公开(公告)号：US20160107438A1

公开(公告)日：2016-04-21

申请号：US14787465

申请日：2013-07-26

申请人： Antonio GRACIA VERDUGO ,  Oriol BORRELL AVILA ,  Ana Cristina GARCIA ALVAREZ ,  HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

发明人： Antonio Gracia Verdugo ,  Oriol Borrell Avila ,  Ana Cristina Garcia Alvarez

IPC分类号： B41J2/045

CPC分类号： B41J2/04535 ,  B41J2/04586 ,  B41J2/16579 ,  B41J2002/1657 ,  B41J2002/16573

摘要： Operation of a printer for printing an image is described herein. It is determined whether ejection of imaging droplets of a print fluid via a set of nozzles for printing an outstanding image portion is sufficient for preventing clogging of the set of nozzles. Upon determining that ejection of imaging droplets for printing the outstanding image portion is sufficient for preventing clogging of the set of nozzles, printing is performed by ejecting only imaging droplets of the print fluid via the set of nozzles. Upon determining that ejection of imaging droplets for printing the outstanding image portion is not sufficient for preventing clogging of the set of nozzles, a servicing procedure is to be executed of to eject purging droplets of the print fluid via the set of nozzles.

摘要翻译： 本文描述了用于打印图像的打印机的操作。 确定是否通过用于打印出色图像部分的一组喷嘴喷射印刷液体的成像液滴足以防止该组喷嘴的堵塞。 当确定用于打印出色图像部分的成像液滴的喷射足以防止该组喷嘴堵塞时，通过经由该组喷嘴仅喷射打印流体的成像液滴来进行打印。 在确定用于打印突出图像部分的成像液滴的喷射不足以防止该组喷嘴堵塞时，将执行维修程序以经由该组喷嘴喷射打印流体的吹扫液滴。

公开(公告)号：US20120283295A1

公开(公告)日：2012-11-08

申请号：US13499517

申请日：2010-09-30

申请人： Cristina Garcia Posada ,  David Selwood ,  John Garthwaite ,  David Baker ,  Lisa Clutterbuck

发明人： Cristina Garcia Posada ,  David Selwood ,  John Garthwaite ,  David Baker ,  Lisa Clutterbuck

IPC分类号： A61K31/4245 ,  C07D417/14 ,  A61K31/427 ,  A61P29/00 ,  A61P27/06 ,  A61P25/00 ,  A61P25/28 ,  A61P25/16 ,  C07D413/14 ,  A61K31/4439

CPC分类号： C07D413/14 ,  C07D417/14

摘要： The invention provides an indazole derivative of formula (1), or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1, R2, R3 and R4 are as defined herein. The indazole derivatives are capable of blockading voltage dependent sodium channels and they are useful in the treatment or prevention of normal tension glaucoma, multiple sclerosis, a motorneurone disease, stroke, spinal cord injury, Alzheimer's disease, Parkinson's disease or pain.

摘要翻译： 本发明提供式（1）的吲唑衍生物或其药学上可接受的盐或N-氧化物，其中R 1，R 2，R 3和R 4如本文所定义。 吲唑衍生物能够阻断电压依赖性钠通道，并且它们可用于治疗或预防正常张力性青光眼，多发性硬化，运动神经元疾病，中风，脊髓损伤，阿尔茨海默病，帕金森病或疼痛。

公开(公告)号：US08252923B2

公开(公告)日：2012-08-28

申请号：US12231982

申请日：2008-09-08

申请人： Robert Edward Babine ,  Shu-Hui Chen ,  Jason Eric Lamar ,  Nancy June Snyder ,  Xicheng Sun ,  Mark Joseph Tebbe ,  Frantz Victor ,  Q. May Wang ,  Yvonne Yee Mai Yip ,  Ivan Collado ,  Cristina Garcia-Paredes ,  Raymond Samuel Parker, III ,  Ling Jin ,  Deqi Guo ,  John Irvin Glass

发明人： Robert Edward Babine ,  Shu-Hui Chen ,  Jason Eric Lamar ,  Nancy June Snyder ,  Xicheng Sun ,  Mark Joseph Tebbe ,  Frantz Victor ,  Q. May Wang ,  Yvonne Yee Mai Yip ,  Ivan Collado ,  Cristina Garcia-Paredes ,  Raymond Samuel Parker, III ,  Ling Jin ,  Deqi Guo ,  John Irvin Glass

IPC分类号： C07D265/34 ,  C07D241/08 ,  C07D275/06 ,  C07D417/02 ,  C07D233/32 ,  C07D403/02 ,  C07D207/08 ,  C07D493/14 ,  C07C229/00

CPC分类号： C07K7/02 ,  A61K38/07 ,  A61K38/08 ,  A61K38/21 ,  A61K38/212 ,  A61K38/215 ,  A61K45/06 ,  C07D209/02 ,  C07D209/52 ,  C07K5/0202 ,  C07K5/0205 ,  C07K5/06052 ,  C07K5/0808 ,  C07K5/101 ,  C07K5/1016 ,  C07K7/06 ,  C07K14/005 ,  C12N2770/24222 ,  Y02P20/55 ,  A61K2300/00

摘要： The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.

摘要翻译： 本发明涉及可用作蛋白酶抑制剂的肽模拟化合物，特别是作为丝氨酸蛋白酶抑制剂，更具体地，涉及丙型肝炎NS3蛋白酶抑制剂; 中间体; 它们的制备方法包括对中间体的新型置换步骤。 本发明还涉及药物组合物和使用该化合物抑制HCV蛋白酶或治疗患有HCV感染或与感染有关的生理病症的患者的方法。 还提供了药物组合，除一种或多种HCV丝氨酸蛋白酶抑制剂外还包含一种或多种表现出抗HCV活性的干扰素和/或一种或多种具有抗HCV活性的化合物和药学上可接受的载体，以及用于治疗或预防的方法 使用该组合物的患者中的HCV感染。 本发明还涉及用于治疗或预防患者HCV感染的试剂盒或药物包装。

公开(公告)号：US20120064034A1

公开(公告)日：2012-03-15

申请号：US13293812

申请日：2011-11-10

申请人： ROBERT EDWARD BABINE ,  SHU HUI CHEN ,  IVAN COLLADO ,  CRISTINA GARCIA-PAREDES ,  JOHN IRVIN GLASS ,  DEQI GUO ,  LING JIN ,  JASON ERIC LAMAR ,  RAYMOND SAMUEL PARKER, III ,  NANCY JUNE SNYDER ,  XICHENG DAVID SUN ,  YVONNE YEE MAI YIP ,  Q. MAY WANG ,  FRANTZ VICTOR ,  MARK JOSEPH TEBBE ,  ROBERT B. PERNI ,  LUC FARMER

发明人： ROBERT EDWARD BABINE ,  SHU HUI CHEN ,  IVAN COLLADO ,  CRISTINA GARCIA-PAREDES ,  JOHN IRVIN GLASS ,  DEQI GUO ,  LING JIN ,  JASON ERIC LAMAR ,  RAYMOND SAMUEL PARKER, III ,  NANCY JUNE SNYDER ,  XICHENG DAVID SUN ,  YVONNE YEE MAI YIP ,  Q. MAY WANG ,  FRANTZ VICTOR ,  MARK JOSEPH TEBBE ,  ROBERT B. PERNI ,  LUC FARMER

IPC分类号： A61K38/08 ,  C07K5/037 ,  A61K38/21 ,  C12N5/071 ,  C07C229/42 ,  C07D209/52 ,  C12N9/99 ,  C07K7/06 ,  A61K38/20

CPC分类号： C07K7/02 ,  A61K38/07 ,  A61K38/08 ,  A61K38/21 ,  A61K38/212 ,  A61K38/215 ,  A61K45/06 ,  C07D209/02 ,  C07D209/52 ,  C07K5/0202 ,  C07K5/0205 ,  C07K5/06052 ,  C07K5/0808 ,  C07K5/101 ,  C07K5/1016 ,  C07K7/06 ,  C07K14/005 ,  C12N2770/24222 ,  Y02P20/55 ,  A61K2300/00

摘要： The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.

公开(公告)号：US20110129814A1

公开(公告)日：2011-06-02

申请号：US12936873

申请日：2009-04-08

申请人： Cristina Garcia Aljaro ,  Xavier Munoz Berbel ,  Francisco Javier Munoz ,  Anicet R. Blanch

发明人： Cristina Garcia Aljaro ,  Xavier Munoz Berbel ,  Francisco Javier Munoz ,  Anicet R. Blanch

IPC分类号： C12Q1/70 ,  C12M1/34

CPC分类号： G01N21/553 ,  G01N33/54373

摘要： The present invention relates to a process and system for detecting and/or quantifying bacteriophages capable of infecting a predetermined bacterial host strain, which is based on the surface plasmon resonance technique that takes place on the conductive material surface of an optical sensor device, and also relates to a microelectronic sensor device for carrying out this process and to the use of this microelectronic sensor device for detecting and/or quantifying bacteriophages.

摘要翻译： 本发明涉及一种用于检测和/或定量能够感染预定细菌宿主菌株的噬菌体的方法和系统，其基于在光学传感器装置的导电材料表面上发生的表面等离子体共振技术，以及 涉及用于执行该过程的微电子传感器装置以及该微电子传感器装置用于检测和/或定量噬菌体的用途。

公开(公告)号：US20100137583A1

公开(公告)日：2010-06-03

申请号：US12231982

申请日：2008-09-08

申请人： Robert Edward Babine ,  Shu-Hui Chen ,  Jason Eric Lamar ,  Nancy June Snyder ,  Xicheng Sun ,  Mark Joseph Tebbe ,  Frantz Victor ,  Q. May Wang ,  Yvonne Yee Mai Yip ,  Ivan Collado ,  Cristina Garcia-Paredes ,  Raymond Samuel Parker, III ,  Ling Jin ,  Deqi Guo ,  John Irvin Glass

发明人： Robert Edward Babine ,  Shu-Hui Chen ,  Jason Eric Lamar ,  Nancy June Snyder ,  Xicheng Sun ,  Mark Joseph Tebbe ,  Frantz Victor ,  Q. May Wang ,  Yvonne Yee Mai Yip ,  Ivan Collado ,  Cristina Garcia-Paredes ,  Raymond Samuel Parker, III ,  Ling Jin ,  Deqi Guo ,  John Irvin Glass

IPC分类号： C07D265/34 ,  C07D265/32 ,  C07D241/08 ,  C07D275/06 ,  C07D417/02 ,  C07D233/32 ,  C07D403/02 ,  C07D207/08 ,  C07D493/14 ,  C07C229/00

CPC分类号： C07K7/02 ,  A61K38/07 ,  A61K38/08 ,  A61K38/21 ,  A61K38/212 ,  A61K38/215 ,  A61K45/06 ,  C07D209/02 ,  C07D209/52 ,  C07K5/0202 ,  C07K5/0205 ,  C07K5/06052 ,  C07K5/0808 ,  C07K5/101 ,  C07K5/1016 ,  C07K7/06 ,  C07K14/005 ,  C12N2770/24222 ,  Y02P20/55 ,  A61K2300/00

摘要： The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.

摘要翻译： 本发明涉及可用作蛋白酶抑制剂的肽模拟化合物，特别是作为丝氨酸蛋白酶抑制剂，更具体地，涉及丙型肝炎NS3蛋白酶抑制剂; 中间体; 它们的制备方法包括对中间体的新型置换步骤。 本发明还涉及药物组合物和使用该化合物抑制HCV蛋白酶或治疗患有HCV感染或与感染有关的生理病症的患者的方法。 还提供了药物组合，除一种或多种HCV丝氨酸蛋白酶抑制剂外还包含一种或多种表现出抗HCV活性的干扰素和/或一种或多种具有抗HCV活性的化合物和药学上可接受的载体，以及用于治疗或预防的方法 使用该组合物的患者中的HCV感染。 本发明还涉及用于治疗或预防患者HCV感染的试剂盒或药物包装。

公开(公告)号：US10427401B2

公开(公告)日：2019-10-01

申请号：US15749450

申请日：2015-10-23

申请人： Hewlett-Packard Development Company, L.P. ,  Ana Cristina Garcia Alvarez ,  Yit Hong Tor

发明人： Ana Cristina Garcia Alvarez ,  Yit Hong Tor

IPC分类号： B41J2/045 ,  B41J2/165

摘要： A printing apparatus includes a printhead having a nozzle to eject liquid and an actuator associated with the nozzle. A controller is provided to activate a recovery sequence including heating the printhead without firing drops in a first phase, activating the actuator to fire 1000 drops or more from the nozzle in a second phase after the first phase, and heating the printhead and applying pressure to expel liquid from the nozzle in a third phase after the second phase.

公开(公告)号：US09138487B2

公开(公告)日：2015-09-22

申请号：US14119497

申请日：2012-05-22

申请人： Micaela Carvajal Alcaraz ,  Cristina Garcia Viguera ,  Diego Angel Moreno Fernandez ,  Maria del Carmen Martinez Ballesta

发明人： Micaela Carvajal Alcaraz ,  Cristina Garcia Viguera ,  Diego Angel Moreno Fernandez ,  Maria del Carmen Martinez Ballesta

IPC分类号： A61K36/31 ,  A61K9/127 ,  A61K47/48 ,  A23L2/52 ,  A23L2/66 ,  A61K8/14 ,  A61Q19/00 ,  A61K8/97 ,  A61K9/50

CPC分类号： A61K47/48815 ,  A23L2/52 ,  A23L2/66 ,  A61K8/14 ,  A61K8/97 ,  A61K9/5068 ,  A61K36/31 ,  A61K2236/00 ,  A61K2236/11 ,  A61Q19/007

摘要： The invention relates to a method for obtaining membrane vesicles enriched in membrane transport proteins of plant origin, for cosmetic or therapeutic use, which can contain other substances, such as natural bioactive compounds. Preferably, said vesicles are obtained from plants of the Brassicaceae (cruciferae) family. In addition, the invention relates to a method for increasing these proteins of plant origin.

摘要翻译： 本发明涉及一种用于获得富含植物来源的用于化妆品或治疗用途的膜转运蛋白的膜囊泡的方法，其可以含有其它物质，例如天然生物活性化合物。 优选地，所述囊泡从十字花科（十字花科）家​​族的植物获得。 此外，本发明涉及增加植物来源的这些蛋白质的方法。

公开(公告)号：US20100160664A1

公开(公告)日：2010-06-24

申请号：US11993753

申请日：2006-06-07

申请人： Pascale COLIN ,  Cristina Garcia-Escomel ,  Jean-Claude Masteau

发明人： Pascale COLIN ,  Cristina Garcia-Escomel ,  Jean-Claude Masteau

IPC分类号： C07F7/12

CPC分类号： C07F7/16

摘要： Process for preparing alkylhalosilanes are provided. The process involve reacting an alkyl halide with a solid body formed of silicon and a catalytic system.

摘要翻译： 提供了制备烷基卤代硅烷的方法。 该方法包括使烷基卤与由硅形成的固体和催化体系反应。

公开(公告)号：US20080275056A1

公开(公告)日：2008-11-06

申请号：US12089420

申请日：2006-10-23

申请人： Alfonso De Dios ,  Cristina Garcia-Paredes ,  Beatriz Lopez Uralde Garmendia ,  Mary Margaret Mader ,  Mark Andrew Pobanz ,  Chuan Shih ,  Boyu Zhong

发明人： Alfonso De Dios ,  Cristina Garcia-Paredes ,  Beatriz Lopez Uralde Garmendia ,  Mary Margaret Mader ,  Mark Andrew Pobanz ,  Chuan Shih ,  Boyu Zhong

IPC分类号： A61K31/496 ,  C07D401/14 ,  A61K31/4725

CPC分类号： C07D403/12 ,  C07D403/14

摘要： The present invention provides kinase inhibitors of Formula (I) wherein R1, R2, and X are as described herein, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供其中R1，R2和X如本文所述的式（I）的激酶抑制剂或其药学上可接受的盐。