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    Linkers For Radiopharmaceutical Compounds
    6.
    发明申请
    Linkers For Radiopharmaceutical Compounds 审中-公开
    放射性药物化合物的接头

    公开(公告)号：US20110280802A1

    公开(公告)日：2011-11-17

    申请号：US13179035

    申请日：2011-07-08

    申请人： Christoph De Haen ,  Adrian D. Nunn ,  Rolf E. Swenson

    发明人： Christoph De Haen ,  Adrian D. Nunn ,  Rolf E. Swenson

    IPC分类号： A61K51/00 ,  C07K14/62 ,  C07K7/06 ,  C07D207/46 ,  C07D257/02 ,  C12N9/96 ,  C07K14/00

    CPC分类号： A61K51/0493 ,  A61K47/64 ,  A61K51/088 ,  C07J41/00 ,  C07K7/23 ,  C07K14/62

    摘要： A new and improved method for extending the half life of pharmaceutical compounds for use in diagnostic imaging or therapy uses a novel linker to attach a diagnostic or therapeutic moiety to a targeting peptide or another diagnostic or therapeutic moiety. The resulting compound may have the general formula M-N—O—P-Q, wherein M is the diagnostic or therapeutic moiety, N—O—P is the linker of the present invention, and Q is the targeting peptide. In another embodiment the compounds may have the formula M-N—O—P-M, wherein M is independently a diagnostic or therapeutic moiety and N—O—P is the linker of the invention. Methods for imaging or treating a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound are further provided. Methods for radiotherapy of a patient using the compounds are further provided, as are methods for preparing a radiotherapeutic agent from the compounds.

    摘要翻译： 用于延长用于诊断成像或治疗的药物化合物的半衰期的新的和改进的方法使用新的接头将诊断或治疗部分附着于靶向肽或另一诊断或治疗部分。 所得化合物可具有通式M-N-O-P-Q，其中M为诊断或治疗部分，N-O-P为本发明的接头，Q为靶向肽。 在另一个实施方案中，化合物可以具有式M-N-O-P-M，其中M独立地是诊断或治疗性部分，N-O-P是本发明的接头。 还提供了使用本发明化合物对患者进行成像或治疗的方法。 还提供了用于从化合物制备诊断显像剂的方法和试剂盒。 还提供了使用该化合物的患者放射治疗的方法，以及从化合物制备放射治疗剂的方法。

    Device for the standardization of signal intensity in the magnetic resonance images formation technique
    9.
    发明授权
    Device for the standardization of signal intensity in the magnetic resonance images formation technique 失效
    磁共振成像技术中信号强度标准化的装置

    公开(公告)号：US6031376A

    公开(公告)日：2000-02-29

    申请号：US802631

    申请日：1997-02-19

    申请人： Angelo Gallotti ,  Christoph De Haen ,  Anne Marie Smith ,  Michael N. Eakins ,  Julius P. Zodda

    发明人： Angelo Gallotti ,  Christoph De Haen ,  Anne Marie Smith ,  Michael N. Eakins ,  Julius P. Zodda

    IPC分类号： A61B5/055 ,  G01R33/28 ,  G01R33/58 ,  G01V3/00

    CPC分类号： G01R33/58 ,  G01R33/281

    摘要： Devices, and a method for the use thereof, for the standardization of signal intensity in the formation of magnetic resonance images of the human body, said devices including one or more straight, bent or flexible closed tubes with an external diameter not greater than 3 cm, an internal diameter of not less than 0.2 cm and a length of not less than 8 cm, made of susbtantially diamagnetic material, other than glass, preferably a plastic material, particularly polyvinyl chloride, each of them being filled with aqueous solutions or gels containing paramagnetic components, said tubes being kept close to the body either by means of the positioning devices of the body to which they are fixed permanently or temporarily, or by fixings which, on one side, can be fixed to the human body and on the other keep the tubes in the required positior.

    摘要翻译： 装置及其使用方法，用于在形成人体的磁共振图像时信号强度的标准化，所述装置包括一个或多个具有不大于3cm直径的弯曲或柔性封闭管 ，不小于0.2cm的内径和不小于8cm的长度，由除玻璃之外的其他抗静电材料制成，优选塑料材料，特别是聚氯乙烯，它们各自填充含有水溶液或凝胶的水溶液或凝胶 顺磁组件，所述管通过身体的定位装置保持靠近身体，它们被永久地或暂时地固定到身体上，或者通过固定在一侧可以固定到人体上并且在另一侧上的固定 将管保持在所需的位置。