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公开(公告)号：US07989206B2
公开(公告)日：2011-08-02
申请号：US12410495
申请日：2009-03-25
申请人： Paul V. Viitanen , Luan Tao , Yuying Zhang , Perry G. Caimi , Laura McCole , Min Zhang , Yat-Chen Chou , Carol M. McCutchen , Mary Ann Franden
发明人： Paul V. Viitanen , Luan Tao , Yuying Zhang , Perry G. Caimi , Laura McCole , Min Zhang , Yat-Chen Chou , Carol M. McCutchen , Mary Ann Franden
CPC分类号： C12N15/74
摘要： Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids. These are high expression promoters useful for expression of chimeric genes in Zymomonas, Zymobacter, and other related bacteria.
摘要翻译： 鉴定为运动发酵单胞菌甘油醛-3-磷酸脱氢酶基因的启动子的突变体，其直接改善可操作地连接的异源核酸的表达水平。 这些是用于在发酵单胞菌，酵母属和其他相关细菌中表达嵌合基因的高表达启动子。
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公开(公告)号：US20090246846A1
公开(公告)日：2009-10-01
申请号：US12410501
申请日：2009-03-25
申请人： PAUL V. VIITANEN , LUAN TAO , YUYING ZHANG , PERRY G. CAIMI , CAROL M. MCCUTCHEN , LAURA MCCOLE , MIN ZHANG , YAT-CHEN CHOU , MARY ANN FRANDEN
发明人： PAUL V. VIITANEN , LUAN TAO , YUYING ZHANG , PERRY G. CAIMI , CAROL M. MCCUTCHEN , LAURA MCCOLE , MIN ZHANG , YAT-CHEN CHOU , MARY ANN FRANDEN
CPC分类号： C12N9/92 , C12N9/0008 , C12N9/1022 , C12N9/1205 , C12P7/065 , Y02E50/17
摘要： Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and when the strain is in addition engineered for expression of xylulokinase, transaldolase and transketolase, improved utilization of xylose is obtained.
摘要翻译： 通过引入含有运动发酵单胞菌甘油醛-3-磷酸脱氢酶基因的突变启动子的嵌合木糖异构酶基因工程化发酵单胞菌菌株。 启动子指导木糖异构酶的增加表达，并且当该菌株另外被设计用于表达木酮糖激酶，转醛醇酶和转酮酶时，获得木糖的改善的利用。
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3.发明申请XYLITOL SYNTHESIS MUTANT OF XYLOSE-UTILIZING ZYMOMONAS FOR ETHANOL PRODUCTION 有权用于乙醇生产的XYLOSE-ZYMOMONAS的XYLITOL合成突变体公开(公告)号：US20080286870A1
公开(公告)日：2008-11-20
申请号：US11862566
申请日：2007-09-27
申请人： Paul V. Viitanen , Yat-Chen Chou , Carol M. McCutchen , Min Zhang
发明人： Paul V. Viitanen , Yat-Chen Chou , Carol M. McCutchen , Min Zhang
摘要： A strain of xylose-utilizing Zymomonas was engineered with a genetic modification to the glucose-fructose oxidoreductase gene resulting in reduced expression of GFOR enzyme activity. The engineered strain exhibits reduced production of xylitol, a detrimental by-product of xylose metabolism. It also consumes more xylose and produces more ethanol during mixed sugar fermentation under process-relevant conditions.
摘要翻译： 用葡萄糖 - 果糖氧化还原酶基因的遗传修饰工程改造了利用木糖的酵母菌菌株，导致GFOR酶活性的降低。 工程化的菌株表现出木糖代谢产生不良副产物木糖醇的减少。 在过程相关条件下，在混合糖发酵过程中，它还消耗更多的木糖并产生更多的乙醇。
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4.发明授权Ethanol production using xylitol synthesis mutant of xylose-utilizing zymomonas 有权使用木糖利用酵母单体的木糖醇合成突变体的乙醇生产公开(公告)号：US07741084B2
公开(公告)日：2010-06-22
申请号：US11862736
申请日：2007-09-27
申请人： Paul V. Viitanen , Carol M. McCutchen , Mark Emptage , Perry G. Caimi , Min Zhang , Yat-Chen Chou
发明人： Paul V. Viitanen , Carol M. McCutchen , Mark Emptage , Perry G. Caimi , Min Zhang , Yat-Chen Chou
摘要： Production of ethanol using a strain of xylose-utilizing Zymomonas with a genetic modification of the glucose-fructose oxidoreductase gene was found to be improved due to greatly reduced production of xylitol, a detrimental by-product of xylose metabolism synthesized during fermentation.
摘要翻译： 发现使用具有葡萄糖 - 果糖氧化还原酶基因的遗传修饰的具有木糖利用的酵母菌菌株的乙醇的生产由于发酵期间合成的木糖代谢的有害副产物木糖醇的产生大大降低而得到改善。
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5.发明申请ETHANOL PRODUCTION USING XYLITOL SYNTHESIS MUTANT OF XYLOSE-UTILIZING ZYMOMONAS 有权使用XYLITOL合成的XYLOSE-ZYMOMONAS合成酶的乙醇生产公开(公告)号：US20080187973A1
公开(公告)日：2008-08-07
申请号：US11862736
申请日：2007-09-27
申请人： PAUL V. VIITANEN , Carol M. McCutchen , Mark Emptage , Perry G. Caimi , Min Zhang , Yat-Chen Chou
发明人： PAUL V. VIITANEN , Carol M. McCutchen , Mark Emptage , Perry G. Caimi , Min Zhang , Yat-Chen Chou
IPC分类号： C12P7/06
摘要： Production of ethanol using a strain of xylose-utilizing Zymomonas with a genetic modification of the glucose-fructose oxidoreductase gene was found to be improved due to greatly reduced production of xylitol, a detrimental by-product of xylose metabolism synthesized during fermentation.
摘要翻译： 发现使用具有葡萄糖 - 果糖氧化还原酶基因的遗传修饰的具有木糖利用的酵母菌菌株的乙醇的生产由于发酵期间合成的木糖代谢的有害副产物木糖醇的产生大大降低而得到改善。
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公开(公告)号：US07998722B2
公开(公告)日：2011-08-16
申请号：US12410501
申请日：2009-03-25
申请人： Paul V. Viitanen , Luan Tao , Yuying Zhang , Perry G. Caimi , Carol M. McCutchen , Laura McCole , Min Zhang , Yat-Chen Chou , Mary Ann Franden
发明人： Paul V. Viitanen , Luan Tao , Yuying Zhang , Perry G. Caimi , Carol M. McCutchen , Laura McCole , Min Zhang , Yat-Chen Chou , Mary Ann Franden
CPC分类号： C12N9/92 , C12N9/0008 , C12N9/1022 , C12N9/1205 , C12P7/065 , Y02E50/17
摘要： Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and when the strain is in addition engineered for expression of xylulokinase, transaldolase and transketolase, improved utilization of xylose is obtained.
摘要翻译： 通过引入含有运动发酵单胞菌甘油醛-3-磷酸脱氢酶基因的突变启动子的嵌合木糖异构酶基因工程化发酵单胞菌菌株。 启动子指导木糖异构酶的增加表达，并且当该菌株另外被设计用于表达木酮糖激酶，转醛醇酶和转酮酶时，获得木糖的改善的利用。
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7.发明授权Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production 有权用于乙醇生产的木糖利用酵母单体的木糖醇合成突变体公开(公告)号：US07741119B2
公开(公告)日：2010-06-22
申请号：US11862566
申请日：2007-09-27
申请人： Paul V. Viitanen , Yat-Chen Chou , Carol M. McCutchen , Min Zhang
发明人： Paul V. Viitanen , Yat-Chen Chou , Carol M. McCutchen , Min Zhang
摘要： A strain of xylose-utilizing Zymomonas was engineered with a genetic modification to the glucose-fructose oxidoreductase gene resulting in reduced expression of GFOR enzyme activity. The engineered strain exhibits reduced production of xylitol, a detrimental by-product of xylose metabolism. It also consumes more xylose and produces more ethanol during mixed sugar fermentation under process-relevant conditions.
摘要翻译： 用葡萄糖 - 果糖氧化还原酶基因的遗传修饰工程改造了利用木糖的酵母菌菌株，导致GFOR酶活性的降低。 工程化的菌株表现出木糖代谢产生不良副产物木糖醇的减少。 在过程相关条件下，在混合糖发酵过程中，它还消耗更多的木糖并产生更多的乙醇。
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公开(公告)号：US20090246876A1
公开(公告)日：2009-10-01
申请号：US12410495
申请日：2009-03-25
申请人： PAUL V. VIITANEN , LUAN TAO , YUYING ZHANG , PERRY G. CAIMI , LAURA MCCOLE , MIN ZHANG , YAT-CHEN CHOU , CAROL M. MCCUTCHEN , MARY ANN FRANDEN
发明人： PAUL V. VIITANEN , LUAN TAO , YUYING ZHANG , PERRY G. CAIMI , LAURA MCCOLE , MIN ZHANG , YAT-CHEN CHOU , CAROL M. MCCUTCHEN , MARY ANN FRANDEN
CPC分类号： C12N15/74
摘要： Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids. These are high expression promoters useful for expression of chimeric genes in Zymomonas, Zymobacter, and other related bacteria.
摘要翻译： 鉴定为运动发酵单胞菌甘油醛-3-磷酸脱氢酶基因的启动子的突变体，其直接改善可操作地连接的异源核酸的表达水平。 这些是用于在发酵单胞菌，酵母属和其他相关细菌中表达嵌合基因的高表达启动子。
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公开(公告)号：US06461840B1
公开(公告)日：2002-10-08
申请号：US09617854
申请日：2000-07-17
IPC分类号： C12P740
CPC分类号： C12P7/46
摘要： This invention relates to a biocatalytic process to produce terephthalic acid and isophthalic acid from p-xylene and m-xylene, respectively. Terephthalic acid has been prepared by oxidizing p-xylene with bacteria belonging to the genus Burkholderia. Conversion of p-xylene into terephthalic acid is accomplished by a single bacterial strain that produces all of the requisite enzymes. In addition, this invention relates to the preparation of isophthalic acid from a mixture of m- and p-xylene.
摘要翻译： 本发明涉及分别从对二甲苯和间二甲苯生产对苯二甲酸和间苯二甲酸的生物催化方法。 对苯二甲酸已经通过用属于伯克霍尔德氏菌属的细菌氧化对二甲苯来制备。 对二甲苯转化成对苯二甲酸是通过产生所有必需酶的单一细菌菌株实现的。 此外，本发明涉及从间二甲苯和对二甲苯的混合物制备间苯二甲酸。
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公开(公告)号：US06187569B1
公开(公告)日：2001-02-13
申请号：US09342579
申请日：1999-06-29
IPC分类号： C12P100
CPC分类号： C12P7/46
摘要： This invention relates to a biocatalytic process to produce terephthalic acid and isophthalic acid from p-xylene and m-xylene, respectively. Terephthalic acid has been prepared by oxidizing p-xylene with bacteria belonging to the genus Burkholderia. Conversion of p-xylene into terephthalic acid is accomplished by a single bacterial strain that produces all of the requisite enzymes. In addition, this invention relates to the preparation of isophthalic acid from a mixture of m- and p-xylene.
摘要翻译： 本发明涉及分别从对二甲苯和间二甲苯生产对苯二甲酸和间苯二甲酸的生物催化方法。 对苯二甲酸已经通过用属于伯克霍尔德氏菌属的细菌氧化对二甲苯来制备。 对二甲苯转化成对苯二甲酸是通过产生所有必需酶的单一细菌菌株实现的。 此外，本发明涉及从间二甲苯和对二甲苯的混合物制备间苯二甲酸。
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