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公开(公告)号：US20080113925A1
公开(公告)日：2008-05-15
申请号：US10562374
申请日：2004-06-23
申请人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Wong Yung-hou , David M. Miller-Martini
发明人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Wong Yung-hou , David M. Miller-Martini
IPC分类号： A61K31/704 , A61K31/58
CPC分类号： A61K31/7048 , A61K31/56 , A61K31/58 , A61K36/481 , C07J1/00
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法和组合物。 这样的组合物包括药物，包括局部和营养制剂。 所述方法和组合物可用于治疗患者的细胞或组织中例如HIV感染，各种退行性疾病和急性或慢性皮肤营养物质中端粒酶活性增加而治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和干细胞增殖。
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公开(公告)号：US08759304B2
公开(公告)日：2014-06-24
申请号：US12718812
申请日：2010-03-05
申请人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
发明人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
CPC分类号： A61K31/7048 , A61K31/56 , A61K31/58 , A61K36/481 , C07J1/00
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法和组合物。 这样的组合物包括药物，包括局部和营养制剂。 所述方法和组合物可用于治疗患者的细胞或组织中例如HIV感染，各种退行性疾病以及急性或慢性皮肤疾病中端粒酶活性增加而治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和干细胞增殖。
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公开(公告)号：US07846904B2
公开(公告)日：2010-12-07
申请号：US10562374
申请日：2004-06-23
申请人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
发明人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
CPC分类号： A61K31/7048 , A61K31/56 , A61K31/58 , A61K36/481 , C07J1/00
摘要： The present invention relates to methods for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The method and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法。 这样的组合物包括药物，包括局部和营养制剂。 该方法和组合物可用于治疗患者的细胞或组织中例如HIV感染，各种退行性疾病以及急性或慢性皮肤营养物质中端粒酶活性增加而治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和干细胞增殖。
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公开(公告)号：US20110071095A1
公开(公告)日：2011-03-24
申请号：US12718812
申请日：2010-03-05
申请人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
发明人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
IPC分类号： A61K31/7048 , C07D307/12 , A61K31/58 , C07H17/04 , A61P17/02 , A61P29/00 , A61P1/04 , C12N5/071 , C12N5/077 , C12Q1/02 , A61P31/18 , A61P25/28 , A61P9/10 , A61P7/06 , A61P27/02 , A61P19/02 , A61P19/08
CPC分类号： A61K31/7048 , A61K31/56 , A61K31/58 , A61K36/481 , C07J1/00
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法和组合物。 这样的组合物包括药物，包括局部和营养制剂。 所述方法和组合物可用于治疗患者的细胞或组织中例如HIV感染，各种退行性疾病以及急性或慢性皮肤疾病中端粒酶活性增加而治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和干细胞增殖。
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公开(公告)号：US09248088B2
公开(公告)日：2016-02-02
申请号：US10562410
申请日：2004-06-24
发明人： Calvin B. Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
摘要： Methods and cosmetic compositions for conditioning the skin, utilizing as active ingredients selected compounds structurally related to astragenols, cycloastragenols, and/or protopanaxatriols, are provided. Such compounds include those of formulas (I), (II) and (III) described herein.
摘要翻译： 提供用于调理皮肤的方法和化妆品组合物，其利用选择的与阿斯特灵醇，环状天冬氨酸和/或原人参三醇结构相关的化合物作为活性成分。 这些化合物包括本文所述的式（I），（II）和（III）的化合物。
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公开(公告)号：US06518268B1
公开(公告)日：2003-02-11
申请号：US09608636
申请日：2000-06-30
申请人： Allison C. Chin , Ryan Holcomb , Mieczyslaw A. Piatyszek , Upinder Singh , Richard L. Tolman , Tsutomu Akama , Yutaka Kanda , Akira Asai , Yoshinori Yamashita , Kaori Endo , Hiroyuki Yamaguchi
发明人： Allison C. Chin , Ryan Holcomb , Mieczyslaw A. Piatyszek , Upinder Singh , Richard L. Tolman , Tsutomu Akama , Yutaka Kanda , Akira Asai , Yoshinori Yamashita , Kaori Endo , Hiroyuki Yamaguchi
IPC分类号： A61K31535
CPC分类号： A61K31/426 , A61K31/4439 , A61K31/506 , C07D277/34 , C07D277/36 , C07D417/06 , C07D417/10 , C07D513/04
摘要： Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.
摘要翻译： 提供噻唑烷二酮化合物，组合物和在体外抑制端粒酶活性的方法以及离体和体内治疗端粒酶介导的病症或疾病。 本发明的方法，化合物和组合物可以单独使用或与其它药理学活性剂组合用于治疗由端粒酶活性介导的病症或疾病，例如治疗癌症。 还公开了用于测定或筛选端粒酶活性抑制剂的新方法。
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公开(公告)号：US06372742B1
公开(公告)日：2002-04-16
申请号：US09608861
申请日：2000-06-30
IPC分类号： A61K314166
CPC分类号： C07D417/06 , A61K31/426 , A61K31/4439 , A61K31/506 , C07D277/34 , C07D277/36 , C07D417/10 , C07D513/04
摘要： 5-(3-Isatinylidinyl)thiazolidineones and 3-(thiazolidinon-5-yl)indoles compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.
摘要翻译： 提供5-（3-异
吲嗪基）噻唑烷酮和3-（噻唑烷酮-5-基）吲哚化合物，组合物和体外抑制端粒酶活性的方法以及离体和体内治疗端粒酶介导的病症或疾病。 本发明的方法，化合物和组合物可以单独使用或与其它药理学活性剂组合用于治疗由端粒酶活性介导的病症或疾病，例如治疗癌症。 还公开了用于测定或筛选端粒酶活性抑制剂的新方法。-
8.发明授权Cancer treatment by combined inhibition of proteasome and telomerase activities 有权癌症治疗联合抑制蛋白酶体和端粒酶活性公开(公告)号：US07998938B2
公开(公告)日：2011-08-16
申请号：US11918581
申请日：2006-04-14
IPC分类号： A16K48/00
CPC分类号： C12N15/1137 , A61K31/454 , A61K45/06 , C12N2310/11 , C12N2310/3145 , C12N2310/3515 , C12Y207/07049 , A61K2300/00
摘要： A method and kit for inhibiting the proliferation of cancer cells are disclosed, based on a combination of a proteasome inhibitor and a telomerase inhibitor. When used in cancer therapy, the two compounds in combination enhance the anti-cancer treatment efficacy obtained with the proteasome inhibitor alone or the telomerase inhibitor alone. Preferably, efficacy is supraadditive or synergistic in nature relative to the combined effects of the individual agents, with minimal exacerbation of side effects.
摘要翻译： 基于蛋白酶体抑制剂和端粒酶抑制剂的组合，公开了抑制癌细胞增殖的方法和试剂盒。 当用于癌症治疗时，两种化合物组合增强了单独使用蛋白酶体抑制剂或单独使用端粒酶抑制剂获得的抗癌治疗功效。 优选地，相对于各个试剂的组合效应，效力是相对于辅助的或协同的，并且副作用的加剧最小化。
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9.发明申请Cancer treatment by combined inhibition of proteasome and telomerase activities 有权癌症治疗联合抑制蛋白酶体和端粒酶活性公开(公告)号：US20100010064A1
公开(公告)日：2010-01-14
申请号：US11918581
申请日：2006-04-14
IPC分类号： A61K31/711 , C12N5/08 , A61K31/69 , A61P35/00 , A61K48/00
CPC分类号： C12N15/1137 , A61K31/454 , A61K45/06 , C12N2310/11 , C12N2310/3145 , C12N2310/3515 , C12Y207/07049 , A61K2300/00
摘要： A method and kit for inhibiting the proliferation of cancer cells are disclosed, based on a combination of a proteasome inhibitor and a telomerase inhibitor. When used in cancer therapy, the two compounds in combination enhance the anti-cancer treatment efficacy obtained with the proteasome inhibitor alone or the telomerase inhibitor alone. Preferably, efficacy is supraadditive or synergistic in nature relative to the combined effects of the individual agents, with minimal exacerbation of side effects.
摘要翻译： 基于蛋白酶体抑制剂和端粒酶抑制剂的组合，公开了抑制癌细胞增殖的方法和试剂盒。 当用于癌症治疗时，两种化合物组合增强了单独使用蛋白酶体抑制剂或单独使用端粒酶抑制剂获得的抗癌治疗功效。 优选地，相对于各个试剂的组合效应，效力是相对于辅助的或协同的，并且副作用的加剧最小化。
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