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公开(公告)号：US10010573B2
公开(公告)日：2018-07-03
申请号：US14529286
申请日：2014-10-31
申请人： CHINA NATIONAL RESEARCH INSTITUTE OF FOOD AND FERMENTATION INDUSTRIES CO., LTD. , PERFECT (CHINA) CO., LTD.
发明人： Shenglin Duan , Muyi Cai , Zhe Dong , Yanqiao Liu , Xue Wang , Shiwei Liu , Jie Liu , Ruilian Hu , Zian Li
IPC分类号： A61K36/899 , A61K36/39 , A61K36/488 , A61K36/734 , A61K38/16 , A61K36/48 , A23L7/143 , A23L33/105 , A23L33/17 , A23L33/18 , A23L33/185
CPC分类号： A61K36/899 , A23L7/143 , A23L33/105 , A23L33/17 , A23L33/18 , A23L33/185 , A23V2002/00 , A61K36/39 , A61K36/48 , A61K36/488 , A61K36/734 , A61K38/168 , A61K2236/00 , A61K2300/00 , A23V2200/3202 , A23V2200/334 , A23V2250/16 , A23V2250/161 , A23V2250/1612 , A23V2250/1642 , A23V2250/21 , A23V2250/2116 , A23V2250/5488
摘要： The present invention relates to a functional engineered rice having alcoholism relief and liver protection functions for those drinking alcohol over an extended period of time or drinking alcohol excessively, and preparation method thereof. The engineered rice comprises six starting materials: coarse rice powder, isolated soy protein, kudzu root extract, corn oligopeptide, purple sweet potato powder, and hawthorn extract, and is prepared by: premixing the starting materials; employing a double screw extruder to conduct texturized processing and forming under high temperature and high pressure; and then drying, dedusting and packaging.
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2.发明申请ENGINEERED RICE HAVING ALCOHOLISM RELIEF AND LIVER PROTECTION FUNCTION, AND PREPARATION METHOD THEREOF 有权具有酒精消除和保护功能的工程水稻及其制备方法公开(公告)号：US20150118336A1
公开(公告)日：2015-04-30
申请号：US14529286
申请日：2014-10-31
申请人： CHINA NATIONAL RESEARCH INSTITUTE OF FOOD AND FERMENTATION INDUSTRIES , PERFECT (CHINA) CO., LTD.
发明人： Shenglin Duan , Muyi CAI , Zhe DONG , Yanqiao LIU , Xue WANG , Shiwei LIU , Jie LIU , Ruilian HU , Zian LI
IPC分类号： A61K36/899 , A61K36/488 , A23L1/305 , A61K36/734 , A23L1/10 , A23L1/30 , A61K38/16 , A61K36/39
CPC分类号： A61K36/899 , A23L7/143 , A23L33/105 , A23L33/17 , A23L33/18 , A23L33/185 , A23V2002/00 , A61K36/39 , A61K36/48 , A61K36/488 , A61K36/734 , A61K38/168 , A61K2236/00 , A61K2300/00 , A23V2200/3202 , A23V2200/334 , A23V2250/16 , A23V2250/161 , A23V2250/1612 , A23V2250/1642 , A23V2250/21 , A23V2250/2116 , A23V2250/5488
摘要： The present invention relates to a functional engineered rice having alcoholism relief and liver protection functions for those drinking alcohol over an extended period of time or drinking alcohol excessively, and preparation method thereof. The engineered rice comprises six starting materials: coarse rice powder, isolated soy protein, kudzu root extract, corn oligopeptide, purple sweet potato powder, and hawthorn extract, and is prepared by: premixing the starting materials; employing a double screw extruder to conduct texturized processing and forming under high temperature and high pressure; and then drying, dedusting and packaging. The coarse cereal components of the engineered rice have the effects of balancing the diet and ensuring nutrition ingestion for those consuming the rice; and the functional factors such as the corn oligopeptide, the kudzu root extract and the like have the functions of enhancing ethanol metabolism inside the body, reducing liver damage, relieving alcoholism and protecting the liver.
摘要翻译： 本发明涉及一种具有酒精中毒功能的功能性工程水稻，其具有延长使用时间或过量饮酒的饮酒者的肝脏保护功能及其制备方法。 工程大米包括六种起始材料：粗米粉，分离的大豆蛋白，葛根提取物，玉米寡肽，紫甘薯粉和山楂提取物，并通过以下方法制备：预混合原料; 采用双螺杆挤出机在高温高压下进行组织加工和成型; 然后干燥，除尘和包装。 工程大米的粗谷物成分具有平衡饮食和确保消费大米的人的营养摄入的效果; 玉米寡肽，葛根提取物等功能因子具有增强体内乙醇代谢功能，减少肝脏损伤，缓解酒精中毒和保护肝脏的功能。
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公开(公告)号：US20180094028A1
公开(公告)日：2018-04-05
申请号：US15834026
申请日：2017-12-06
发明人： MUYI CAI , HUAIYU GU , JUN LU , XINGCHANG PAN , YONG MA , LIANG CHEN
摘要： Provided is an active peptide for inhibiting an AMPA receptor and a preparation method and use thereof. The method for preparing the active peptide comprises the following steps: 1) soaking a salmon skin and crushing, adding water and beating, and then adjusting pH to 6.5-7.5; 2) subjecting to a first enzymolysis using a neutral protease; 3) subjecting to a second enzymolysis using papain enzyme and then inactivating enzyme; and 4) centrifuging the enzymatic hydrolysate, and then subjecting the centrifuged supernatant to membrane filtration, concentration and decoloration, to prepare the active peptide. The active peptide contains a tetrapeptide with an amino-acid sequence of Glu-Gly-Ala-Arg. The tetrapeptide has good solubility, can selectively inhibit neuronal synaptic transmission caused by an AMPA receptor, and has a significant antiepileptic effect.
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4.发明申请公开(公告)号：US20140147554A1
公开(公告)日：2014-05-29
申请号：US14166643
申请日：2014-01-28
发明人： Muyi Cai , Ruizeng Gu , Jun Lu , Weixue Yi , Zhe Dong , Yong Ma , Xingchang Pan , Yaguang Xu , Yongqing Ma , Feng Lin , Zhentao Jin , Wenying Liu , Liang Chen , Lu Lu
CPC分类号： A23L2/02 , A23L2/382 , A23L2/60 , A23L2/66 , A23L33/135 , A23L33/14 , A23L33/18 , A23L33/21 , A23V2002/00 , A23V2200/318 , A23V2200/3202 , A23V2200/3204 , A23V2250/042 , A23V2250/284 , A23V2250/5422 , A23V2250/76
摘要： The present invention discloses an enzyme beverage of natural garden stuff and a method for preparing the same. The enzyme beverage is prepared from a fresh juice extracted from fresh garden stuffs and added with marine fish-skin collagen peptide, as a fermentation substrate, by dilution, blending and sterilization followed by stepwise fermentation with lactobacillus and yeast in sequence. With stepwise fermentation of the garden stuff juice from two or more fresh garden stuffs with lactobacillus and yeast, and the addition of marine fish-skin collagen peptide for accelerating growth and metabolism of fermenting strains, said beverage contains more abundant metabolites from the nutritional ingredients of the natural garden stuffs, and will bring more beneficial and nutritional effects on health.
摘要翻译： 本发明公开了一种天然花园材料的酶饮料及其制备方法。 该酶饮料由新鲜花园材料提取的新鲜果汁制成，并通过稀释，混合和灭菌，然后依次用乳杆菌和酵母进行逐步发酵，作为发酵底物，加入海洋鱼皮胶原肽。 从两个或更多新鲜的园艺产品中，用乳杆菌和酵母逐步发酵花生酱汁，并加入海洋鱼皮胶原蛋白肽以加速发酵菌株的生长和代谢，所述饮料含有更丰富的营养成分的代谢物 天然花园的东西，并将为健康带来更多的有益和营养的影响。
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公开(公告)号：US10800810B2
公开(公告)日：2020-10-13
申请号：US15834026
申请日：2017-12-06
发明人： Muyi Cai , Huaiyu Gu , Jun Lu , Xingchang Pan , Yong Ma , Liang Chen
摘要： Provided is an active peptide for inhibiting an AMPA receptor and a preparation method and use thereof. The method for preparing the active peptide comprises the following steps: 1) soaking a salmon skin and crushing, adding water and beating, and then adjusting pH to 6.5-7.5; 2) subjecting to a first enzymolysis using a neutral protease; 3) subjecting to a second enzymolysis using papain enzyme and then inactivating enzyme; and 4) centrifuging the enzymatic hydrolysate, and then subjecting the centrifuged supernatant to membrane filtration, concentration and decoloration, to prepare the active peptide. The active peptide contains a tetrapeptide with an amino-acid sequence of Glu-Gly-Ala-Arg. The tetrapeptide has good solubility, can selectively inhibit neuronal synaptic transmission caused by an AMPA receptor, and has a significant antiepileptic effect.
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6.发明申请公开(公告)号：US20170143001A1
公开(公告)日：2017-05-25
申请号：US15424715
申请日：2017-02-03
发明人： MUYI CAI , RUIZENG GU , JUN LU , TAO MA , XINGCHANG PAN , ZHE DONG , YONG MA , YAGUANG XU , YONGQING MA , ZHENTAO JIN , LIANG CHEN , LU LU , WENYING LIU , YING WEI , HAIXIN ZHANG , YAN LIU , KELU CAO , JING WANG , GUOMING LI , MING ZHOU , HUI CHEN , JIAJI LI
CPC分类号： A23J3/16 , A23J3/34 , C12P21/06 , C12Y304/21062 , C12Y304/22002 , C12Y304/24028
摘要： The present invention provides a soybean oligopeptide with low allergenicity and little bitterness and its preparation method and application. The preparation method includes the following steps: 1) mixing a soybean protein powder with water to obtain a soybean protein solution, and then performing thermal denaturation on the soybean protein solution, to prepare a denatured protein solution; 2) adjusting pH value of the denatured protein solution to 6-9, and then adding a neutral protease and papain to conduct a first enzymolysis, to obtain a first enzymatic hydrolysate; 3) adding an alkaline protease and a flavor protease into the first enzymatic hydrolysate to conduct a second enzymolysis, and after performing enzyme inactivation, to obtain a second enzymatic hydrolysate; and 4) centrifuging the second enzymatic hydrolysate, and performing membrane filtration on centrifuged supernatant liquid, to obtain the soybean oligopeptide with low allergenicity and little bitterness.
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公开(公告)号：US20170164638A1
公开(公告)日：2017-06-15
申请号：US15442574
申请日：2017-02-24
发明人： MUYI CAI , RUIZENG GU , JUN LU , TAO MA , XINGCHANG PAN , ZHE DONG , YONG MA , YAGUANG XU , YONGQING MA , ZHENTAO JIN , LIANG CHEN , LU LU , WENYING LIU , YING WEI , HAIXIN ZHANG , YAN LIU , KELU CAO , JING WANG , GUOMING LI , MING ZHOU
CPC分类号： A23J1/04 , A23J3/04 , A23J3/34 , A23J3/341 , A23L17/20 , A23L33/17 , A23L33/18 , A23V2002/00 , C07K14/461 , A23V2200/304 , A23V2250/542 , A23V2250/55
摘要： Disclosed are a fish protein oligopeptide with low allergenicity and slight fishiness, and industrial preparation method and application thereof The method comprises the following steps: 1) washing fresh fish flesh and/or fish wastes, crushing, and adding water to obtain a mixture; 2) performing thermal denaturation on the mixture to obtain a denaturized protein solution; 3) centrifuging the denaturized protein solution to obtain a precipitate, and adding water into the precipitate and grinding, to obtain a slurry; 4) adjusting the slurry to pH 6-9, and sequentially adding a neutral protease, a papain and an alkaline protease to conduct enzymolysis, and after enzyme inactivation, to obtain an enzymatic hydrolysate; 5) centrifuging the enzymatic hydrolysate, and performing membrane filtration on centrifuged supernatant, to obtain the fish protein oligopeptide with low allergenicity and slight fishiness. The method completely eliminates the allergenicity and fishiness of fish proteins, and prevents release of bitter components.
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公开(公告)号：US09974321B2
公开(公告)日：2018-05-22
申请号：US15442574
申请日：2017-02-24
发明人： Muyi Cai , Ruizeng Gu , Jun Lu , Tao Ma , Xingchang Pan , Zhe Dong , Yong Ma , Yaguang Xu , Yongqing Ma , Zhentao Jin , Liang Chen , Lu Lu , Wenying Liu , Ying Wei , Haixin Zhang , Yan Liu , Kelu Cao , Jing Wang , Guoming Li , Ming Zhou
CPC分类号： A23J1/04 , A23J3/04 , A23J3/34 , A23J3/341 , A23L17/20 , A23L33/17 , A23L33/18 , A23V2002/00 , C07K14/461 , A23V2200/304 , A23V2250/542 , A23V2250/55
摘要： Disclosed are a fish protein oligopeptide with low allergenicity and slight fishiness, and industrial preparation method and application thereof. The method comprises the following steps: 1) washing fresh fish flesh and/or fish wastes, crushing, and adding water to obtain a mixture; 2) performing thermal denaturation on the mixture to obtain a denaturized protein solution; 3) centrifuging the denaturized protein solution to obtain a precipitate, and adding water into the precipitate and grinding, to obtain a slurry; 4) adjusting the slurry to pH 6-9, and sequentially adding a neutral protease, a papain and an alkaline protease to conduct enzymolysis, and after enzyme inactivation, to obtain an enzymatic hydrolysate; 5) centrifuging the enzymatic hydrolysate, and performing membrane filtration on centrifuged supernatant, to obtain the fish protein oligopeptide with low allergenicity and slight fishiness. The method completely eliminates the allergenicity and fishiness of fish proteins, and prevents release of bitter components.
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公开(公告)号：US09609883B2
公开(公告)日：2017-04-04
申请号：US14515457
申请日：2014-10-15
发明人： Muyi Cai , Ruizeng Gu , Jun Lu , Feng Lin , Yong Ma , Zhe Dong , Xingchang Pan , Yongqing Ma , Yaguang Xu , Zhentao Jin , Liang Chen , Wenying Liu , Ying Wei , Haixin Zhang , Lu Lu , Yan Liu , Tao Ma , Simeng Jiang , Kelu Cao , Jing Wang
摘要： The present invention discloses a method for producing wheat glutamine peptide using wheat gluten powder as raw material, belonging to the fields of food and biotechnology. The method includes the steps of: performing enzymolysis in two steps using Alcalase and papain with the wheat gluten powder as raw material, to obtain the wheat glutamine peptide with components with molecular weight of less than 1000 Da being more than 90%, characteristic glutamine peptide segment glutamine-arginine-glutamine (Gln-Arg-Gln, QRQ) content being more than 2.0% and glutamine content being up to 23.54% by treating the enzymatic hydrolysate by centrifugation, ultrafiltration, concentration, spray drying, etc. The produced glutamine peptide can be used as functional nutrition composition ingredient in the development and production of ordinary foods, health foods and medicines.
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公开(公告)号：US09534026B2
公开(公告)日：2017-01-03
申请号：US14583058
申请日：2014-12-24
发明人： Muyi Cai , Feng Lin , Yan Liu , Haixin Zhang , Ruizeng Gu , Jun Lu , Ying Wei
IPC分类号： C12N5/00 , C07K14/415 , C12P21/06
CPC分类号： C07K14/415 , C12N5/0043 , C12N2500/76 , C12P21/06 , C12Y304/00 , Y02P20/52
摘要： The present invention provides a corn active peptide additive for cell culture medium, wherein in the corn active peptide additive, oligopeptides with molecular weight of lower than 1000 Dalton account for equal to or more than 90 wt % of total proteins, and the oligopeptides at least comprise one or more of AP, SAP, PAL, VNAP, PSSQ, and TQPGPQ. The corn active peptide additive of the present invention can be compounded with various basic culture mediums for serum-free culture of various animal cells, which not only substantially lowers the cost for cell culturing and reduces pollution and other problems caused by an animal derived component, but also can promote cell proliferation, improve cell viability and enhance expression of cell products.
摘要翻译： 本发明提供了一种用于细胞培养基的玉米活性肽添加剂，其中在玉米活性肽添加剂中，分子量低于1000道尔顿的寡肽占总蛋白质的90重量％以上，寡肽至少 包括AP，SAP，PAL，VNAP，PSSQ和TQPGPQ中的一个或多个。 本发明的玉米活性肽添加剂可以与各种碱性培养基混合，用于各种动物细胞的无血清培养，不仅大大降低了细胞培养的成本，还减少了由动物衍生成分引起的污染和其它问题， 而且可以促进细胞增殖，提高细胞活力，增强细胞产物的表达。
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