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公开(公告)号：US08329438B2
公开(公告)日：2012-12-11
申请号：US12646907
申请日：2009-12-23
申请人： Christopher Savile , Vesna Mitchell , Xiyun Zhang , Gjalt Huisman
发明人： Christopher Savile , Vesna Mitchell , Xiyun Zhang , Gjalt Huisman
IPC分类号： C12N9/02
CPC分类号： C12N9/001 , C07K2319/00 , C12N9/0036 , C12N15/00 , C12P7/24 , C12P7/26 , C12P7/52 , C12P7/62 , C12P13/002 , C12Y103/01031 , C12Y106/99001 , Y02P20/52
摘要： The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
摘要翻译： 本公开涉及具有改进性质的工程化烯酮还原酶多肽，编码工程改造多肽的多核苷酸，相关载体，宿主细胞和用于制备工程化烯酮还原酶多肽的方法。 本公开还提供了使用工程化烯酮还原酶多肽进行化学转化的方法。
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公开(公告)号：US20100190218A1
公开(公告)日：2010-07-29
申请号：US12646907
申请日：2009-12-23
申请人： Christopher Savile , Vesna Mitchell , Xiyun Zhang , Gjalt Huisman
发明人： Christopher Savile , Vesna Mitchell , Xiyun Zhang , Gjalt Huisman
CPC分类号： C12N9/001 , C07K2319/00 , C12N9/0036 , C12N15/00 , C12P7/24 , C12P7/26 , C12P7/52 , C12P7/62 , C12P13/002 , C12Y103/01031 , C12Y106/99001 , Y02P20/52
摘要： The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
摘要翻译： 本公开涉及具有改进性质的工程化烯酮还原酶多肽，编码工程改造多肽的多核苷酸，相关载体，宿主细胞和用于制备工程化烯酮还原酶多肽的方法。 本公开还提供了使用工程化烯酮还原酶多肽进行化学转化的方法。
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公开(公告)号：US08617853B2
公开(公告)日：2013-12-31
申请号：US13329986
申请日：2011-12-19
申请人： Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James Lalonde , Gjalt Huisman
发明人： Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James Lalonde , Gjalt Huisman
CPC分类号： C12N9/0006 , C12P17/12
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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4.发明申请KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (S,E)-METHYL 2-(3-(3-(2-(7-CHLOROQUINOLIN-2-YL)VINYL)PHENYL)-3-HYDROXYPROPYL)BENZOATE 有权（S，E） - 甲基2-（3-（3-（2-（7-氯代环戊烯-2-基）乙烯基）苯基）-3-羟基丙基）苯甲酸酯的甜菜碱多糖公开(公告)号：US20120184000A1
公开(公告)日：2012-07-19
申请号：US13329986
申请日：2011-12-19
申请人： Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James Lalonde , Gjalt Huisman
发明人： Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James Lalonde , Gjalt Huisman
IPC分类号： C12P17/12
CPC分类号： C12N9/0006 , C12P17/12
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。
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5.发明授权Polypeptides for a ketoreductase-mediated stereoselective route to alpha chloroalcohols 有权用于酮还原酶介导的对α-氯代醇的立体选择性途径的多肽公开(公告)号：US08796002B2
公开(公告)日：2014-08-05
申请号：US13378618
申请日：2010-06-22
CPC分类号： C12N9/0006 , C12N9/0008 , C12P7/28 , C12P13/02 , C12P17/02 , C12Y101/01184
摘要： The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α chloroalcohols from α chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
摘要翻译： 本公开涉及工程化酮还原酶多肽及其用于从α-氯代酮制备α-氯代醇的用途。 还提供了编码工程化酮还原酶多肽和能够表达工程化酮还原酶多肽的宿主细胞的多核苷酸。
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6.发明授权Ketoreductases for the production of (S,E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hroxypropyl)benzoate 有权用于生产（S，E）-2-（3-（3-（2-（7-氯喹啉-2-基）乙烯基）苯基）-3-羟基丙基）苯甲酸甲酯的酮还原酶公开(公告)号：US08088610B2
公开(公告)日：2012-01-03
申请号：US12240986
申请日：2008-09-29
申请人： Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James LaLonde , Gjalt W. Huisman
发明人： Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James LaLonde , Gjalt W. Huisman
CPC分类号： C12N9/0006 , C12P17/12
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。
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公开(公告)号：US08759064B2
公开(公告)日：2014-06-24
申请号：US13107849
申请日：2011-05-13
CPC分类号： C12N9/2437 , C12N15/52 , C12N15/80 , C12N15/81 , C12P7/04 , C12P7/10 , C12P19/02 , C12P19/14 , C12P2203/00 , Y02E50/16
摘要： The invention relates to recombinant expression of variant forms of C1 CBH1a and homologs thereof, having improved thermostability, low-pH tolerance, specific activity and other desirable properties. Also provided are methods for producing ethanol and other valuable organic compounds by combining cellobiohydrolase variants with cellulosic materials.
摘要翻译： 本发明涉及C1 CBH1a及其同系物的变体形式的重组表达，具有改善的热稳定性，低pH耐受性，比活性和其它所需性质。 还提供了通过将纤维二糖水解酶变体与纤维素材料结合来生产乙醇和其它有价值的有机化合物的方法。
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公开(公告)号：US08383346B2
公开(公告)日：2013-02-26
申请号：US12562988
申请日：2009-09-18
申请人： Jeffrey Colbeck , Benjamin Mijts , Lorraine Joan Giver , Richard J. Fox , Vesna Mitchell , Bumshik Robert Pak , Lynne Gilson
发明人： Jeffrey Colbeck , Benjamin Mijts , Lorraine Joan Giver , Richard J. Fox , Vesna Mitchell , Bumshik Robert Pak , Lynne Gilson
CPC分类号： C12N15/1086 , C12N15/102 , C12N15/1093 , C12Q1/6876 , C40B40/06 , C40B50/06
摘要： The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.
摘要翻译： 本公开涉及用于有效合成，克隆，转化和筛选多核苷酸变体的大型不同文库的方法，其包含相对于参照多核苷酸的明确的核苷酸差异。
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公开(公告)号：US08535910B2
公开(公告)日：2013-09-17
申请号：US13349514
申请日：2012-01-12
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
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10.发明申请公开(公告)号：US20120190086A1
公开(公告)日：2012-07-26
申请号：US13378618
申请日：2010-06-22
CPC分类号： C12N9/0006 , C12N9/0008 , C12P7/28 , C12P13/02 , C12P17/02 , C12Y101/01184
摘要： The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α chloroalcohols from α chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
摘要翻译： 本公开涉及工程化酮还原酶多肽及其用于从α-氯代酮制备α-氯代醇的用途。 还提供了编码工程化酮还原酶多肽和能够表达工程化酮还原酶多肽的宿主细胞的多核苷酸。
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