公开(公告)号：US20110166417A1

公开(公告)日：2011-07-07

申请号：US12863265

申请日：2009-01-21

Applicant: Chia-Ying Lin

Inventor： Chia-Ying Lin

IPC: A61B1/06 ,  A61K38/18 ,  A61K9/00

CPC classification number: F01N13/08 ,  F01N2290/00 ,  F01N2470/30

Abstract: The present invention relates, in general to methods for treating degenerative cartilage in an individual comprising administering a composition that increases bone morphogenic protein (BMP) expression directly into injured or damaged cartilage, such as in a vertebral disc or a joint, wherein the composition is in a controlled release formulation.

Abstract translation: 本发明一般涉及用于治疗个体中退行性软骨的方法，其包括施用将骨形态发生蛋白（BMP）表达直接增加到损伤或损伤的软骨中的组合物，例如在椎间盘或关节中，其中组合物为 在控释制剂中。

公开(公告)号：US07674718B2

公开(公告)日：2010-03-09

申请号：US12025050

申请日：2008-02-04

Applicant: Chia-Ho Liu ,  Chieh-Yu Tsai ,  Wei-Chen Lin ,  Chia-Ying Lin

Inventor： Chia-Ho Liu ,  Chieh-Yu Tsai ,  Wei-Chen Lin ,  Chia-Ying Lin

IPC: H01L21/302 ,  H01L21/461

CPC classification number: H01L21/31116 ,  H01L21/823468

Abstract: A method for forming spacers of different sizes includes the following steps. First a substrate is provided, which has a first element, a second element, a first material layer and a second material layer thereon. A first dry etching is performed to remove part of the second material layer to form a first spacer by the first element and to form a second side wall by the second element, so that the first material layer between the first spacer and the second side wall is exposed to become a damaged first material layer. A trimming procedure is performed to trim the damaged first material layer. A mask is used to cover the first element, the first spacer and part of the first material layer then a wet etching is performed to remove the second side wall.

Abstract translation: 用于形成不同尺寸的间隔物的方法包括以下步骤。 首先，提供具有第一元件，第二元件，第一材料层和第二材料层的基板。 执行第一干蚀刻以去除第二材料层的一部分以通过第一元件形成第一间隔物并且由第二元件形成第二侧壁，使得第一间隔物和第二侧壁之间的第一材料层 被暴露成为损坏的第一材料层。 执行修剪程序以修整损坏的第一材料层。 掩模用于覆盖第一元件，第一间隔物和第一材料层的一部分，然后进行湿蚀刻以除去第二侧壁。

公开(公告)号：US20120330423A1

公开(公告)日：2012-12-27

申请号：US13595333

申请日：2012-08-27

Applicant: Chia-Ying Lin ,  Frank LaMarca ,  Stephen E. Feinberg ,  William L. Murphy ,  James R. Adox ,  Scott J. Hollister

Inventor： Chia-Ying Lin ,  Frank LaMarca ,  Stephen E. Feinberg ,  William L. Murphy ,  James R. Adox ,  Scott J. Hollister

IPC: A61F2/44 ,  A61P19/08 ,  A61K35/28 ,  A61K9/00 ,  A61K35/32

CPC classification number: A61F2/442 ,  A61F2/28 ,  A61F2/2846 ,  A61F2/30767 ,  A61F2/30942 ,  A61F2/3662 ,  A61F2/389 ,  A61F2002/2817 ,  A61F2002/30004 ,  A61F2002/30014 ,  A61F2002/30034 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30224 ,  A61F2002/30271 ,  A61F2002/30578 ,  A61F2002/30599 ,  A61F2002/30604 ,  A61F2002/30616 ,  A61F2002/30761 ,  A61F2002/30777 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30838 ,  A61F2002/30841 ,  A61F2002/30884 ,  A61F2002/30892 ,  A61F2002/3092 ,  A61F2002/30948 ,  A61F2002/30962 ,  A61F2002/30968 ,  A61F2002/3097 ,  A61F2002/30991 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0014 ,  A61F2250/0018 ,  A61F2250/0031 ,  A61F2250/0063 ,  A61F2250/0098 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00293 ,  A61F2310/00796 ,  A61F2310/00976 ,  B33Y50/00 ,  B33Y80/00

Abstract: Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The methodology utilizes either magnetic resonance images or combined magnetic resonance and computed tomography images as a template for creating either the intervertebral scaffold or the joint repair scaffold (e.g., osteochondral scaffold) with fixation to the underlying bone. The disc scaffold design may include an outer annulus that may contain desired structures and a central nucleus pulposus region that could either contain a designed microstructure or a contained hydrogel. The osteochondral scaffold may include a bone compartment interface with a cartilage compartment. The bone compartment may interface with a cutout portion of the bone through fixation components. Different microstructure designs may be created for the bone and cartilage compartment to represent desired mechanical and mass transport properties. The microstructure controls elastic and permeability property distribution within the scaffold.

Abstract translation: 公开了椎间盘修复支架和铰接关节修复支架的工程和制备方法。 该方法利用磁共振图像或组合磁共振和计算机断层摄影图像作为模板，用于创建椎间骨支架或关节修复支架（例如骨软骨骨架），固定于下面的骨。 椎间盘支架设计可以包括可以包含所需结构的外环和可以包含设计的微结构或所含的水凝胶的中心髓核区。 骨软骨支架可以包括与软骨隔室的骨隔室界面。 骨隔室可以通过固定部件与骨的切口部分相接触。 可以为骨和软骨隔室创建不同的微结构设计来表示所需的机械和质量传输性质。 微结构控制支架内的弹性和渗透性分布。

公开(公告)号：US20070270844A1

公开(公告)日：2007-11-22

申请号：US11800086

申请日：2007-05-03

Applicant: Chia-Ying Lin ,  Scott Hollister ,  Frank La Marca

Inventor： Chia-Ying Lin ,  Scott Hollister ,  Frank La Marca

IPC: A61F2/44

CPC classification number: A61F2/4455 ,  A61F2/28 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30599 ,  A61F2002/30622 ,  A61F2002/448 ,  A61F2002/449 ,  A61F2210/0004 ,  A61F2250/0063 ,  A61F2310/00365

Abstract: A biodegradable implant for use in intertransverse process spinal fusion having an absorbable matrix having a bone generating material disposed therein. A molded biodegradable case being made of bioabsorbable polymer can at least partially surround the absorbable matrix to carry a substantial portion of compression force relative to said absorbable matrix.

Abstract translation: 一种可用于跨过程脊柱融合的可生物降解植入物，其具有设置在其中的骨发生材料的可吸收基质。 由生物可吸收聚合物制成的模制的可生物降解的壳体可以至少部分地围绕可吸收的基质以承载相对于所述可吸收的基质的大部分压缩力。

公开(公告)号：US09724205B2

公开(公告)日：2017-08-08

申请号：US11800086

申请日：2007-05-03

Applicant: Chia-Ying Lin ,  Scott J. Hollister ,  Frank La Marca

Inventor： Chia-Ying Lin ,  Scott J. Hollister ,  Frank La Marca

IPC: A61F2/44 ,  A61F2/28 ,  A61F2/30

CPC classification number: A61F2/4455 ,  A61F2/28 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30599 ,  A61F2002/30622 ,  A61F2002/448 ,  A61F2002/449 ,  A61F2210/0004 ,  A61F2250/0063 ,  A61F2310/00365

Abstract: A biodegradable implant for use in intertransverse process spinal fusion having an absorbable matrix having a bone generating material disposed therein. A molded biodegradable case being made of bioabsorbable polymer can at least partially surround the absorbable matrix to carry a substantial portion of compression force relative to said absorbable matrix.

公开(公告)号：US09439948B2

公开(公告)日：2016-09-13

申请号：US11927322

申请日：2007-10-29

Applicant: Chia-Ying Lin ,  Frank LaMarca ,  William L. Murphy ,  Scott J. Hollister

Inventor： Chia-Ying Lin ,  Frank LaMarca ,  William L. Murphy ,  Scott J. Hollister

IPC: A61F2/44 ,  A61K38/18 ,  A61K38/30 ,  A61B17/70 ,  A61F2/30

CPC classification number: A61K38/1875 ,  A61B17/7059 ,  A61F2/4455 ,  A61F2002/30011 ,  A61F2002/30013 ,  A61F2002/30032 ,  A61F2002/30056 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30303 ,  A61F2002/30578 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30838 ,  A61F2002/30878 ,  A61F2002/30884 ,  A61F2002/30892 ,  A61F2002/30899 ,  A61F2002/4485 ,  A61F2210/0004 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00089 ,  A61F2310/00113 ,  A61F2310/00131 ,  A61F2310/00149 ,  A61F2310/00155 ,  A61F2310/00293 ,  A61F2310/00796 ,  A61F2310/0097 ,  A61F2310/00976 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/30

Abstract: A cage for facilitating fusion of bones, such as vertebrae, or fusion of adjacent bone surfaces is disclosed. In one form, the cage includes a plurality of spaced apart walls comprising a biodegradable polymeric material (e.g., polycaprolactone); an osteoconductive mineral coating (e.g., a calcium compound) on at least a portion of the walls; and a bioactive agent (e.g., a bone morphogenetic protein) associated with the polymeric material and/or the coating. The bioactive agent is present in amount that induces ossification between the bones or adjacent bone surfaces. The cage may also include a fixation plate connected to at least one of the walls.

Abstract translation: 公开了一种用于促进诸如椎骨之类的骨骼融合或相邻骨表面融合的笼子。 在一种形式中，笼包括多个间隔开的壁，包括可生物降解的聚合材料（例如聚己内酯）; 在壁的至少一部分上的骨传导性矿物涂层（例如钙化合物）; 和与聚合物材料和/或涂层相关联的生物活性剂（例如骨形态发生蛋白）。 生物活性剂的存在量是引起骨骼或相邻骨表面之间的骨化。 保持架还可以包括连接到至少一个壁的固定板。

公开(公告)号：US08275594B2

公开(公告)日：2012-09-25

申请号：US11927281

申请日：2007-10-29

Applicant: Chia-Ying Lin ,  Frank LaMarca ,  Stephen E. Feinberg ,  William L. Murphy ,  James R. Adox ,  Scott J. Hollister

Inventor： Chia-Ying Lin ,  Frank LaMarca ,  Stephen E. Feinberg ,  William L. Murphy ,  James R. Adox ,  Scott J. Hollister

IPC: G06G7/58

CPC classification number: A61F2/442 ,  A61F2/28 ,  A61F2/2846 ,  A61F2/30767 ,  A61F2/30942 ,  A61F2/3662 ,  A61F2/389 ,  A61F2002/2817 ,  A61F2002/30004 ,  A61F2002/30014 ,  A61F2002/30034 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30224 ,  A61F2002/30271 ,  A61F2002/30578 ,  A61F2002/30599 ,  A61F2002/30604 ,  A61F2002/30616 ,  A61F2002/30761 ,  A61F2002/30777 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30838 ,  A61F2002/30841 ,  A61F2002/30884 ,  A61F2002/30892 ,  A61F2002/3092 ,  A61F2002/30948 ,  A61F2002/30962 ,  A61F2002/30968 ,  A61F2002/3097 ,  A61F2002/30991 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0014 ,  A61F2250/0018 ,  A61F2250/0031 ,  A61F2250/0063 ,  A61F2250/0098 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00293 ,  A61F2310/00796 ,  A61F2310/00976 ,  B33Y50/00 ,  B33Y80/00

Abstract: Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The methodology utilizes either magnetic resonance images or combined magnetic resonance and computed tomography images as a template for creating either the intervertebral scaffold or the joint repair scaffold (e.g., osteochondral scaffold) with fixation to the underlying bone. The disc scaffold design may include an outer annulus that may contain desired structures and a central nucleus pulposus region that could either contain a designed microstructure or a contained hydrogel. The osteochondral scaffold may include a bone compartment interface with a cartilage compartment. The bone compartment may interface with a cutout portion of the bone through fixation components. Different microstructure designs may be created for the bone and cartilage compartment to represent desired mechanical and mass transport properties. The scaffolds are designed with a microstructure that controls elastic and permeability property distribution within the scaffold.

Abstract translation: 公开了椎间盘修复支架和铰接关节修复支架的工程和制备方法。 该方法利用磁共振图像或组合磁共振和计算机断层摄影图像作为模板，用于创建椎间骨支架或关节修复支架（例如骨软骨骨架），固定于下面的骨。 椎间盘支架设计可以包括可以包含所需结构的外环和可以包含设计的微结构或所含的水凝胶的中央髓核区。 骨软骨支架可以包括与软骨隔室的骨隔室界面。 骨隔室可以通过固定部件与骨的切口部分相接触。 可以为骨和软骨隔室创建不同的微结构设计来表示所需的机械和质量传输性质。 支架被设计成具有控制支架内的弹性和渗透性分布的微结构。

公开(公告)号：US07979150B2

公开(公告)日：2011-07-12

申请号：US10581424

申请日：2004-12-03

Applicant: Chia-Ying Lin ,  Scott J. Hollister

Inventor： Chia-Ying Lin ,  Scott J. Hollister

IPC: G06F19/00

CPC classification number: G06F19/00 ,  A61B17/866 ,  A61B2017/00004 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/30942 ,  A61F2/30965 ,  A61F2/447 ,  A61F2002/2825 ,  A61F2002/2835 ,  A61F2002/2839 ,  A61F2002/30006 ,  A61F2002/30062 ,  A61F2002/30838 ,  A61F2002/30952 ,  A61F2002/4475 ,  A61F2002/448 ,  A61F2210/0004 ,  A61F2250/0015 ,  A61F2250/0018 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00293 ,  A61F2310/00365 ,  A61L31/148

Abstract: A method of manufacturing biodegradable/bioresorbable tissue augmentation/reconstruction devices by defining material density distributions at selected time points during a material degradation lifecycle. These different density distributions are then superposed using general linear and/or nonlinear functions that could include both time and degraded base stiffness weighting factors. The material density distribution may be created using topology optimization, image-based design or computed aided design methods to create a degradable device that retains sufficient physical properties (ie modulus, strength, electrical conductivity, thermal conductivity) through the material degradation lifecycle process. Thus, any bulk degrading material can be designed using this process for any tissue augmentation/reconstruction application.

Abstract translation: 通过在材料降解生命周期期间的选定时间点定义材料密度分布来制造可生物降解/生物可再吸收的组织增强/重建装置的方法。 然后使用可以包括时间和退化的基础刚度加权因子的一般线性和/或非线性函数来叠加这些不同的密度分布。 可以使用拓扑优化，基于图像的设计或计算的辅助设计方法来创建材料密度分布，以创建通过材料降解生命周期过程保留足够的物理性质（即模量，强度，导电性，导热性）的可降解装置。 因此，任何大量降解材料可以使用该方法设计用于任何组织增加/重建应用。

公开(公告)号：US20090197417A1

公开(公告)日：2009-08-06

申请号：US12025050

申请日：2008-02-04

Applicant: Chia-Ho Liu ,  Chieh-Yu Tsai ,  Wei-Chen Lin ,  Chia-Ying Lin

Inventor： Chia-Ho Liu ,  Chieh-Yu Tsai ,  Wei-Chen Lin ,  Chia-Ying Lin

IPC: H01L21/311

CPC classification number: H01L21/31116 ,  H01L21/823468

Abstract: A method for forming spacers of different sizes includes the following steps. First a substrate is provided, which has a first element, a second element, a first material layer and a second material layer thereon. A first dry etching is performed to remove part of the second material layer to form a first spacer by the first element and to form a second side wall by the second element, so that the first material layer between the first spacer and the second side wall is exposed to become a damaged first material layer. A trimming procedure is performed to trim the damaged first material layer. A mask is used to cover the first element, the first spacer and part of the first material layer then a wet etching is performed to remove the second side wall.

Abstract translation: 用于形成不同尺寸的间隔物的方法包括以下步骤。 首先，提供具有第一元件，第二元件，第一材料层和第二材料层的基板。 执行第一干蚀刻以去除第二材料层的一部分以通过第一元件形成第一间隔物并且由第二元件形成第二侧壁，使得第一间隔物和第二侧壁之间的第一材料层 被暴露成为损坏的第一材料层。 执行修剪程序以修整损坏的第一材料层。 掩模用于覆盖第一元件，第一间隔物和第一材料层的一部分，然后进行湿蚀刻以除去第二侧壁。

公开(公告)号：US20080195211A1

公开(公告)日：2008-08-14

申请号：US11927281

申请日：2007-10-29

Applicant: Chia-Ying Lin ,  Frank LaMarca ,  Stephen E. Feinberg ,  William L. Murphy ,  James R. Adox ,  Scott J. Hollister

Inventor： Chia-Ying Lin ,  Frank LaMarca ,  Stephen E. Feinberg ,  William L. Murphy ,  James R. Adox ,  Scott J. Hollister

IPC: A61F2/44 ,  G06G7/60

CPC classification number: A61F2/442 ,  A61F2/28 ,  A61F2/2846 ,  A61F2/30767 ,  A61F2/30942 ,  A61F2/3662 ,  A61F2/389 ,  A61F2002/2817 ,  A61F2002/30004 ,  A61F2002/30014 ,  A61F2002/30034 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30224 ,  A61F2002/30271 ,  A61F2002/30578 ,  A61F2002/30599 ,  A61F2002/30604 ,  A61F2002/30616 ,  A61F2002/30761 ,  A61F2002/30777 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30838 ,  A61F2002/30841 ,  A61F2002/30884 ,  A61F2002/30892 ,  A61F2002/3092 ,  A61F2002/30948 ,  A61F2002/30962 ,  A61F2002/30968 ,  A61F2002/3097 ,  A61F2002/30991 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0014 ,  A61F2250/0018 ,  A61F2250/0031 ,  A61F2250/0063 ,  A61F2250/0098 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00293 ,  A61F2310/00796 ,  A61F2310/00976 ,  B33Y50/00 ,  B33Y80/00

Abstract: Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The methodology utilizes either magnetic resonance images or combined magnetic resonance and computed tomography images as a template for creating either the intervertebral scaffold or the joint repair scaffold (e.g., osteochondral scaffold) with fixation to the underlying bone. The disc scaffold design may include an outer annulus that may contain desired structures and a central nucleus pulposus region that could either contain a designed microstructure or a contained hydrogel. The osteochondral scaffold may include a bone compartment interface with a cartilage compartment. The bone compartment may interface with a cutout portion of the bone through fixation components. Different microstructure designs may be created for the bone and cartilage compartment to represent desired mechanical and mass transport properties. The scaffolds are designed with a microstructure that controls elastic and permeability property distribution within the scaffold.

Abstract translation: 公开了椎间盘修复支架和铰接关节修复支架的工程和制备方法。 该方法利用磁共振图像或组合磁共振和计算机断层摄影图像作为模板，用于创建椎间骨支架或关节修复支架（例如骨软骨骨架），固定于下面的骨。 椎间盘支架设计可以包括可以包含所需结构的外环和可以包含设计的微结构或所含的水凝胶的中央髓核区。 骨软骨支架可以包括与软骨隔室的骨隔室界面。 骨隔室可以通过固定部件与骨的切口部分相接触。 可以为骨和软骨隔室创建不同的微结构设计来表示所需的机械和质量传输性质。 支架被设计成具有控制支架内的弹性和渗透性分布的微结构。