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公开(公告)号：US08889380B2
公开(公告)日：2014-11-18
申请号：US13604323
申请日：2012-09-05
CPC分类号： C12P17/182 , C12N9/1096 , C12N15/52 , C12N15/62 , C12P13/001 , C12Y206/01018 , Y02P20/52
摘要： The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译： 本公开涉及具有转氨酶活性的多肽，编码多肽的多核苷酸以及使用该多肽的方法。
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公开(公告)号：US08329438B2
公开(公告)日：2012-12-11
申请号：US12646907
申请日：2009-12-23
申请人： Christopher Savile , Vesna Mitchell , Xiyun Zhang , Gjalt Huisman
发明人： Christopher Savile , Vesna Mitchell , Xiyun Zhang , Gjalt Huisman
IPC分类号： C12N9/02
CPC分类号： C12N9/001 , C07K2319/00 , C12N9/0036 , C12N15/00 , C12P7/24 , C12P7/26 , C12P7/52 , C12P7/62 , C12P13/002 , C12Y103/01031 , C12Y106/99001 , Y02P20/52
摘要： The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
摘要翻译： 本公开涉及具有改进性质的工程化烯酮还原酶多肽，编码工程改造多肽的多核苷酸，相关载体，宿主细胞和用于制备工程化烯酮还原酶多肽的方法。 本公开还提供了使用工程化烯酮还原酶多肽进行化学转化的方法。
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3.发明授权Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine 有权用于从3-芳基-3-酮基丙胺生产3-芳基-3-羟基丙胺的酮还原酶多肽公开(公告)号：US08288141B2
公开(公告)日：2012-10-16
申请号：US12549293
申请日：2009-08-27
CPC分类号： C12P17/00 , C12N9/0006 , C12P13/001 , C12Y101/01164 , C12Y101/01184
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。 优化工程化的酮还原酶多肽，用于催化N-甲基-3-酮-3-（2-噻吩基）-1-丙胺向（S）-N-甲基-3-羟基-3-（2-噻吩基） -1-丙胺。
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4.发明授权Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine 有权用于从3-芳基-3-酮基丙胺生产3-芳基-3-羟基丙胺的酮还原酶多肽公开(公告)号：US08426178B2
公开(公告)日：2013-04-23
申请号：US12549154
申请日：2009-08-27
CPC分类号： C12N9/0006 , C12P13/001 , C12P17/00 , C12P41/002
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)—N,N-dimethyl-3-hydroxy-3-(2- thienyl)-1-propanamine.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。 优化了工程化酮还原酶多肽，用于催化N，N-二甲基-3-酮-3-（2-噻吩基）-1-酮基丙胺转化为（S）-N，N-二甲基-3-羟基-3-（ 2-噻吩基）-1-丙胺。
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公开(公告)号：US20100190218A1
公开(公告)日：2010-07-29
申请号：US12646907
申请日：2009-12-23
申请人： Christopher Savile , Vesna Mitchell , Xiyun Zhang , Gjalt Huisman
发明人： Christopher Savile , Vesna Mitchell , Xiyun Zhang , Gjalt Huisman
CPC分类号： C12N9/001 , C07K2319/00 , C12N9/0036 , C12N15/00 , C12P7/24 , C12P7/26 , C12P7/52 , C12P7/62 , C12P13/002 , C12Y103/01031 , C12Y106/99001 , Y02P20/52
摘要： The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
摘要翻译： 本公开涉及具有改进性质的工程化烯酮还原酶多肽，编码工程改造多肽的多核苷酸，相关载体，宿主细胞和用于制备工程化烯酮还原酶多肽的方法。 本公开还提供了使用工程化烯酮还原酶多肽进行化学转化的方法。
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公开(公告)号：US08921079B2
公开(公告)日：2014-12-30
申请号：US13378963
申请日：2010-06-21
申请人： Gregory Hughes , Paul N. Devine , Fred J. Fleitz , Brendan T. Grau , John Limanto , Christopher Savile , Emily Mundorff
发明人： Gregory Hughes , Paul N. Devine , Fred J. Fleitz , Brendan T. Grau , John Limanto , Christopher Savile , Emily Mundorff
CPC分类号： C12P17/10 , C12N9/1096 , C12P13/001 , C12P13/04 , C12P17/12 , C12P17/182 , C12Y206/01 , Y02P20/52
摘要： The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
摘要翻译： 本公开涉及在由前手性酮合成手性胺时使用转氨酶多肽的方法。
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公开(公告)号：US08293507B2
公开(公告)日：2012-10-23
申请号：US12714397
申请日：2010-02-26
CPC分类号： C12P17/182 , C12N9/1096 , C12N15/52 , C12N15/62 , C12P13/001 , C12Y206/01018 , Y02P20/52
摘要： The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译： 本公开涉及具有转氨酶活性的多肽，编码多肽的多核苷酸以及使用该多肽的方法。
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公开(公告)号：US08877475B2
公开(公告)日：2014-11-04
申请号：US13610166
申请日：2012-09-11
CPC分类号： C12P17/00 , C12N9/0006 , C12P13/001 , C12Y101/01164 , C12Y101/01184
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。 优化工程化的酮还原酶多肽，用于催化N-甲基-3-酮-3-（2-噻吩基）-1-丙胺向（S）-N-甲基-3-羟基-3-（2-噻吩基） -1-丙胺。
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公开(公告)号：US20130005017A1
公开(公告)日：2013-01-03
申请号：US13610166
申请日：2012-09-11
CPC分类号： C12P17/00 , C12N9/0006 , C12P13/001 , C12Y101/01164 , C12Y101/01184
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
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公开(公告)号：US20120329108A1
公开(公告)日：2012-12-27
申请号：US13604323
申请日：2012-09-05
CPC分类号： C12P17/182 , C12N9/1096 , C12N15/52 , C12N15/62 , C12P13/001 , C12Y206/01018 , Y02P20/52
摘要： The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译： 本公开涉及具有转氨酶活性的多肽，编码多肽的多核苷酸以及使用该多肽的方法。
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