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    Method and Device for Determining a Level of Ventilatory Assist to a Patient
    2.
    发明申请
    Method and Device for Determining a Level of Ventilatory Assist to a Patient 有权
    用于确定患者通气辅助水平的方法和装置

    公开(公告)号：US20120006327A1

    公开(公告)日：2012-01-12

    申请号：US13144129

    申请日：2010-01-14

    申请人： Christer Sinderby ,  Jennifer Beck

    发明人： Christer Sinderby ,  Jennifer Beck

    IPC分类号： A61M16/00

    CPC分类号： A61M16/0051 ,  A61B5/0488 ,  A61B5/08 ,  A61M16/026 ,  A61M2016/0027

    摘要： A method and device for determining a level of ventilatory assist to be delivered to a patient by a mechanical ventilator in response to a measure of a patient's neural respiratory drive multiplied by an amplification factor, wherein an existing predicted ventilatory assist pressure is calculated and an existing resulting pressure delivered to the patient by the mechanical ventilator is measured. The amplification factor is changed from an existing amplification factor to a new amplification factor, a new predicted ventilatory assist pressure is calculated using the new amplification factor, and a new resulting pressure delivered to the patient by the mechanical ventilator after the amplification factor has been changed is measured. The new and existing predicted ventilatory assist pressures are compared to determine an anticipated change in pressure that will be delivered to the patient, and the new and existing resulting pressures are compared to determine an actual change in pressure delivered to the patient by the mechanical ventilator. The anticipated and actual changes in pressure are compared and a decision to increase, maintain or decrease the amplification factor is delivered in response to the comparison between the anticipated change and the actual change in pressure.

    摘要翻译： 一种方法和装置，用于响应于患者的神经呼吸驱动器的乘积乘以放大系数来确定由机械呼吸机传送给患者的通气辅助水平，其中计算现有预测的通气辅助压力并存在现有的 测量由机械呼吸机输送给病人的压力。 放大因子从现有的放大因子改变为新的放大因子，使用新的放大因子计算新的预测的通气辅助压力，并且在放大因子被改变之后由机械呼吸机传递给患者的新的所得压力 被测量。 比较新的和现有的预测的通气辅助压力以确定将被递送给患者的预期压力变化，并且比较新的和现有的所得压力，以确定由机械呼吸机传递给患者的压力的实际变化。 比较压力的预期和实际变化，并响应于预期变化与实际压力变化之间的比较来提供增加，维持或降低放大系数的决定。

    Proportional pressure assist ventilation controlled by a diaphragm electromyographic signal
    3.
    发明授权
    Proportional pressure assist ventilation controlled by a diaphragm electromyographic signal 有权
    比例压力辅助通气由隔膜肌电信号控制

    公开(公告)号：US07661427B2

    公开(公告)日：2010-02-16

    申请号：US10405291

    申请日：2003-04-02

    申请人： Christer Sinderby ,  Jennifer Beck

    发明人： Christer Sinderby ,  Jennifer Beck

    IPC分类号： A61B5/04 ,  F16K31/02

    CPC分类号： A61B5/0492 ,  A61M16/0051 ,  A61M16/026 ,  A61M2210/1014 ,  A61M2230/08 ,  A61M2230/60 ,  Y10S128/925

    摘要： A closed loop system uses (a) the intensity of the diaphragm electromyogram (EMG) for a given inspiratory volume; (b) the inspiratory volume for a given EMG intensity; or (c) a combination of (a) and (b); in view of controlling the level of gas flow, gas volume or gas pressure delivered by a mechanical (lung) ventilator. The closed loop ventilator system enables for automatic or manual adjustment of the level of inspiratory support in proportion to changes in the neuro-ventilatory efficiency such that the neural drive remains stable at a desired target level. An alarm can also be used to detect changes in neuroventilatory efficiency in view of performing manual adjustments.

    摘要翻译： 闭环系统使用（a）给定吸气体积的隔膜肌电图（EMG）的强度; （b）给定EMG强度的吸气量; 或（c）（a）和（b）的组合; 考虑到控制由机械（肺）通气机输送的气体流量，气体体积或气体压力的水平。 闭环呼吸机系统能够与神经通气效率的变化成比例地自动或手动地调整吸气支持水平，使得神经驱动器保持稳定在期望的目标水平。 鉴于执行手动调整，报警器也可用于检测神经病效率的变化。

    Target drive ventilation gain controller and method
    5.
    发明申请
    Target drive ventilation gain controller and method 审中-公开
    目标驱动通风增益控制器和方法

    公开(公告)号：US20060060190A1

    公开(公告)日：2006-03-23

    申请号：US11268117

    申请日：2005-11-07

    申请人： Christer Sinderby

    发明人： Christer Sinderby

    IPC分类号： A61M11/00 ,  A61M16/00

    CPC分类号： A61N1/05 ,  A61M16/026 ,  A61M2210/1014 ,  A61M2230/08 ,  A61M2230/60

    摘要： A gain controller and method for controlling the value of a gain is used in conjunction with an electrode array for detecting a signal representative of respiratory drive output of a patient during inspiration, and a lung ventilator for assisting inspiration of the patient. The gain controller comprises an input for receiving the signal representative of respiratory drive output; a comparator for determining whether the signal representative of respiratory drive output is higher or lower than a target drive signal; and a gain adjustment unit for increasing the value of a gain when the amplitude of the signal representative of respiratory drive output is higher than the amplitude of the target drive signal and for decreasing the value of this gain when the amplitude of the signal representative of respiratory drive output is lower than the amplitude of the target drive signal. The gain is applied to the signal representative of respiratory drive output to produce an amplified respiratory drive output representative signal used for controlling the lung ventilator. The advantage of target drive ventilation is that this mode of ventilation does not depend on pressure, flow or volume measurements. A leaky ventilatory line will introduce a change in respiratory drive which will change the ventilatory assist in order to return the respiratory drive to its target level. Also, changes in the patient's metabolic or patho-physiological status which result in altered respiratory drive will be compensated.

    摘要翻译： 用于控制增益值的增益控制器和方法与用于在吸气期间检测代表患者的呼吸驱动输出的信号的电极阵列结合使用，以及用于辅助患者的吸气的肺呼吸机。 增益控制器包括用于接收代表呼吸驱动输出的信号的输入端; 用于确定代表呼吸驱动输出的信号是否高于或低于目标驱动信号的比较器; 以及增益调整单元，用于当表示呼吸驱动输出的信号的幅度高于目标驱动信号的幅度时增加增益的值，并且当表示呼吸的信号的幅度时减小该增益的值 驱动输出低于目标驱动信号的幅度。 增益被应用于代表呼吸驱动输出的信号，以产生用于控制肺呼吸机的放大的呼吸驱动输出代表信号。 目标驱动器通风的优点在于这种通风方式不依赖于压力，流量或体积测量。 泄漏的通气线将引入呼吸驱动器的变化，这将改变通气辅助以使呼吸驱动器返回到其目标水平。 此外，患者代谢或病理生理状态的变化导致呼吸道传播改变将得到补偿。

    Combined positive and negative pressure assist ventilation
    7.
    发明授权
    Combined positive and negative pressure assist ventilation 有权
    联合正负压辅助通气

    公开(公告)号：US07909034B2

    公开(公告)日：2011-03-22

    申请号：US10576636

    申请日：2004-10-21

    申请人： Christer Sinderby ,  Jennifer Beck ,  Christer Ström

    发明人： Christer Sinderby ,  Jennifer Beck ,  Christer Ström

    IPC分类号： A61M16/00

    CPC分类号： A61H31/02 ,  A61H2031/025 ,  A61H2201/5061 ,  A61H2205/083 ,  A61M16/022 ,  A61M2230/08 ,  A61M2230/60

    摘要： The present invention relates to a method of delivering combined positive and negative pressure assist ventilation to a patient, wherein a positive pressure is applied to the patient's airways to inflate the patient's lungs, a negative pressure is applied around the patient's ribcage and/or abdomen in order to reduce a load imposed by the ribcage and/or abdomen on the patient's lungs, and application of the positive and negative pressures is synchronized. The present invention also relates to a system for delivering combined positive and negative pressure assist ventilation to a patient, comprising a positive pressure ventilator connected to the patient's airways for applying a positive pressure to the patient's airways to inflate the patient's lungs, a negative pressure ventilator installed on the patient's ribcage and/or abdomen for applying a negative pressure around the patient's ribcage and/or abdomen in order to reduce a load imposed by the ribcage and/or abdomen on the patient's lungs, and a controller for synchronizing operation of the positive and negative pressure ventilators.

    摘要翻译： 本发明涉及一种向患者输送组合的正压力和负压辅助通气的方法，其中向患者的气道施加正压以使患者的肺膨胀，在患者的胸部和/或腹部周围施加负压 以减轻胸腔和/或腹部对患者肺部的负荷，同时施加正压和负压。 本发明还涉及一种用于向患者输送组合的正压力和负压辅助通气的系统，包括连接到患者气道的正压呼吸机，用于向患者的气道施加正压以使患者的肺膨胀，负压呼吸机 安装在患者的胸腔和/或腹部上，以在患者胸部和/或腹部周围施加负压，以便减少胸腔和/或腹部对患者的肺部施加的负荷，以及控制器，用于使阳性 和负压通气机。

    Method and device responsive to diaphragmatic activity for adjusting positive pressure assist during expiration
    8.
    发明授权
    Method and device responsive to diaphragmatic activity for adjusting positive pressure assist during expiration 有权
    响应于隔膜活动的方法和装置，用于调节呼气期间的正压辅助

    公开(公告)号：US07472702B2

    公开(公告)日：2009-01-06

    申请号：US10808722

    申请日：2004-03-25

    申请人： Jennifer Beck ,  Christer Sinderby

    发明人： Jennifer Beck ,  Christer Sinderby

    IPC分类号： A61M11/00

    CPC分类号： A61M16/024 ,  A61M2016/0021 ,  A61M2210/1014 ,  A61M2230/63

    摘要： A method and device for controlling positive pressure assist to a patient during expiration, measure a level of electrical activity of a patient's respiration-related muscle during expiration. In response to the measured level of electrical activity, a level of positive pressure assist to the patient during expiration is adjusted in view of minimizing the level of electrical activity of the patient's respiration-related muscle during expiration.

    摘要翻译： 一种用于在呼气期间控制对患者的正压辅助的方法和装置，测量在呼气期间患者呼吸相关肌肉的电活动水平。 考虑到所测量的电活动水平，考虑到在呼气期间最小化患者呼吸相关肌肉的电活动水平，调整在呼气期间向患者辅助的正压水平。