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公开(公告)号：US20100092534A1
公开(公告)日：2010-04-15
申请号：US12249576
申请日：2008-10-10
IPC分类号： A61F2/04 , A61K31/58 , A61K31/4355
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/45
摘要： Described herein are implantable medical devices useful in treating vascular conditions such as restenosis. In one embodiment, stents are described in which a combination of bioactive agents is described for local delivery in the vasculature. The combination of bioactive agents comprises at least one compound capable of inhibiting smooth muscle cell proliferation and at least one compound capable of mitigating MCP- and/or TF induction. For example, a compound capable of inhibiting smooth muscle cell proliferation is a mTOR inhibitor and a compound capable of mitigating MCP-1 and/or TF induction is a corticosteroid.
摘要翻译： 本文描述了可用于治疗诸如再狭窄的血管病变的可植入医疗装置。 在一个实施方案中，描述了支架，其中描述了生物活性剂的组合用于脉管系统中的局部递送。 生物活性剂的组合包含至少一种能够抑制平滑肌细胞增殖的化合物和至少一种能够减轻MCP-和/或TF诱导的化合物。 例如，能够抑制平滑肌细胞增殖的化合物是mTOR抑制剂，能够缓解MCP-1和/或TF诱导的化合物是皮质类固醇。
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公开(公告)号：US20070142905A1
公开(公告)日：2007-06-21
申请号：US11567821
申请日：2006-12-07
申请人： Ayala Hezi-Yamit , Carol Sullivan , Jennifer Wong
发明人： Ayala Hezi-Yamit , Carol Sullivan , Jennifer Wong
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/436
摘要： Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain NF-kappaB inhibitors, particularly certain dialkyl fumarates, are disclosed. Dimethyl fumarate is a particularly preferred dialkyl fumarate. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the dialkyl fumarate with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-dialkyl fumarate blends are disclosed. Additionally, medical devices having a coating comprising at least one dialkyl fumarate in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.
摘要翻译： 公开了具有抗再狭窄涂层的可植入医疗装置。 具体地，公开了具有某些NF-κB抑制剂，特别是某些二烷基富马酸盐的包衣的可植入医疗器械。 富马酸二甲酯是特别优选的富马酸二烷基酯。 抗再狭窄医疗器械包括支架，导管，微粒，探针和血管移植物。 血管内支架是优选的医疗装置。 可以使用本领域已知的任何方法涂覆医疗装置，包括在施加涂层之前将富马酸二烷基酯与生物相容性聚合物混合。 此外，公开了完全由生物相容性聚合物 - 富马酸二烷基酯混合物组成的医疗装置。 此外，还公开了具有包含至少一种富马酸二烷基酯与至少一种另外的治疗剂组合的涂层的医疗装置。 此外，还公开了使用和制备抗再狭窄植入式装置的相关方法。
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3.发明申请公开(公告)号：US20090297576A1
公开(公告)日：2009-12-03
申请号：US12131606
申请日：2008-06-02
申请人： Ayala Hezi-Yamit , Jennifer Wong
发明人： Ayala Hezi-Yamit , Jennifer Wong
IPC分类号： A61K9/00 , A61K31/443 , A61K31/56 , A61K33/00 , A61K31/662 , A61K39/395 , A61K31/7052 , A61K31/4353 , A61P9/00
CPC分类号： A61K9/1647 , A61K9/0024 , A61K31/4353 , A61K31/443 , A61K31/56 , A61K31/662 , A61K31/7052 , A61K45/06 , A61L31/10 , A61L31/16 , A61L2300/432 , A61L2300/45 , A61L2300/606 , A61K2300/00
摘要： Described herein are methods and medical devices used to deliver bioactive agents locally to patients in need of treatment and/or prevention of cardiovascular conditions Local delivery of protease-activated receptor 1 (PAR-1) antagonists are described herein from implantable medical devices including, but not limited to, stents.
摘要翻译： 本文描述了用于将生物活性剂局部递送给需要治疗和/或预防心血管疾病的患者的方法和医疗装置。本文从可植入医疗装置中描述了蛋白酶活化受体1（PAR-1）拮抗剂的局部递送，包括但不限于 不限于支架。
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公开(公告)号：US07844653B2
公开(公告)日：2010-11-30
申请号：US11432848
申请日：2006-05-12
申请人： James M. Simkins , John M. Thendean , Vasisht Mantra Vadi , Bernard J. New , Jennifer Wong , Anna Wing Wah Wong , Alvin Y. Ching
发明人： James M. Simkins , John M. Thendean , Vasisht Mantra Vadi , Bernard J. New , Jennifer Wong , Anna Wing Wah Wong , Alvin Y. Ching
IPC分类号： G06F7/38
CPC分类号： G06F7/02 , G06F7/5443 , G06F7/57 , G06F7/575 , G06F2207/025 , G06F2207/3828 , G06K9/00986 , H03K19/1737
摘要： A digital signal processing circuit having a pre-adder circuit includes; a first register block and a pre-adder circuit coupled to a multiplier circuit and to a set of multiplexers, where the set of multiplexers are controlled by an opcode, and where the pre-adder circuit has a first adder circuit; and an arithmetic logic unit (ALU) having a second adder circuit and coupled to the set of multiplexers.
摘要翻译： 具有预加法器电路的数字信号处理电路包括： 耦合到乘法器电路和一组多路复用器的第一寄存器块和预加法器电路，其中多路复用器组由操作码控制，并且其中预加法器电路具有第一加法器电路; 以及具有第二加法器电路并耦合到所述多路复用器组的算术逻辑单元（ALU）。
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5.发明授权Enzyme-catalyzed metal deposition for the enhanced in situ detection of immunohistochemical epitopes and nucleic acid sequences 有权酶催化的金属沉积用于增强免疫组织化学表位和核酸序列的原位检测公开(公告)号：US07632652B2
公开(公告)日：2009-12-15
申请号：US10877919
申请日：2004-06-24
IPC分类号： C12Q1/42 , C12Q1/44 , C12Q1/54 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/567
CPC分类号： G01N33/581 , C07F9/093 , C07F9/65517 , C07F9/65522 , C07H15/20 , C07H15/24 , C07H15/26
摘要： The invention is directed to novel compositions of matter and methods of detecting in situ an immunohistochemical epitope or nucleic acid sequence of interest in a biological sample comprising binding an enzyme-labeled conjugate molecule to the epitope or sequence of interest in the presence of a redox-inactive reductive species and a soluble metal ion, thereby facilitating the reduction of the metal ion to a metal atom at or about the point where the enzyme is anchored. Novel phosphate derivatives of reducing agents are described that when exposed to a phosphatase are activated to their reducing form, thereby reducing metal ions to insoluble metal.
摘要翻译： 本发明涉及物质的新组合物和原位检测生物样品中感兴趣的免疫组织化学表位或核酸序列的方法，包括在氧化还原反应的存在下将酶标记的缀合物分子与感兴趣的表位或序列结合， 无活性还原物质和可溶性金属离子，从而有助于金属离子在酶被锚定的位置处或附近还原成金属原子。 描述了还原剂的新型磷酸酯衍生物，当暴露于磷酸酶被活化成其还原形式时，从而将金属离子还原成不溶性金属。
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公开(公告)号：US07314174B1
公开(公告)日：2008-01-01
申请号：US10970964
申请日：2004-10-22
CPC分类号： H03K19/177
摘要： A system for programming configuration memory cells in an integrated circuit. The system includes: a set of data registers, wherein a member of the set has a temporary storage for a fixed number of configuration bits; and a plurality of rows, each row has a plurality of columns, wherein configuration memory cells in a selected column and in a selected row are programmed using the fixed number of configuration bits.
摘要翻译： 一种用于在集成电路中编程配置存储单元的系统。 该系统包括：一组数据寄存器，其中该组的成员具有固定数量的配置位的临时存储; 和多行，每行具有多个列，其中使用固定数量的配置位对所选列和所选行中的配置存储单元进行编程。
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7.发明授权Segmented dataline scheme in a memory with enhanced full fault coverage memory cell testability 有权具有增强的全故障覆盖存储器单元可测性的存储器中的分段数据线方案公开(公告)号：US07142442B1
公开(公告)日：2006-11-28
申请号：US10796750
申请日：2004-03-08
CPC分类号： G11C29/50 , G11C7/12 , G11C11/41 , G11C11/419 , G11C2029/1204
摘要： A memory includes a plurality of row segments, with each row segment having a number of memory cells coupled to a corresponding dataline segment pair. Dataline driver circuits are provided between row segments to buffer signals on adjacent dataline segments. A control circuit is coupled to at least one row segment, and provides control signals to the at least one row segment and to the dataline driver circuits.
摘要翻译： 存储器包括多个行段，其中每个行段具有耦合到对应的数据段段对的多个存储器单元。 数据线驱动器电路提供在行段之间以缓冲相邻数据段上的信号。 控制电路耦合到至少一个行段，并且向至少一个行段和数据线驱动器电路提供控制信号。
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公开(公告)号：US20060230092A1
公开(公告)日：2006-10-12
申请号：US11433369
申请日：2006-05-12
申请人： Alvin Ching , Jennifer Wong , Bernard New , James Simkins , John Thendean , Anna Wong , Vasisht Vadi
发明人： Alvin Ching , Jennifer Wong , Bernard New , James Simkins , John Thendean , Anna Wong , Vasisht Vadi
IPC分类号： G06F7/38
CPC分类号： G06F7/02 , G06F7/5443 , G06F7/57 , G06F7/575 , G06F2207/025 , G06F2207/3828 , G06K9/00986 , H03K19/1737
摘要： A physical floorplan for a digital signal processing (DSP) block including; an interconnect column having a plurality of programmable interconnect elements; a first DSP element having a plurality of first columns, a first output register column of the plurality of first columns positioned adjacent to the interconnect column; and a second DSP element, having a plurality of second columns a second output register column of the plurality of second columns positioned adjacent to the interconnect column.
摘要翻译： 数字信号处理（DSP）块的物理平面图，包括： 具有多个可编程互连元件的互连柱; 具有多个第一列的第一DSP元件，与所述互连列相邻定位的所述多个第一列中的第一输出寄存器列; 以及第二DSP元件，具有多个第二列，所述多个第二列的第二输出寄存器列与所述互连列相邻。
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公开(公告)号：US20060190516A1
公开(公告)日：2006-08-24
申请号：US11408364
申请日：2006-04-21
申请人： James Simkins , Jennifer Wong , Bernard New , Alvin Ching , John Thendean , Anna Wong , Vasisht Vadi , David Schultz
发明人： James Simkins , Jennifer Wong , Bernard New , Alvin Ching , John Thendean , Anna Wong , Vasisht Vadi , David Schultz
IPC分类号： G06F7/38
CPC分类号： G06K9/00986 , G06F7/02 , G06F7/5443 , G06F7/57 , G06F7/575 , G06F2207/025 , G06F2207/3828 , H03K19/1737
摘要： A digital signal processing circuit including: a multiplier circuit; a plurality of. multiplexers coupled to the multiplier circuit and controlled by a first opcode; and an arithmetic logic unit coupled to plurality of multiplexers and controlled by a second opcode.
摘要翻译： 一种数字信号处理电路，包括：乘法器电路; 多个。 耦合到乘法器电路并由第一操作码控制的多路复用器; 以及耦合到多个多路复用器并由第二操作码控制的算术逻辑单元。
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公开(公告)号：US06981153B1
公开(公告)日：2005-12-27
申请号：US09724975
申请日：2000-11-28
CPC分类号： H04N21/23476 , G06F17/5054 , G06F21/76
摘要： It is sometimes desirable to protect a design used in a PLD from being copied. If the design is stored in a different device from the PLD and read into the PLD through a bitstream, the design may be encrypted as it is read into the PLD and decrypted within the PLD before being loaded into configuration memory cells for configuring the PLD. According to the invention, in such a device, a method is provided to prevent the design from being read back from the PLD in its decrypted state if it had been encrypted when loaded into the PLD.
摘要翻译： 有时期望保护PLD中使用的设计不被复制。 如果设计存储在与PLD不同的设备中并且通过比特流读入PLD，则在加载到用于配置PLD的配置存储器单元之前，设计可以在PLD中被读入PLD并被解密并被解密。 根据本发明，在这种设备中，提供了一种方法，用于防止在被加载到PLD中时将设计从PLD解密的状态下读回PLD。
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