-
公开(公告)号：US20130281394A1
公开(公告)日：2013-10-24
申请号：US13880720
申请日：2011-10-18
IPC分类号： C07C309/46 , A61K31/167 , C07C233/75 , C07D307/85 , A61K31/343 , C07D317/68 , A61K31/36 , C07C237/08 , A61K31/198 , C07D209/20 , A61K31/405 , C07C69/533 , A61K31/216 , C07C69/28 , A61K31/704 , A61K31/7016 , A61K31/4709 , A61K31/201 , C07C235/64
CPC分类号： C07C309/46 , A61K9/2054 , A61K9/2086 , A61K9/2846 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/197 , A61K31/198 , A61K31/201 , A61K31/216 , A61K31/343 , A61K31/36 , A61K31/405 , A61K31/4709 , A61K31/7016 , A61K31/704 , A61K38/05 , C07C69/28 , C07C69/533 , C07C233/75 , C07C235/64 , C07C237/08 , C07D209/20 , C07D307/85 , C07D317/68
摘要： Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.
摘要翻译： 本文提供了通过施用包含化学感应受体配体的组合物来治疗与化学感觉受体相关的病症的方法，包括糖尿病，肥胖症和其它代谢疾病，病症或病症。 本文还提供了用于本发明方法的化学感应受体配体组合物及其制备方法。
-
公开(公告)号：US20130303466A1
公开(公告)日：2013-11-14
申请号：US13880718
申请日：2011-10-18
IPC分类号： A61K38/06 , A61K31/4402 , A61K31/44 , A61K31/341 , A61K31/357 , A61K31/365 , A61K31/704 , A61K31/661 , A61K31/121 , A61K31/4015 , A61K31/198 , A61K31/23
CPC分类号： A61K38/06 , A61K31/121 , A61K31/198 , A61K31/23 , A61K31/231 , A61K31/341 , A61K31/357 , A61K31/365 , A61K31/401 , A61K31/4015 , A61K31/44 , A61K31/4402 , A61K31/661 , A61K31/683 , A61K31/704 , A61K45/06 , C07K5/0215 , C07K5/0808 , C07K5/0815 , C07K5/0819
摘要： Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.
-
公开(公告)号：US20130281387A1
公开(公告)日：2013-10-24
申请号：US13880719
申请日：2011-10-18
IPC分类号： A61K31/706 , A61K45/06 , A61K31/194 , A61K31/165 , A61K31/255 , A61K31/661 , A61K31/662 , A61K31/44 , A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/426 , A61K31/42 , A61K31/341 , A61K31/704 , A61K31/20 , A61K31/7008
CPC分类号： A61K31/706 , A61K31/164 , A61K31/165 , A61K31/185 , A61K31/194 , A61K31/195 , A61K31/198 , A61K31/20 , A61K31/23 , A61K31/231 , A61K31/255 , A61K31/275 , A61K31/341 , A61K31/415 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4439 , A61K31/4545 , A61K31/5377 , A61K31/661 , A61K31/662 , A61K31/7008 , A61K31/7034 , A61K31/704 , A61K45/06
摘要： Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.
-
公开(公告)号：US20100267643A1
公开(公告)日：2010-10-21
申请号：US12763926
申请日：2010-04-20
IPC分类号： A61K38/05 , A61K31/70 , A61K31/235 , A61K31/352 , A61K31/35 , A61K31/13 , A61K31/195 , A61K31/20
CPC分类号： A61K31/13 , A61K31/195 , A61K31/20 , A61K31/235 , A61K31/35 , A61K31/352 , A61K31/70 , A61K38/22 , A61K38/26 , A61K2300/00
摘要： Provided herein are compositions and methods for treating diabetes, obesity, and other metabolic diseases, disorders or conditions with chemosensory receptor ligands. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.
摘要翻译： 本文提供了用于治疗糖尿病，肥胖症和其它代谢疾病，病症或具有化学感受受体配体的病症的组合物和方法。 本文还提供了可用于本发明方法的药物组合物。
-
公开(公告)号：US20130338095A1
公开(公告)日：2013-12-19
申请号：US13880717
申请日：2011-10-18
IPC分类号： C07H19/20 , C07D213/56 , C07D285/16 , C07F7/08 , C07D241/24 , C07D495/04 , C07D317/68 , C07D493/04
CPC分类号： C07H19/20 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/216 , A61K31/277 , A61K31/34 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/4402 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/444 , A61K31/4965 , A61K31/497 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/549 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07C233/11 , C07C233/51 , C07C233/65 , C07C235/34 , C07C235/46 , C07C235/48 , C07C235/78 , C07C255/57 , C07C275/30 , C07C275/34 , C07C323/62 , C07C2601/14 , C07C2602/10 , C07D213/40 , C07D213/56 , C07D241/24 , C07D285/16 , C07D317/68 , C07D333/24 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D493/04 , C07D495/04 , C07F7/0812 , C07F9/65586 , C07H7/02
摘要： Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.
-
公开(公告)号：US20120177730A1
公开(公告)日：2012-07-12
申请号：US13345135
申请日：2012-01-06
申请人： Alain D. BARON , Martin R. BROWN , Christopher R.G. JONES , Nigel R.A. BEELEY , Mark S. FINEMAN
发明人： Alain D. BARON , Martin R. BROWN , Christopher R.G. JONES , Nigel R.A. BEELEY , Mark S. FINEMAN
CPC分类号： A61K31/155 , A61K9/0053 , A61K9/2054 , A61K9/209 , A61K9/2846 , A61K9/4808 , A61K31/19 , A61K31/198 , A61K31/7016 , A61K31/704 , A61K45/06
摘要： Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a chemosensory receptor ligand, such as a bitter receptor ligand. Also provided herein are chemosensory receptor ligand compositions, including bitter receptor ligand compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
摘要翻译： 本文提供了通过施用包含化学感应受体配体如苦味受体配体的组合物来治疗与化学感觉受体相关的病症（包括糖尿病，肥胖症和其它代谢疾病，病症或病症）的方法。 本文还提供了化学感应受体配体组合物，包括苦味受体配体组合物及其制备用于本发明方法的方法。 本文还提供包含二甲双胍及其盐及其使用方法的组合物。
-
公开(公告)号：US20120094942A1
公开(公告)日：2012-04-19
申请号：US13276177
申请日：2011-10-18
IPC分类号： A61K31/4709 , A61K31/7016 , A61K31/198 , A61K31/201 , A61K31/353 , A61K31/155 , A61K31/7032 , A61K31/194 , A61K31/575 , A61P7/12 , A61P3/04 , A61P3/00 , A61P3/10 , A61P19/10 , A61P21/00 , A61P37/00 , A61P1/00 , A61P25/24 , A61P25/22 , A61P25/00 , A61K31/20 , A61K31/704
CPC分类号： A61K31/7016 , A61K31/155 , A61K31/194 , A61K31/198 , A61K31/216 , A61K31/353 , A61K31/4709 , A61K31/575 , A61K31/7032 , A61K31/704 , A61K45/06 , A61K2300/00
摘要： Provided herein are methods of modulating hormone concentrations in a subject comprising the administration of a composition comprising a chemosensory receptor ligand, wherein the composition is adapted to deliver the ligand to one or more regions of the intestine of said subject. Also provided are methods directed to the modulation of circulating concentrations of one or more of GLP-1 (total), GLP-1 (active), GLP-2, oxyntomodulin, PYY (total), PYY 3-36, CCK, GIP, insulin, C-peptide, glycentin, uroguanylin amylin, and ghrelin (total), ghrelin (active) and glucagon.
摘要翻译： 本文提供调节受试者中激素浓度的方法，包括施用包含化学感应受体配体的组合物，其中所述组合物适于将配体递送至所述受试者的肠道的一个或多个区域。 还提供了用于调节GLP-1（总），GLP-1（活性），GLP-2，胃泌酸调节蛋白，PYY（总），PYY 3-36，CCK，GIP中的一种或多种的循环浓度的方法， 胰岛素，C-肽，甘氨酸，尿鸟嘌呤基胰岛淀粉样多肽和生长素释放肽（总），生长素释放肽（活性）和胰高血糖素。
-
公开(公告)号：US20140030332A1
公开(公告)日：2014-01-30
申请号：US13978514
申请日：2012-01-06
申请人： Alain D. Baron , Martin R. Brown , Christopher R.G. Jones , Nigel R.A. Beeley , Mark S. Fineman
发明人： Alain D. Baron , Martin R. Brown , Christopher R.G. Jones , Nigel R.A. Beeley , Mark S. Fineman
IPC分类号： A61K31/155 , A61K31/704 , A61K9/00 , A61K31/198 , A61K45/06 , A61K31/19 , A61K31/7016
CPC分类号： A61K31/155 , A61K9/0053 , A61K9/2054 , A61K9/209 , A61K9/2846 , A61K9/4808 , A61K31/19 , A61K31/198 , A61K31/7016 , A61K31/704 , A61K45/06
摘要： Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a chemosensory receptor ligand, such as a bitter receptor ligand. Also provided herein are chemosensory receptor ligand compositions, including bitter receptor ligand compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
摘要翻译： 本文提供了通过施用包含化学感应受体配体如苦味受体配体的组合物来治疗与化学感觉受体相关的病症（包括糖尿病，肥胖症和其它代谢疾病，病症或病症）的方法。 本文还提供了化学感应受体配体组合物，包括苦味受体配体组合物及其制备用于本发明方法的方法。 本文还提供包含二甲双胍及其盐及其使用方法的组合物。
-
公开(公告)号：US20110065660A1
公开(公告)日：2011-03-17
申请号：US12907909
申请日：2010-10-19
IPC分类号： A61K31/704 , A61K31/7016 , A61K31/575 , A61K31/439 , A61K31/198 , A61K31/20 , A61K31/499 , A61K31/201 , A61P3/00
CPC分类号： A61K31/7016 , A61K31/13 , A61K31/195 , A61K31/198 , A61K31/20 , A61K31/202 , A61K31/235 , A61K31/35 , A61K31/352 , A61K31/4709 , A61K31/575 , A61K31/70 , A61K45/06
摘要： Provided herein are methods for treating diabetes, obesity, and other metabolic diseases, disorders or conditions comprising chemosensory receptor ligands. Also provided herein are chemosensory receptor ligand compositions and the preparation thereof for the methods of the present invention.
摘要翻译： 本文提供了治疗糖尿病，肥胖症和包含化学感受受体配体的其它代谢疾病，病症或病症的方法。 本文还提供了化学感应受体配体组合物及其制备方法用于本发明的方法。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.043 秒)
