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公开(公告)号：US10655103B2
公开(公告)日：2020-05-19
申请号：US12790389
申请日：2010-05-28
IPC分类号： A61K48/00 , C12N5/077 , C12N5/0775 , A61K35/00
摘要： An isolated mammalian progenitor cell or its progeny, isolated from articular cartilage, is disclosed. Further is disclosed an equine progenitor cell isolated from the surface zone of equine articular cartilage tissue and uses thereof. Also disclosed are a method of tissue repair, a medicament, and a method of treating mammalian cartilage damage using such progenitor cells or progeny.
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公开(公告)号：US08357534B2
公开(公告)日：2013-01-22
申请号：US12526194
申请日：2008-02-06
CPC分类号： A61L27/3817 , A61L2430/06 , C12N5/0668 , C12N2509/00 , C12N2533/52
摘要： The invention concerns a human stem cell isolated from the full depth of human cartilage tissue and/or isolated from aged human cartilage; and uses thereof.
摘要翻译： 本发明涉及从人类软骨组织的全深度分离和/或从老年人软骨分离的人类干细胞; 及其用途。
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公开(公告)号：US20100291046A1
公开(公告)日：2010-11-18
申请号：US12790389
申请日：2010-05-28
CPC分类号： C12N5/0655 , A61K35/00 , C12N5/0668 , C12N2501/115
摘要： An isolated mammalian progenitor cell or its progeny, isolated from articular cartilage, is disclosed. Further is disclosed an equine progenitor cell isolated from the surface zone of equine articular cartilage tissue and uses thereof. Also disclosed are a method of tissue repair, a medicament, and a method of treating mammalian cartilage damage using such progenitor cells or progeny.
摘要翻译： 公开了从关节软骨分离的分离的哺乳动物祖细胞或其后代。 还公开了从马关节软骨组织的表面区域分离的马祖细胞及其用途。 还公开了组织修复的方法，药物和使用这种祖细胞或后代治疗哺乳动物软骨损伤的方法。
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公开(公告)号：US09452238B2
公开(公告)日：2016-09-27
申请号：US10333973
申请日：2001-07-30
IPC分类号： A61F2/28 , A01N63/00 , C12N5/00 , A61L27/38 , C12N5/077 , C12N5/0775 , C12N5/071 , A61F2/30 , A61K35/12
CPC分类号： A61L27/3817 , A61F2/30756 , A61F2002/30766 , A61K35/12 , A61L27/3852 , A61L2430/06 , C12N5/0068 , C12N5/0655 , C12N5/0662 , C12N5/0697 , C12N2501/15 , C12N2501/39 , C12N2501/42 , C12N2501/585 , C12N2502/1317 , C12N2502/1358 , C12N2502/1394 , C12N2509/00 , C12N2533/50 , C12N2533/52
摘要： An implant, artificial or semi-artificial at implantation, for repairing an articular cartilage and osteochondral defect site in a mammalian, such as a human. The implant having at least a first surface and a second surface. The first surface shaped for being press-fitted into the defect site to create an interface between the first surface and a bone-cartilage region of the defect site, and the second surface shaped for being press-fitted into the defect site to create an interface between the second surface and an articular cartilage region of the defect site. The implant being seeded, prior to implantation, with chondroprogenitor cells, including superficial zone chondroprogenitor cells.
摘要翻译： 在植入时人造或半人造植入物，用于修复哺乳动物（例如人）中的关节软骨和骨软骨缺损部位。 植入物具有至少第一表面和第二表面。 所述第一表面被成形为压入所述缺陷部位以在所述缺陷部位的所述第一表面和骨 - 软骨区域之间形成界面，所述第二表面被成形为压配合到所述缺陷部位以形成界面 在第二表面和缺损部位的关节软骨区域之间。 种植体在植入前接种，包括软骨祖细胞，包括表浅区软骨细胞。
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公开(公告)号：US20100098736A1
公开(公告)日：2010-04-22
申请号：US12526194
申请日：2008-02-06
CPC分类号： A61L27/3817 , A61L2430/06 , C12N5/0668 , C12N2509/00 , C12N2533/52
摘要： The invention concerns a human stem cell isolated from the full depth of human cartilage tissue and/or isolated from aged human cartilage; and uses thereof.
摘要翻译： 本发明涉及从人类软骨组织的全深度分离和/或从老年人软骨分离的人类干细胞; 及其用途。
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