公开(公告)号：US5705678A

公开(公告)日：1998-01-06

申请号：US775192

申请日：1996-12-30

申请人： Takeshi Nakai ,  Dai Kitamoto ,  Noboru Sayo

发明人： Takeshi Nakai ,  Dai Kitamoto ,  Noboru Sayo

IPC分类号： B01J31/22 ,  C07B61/00 ,  C07C45/51 ,  C07C45/54 ,  C07C45/72 ,  C07C49/17 ,  C07C67/31 ,  C07C67/343 ,  C07C67/347 ,  C07C69/732 ,  C07F7/00 ,  C07F7/28 ,  C07C69/73

CPC分类号： B01J31/223 ,  B01J31/2226 ,  C07C45/511 ,  C07C45/72 ,  C07C67/343 ,  C07C67/347 ,  C07F7/006 ,  B01J2231/341 ,  B01J2531/0266 ,  B01J2531/46 ,  B01J2540/34

摘要： A novel oxotitanium complex represented by general formula (I) is disclosed: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a phenyl group, a substituted phenyl group, a trialkylsilyl group, a monoalkyldiphenylsilyl group, a dialkylmonophenylsilyl group, a triphenylsilyl group, a substituted triphenylsilyl group, or a lower alkoxycarbonyl group, provided that R.sup.1 and R.sup.2 may be bonded to each other to form a hydrocarbon ring or a substituted hydrocarbon ring in cooperation with the carbon atoms to which R.sup.1 and R.sup.2 are bonded; R.sup.3 and R.sup.4 may be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a benzoyl group, a benzenesulfonyl group, or a halogen atom, provided that R.sup.3 and R.sup.4 may be bonded to each other to form a hydrocarbon ring or a substituted hydrocarbon ring in cooperation with the carbon atoms to which R.sup.3 and R.sup.4 are bonded; and n is 1 or 2. The novel oxotitanium complex is useful as an asymmetric reaction catalyst. A process for producing a .beta.-hydroxy ketone or an .alpha.-hydroxy carboxylic acid ester in the presence of the novel oxotitanium complex is also disclosed.

公开(公告)号：US20120070396A1

公开(公告)日：2012-03-22

申请号：US13276670

申请日：2011-10-19

申请人： Michiko Suzuki ,  Masaru Kitagawa ,  Shuhei Yamamoto ,  Atsushi Sogabe ,  Dai Kitamoto ,  Tomotake Morita ,  Tokuma Fukuoka ,  Tomohiro Imura

发明人： Michiko Suzuki ,  Masaru Kitagawa ,  Shuhei Yamamoto ,  Atsushi Sogabe ,  Dai Kitamoto ,  Tomotake Morita ,  Tokuma Fukuoka ,  Tomohiro Imura

IPC分类号： A61K8/60 ,  A61Q1/10 ,  A61Q1/08 ,  A61Q1/06 ,  A61Q19/08 ,  A61Q19/00

CPC分类号： C07H15/04 ,  A23L33/10 ,  A61K8/60 ,  A61K31/7032 ,  A61K36/06 ,  A61Q19/08 ,  C07H15/06 ,  C11D1/662

摘要： The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.

摘要翻译： 本发明包括作为活性成分的至少一种生物表面活性剂，特别是甘露糖基糖醇脂质（如MEL和MML）或三酰化甘露糖基糖醇脂质。 这提供了对细胞的活化和抗衰老作用优异的活化剂和抗老化剂，并且长时间安全使用，还提供化妆品，准药物，药物和饮料和食品 包括活化剂和抗老化剂作为活性成分。 此外，本发明提供了分子结构中的甘露糖基赤藓糖醇骨架为1-O-和 - D-吡喃甘露糖基 - 内消旋赤藓糖醇的MEL及使用微生物制备MEL的方法。

公开(公告)号：US20110257116A1

公开(公告)日：2011-10-20

申请号：US13170432

申请日：2011-06-28

申请人： Masaru Kitagawa ,  Michiko Suzuki ,  Shuhei Yamamoto ,  Atsushi Sogabe ,  Dai Kitamoto ,  Tomohiro Imura ,  Tokuma Fukuoka ,  Tomotake Morita

发明人： Masaru Kitagawa ,  Michiko Suzuki ,  Shuhei Yamamoto ,  Atsushi Sogabe ,  Dai Kitamoto ,  Tomohiro Imura ,  Tokuma Fukuoka ,  Tomotake Morita

IPC分类号： A61K8/60 ,  A61Q19/00

CPC分类号： A61K8/602 ,  A61Q19/00 ,  A61Q19/008

摘要： The present invention relates to a cosmetic for skin roughness improvement/skin care containing a biosurfactant, particularly MEL-A, MEL-B or MEL-C.

摘要翻译： 本发明涉及含有生物表面活性剂，特别是MEL-A，MEL-B或MEL-C的用于皮肤粗糙度改善/护肤的化妆品。

公开(公告)号：US20100168405A1

公开(公告)日：2010-07-01

申请号：US12376805

申请日：2007-08-07

申请人： Michiko Suzuki ,  Masaru Kitagawa ,  Shuhei Yamamoto ,  Atsushi Sogabe ,  Dai Kitamoto ,  Tomotake Morita ,  Tokuma Fukuoka ,  Tomohiro Imura

发明人： Michiko Suzuki ,  Masaru Kitagawa ,  Shuhei Yamamoto ,  Atsushi Sogabe ,  Dai Kitamoto ,  Tomotake Morita ,  Tokuma Fukuoka ,  Tomohiro Imura

IPC分类号： C07H15/04

CPC分类号： C07H15/04 ,  A23L33/10 ,  A61K8/60 ,  A61K31/7032 ,  A61K36/06 ,  A61Q19/08 ,  C07H15/06 ,  C11D1/662

摘要： The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.

公开(公告)号：US5714624A

公开(公告)日：1998-02-03

申请号：US775205

申请日：1996-12-30

申请人： Takeshi Nakai ,  Dai Kitamoto ,  Noboru Sayo

发明人： Takeshi Nakai ,  Dai Kitamoto ,  Noboru Sayo

IPC分类号： B01J31/22 ,  C07B61/00 ,  C07C45/51 ,  C07C45/54 ,  C07C45/72 ,  C07C49/17 ,  C07C67/31 ,  C07C67/343 ,  C07C67/347 ,  C07C69/732 ,  C07F7/00 ,  C07F7/28

CPC分类号： B01J31/223 ,  B01J31/2226 ,  C07C45/511 ,  C07C45/72 ,  C07C67/343 ,  C07C67/347 ,  C07F7/006 ,  B01J2231/341 ,  B01J2531/0266 ,  B01J2531/46 ,  B01J2540/34

摘要： A novel oxotitanium complex represented by general formula (I) is disclosed: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a phenyl group, a substituted phenyl group, a trialkylsilyl group, a monoalkyldiphenylsilyl group, a dialkylmonophenylsilyl group, a triphenylsilyl group, a substituted triphenylsilyl group, or a lower alkoxycarbonyl group, provided that R.sup.1 and R.sup.2 may be bonded to each other to form a hydrocarbon ring or a substituted hydrocarbon ring in cooperation with the carbon atoms to which R.sup.1 and R.sup.2 are bonded; R.sup.3 and R.sup.4 may be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a benzoyl group, a benzenesulfonyl group, or a halogen atom, provided that R.sup.3 and R.sup.4 may be bonded to each other to form a hydrocarbon ring or a substituted hydrocarbon ring in cooperation with the carbon atoms to which R.sup.3 and R.sup.4 are bonded; and n is 1 or 2. The novel oxotitanium complex is useful as an asymmetric reaction catalyst. A process for producing a .beta.-hydroxy ketone or an .alpha.-hydroxy carboxylic acid ester in the presence of the novel oxotitanium complex is also disclosed.

摘要翻译： 公开了由通式（I）表示的新型氧代钛络合物：其中R 1和R 2可以相同或不同，各自表示氢原子，低级烷基，低级烷氧基，卤素原子 苯基，取代苯基，三烷基甲硅烷基，单烷基二苯基甲硅烷基，二烷基单苯基甲硅烷基，三苯基甲硅烷基，取代的三苯基甲硅烷基或低级烷氧基羰基，条件是R 1和R 2可以彼此键合形成 与R1和R2键合的碳原子配合的烃环或取代的烃环; R 3和R 4可以相同或不同，并且各自表示氢原子，低级烷基，低级烷氧基，苯甲酰基，苯磺酰基或卤素原子，条件是R 3和R 4可以彼此键合 与R3和R4键合的碳原子一起形成烃环或取代的烃环; 并且n为1或2.新型氧钛复合物可用作不对称反应催化剂。 还公开了在新型氧代钛络合物存在下生产β-羟基酮或α-羟基羧酸酯的方法。

公开(公告)号：US07989599B2

公开(公告)日：2011-08-02

申请号：US12367870

申请日：2009-02-09

申请人： Michiko Suzuki ,  Masaru Kitagawa ,  Shuhei Yamamoto ,  Atsushi Sogabe ,  Dai Kitamoto ,  Tomotake Morita ,  Tokuma Fukuoka ,  Tomohiro Imura

发明人： Michiko Suzuki ,  Masaru Kitagawa ,  Shuhei Yamamoto ,  Atsushi Sogabe ,  Dai Kitamoto ,  Tomotake Morita ,  Tokuma Fukuoka ,  Tomohiro Imura

IPC分类号： C07H15/00 ,  C12P19/44 ,  C07H15/04 ,  C07H1/00

CPC分类号： C07H15/04 ,  A23L33/10 ,  A61K8/60 ,  A61K31/7032 ,  A61K36/06 ,  A61Q19/08 ,  C07H15/06 ,  C11D1/662

摘要： The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.

摘要翻译： 本发明包括作为活性成分的至少一种生物表面活性剂，特别是甘露糖基糖醇脂质（如MEL和MML）或三酰化甘露糖基糖醇脂质。 这提供了对细胞的活化和抗衰老作用优异的活化剂和抗老化剂，并且长时间安全使用，还提供化妆品，准药物，药物和饮料和食品 包括活化剂和抗老化剂作为活性成分。 此外，本发明提供了分子结构中的甘露糖基赤藓糖醇骨架为1-O-和 - D-吡喃甘露糖基 - 内消旋赤藓糖醇的MEL及使用微生物制备MEL的方法。

公开(公告)号：US20100228013A1

公开(公告)日：2010-09-09

申请号：US12367870

申请日：2009-02-09

申请人： Michiko Suzuki ,  Masaru Kitagawa ,  Shuhei Yamamoto ,  Atsushi Sogabe ,  Dai Kitamoto ,  Tomotake Morita ,  Tokuma Fukuoka ,  Tomohiro Imura

发明人： Michiko Suzuki ,  Masaru Kitagawa ,  Shuhei Yamamoto ,  Atsushi Sogabe ,  Dai Kitamoto ,  Tomotake Morita ,  Tokuma Fukuoka ,  Tomohiro Imura

IPC分类号： C07H15/04 ,  C12P19/44

CPC分类号： C07H15/04 ,  A23L33/10 ,  A61K8/60 ,  A61K31/7032 ,  A61K36/06 ,  A61Q19/08 ,  C07H15/06 ,  C11D1/662

摘要： The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.

摘要翻译： 本发明包括作为活性成分的至少一种生物表面活性剂，特别是甘露糖基糖醇脂质（如MEL和MML）或三酰化甘露糖基糖醇脂质。 这提供了对细胞的活化和抗衰老作用优异的活化剂和抗老化剂，并且长时间安全使用，还提供化妆品，准药物，药物和饮料和食品 包括活化剂和抗老化剂作为活性成分。 此外，本发明提供了分子结构中的甘露糖基赤藓糖醇骨架为1-O-和 - D-吡喃甘露糖基 - 内消旋赤藓糖醇的MEL及使用微生物制备MEL的方法。

公开(公告)号：US20100004472A1

公开(公告)日：2010-01-07

申请号：US12094727

申请日：2006-11-21

申请人： Masaru Kitagawa ,  Michiko Suzuki ,  Shuhei Yamamoto ,  Atsushi Sogabe ,  Dai Kitamoto ,  Tomohiro Imura ,  Tokuma Fukuoka ,  Tomotake Morita

发明人： Masaru Kitagawa ,  Michiko Suzuki ,  Shuhei Yamamoto ,  Atsushi Sogabe ,  Dai Kitamoto ,  Tomohiro Imura ,  Tokuma Fukuoka ,  Tomotake Morita

IPC分类号： C07D309/10

CPC分类号： A61K8/602 ,  A61Q19/00 ,  A61Q19/008

摘要： The present invention relates to a cosmetic for skin roughness improvement/skin care containing a biosurfactant, particularly MEL-A, MEL-B or MEL-C.

摘要翻译： 本发明涉及含有生物表面活性剂，特别是MEL-A，MEL-B或MEL-C的用于皮肤粗糙度改善/护肤的化妆品。

公开(公告)号：US5616751A

公开(公告)日：1997-04-01

申请号：US401800

申请日：1995-03-10

申请人： Takeshi Nakai ,  Dai Kitamoto ,  Noboru Sayo

发明人： Takeshi Nakai ,  Dai Kitamoto ,  Noboru Sayo

IPC分类号： B01J31/22 ,  C07B61/00 ,  C07C45/51 ,  C07C45/54 ,  C07C45/72 ,  C07C49/17 ,  C07C67/31 ,  C07C67/343 ,  C07C67/347 ,  C07C69/732 ,  C07F7/00 ,  C07F7/28

CPC分类号： B01J31/223 ,  B01J31/2226 ,  C07C45/511 ,  C07C45/72 ,  C07C67/343 ,  C07C67/347 ,  C07F7/006 ,  B01J2231/341 ,  B01J2531/0266 ,  B01J2531/46 ,  B01J2540/34

摘要： A novel oxotitanium complex represented by general formula (I) is disclosed: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a phenyl group, a substituted phenyl group, a trialkylsilyl group, a monoalkyldiphenylsilyl group, a dialkylmonophenylsilyl group, a triphenylsilyl group, a substituted triphenylsilyl group, or a lower alkoxycarbonyl group, provided that R.sup.1 and R.sup.2 may be bonded to each other to form a hydrocarbon ring or a substituted hydrocarbon ring in cooperation with the carbon atoms to which R.sup.1 and R.sup.2 are bonded; R.sup.3 and R.sup.4 may be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a benzoyl group, a benzenesulfonyl group, or a halogen atom, provided that R.sup.3 and R.sup.4 may be bonded to each other to form a hydrocarbon ring or a substituted hydrocarbon ring in cooperation with the carbon atoms to which R.sup.3 and R.sup.4 are bonded; and n is 1 or 2. The novel oxotitanium complex is useful as an asymmetric reaction catalyst. A process for producing a .beta.-hydroxy ketone or an .alpha.-hydroxy carboxylic acid ester in the presence of the novel oxotitanium complex is also disclosed.

摘要翻译： 公开了由通式（I）表示的新型氧代钛络合物：其中R 1和R 2可以相同或不同，各自表示氢原子，低级烷基，低级烷氧基，卤素原子 苯基，取代苯基，三烷基甲硅烷基，单烷基二苯基甲硅烷基，二烷基单苯基甲硅烷基，三苯基甲硅烷基，取代的三苯基甲硅烷基或低级烷氧基羰基，条件是R 1和R 2可以彼此键合形成 与R1和R2键合的碳原子配合的烃环或取代的烃环; R 3和R 4可以相同或不同，并且各自表示氢原子，低级烷基，低级烷氧基，苯甲酰基，苯磺酰基或卤素原子，条件是R 3和R 4可以彼此键合 与R3和R4键合的碳原子一起形成烃环或取代的烃环; 并且n为1或2.新型氧钛复合物可用作不对称反应催化剂。 还公开了在新型氧代钛络合物存在下生产β-羟基酮或α-羟基羧酸酯的方法。