D'OPTIQUE THEORIQUE ET APPLIQUEE , UNIVERSITE PARIS-SACLAY
IPC分类号： G02B5/02
CPC分类号： G02B5/0226
摘要： Nanostructured surface coating (1) configured to generate visual appearances in a visible spectrum range, comprising: —a first layer comprising a random distribution of nanoparticles (2); —a substrate (3), on which the first layer is arranged; —the nanoparticles having an optical refraction index npart having a value suitable for each individually diffusing the incident light; —the nanoparticles being arranged so that the mean distance between two adjacent particles d is defined in accordance with the following relationship so as to produce interference between the light diffused by the particles: 2 R≤d≤max (λ/np), where R is the smallest geometric radius of a circle surrounding the particle, λ is the greatest wavelength of the visible spectrum, and np is the optical refractive index of the medium in which the nanoparticles are dispersed.
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公开(公告)号：US11905253B2
公开(公告)日：2024-02-20
申请号：US17049680
申请日：2019-04-19
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE DE RENNES 1 , CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX , INSTITUT BERGONIE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE BORDEAUX
IPC分类号： C07D233/64 , A61P37/00 , A61K45/06
CPC分类号： C07D233/64 , A61K45/06 , A61P37/00
摘要： The present invention relates the field of reducing CD95-mediated cell motility in a subject, in particular for their use in the reduction of CD-95 mediated cancer cell motility, the reduction of CD95-mediated lymphocyte motility and/or B cell maturation, or the treatment of B-cell tumors, in a subject. The inventors identified a novel family of compounds having the ability to disrupt CD95/PLCγ1 interaction and to neutralize the CD95-mediated calcium signaling pathway and cell migration in human peripheral blood lymphocytes (PBLs) and Th17 cells. Thus, the present invention relates to compounds of formula (A) as defined in the present text, to a pharmaceutical composition comprising said compounds in a pharmaceutically acceptable medium and to the use of these compounds and compositions as medicament, in particular for their use in the reduction or treatment of the above-mentioned pathologies, and in particular in the treatment of cancers and autoimmune inflammatory disease such as systemic lupus erythematosus, inflammatory condition and Th17-mediated disease.
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公开(公告)号：US11904268B2
公开(公告)日：2024-02-20
申请号：US18067120
申请日：2022-12-16
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—
CPC分类号： B01D53/02 , B01J20/20 , B01D2253/106 , B01D2253/306 , B01D2253/308 , B01D2258/06 , B01J20/103 , B01J20/22 , B01J20/28057
摘要： A method for preparing a nanoporous silica sol-gel matrix containing at least one amine reactant selected from hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, tetraethylenepentamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof, said method including the following steps: a) synthesising a gel from tetramethoxysilane or from a mixture of tetramethoxysilane and another organosilicon precursor selected from among phenyltrimethoxysilane, phenyltriethoxysilane, a fluoroalkyltrimethoxysilane, a fluoroalkyltriethoxysilane, a chloroalkylmethoxysilane, a chloroalkylethoxysilane, an alkyltrimethoxysilane, an alkyltriethoxysilane, an aminopropyltriethoxysilane and the mixtures thereof, the synthesis being performed in an aqueous medium at a temperature ranging from 10 to 70° C. in the presence of at least one amine reactant selected from among hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof; b) drying the gel obtained during step a) so as to obtain a sol-gel matrix containing at least one amine reactant.
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5.发明公开公开(公告)号：US20240032889A1
公开(公告)日：2024-02-01
申请号：US17631929
申请日：2020-07-31
申请人： SUPERSONIC IMAGINE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS , Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris
发明人： William LAMBERT , Alexandre AUBRY , Mathias FINK , Laura COBUS
CPC分类号： A61B8/0833 , A61B8/5207 , A61B8/4488
摘要： Method for non-invasively characterizing a heterogeneous medium using ultrasound, comprising a step of generating a series of incident ultrasonic waves, a step of recording an experimental reflection matrix Rui(t) defined between the input emission basis (i) and an output reception basis (u), a step of determining a response REP(r, Δr) of the medium between an input virtual transducer (TVin) calculated based on an input focusing of the experimental reflection matrix that creates an input focal spot around a first point (P1), and an output virtual transducer (TVout) calculated based on an output focusing of the experimental reflection matrix that creates an output focal spot around a second point (P2), said response being expressed as a function of a central point (PC) of spatial position (r) in the medium located midway between the first and second points (P1, P2).
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公开(公告)号：US20240018715A1
公开(公告)日：2024-01-18
申请号：US18032044
申请日：2021-10-15
申请人： Centre National de la Recherche Scientifique (CNRS) , Universite Jean Monnet Saint Etienne , La Tannerie Vegetale , Université Claude Bernard Lyon 1
发明人： Fanny DELEAGE , Yvan CHALAMET
CPC分类号： D06N3/0061 , C14C3/26
摘要： The present disclosure relates to a method for the preparation, from a mixture comprising (i) plant proteins, (ii) one or more plant tanning agents, (iii) one or more plasticizers, of a biobased material that may resemble animal leather.
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7.发明公开公开(公告)号：US20240011940A1
公开(公告)日：2024-01-11
申请号：US18254881
申请日：2021-12-03
发明人： Guilhem LARRIEU
IPC分类号： G01N27/414
CPC分类号： G01N27/4146 , G01N27/4148
摘要： The invention relates to a method for manufacturing a platform for cellular interfacing, the platform being manufactured over a predetermined bulk substrate, the method being a top-down method.
According to the invention, such a method comprises the following steps in order:
creating (E10) vertical nanowires over the bulk substrate;
depositing (E30) a Si layer
creating (E40) the access lines for accessing the nanowires;
selective silicidation (E50) of the access lines and of the nanowires;
metal structuring (E60) of the access lines;
depositing (E60) an insulating layer for liquid measurement;
selective removal (E70) of the insulating layer on the nanoprobes.-
公开(公告)号：US20240006082A1
公开(公告)日：2024-01-04
申请号：US18252831
申请日：2021-11-16
申请人： HOSPICES CIVILS DE LYON , UNIVERSITE CLAUDE BERNARD LYON 1 , ECOLE NORMALE SUPERIEURE DE LYON , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSERM (Institut National de la Sante et de la Recherche Medicale)
摘要： The present invention relates to a method for detecting an infectious transmission in a population, the method being characterised in that it comprises implementing, by data processing means (20) of a client (2), steps of: (b) for a plurality of infectious agent isolates, each associated with an individual of said population, obtaining a vector with values descriptive of the isolate; (c) for each pair of a first isolate (X) and a second isolate (Y) of the plurality, respectively associated with a first individual and a second individual of said population: (c1) calculating a first number of isolates (n(X)) corresponding to the number of isolates of said plurality having a distance to the first isolate (X) less than or equal to a reference distance between the first and second isolates (X, Y), and a second number of isolates (n(Y)) corresponding to the number of isolates of said plurality having a distance to the second isolate (Y) less than or equal to said reference distance between the first and second isolates (X, Y), each distance between two isolates being representative of a dissimilarity between the vectors of values descriptive of these two isolates; (c2) estimating a probability (TXY) of direct infectious transmission between the first and second individuals as a function of said first and second number of isolates (n(X), n(Y)); (d) detecting or not detecting an infectious transmission in said population as a function of the estimated probabilities (TXY) of direct infectious transition between each pair of individuals.
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公开(公告)号：US20240000833A1
公开(公告)日：2024-01-04
申请号：US18309047
申请日：2023-04-28
申请人： Institut National de la Santé et de la Recherche Médicale , Universite d'Aix Marseille , Centre National de la Recherche Scientifique (CNRS) , Max Delbruck Center for Molecular Medicine (MDC)
CPC分类号： A61K35/15 , C12N5/0645 , A61P31/12 , A61P31/04 , A61P31/10 , A61P35/00 , C12N2501/22
摘要： The present invention relates to methods for expanding a population of alveolar macrophages in a long term culture. In particular, an object of the present invention relates to a method of expanding a population of alveolar macrophages in a long term culture comprising culturing the population of alveolar macrophages in a culture medium supplemented with an amount of GM-CSF.
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公开(公告)号：US11857604B2
公开(公告)日：2024-01-02
申请号：US16755866
申请日：2018-10-12
申请人： NH THERAGUIX , Universite Claude Bernard Lyon 1 , Centre National de La Recherche Scientifique—CNRS—
发明人： Olivier Tillement , François Lux , Fabien Rossetti , Vu-Long Tran , Clélia Mathieu , Myleva Dahan
IPC分类号： A61K38/31 , A61K47/69 , A61P35/00 , A61K33/243 , A61K9/14 , A61K31/704 , A61K49/00 , A61K49/12 , A61K49/18 , B82Y5/00 , A61K33/244 , A61K9/00
CPC分类号： A61K38/31 , A61K9/146 , A61K31/704 , A61K33/243 , A61K33/244 , A61K47/6929 , A61K49/0002 , A61K49/128 , A61K49/1881 , A61P35/00 , B82Y5/00 , A61K9/0019
摘要： The present invention relates to the field of nanovectors for the delivery of active substances in the body, in particular for the treatment of tumours. In particular, the use of these nanovectors makes it possible to improve the pharmacokinetics of the active substances with a more selective delivery, for example in the tumour tissues.
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